Gabapentin Disrupts Binding of Perlecan to the α₂δ₁ Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation by Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson

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The Historical Context of the Emergence of Health Systems Science (HSS): Changes in the U.S. Healthcare System and Medical Education from the 1910s to the 2010s by Hyejung Grace KONG

“…According to statistics from 2019 to 2020, 129 universities, or 83.2% of all allopathic and osteopathic medical schools taught HSS before medical clerkship. …”
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Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism by Chen X, Daniels NA, Cottrill D, Cao Y, Wang X, Li Y, Shriwas P, Qian Y, Archer MW, Whitticar NB, Jahan I, Nunemaker CS, Guo A

“…Xiaozhuo Chen,1– 7 Nigel A Daniels,1,4,5,8 David Cottrill,2,3 Yanyang Cao,2,3 Xuan Wang,2,3 Yunsheng Li,2 Pratik Shriwas,2,3 Yanrong Qian,2 Michael W Archer,1,4 Nicholas B Whitticar,4,9 Ishrat Jahan,1,4 Craig S Nunemaker,1,3– 5 Aili Guo10 1The Diabetes Institute at Ohio University, Athens, OH, 45701, USA; 2The Edison Biotechnology Institute, Athens, OH, 45701, USA; 3Department of Biological Sciences, Athens, OH, 45701, USA; 4Department of Biomedical Sciences, Athens, OH, 45701, USA; 5Heritage College of Osteopathic Medicine, Athens, OH, 45701, USA; 6Interdisciplinary Graduate Program in Molecular and Cellular Biology, Athens, OH, 45701, USA; 7Department of Chemistry and Biochemistry, Athens, OH, 45701, USA; 8Department of Specialty Medicine, Athens, OH, 45701, USA; 9Translational Biomedical Sciences Program, Ohio University, Athens, OH, 45701, USA; 10Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis (UC Davis) School of Medicine, UC Davis Health Science, Sacramento, CA, 95817, USACorrespondence: Aili GuoDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis (UC Davis) School of Medicine, UC Davis Health Science, PSSB, G400, 4150 V St., Sacramento, CA, 95817, USATel +1 916-734-3730Fax +1 916-734-2292Email alguo@ucdavis.eduCraig S NunemakerDepartment of Biomedical Sciences, 1 Ohio University, Athens, OH, 45701, USATel +1 740-593-2387Fax +1 740-593-4795Email nunemake@ohio.eduPurpose: Previously we showed that natural compound α-penta-galloyl-glucose (α-PGG) and its synthetic derivative 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose (6Cl-TGQ) act to improve insulin signaling in adipocytes by increasing glucose transport. …”
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More than just oral PrEP: exploring interest in rectal douche, dissolvable implant, removable implant and injection HIV prevention approaches among racially diverse men who have se... by Mariana Pardes, Abby E Rudolph, Amanda E Tanner, Scott D Rhodes, Elwin Wu, Omar Martinez, Ethan Levine, Miguel Munoz-Laboy, Alex Carballo-Diéguez, José Arturo Bauermeister, Alexi Chacon, Jeffrey Jacobson, Robert Bettiker, Madeline Sutton, Lilli Mann, Omar Valentin, Ariel Ilarraza, Robin Davison, Maria Isabel Fernandez

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Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome by Dorottya Nagy-Szakal, Brent L. Williams, Nischay Mishra, Xiaoyu Che, Bohyun Lee, Lucinda Bateman, Nancy G. Klimas, Anthony L. Komaroff, Susan Levine, Jose G. Montoya, Daniel L. Peterson, Devi Ramanan, Komal Jain, Meredith L. Eddy, Mady Hornig, W. Ian Lipkin

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Dysbiosis in the Dead: Human Postmortem Microbiome Beta-Dispersion as an Indicator of Manner and Cause of Death by Sierra F. Kaszubinski, Jennifer L. Pechal, Katelyn Smiles, Carl J. Schmidt, Carl J. Schmidt, Heather R. Jordan, Mariah H. Meek, Mariah H. Meek, Mariah H. Meek, M. Eric Benbow, M. Eric Benbow, M. Eric Benbow

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2494 Selectives: Implementing self-directed collaborative selectives as part of a curriculum for pre-health care professional students by Leonor Corsino, Stephanie A. Freel, Melanie Bonner, Joan Wilson, Christie McCray, Maureen Cullins, Linda S. Lee, Kathryn M. Andolsek

“…Since the implementation of the curriculum, at least 53 of 70 students who have applied (76%) were admitted to health professions or other graduate schools despite having lower initial MCAT and undergraduate GPAs in aggregate than the average of students who matriculate to allopathic medical school programs: 41 to medical schools, 3 to dental school, 2 each to osteopathic and physician assistant schools and 1 each to physical therapy, business school and law school. …”
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Remote and semi-automated methods to conduct a decentralized randomized clinical trial by Teresa Cafaro, Patrick J. LaRiccia, Brigid Bandomer, Helen Goldstein, Tracy L. Brobyn, Krystal Hunter, Satyajeet Roy, Kevin Q. Ng, Ludmil V. Mitrev, Alan Tsai, Denise Thwing, Mary Ann Maag, Myung K. Chung, Noud van Helmond

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Recurrent/Subsequent Stroke and Associated Outcomes in Geriatric Patients with OSA and Prior Stroke Events: A Retrospective Study Using the 2019 National Inpatient Sample by Rupak Desai, Sandeep Singh, Sai Priyanka Mellacheruvu, Adil Sarvar Mohammed, Roshni Soni, Ayodya Perera, Venkata Akhil Makarla, Sarayu Santhosh, Muneeb Ali Siddiqui, Bilal Khan Mohammed, Zaki Ur Rahman Mohammed, Zainab Gandhi, Ankit Vyas, Akhil Jain, Rajesh Sachdeva, Gautam Kumar

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In silico and in vivo evaluation of the anti-cryptosporidial activity of eugenol by Hattan S. Gattan, Hattan S. Gattan, Majed H. Wakid, Majed H. Wakid, Rowaid M. Qahwaji, Sarah Altwaim, Sarah Altwaim, Haifaa A. Mahjoub, Mashael S. Alfaifi, Hayam Elshazly, Hayam Elshazly, Wafa Abdullah I. Al-Megrin, Eman Abdullah Alshehri, Hatem A. Elshabrawy, Asmaa M. El-kady

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Current Understanding of COVID-19 Clinical Course and Investigational Treatments by Richard B. Aguilar, Patrick Hardigan, Bindu Mayi, Darby Sider, Jared Piotrkowski, Jinesh P. Mehta, Jenankan Dev, Yelenis Seijo, Antonio Lewis Camargo, Luis Andux, Kathleen Hagen, Marlow B. Hernandez

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The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation by Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang

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UPLC-Q/TOF-MS coupled with multivariate analysis for comparative analysis of metabolomic in Dendrobium nobile from different growth altitudes by An-jing Lu, Li-gang Cao, Dao-peng Tan, Lin Qin, Yan-liu Lu, Yong-xia Zhao, Yong Qian, Chao-jun Bai, Ji-yong Yang, Hua Ling, Jing-shan Shi, Zhou Yang, Yu-qi He

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Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Infla... by Albrakati A, Alsharif KF, Al omairi NE, Alsanie WF, Almalki ASA, Abd Elmageed ZY, Elshopakey GE, Lokman MS, Bauomy AA, Abdel Moneim AE, Kassab RB

“…Ashraf Albrakati,1 Khalaf F Alsharif,2 Naif E Al omairi,3 Walaa F Alsanie,2 Abdulraheem SA Almalki,4 Zakaria Y Abd Elmageed,5 Gehad E Elshopakey,6 Maha S Lokman,7,8 Amira A Bauomy,9 Ahmed E Abdel Moneim,8 Rami B Kassab8,10 1Department of Human Anatomy, College of Medicine, Taif University, Taif, Saudi Arabia; 2Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; 3Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia; 4Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia; 5Department of Pharmacology, Edward via College of Osteopathic Medicine, University of Louisiana at Monroe, Monroe, LA, USA; 6Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt; 7Biology Department, College of Science and Humanities, Prince Sattam bin Abdul Aziz University, Alkharj, Saudi Arabia; 8Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt; 9Department of Science Laboratories, College of Science and Arts, Qassim University, ArRassAl-Qassim, Saudi Arabia; 10Biology Department, Faculty of Science and Arts, Al Baha University, Al Makhwah Branch, Al Baha, Saudi ArabiaCorrespondence: Ahmed E Abdel MoneimDepartment of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, EgyptTel +20 1153322079Email aest1977@hotmail.comPurpose: Depression is a mood disorder accompanied by intensive molecular and neurochemical alterations. …”
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Human Tumor Targeted Cytotoxic Mast Cells for Cancer Immunotherapy by Mohammad Fereydouni, Elnaz Ahani, Parth Desai, Mona Motaghed, Anthony Dellinger, Dean D. Metcalfe, Yuzhi Yin, Sung Hyun Lee, Tal Kafri, Aadra P. Bhatt, Kristen Dellinger, Christopher L. Kepley

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Dissociation of pulse wave velocity and aortic wall stiffness in diabetic db/db mice: The influence of blood pressure by Patricia E. McCallinhart, Patricia E. McCallinhart, Yong Ung Lee, Yong Ung Lee, Avione Lee, Avione Lee, Mircea Anghelescu, Jeffrey R. Tonniges, Ed Calomeni, Gunjan Agarwal, Gunjan Agarwal, Joy Lincoln, Joy Lincoln, Joy Lincoln, Aaron J. Trask, Aaron J. Trask, Aaron J. Trask, Aaron J. Trask

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Evaluation of Spin in the Abstracts of Systematic Reviews and Meta-analyses Covering Treatments for Achilles Tendon Ruptures by Marvin Carr BS, David Dye BS, Wade Arthur BS, Ryan Ottwell BS, Byron Detweiler DO, Wesley Stotler DO, Bryan Hawkins MD, Drew N. Wright MLS, Micah Hartwell PhD, Suhao Chen MS, Zhuqi Miao PhD, Matt Vassar PhD

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Selenium Nanoparticles with Prodigiosin Rescue Hippocampal Damage Associated with Epileptic Seizures Induced by Pentylenetetrazole in Rats by Naif E. Al Omairi, Ashraf Albrakati, Khalaf F. Alsharif, Abdulraheem S. Almalki, Walaa Alsanie, Zakaria Y. Abd Elmageed, Dalia Zaafar, Maha S. Lokman, Amira A. Bauomy, Saied K. Belal, Mohamed M. Abdel-Daim, Ahmed E. Abdel Moneim, Hussain Alyami, Rami B. Kassab

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Prevalence of COVID‐19 vaccine reactogenicity among Bangladeshi physicians by Md. Anwarul Azim Majumder, Afzalunnessa Binte Lutfor, Ahbab Mohammad Fazle Rabbi, A. B. M. Muksudul Alam, Mizanur Rahman, Narayan Saha, Michael H. Campbell, Mainul Haque, Kamrun Nessa, Mohib Ullah Khondoker, Tapas Ranjan Das, Sayeeda Rahman, Fauzia Jahan, Saidur Rahman Mashreky, Abrar Wahab, Md. Tosaddeque Hossain Siddiqui, Karisha Hinkson‐Lacorbiniere, Roksana Ivy, Rezaul Islam, Yusuf Haider, Eliza Omar, S. M. Moslehuddin Ahmed, A. M. Selim Reza, A. K. M. Daud, Muiz Uddin Ahmed Choudhury, Md. Abed Hossain, Abdul Matin Pappu, Nusrat Jahan, Mohammed S. Razzaque

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What names for covert awareness? A systematic review by Caroline Schnakers, Chase Bauer, Rita Formisano, Enrique Noé, Roberto Llorens, Roberto Llorens, Nicolas Lejeune, Nicolas Lejeune, Michele Farisco, Michele Farisco, Liliana Teixeira, Ann-Marie Morrissey, Sabrina De Marco, Vigneswaran Veeramuthu, Kseniya Ilina, Kseniya Ilina, Brian L. Edlow, Olivia Gosseries, Olivia Gosseries, Matteo Zandalasini, Francesco De Bellis, Aurore Thibaut, Aurore Thibaut, Anna Estraneo, Anna Estraneo

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