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4421
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
Published 2021-01-01“…Ewing’s sarcoma (ES) samples also showed high expression, but displayed intra- and intertumor heterogeneity. Osteosarcoma had low to intermediate expression with a high percentage of GD2-negative cells. …”
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4422
Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bon...
Published 2023-03-01“…Participants must have an Eastern Cooperative Oncology Group Performance Status score of two or less, newly diagnosed disease, and histopathologic confirmation of pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone involvement, or non-RMS soft tissue sarcoma with bone involvement. …”
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4423
The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes
Published 2020-07-01“…In this study, we further investigated whether mtDYN bridges the gap between nutrient excess and chronic inflammation in T2D.Methods: Trans-mitochondrial cybrid cells derived from the 143B human osteosarcoma cell line were cultured in a medium containing glucose (25 mM) with or without saturated fatty acid (0.25 mM BSA-conjugated palmitate), and the expression of innate immunity/inflammasome molecules was compared between cybrid B4 (the major T2D-susceptible haplogroup among the Chinese population) and cybrid D4 (the major T2D-resistant haplogroup among the Chinese population). …”
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4424
Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities are defined by a specific DNA methylation profile in pediatric and juvenile population
Published 2024-01-01“…The remaining 10/27 MPNSTs variably classified as schwannoma, osteosarcoma, BCOR-altered sarcoma, rhabdomyosarcoma (RMS)-MYOD1 mutant, RMS-like, and embryonal RMS or did not match with any defined entity. …”
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4425
Long Non-Coding RNA CASC19 Sponges microRNA-532 and Promotes Oncogenicity of Clear Cell Renal Cell Carcinoma by Increasing ETS1 Expression [Retraction]
Published 2023-07-01“…Long Non-Coding RNA ASB16-AS1 Functions as a miR-760 Sponge to Facilitate the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression. Onco Targets Ther. 2020;13:2261–2274. https://doi.org/10.2147/OTT.S240022 (RETRACTED). …”
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4426
Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage
Published 2023-08-01“…The BENCHISTA project aims to understand these differences and to encourage the application of the Toronto Staging Guidelines (TG) by Population-Based Cancer Registries (PBCRs) to the most common solid paediatric cancers.MethodsPBCRs within and outside Europe were invited to participate and identify all cases of Neuroblastoma, Wilms Tumour, Medulloblastoma, Ewing Sarcoma, Rhabdomyosarcoma and Osteosarcoma diagnosed in a consecutive three-year period (2014-2017) and apply TG at diagnosis. …”
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4427
The Clinical Impact of Methotrexate-Induced Stroke-Like Neurotoxicity in Paediatric Departments: An Italian Multi-Centre Case-Series
Published 2022-06-01“…Eleven patients were included in the study.ResultsThe underlying disease was acute lymphoblastic leukemia type B in 10/11 patients, while fibroblastic osteosarcoma was present in a single subject. The median age at diagnosis was 11 years (range 4–34), and 64% of the patients were women. …”
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4428
Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology
Published 2022-03-01“…In recent years, a growing body of evidence has proved the potential therapeutic effects of erianin on various cancers, including hepatoma, melanoma, non-small-cell lung carcinoma, myelogenous leukemia, breast cancer, and osteosarcoma. Especially, the pharmacological activities of erianin, such as antioxidant and anticancer activity, have been frequently demonstrated by plenty of studies. …”
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4429
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure
Published 2023-03-01“…Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model. …”
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4430
Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
Published 2024-01-01“…Results We show that Ru1 is capable of inhibiting CSC OXPHOS function in vitro, and more importantly, it presents excellent anti-cancer activity, with low toxicity, across a large panel of human pancreatic PDXs, as well as in colorectal cancer and osteosarcoma PDXs. Mechanistic studies suggest that this activity stems from Ru1 binding to the D-loop region of the mitochondrial DNA of CSCs, inhibiting OXPHOS complex-associated transcription, leading to reduced mitochondrial oxygen consumption, membrane potential, and ATP production, all of which are necessary for CSCs, which heavily depend on mitochondrial respiration. …”
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4431
Potential differentiation of human amniotic epithelial stem and mesenchymal bone marrow cells into cardiomyocytes
Published 2015“…However the same cells have been reported to promote tumour growth when injected in mouse with osteosarcoma which also promoted pulmonary metastasis. …”
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4432
A reverse transcriptase-mediated ribosomal RNA depletion (RTR2D) strategy for the cost-effective construction of RNA sequencing libraries
Published 2020-07-01“…In a proof-of-principle study, we found that RNA-seq dataset from RTR2D-depleted rRNA samples identified more differentially expressed mRNAs and lncRNAs regulated by Nutlin3A in human osteosarcoma cells than that from NEBNext rRNA Depletion samples, suggesting that RTR2D may have lower off-target depletion of non-rRNA transcripts. …”
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4433
Homeward
Published 2022-04-01“…But in the towering shadows of outspread branches, a voracious beetle (chondrogenic osteosarcoma) was boring through the bark and into the concentric rings of the wood underneath. …”
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4434
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
Published 2022-10-01“…Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. …”
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4435
Myositis ossificans in the infraspinatus muscle: The key to diagnosis
Published 2019-11-01“…Abstract The zone phenomenon is the most important diagnostic feature in differentiating myositis ossificans from malignancies such as osteosarcomas, which calcify from the center to the periphery and its presence in our late‐stage lesion was the key to diagnosis.…”
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4436
Malignant osteoblastoma of the skull.
Published 1993“…These tumours are extremely rare and share several histological features with the benign osteoblastomas and low grade osteosarcomas. They may be associated with local invasion and pulmonary metastases. …”
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4437
Primary Sarcoma of the Head and Neck: Three Years’ Experience in a Tertiary Care Cancer Center
Published 2022-01-01“…In adults, osteosarcomas were commonest followed by conventional grade 1 chondrosarcoma. …”
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4438
Incidencia y distribución de tumores sólidos malignos en niños de 0-15 años, según tipo histológico, edad y género
Published 2018-08-01“…En niños de 10 a 12 años fueron los Rabdomiosarcomas y Osteosarcomas, con un predominio en el sexo masculino (59,6%). …”
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4439
Li–Fraumeni Syndrome: Mutation of <i>TP53</i> Is a Biomarker of Hereditary Predisposition to Tumor: New Insights and Advances in the Treatment
Published 2022-07-01“…The most frequent tumors that arise in patients under the age of 45 are osteosarcomas, soft-tissue sarcomas, breast tumors in young women, leukemias/lymphomas, brain tumors, and tumors of the adrenal cortex. …”
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4440
Simposium de oncopediatría
Published 2019-09-01“…SOLCA atiende alrededor de 10,000 pacientes nuevos por año, de los que 1,900 son pacientes con diagnóstico confirmado de cáncer, un 10% de ese total son niños, de los que una gran parte de estos pacientes tienen leucemias, seguido de los tumores cerebrales, linfomas, nefroblastomas, osteosarcomas, retinoblastomas, neuroblastomas, rabdomiosarcomas y hepatoblastomas, en ese orden de frecuencia que no es la que comúnmente se encuentra en los países desarrollados. …”
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