Assessment of pain severity among metastasized cancer patients in oncology clinic and oncology ward, Hospital Universiti Sains Malaysia by Eleanor Usun, Uben

“…The study found that osteosarcoma patients and evidence of bone metastasized reported to have the highest prevalence of severe pain as compared to other cancer patients. …”
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Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy by Jayakumar Vadakekolathu, David J. Boocock, Kirti Pandey, Barbara-ann Guinn, Antoine Legrand, Amanda K. Miles, Clare Coveney, Rochelle Ayala, Anthony W. Purcell, Stephanie E. McArdle

“…We investigated the molecular changes that occurred after the <i>TP53</i> null osteosarcoma cells, SaOS-2, were transfected with one of two conformational p53-mutants, either R175H or R273H. …”
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Persistent Exposure to Fusobacterium nucleatum Triggers Chemokine/Cytokine Release and Inhibits the Proliferation and Osteogenic Differentiation Capabilities of Human Gingiva-Deriv... by Wenyan Kang, Wenyan Kang, Xiaoli Ji, Xiaoli Ji, Xiujun Zhang, Di Tang, Qiang Feng, Qiang Feng

“…Intriguingly, we discovered that the 64 cell differentiation-related differentially expressed genes (DEGs) were significantly enriched in cancer-related pathways, such as bone cancer, osteosarcoma and bone marrow cancer, which provides new insight into tumorigenesis during the process of GMSC osteogenic differentiation. …”
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Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy by Alicia M. Johnson, Paula V. Bennett, Katherine Z. Sanidad, Anthony Hoang, James H. Jardine, Deborah J. Keszenman, Deborah J. Keszenman, Paul F. Wilson, Paul F. Wilson

“…Treatment of normal NFF28 primary fibroblasts and U2OS osteosarcoma, A549 lung carcinoma, and U87MG glioma cells with 5–10 µM HDACi concentrations 18 h prior to cesium-137 gamma irradiation resulted in radiosensitization measured by clonogenic survival assays and increased levels of colocalized gamma-H2AX/53BP1 foci induction. …”
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EXPRESSION OF COL6A1 IN SARCOMA TISSUE AND ITS SIGNIFICANCE by HU Weiquan, ZHAO Qinfei, ZHU Longyu, HU Suping, CHEN Fangfang

“…Results Compared with normal tissue, there was a significant increase in the expression level of COL6A1 in osteosarcoma, soft tissue sarcoma, and clear cell sarcoma of the kidney. …”
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miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia [Retraction] by Wang D, Chen J, Ding Y, Kong H, You H, Zhao Y, Wei H, Liu Y

“…Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells. J Orthop Surg Res. 2019;14:398. https://doi.org/10.1186/s13018-019-1404-6, respectively. …”
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Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing by Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick, Joseph A. Ludwig

“…To determine whether sarcomas – tumors of mesenchymal origin – are subject to the same technical artifacts, we profiled patient-derived tumor explants (PDXs) propagated from three aggressive subtypes: osteosarcoma (OS), Ewing sarcoma (ES), desmoplastic small round cell tumor (DSRCT). …”
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An Exploration of Small Molecules That Bind Human Single-Stranded DNA Binding Protein 1 by Zachariah P. Schuurs, Alexander P. Martyn, Carl P. Soltau, Sam Beard, Esha T. Shah, Mark N. Adams, Laura V. Croft, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi

“…Three compounds with nanomolar affinity for hSSB1 were identified, exhibiting cytotoxicity in an osteosarcoma cell line. To our knowledge, this is the first study to identify small molecules that modulate hSSB1 activity. …”
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The Role of Immunohistochemistry in the Analysis of the Spectrum of Small Round Cell Tumours at a Tertiary Care Centre by Lawrence D’Cruze, Ruma Dutta, Shalinee Rao, Anuradha R, Suresh Varadarajan, Sarah Kuruvilla

“…Results: Forty three cases of small round cell tumours were analysed, which included 19 cases of NHL (non Hodgkin’s lymphoma), 6 cases of Ewing/PNETs (primitive neuroectodermal tumours), 3 cases of atypical carcinoid, 3 cases of olfactory neuroblastoma, 2 cases each of rhabdomyosarcoma, Wilms tumour, neuroblastoma and synovial sarcoma and 1 case each of small cell osteosarcoma, small (oat) cell carcinoma, medulloblastoma and hepatoblastoma. …”
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Clinicopathological and genetic study of a rare occurrence: Malignant transformation of fibrous dysplasia of the jaws by Ruirui Shi, Xuefen Li, Jianyun Zhang, Feng Chen, Ming Ma, Yanrui Feng, Tiejun Li

“…Methods We present the detailed clinical course of three cases of osteosarcoma arising from FD of the jaws and explore the genetic aberrations by Sanger sequencing, whole‐exome sequencing (WES) and immunohistochemistry (IHC). …”
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The Effect of Electrode Topography on the Magnetic Properties and MRI Application of Electrochemically-Deposited, Synthesized, Cobalt-Substituted Hydroxyapatite by Wei-Chun Lin, Chun-Chao Chuang, Chen-Jung Chang, Ya-Hsu Chiu, Min Yan, Cheng-Ming Tang

“…Evaluation of biocompatibility of CoHA using human osteosarcoma cells (MG63) indicated no toxic effects. …”
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Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy by Hongzhi Hu, Xiangtian Deng, Qingcheng Song, Wenbo Yang, Yiran Zhang, Weijian Liu, Shangyu Wang, Zihui Liang, Xin Xing, Jian Zhu, Junzhe Zhang, Zengwu Shao, Baichuan Wang, Yingze Zhang

“…More importantly, remarkable inhibition of tumor growth was observed in a subcutaneous xenograft model of osteosarcoma (OS) with negligible side effects. Conclusions The synergistic therapy efficacy was confirmed by effectively inducing cancer cell death in vitro and completely eradicating the tumors in vivo. …”
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Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL^®platform by Cunningham Julie M, Jenkins Robert B, Wickham-Garcia Eliza, April Craig S, Chen Beiyun, Dueck Amylou C, McCullough Ann E, Oberg Ann L, Zschunke Michael A, Asmann Yan W, Anderson S Keith, Eckel-Passow Jeanette E, Reinholz Monica M, Jen Jin, Perez Edith A, Fan Jian-Bing, Lingle Wilma L

“…In both panels, <it>erythroblastic leukemia viral oncogene homolog 2 </it>(<it>ERBB2</it>) was the most differentially expressed gene between the HER2 + and HER2 - tumors and seven additional genes had p-values < 0.05 and log2 -fold changes > |0.5| in expression between HER2 + and HER2 - tumors: <it>topoisomerase II alpha </it>(<it>TOP2A</it>), <it>cyclin a2 </it>(<it>CCNA2</it>), <it>v-fos fbj murine osteosarcoma viral oncogene homolog </it>(<it>FOS</it>), <it>wingless-type mmtv integration site family, member 5a </it>(<it>WNT5A</it>), <it>growth factor receptor-bound protein </it><it>7 </it>(<it>GRB7</it>), <it>cell division cycle 2 </it>(<it>CDC2</it>), <it>and baculoviral iap repeat-containing protein 5 </it>(<it>BIRC5</it>). …”
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Mechanisms Behind the Pharmacological Application of Biochanin-A: A review [version 3; peer review: 2 approved] by Anoop Kishore, Rekha R. Shenoy, Pawan G. Nayak, Abhinav Kanwal, Krupa Thankam George, G.L. Viswanatha, Fathima Beegum, Divya K.P, K. Nandakumar, P.V. Anuranjana

“…With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. …”
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A Comprehensive Understanding of the Genomic Bone Tumor Landscape: A Multicenter Prospective Study by Xianbiao Xie, Yiying Bian, Haomiao Li, Junqiang Yin, Lantian Tian, Renbing Jiang, Ziliang Zeng, Xiaoliang Shi, Zixiong Lei, Changhe Hou, Yueting Qu, Liwei Wang, Jingnan Shen

“…The amplification of genes such as NCOR1, VEGFA, and CCND3 mainly occurred in osteosarcoma. Germline mutation analysis reveal a high frequency of HRD related mutations (46.4%, 13/28) in this cohort. …”
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73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma by Kunal Baxi, Jiangfei Chen, Amanda Lipsitt, Nicole Hensch, Long Wang, Abhik Bandopadhyay, Aaron Sugalski, Andrea Gilbert, Eleanor Chen, Peter Houghton, Gail Tomlinson, Myron Ignatius

“…We co-expressed TP53C176F (found in two ERMS patients) and TP53P153del (identified in a patient with osteosarcoma in our clinic) in zebrafish ERMS, and find that the TP53C176F allele significantly suppressed tumor initiation with effects predominantly on enhanced apoptosis. …”
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Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1 by Sara H. Osum, Adrienne L. Watson, David A. Largaespada

“…The use of animals with naturally occurring disease has been effective for studying osteosarcoma, lymphoma, and diabetes. Spontaneous NF-like symptoms including neurofibromas and malignant peripheral nerve sheath tumors (MPNST) have been documented in several large animal species and share biological and clinical similarities with human NF1. …”
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Invasive aspergillosis in children and adolescents with solid tumors: clinical cases and registry analysis by Yu. V. Dinikina, O. V. Shadrivova, M. B. Belogurova, Yu. E. Melekhina, S. M. Ignatyeva, T. S. Bogomolova, E. G. Boychenko, S. A. Kuleva, A. S. Kolbin, N. N. Klimko

“…Background diseases were: central nervous system tumors – 33.5 %, neuroblastoma – 33.5 %, osteosarcoma – 11.0 %, Wilms tumor – 11.0 %, hemangioblastoma – 11.0 %. …”
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Neoplasias espontâneas em ratos Wistar de um centro de criação de animais de laboratório do Estado do Rio de Janeiro, Brasil Spontaneous neoplasms in Wistar rats from a center for... by Marcele Nogueira de Sousa Trotte, Rodrigo Caldas Menezes, Rogerio Tortelly

“…The neoplasms were diagnosed with the following occurrences: mammary carcinoma (42.1%), mammary fibroadenoma (13.2%), hemangiosarcoma (7.9%), adenoma of the pituitary gland (7.9%), mammary adenoma (5.3%), fibrosarcoma (5.3%), primary papillary pulmonary adenocarcinoma (2.6%), sebaceous epithelioma (2.6%), ganglioneuroblastoma in the adrenal gland (2.6%), leiomyoma of the uterus (2.6%), mesothelioma (2.6%), osteosarcoma osteoblastic (2.6%), papilloma (2.6%). In this study the prevalence of spontaneous neoplasms was lower than the ones found in similar studies and the malignant tumors predominated. …”
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Surface modification of Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for enhanced biocompatibility in implant applications by Kirti Tiwari, Andreu Blanquer, Cristina Pavan, Maura Tomatis, Nora Fernandez Navas, Federico Scaglione, Gianluca Fiore, Francesco Turci, Carme Nogués, Paola Rizzi

“…The treated sample surface demonstrated good hemocompatibility and cytocompatibility with primary human osteoblast cells (HOb) and human osteosarcoma cell line (Saos-2). Additionally, the treated samples showed higher ability to produce reactive oxygen species with respect to pristine samples, which could be convenient for preserving the implant from bacterial contamination. …”
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