Specialized Dental Care in the Brazilian Unified National Health System (SUS) by Samuel Trezena, Fabrício Emanuel Soares de Oliveira, Verônica Oliveira Dias, Petrônio José de Lima Martelli, Daniella Reis Barbosa Martelli, Hercílio Martelli Júnior

“…There was an increase in the mean number of days to be seen at the CEO in all analyzed specialties (p<0.001) and 85.2% of the CEO's managers reported that there is a reference for oral cancer confirmed cases. Conclusion: Between the PMAQ-CEO cycles the number of CEO has increased, but there are still a big pent-up demand and the presence of care gaps. …”
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Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs. by Patrizio Castagnola, Gabriele Zoppoli, Sergio Gandolfo, Massimiliano Monticone, Davide Malacarne, Gabriella Cirmena, David Brown, Cinzia Aiello, Massimo Maffei, Roberto Marino, Walter Giaretti, Monica Pentenero

“…Our study shows that: i) aneuploidy, global genomic imbalance (measured as the total number of CNAs) and specific focal CNAs occur early in the development of oral cancer and become more frequent at later stages; ii) OPMDs limited to tongue (TNG) mucosa display a higher frequency of aneuploidy compared to OPMDs confined to buccal mucosa (BM) as measured by DNA-FCM; iii) TNG OPMDs/OSCCs show peculiar features of CIN compared to BM OPMDs/OSCCs given the preferential association with total broad and specific focal CNA gains. …”
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Effects of methylene blue photodynamic therapy on oral carcinoma and leukoplakia cells by Mina N. Le, Beverly R. Wuertz, Merrill A. Biel, Rachel L. Thompson, Frank G. Ondrey

“…Conclusion This work demonstrates that MB‐mediated PDT can downregulate MMPs which are critical to the invasion and metastasis of oral cancer. These results suggest that MB PDT could be a clinically significant and cost‐effective treatment for oral leukoplakia and carcinoma. …”
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Exploring the Link between Head and Neck Cancer and Elevated Risk of Rheumatoid Arthritis: A National Population-Based Cohort Study by Chulho Kim, Hyunjae Yu, Dong-Kyu Kim

“…Notably, subgroup analysis according to cancer subtype revealed that only oral cancer survivors had an increased risk of developing RA. …”
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New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases by Li Cui, Jiarong Zheng, Ye Lu, Pei Lin, Yunfan Lin, Yucheng Zheng, Rongwei Xu, Zizhao Mai, Bing Guo, Xinyuan Zhao

“…It highlights their importance as biomarkers in oral diseases like periodontitis and oral cancer, and underscores their potential in monitoring systemic conditions. …”
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Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory by Dionne, K.R., Warnakulasuriya, S., Zain, R., Cheong, S.C.

“…We describe laboratory OPMD models that can be used to not only to reveal the genetic and molecular intricacies of oral cancer but also to develop novel screening methods and therapeutic approaches. …”

A dental-anthropological study of health and illness behaviour among Orang Asli of the Semai Tribe: the perspective of traditional healers by Saub, Roslan, Jaafar, N.

“…Information about common oral diseases and conditions were illustrated with enlarged pictures of dental caries, periodontal disease, oral cancer and cleft. The most common oral problem was toothache. …”
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ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by <em>Usnea barbata</em> Oil Extract—An In Vitro Study by Violeta Popovici, Adina Magdalena Musuc, Elena Matei, Oana Karampelas, Emma Adriana Ozon, Georgeta Camelia Cozaru, Verginica Schröder, Laura Bucur, Ludmila Aricov, Mihai Anastasescu, Mariana Așchie, Victoria Badea, Dumitru Lupuliasa, Cerasela Elena Gîrd

“…At a substantially higher ROS level in blood cells (5250.00 × 10⁴), the processes that lead to cell death—NS (30.05%), cell cycle arrest in G0/G1 (86.30%), DNA fragmentation (0.72%), and autophagy (39.37%)—are considerably lower than in CLS-354 oral cancer cells. Our work reveals the ROS-mediated anticancer potential of UBO through DNA damage and autophagy. …”
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Oral Administration of Cancer Vaccines: Challenges and Future Perspectives by Marta Gambirasi, Amin Safa, Idris Vruzhaj, Aurora Giacomin, Franca Sartor, Giuseppe Toffoli

“…Based on the immunogenicity of the gastrointestinal tract, this review critically analyses the challenges and recent advances and provides insights into the future development of oral cancer vaccines.…”
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The Potential Role of Ionic Liquid as a Multifunctional Dental Biomaterial by Md Iqbal Hossain, Abdullah Bin Shams, Shuvashis Das Gupta, Gary J. Blanchard, Ali Mobasheri, Ehsanul Hoque Apu

“…They also serve as sensors for dental chairside usage to detect oral cancer, periodontal lesions, breath-based sobriety, and dental hard tissue defects. …”
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Advances in the oral microbiota and rapid detection of oral infectious diseases by Xuan Xiao, Xuan Xiao, Shangfeng Liu, Hua Deng, Yuhan Song, Yuhan Song, Liang Zhang, Zhifeng Song, Zhifeng Song

“…Several studies have shown that the dysregulation of the oral microbiota plays a crucial role in human health conditions, such as dental caries, periodontal disease, oral cancer, other oral infectious diseases, cardiovascular diseases, diabetes, bacteremia, and low birth weight. …”
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A bibliometric and visualized in oral microbiota and cancer research from 2013 to 2022 by Zhiyu Gu, Yunkun Liu

“…The high frequency of keywords revealed key topics, including cancer (colorectal cancer, oral cancer), oral microbiota (Fusobacterium nucleatum, Porphyromonas gingivalis), and inflammation (periodontal disease). …”
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Benefits of surgical obturators in oral maxillofacial rehabilitation. Review of literature by Madelaine Bárbara Jiménez Gutiérrez, José Miguel Robaina Ruiz, Iván Díaz Cal

“…<br /><strong>Methods:</strong> Study of bibliographic review in 64 publications between 1978-2019 on the use of obturator prosthesis. 153 documents from the MEDLINE, PubMed and SciELO reference systems databases were consulted, screened and indexed on the Web of Sciences, Scopus, Redalyc and Latindex, with the use of the following descriptors: oral obturator, obturator prosthesis, oral cancer. <br /><strong>Development:</strong> Prosthetic or palatal obturators are indicated to seal the surgically or congenitally exposed tissues of the oral cavity, and are a fundamental substitute for the hard palate, alveolar bone and surrounding soft tissues. …”
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Pyroptosis-related gene-based prognostic signature for predicting the overall survival of oral squamous cell carcinoma patients by Deliang Zeng, Xiao Wang, Shuning Zhang, Ao Zheng, Qingfeng Huang, Lingyan Cao

“…PurposeOral squamous cell carcinoma (OSCC) is the most common oral cancer worldwide. Pyroptosis is a type of programmed cell death mediated by caspase, accompanied by an inflammatory response, and plays an important role in cancer progression. …”
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Current Technologies and Recent Developments for Screening of HPV-Associated Cervical and Oropharyngeal Cancers by Sunny S. Shah, Satyajyoti Senapati, Flora Klacsmann, Daniel L. Miller, Jeff J. Johnson, Hsueh-Chia Chang, M. Sharon Stack

“…We review established methods for screening of cervical and oral cancer as well as commercially-available techniques for detection of HPV DNA. …”
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HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. by Mohamed I Khalil, Canchai Yang, Lexi Vu, Smriti Chadha, Harrison Nabors, Craig Welbon, Claire D James, Iain M Morgan, William C Spanos, Dohun Pyeon

“…Further, MARCHF8 knockout in mouse oral cancer cells expressing HPV16 E6 and E7 augments cancer cell apoptosis and suppresses tumor growth in vivo. …”
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Feulgen stain as a special stain for mitotic figures and apoptotic bodies in oral squamous cell carcinoma by Sankari Radhakrishnan, Ramesh Venkatapathy, P D Balamurali, Karthik Shree V Prashad, B Premalatha, Saikat Chakraborty

“…Background: Oral cancer is one of the most prevalent cancers worldwide. …”
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Identifying related cancer types based on their incidence among people with multiple cancers by Spinelli John J, Abanto Zenaida U, Bajdik Chris D, Brooks-Wilson Angela, Gallagher Richard P

“…Among both men and women, the combinations of esophageal cancer with melanoma, and kidney cancer with oral cancer, are observed more than twice as often as expected.…”
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Diversity of the Origin of Cancer Stem Cells in Oral Squamous Cell Carcinoma and Its Clinical Implications by Chonji Fukumoto, Daisuke Uchida, Hitoshi Kawamata

“…Oral squamous cell carcinoma (OSCC) histopathologically accounts for ≥90% of oral cancer. Many clinicopathological risk factors for OSCC have also been proposed, and postoperative therapy is recommended in guidelines based on cancer stage and other risk factors. …”
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Nanoparticles-based detection of metalloproteinase by Chua, Kellyn Jia Ling

“…A group of matrix metalloproteinase, MMPs, can be used as cancer indicators, of which, a subset of the family known as MMP-7, also known as matrilysin, are used to flag out and detect numerous forms of cancer such as gastrointestinal cancer or oral cancer to name a few. As cancer is a common illness that affect the life of many, it is of utmost importance that it is detected earlier in order to reduce the overall mortality rate. …”
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