POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas. by Bente Vilming Elgaaen, Kari Bente Foss Haug, Junbai Wang, Ole Kristoffer Olstad, Dario Fortunati, Mathias Onsrud, Anne Cathrine Staff, Torill Sauer, Kaare M Gautvik

“…Previously, we reported a limited number of mRNAs strongly upregulated in human osteosarcomas and other malignancies, and six were selected to be tested for a possible association with three subgroups of ovarian carcinomas and clinical parameters. …”
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αB-crystallin as a promising target in pathological conditions – A review by Marta Maksimiuk, Aleksandra Sobiborowicz, Agnieszka Tuzimek, Andrzej Deptała, Aleksandra Czerw, Anna Maria Badowska-Kozakiewicz

“…Considering other malignancies, its various roles were established in colorectal and gastric cancers, head and neck squamous cell carcinomas and osteosarcomas. Conclusions Further studies concerning αB-crystallin seem to be enormously promising, as they might improve our understanding of common human pathologies as well as contemporary diagnostics and treatment.…”
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Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience by Hammas Nawal, Laila Chbani, Youssef Alaoui Lamrani, Hind El, Harmouch Taoufiq, Siham Tizniti, Afaf Amarti

“…</p> <p>Results</p> <p>Immunohistochemical analysis showed a P63 nuclear expression in all giant cell tumors of bone, in 50% of osteoid osteomas, 40% of aneurysmal bone cysts, 37.5% of osteoblastomas, 33.3% of chondromyxoide fibromas, 25% of non ossifiant fibromas and 8.3% of osteosarcomas. Only one case of chondroblastoma was included in this series and expressed p63. …”
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Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours by Kresse Stine H, Szuhai Karoly, Barragan-Polania Ana H, Rydbeck Halfdan, Cleton-Jansen Anne-Marie, Myklebost Ola, Meza-Zepeda Leonardo A

“…Bone tumours like osteosarcomas are heterogeneous tumours with complex karyotypes that may be difficult to interpret, and it is of importance to be able to well separate the copy number levels and detect copy number changes in subpopulations. …”
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A 3D-printed patient-specific modular implants for pelvic reconstruction of bone tumors involving the sacroiliac joint by Zhaorui Lv, Zhenfeng Li, Qiang Yang, Jianmin Li

“…Two female and four male patients with a mean age of 41.83 years (range 25–65 years) were included. Two were osteosarcomas, two chondrosarcomas, one malignant fibrous histiocytoma, and one giant cell tumor of bone. …”
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Biological reconstruction of the bone defects with free fibula flap after resections of extremity located bone tumors: Clinical and radiological short-term results by Onur Basci, Bulent Erol

“…Diagnoses included five osteosarcomas, six Ewing's sarcomas, one high-grade chondrosarcoma, and one aneurysmal bone cyst. …”
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Loss of Function of the Retinoblastoma Gene Affects Gap Junctional Intercellular Communication and Cell Fate in Osteoblasts by Elisha Pendleton, Anthony Ketner, Phil Ransick, Doug Ardekani, Thomas Bodenstine, Nalini Chandar

“…Loss of function of the Retinoblastoma gene (RB1) due to mutations is commonly seen in human osteosarcomas. One of the Rb1 gene functions is to facilitate cell fate from mesenchymal stem cells to osteoblasts and prevent adipocyte differentiations. …”
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Incidence rates of the most common canine tumors based on data from the Swiss Canine Cancer Registry (2008 to 2020). by Elena Sophie Dhein, Ulla Heikkilä, Anna Oevermann, Sohvi Blatter, Daniela Meier, Sonja Hartnack, Franco Guscetti

“…Potential novel breed-specific predispositions were uncovered, with high IRs for several benign and malignant tumors in Polski Owczarek Nizinnys (overall IR: 3'303; 95%CI 2'502-3'864) and high IRs for malignant tumors in Russian Black Terriers (melanomas: 345; 95%CI 138-708), Field Spaniels (adenocarcinomas: 376; CI95% 138-817), Dogo Argentinos (mast cell tumors: 844; CI95% 591-1'169), King Charles Spaniels and Manchester Terriers (lymphomas: 319; CI95% 137-627 and 302; CI95% 98-704, respectively), Landseers (osteosarcomas: 74; CI95% 15-216), Bouvier des Flandres (hemangiosarcomas: 127; CI95% 26-371), and Bearded Collies and Cane Corso Italianos (gliomas: 91; CI95% 45-162 and 34; CI95% 7-99, respectively). …”
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MSH-5: índice para la detección oportuna de tumores malignos de rodilla by Gustavo Rivera-Saldívar, Rubén Torres-Gonzalez, Alejandra Cario-Méndez, Romeo Tecualt-Gómez, Rubén Amaya-Zepeda, Armando Alcántara-Corona, Silvestre Fuentes-Figueroa

“…El diagnóstico erróneo más frecuente es tendinitis, en el cual el 31% corresponden a osteosarcomas y el 21% a sarcomas de Ewing. Objetivo. …”
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Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy by Bassel Nazha, Cengiz Inal, Taofeek K. Owonikoko

“…Disialoganglioside GD2 is highly expressed by almost all neuroblastomas, by most melanomas and retinoblastomas, and by many Ewing sarcomas and, to a more variable degree, by small cell lung cancer, gliomas, osteosarcomas, and soft tissue sarcomas. Successful treatment of disialoganglioside GD2-expressing tumors with anti-GD2 monoclonal antibodies is hindered by pharmacologic factors such as insufficient antibody affinity to mediate antibody-dependent cell-mediated cytotoxicity, inadequate penetration of antibody into the tumor microenvironment, and toxicity related to disialoganglioside GD2 expression by normal tissues such as peripheral sensory nerve fibers. …”
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2-APCAs, the Novel Microtubule Targeting Agents Active against Distinct Cancer Cell Lines by Sergei Boichuk, Aigul Galembikova, Firuza Bikinieva, Pavel Dunaev, Aida Aukhadieva, Kirill Syuzov, Svetlana Zykova, Nazim Igidov, Alexander Ksenofontov, Pavel Bocharov

“…Here, we report the discovery of 2-amino-pyrrole-carboxamides (2-APCAs), a novel class of MTA, which effectively inhibited the growth of the broad spectrum of cancer cell lines in vitro, including various types of breast, prostate, and non-small lung cancer (NSLC), soft tissue sarcomas (STS) (e.g., leio-, rhabdomyo-, and fibrosarcomas), osteosarcomas and gastrointestinal stromal tumors (GISTs). …”
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DIAGNOSTIC ACCURACY OF MAGNETIC RESONANCE IMAGING IN DIAGNOSING BONE TUMORS KEEPING HISTOPATHOLOGICAL CORRELATION AS GOLD STANDARD by Ambreen Farooq, Shahla Zameer, Rehana Khadim, Anum Manzoor

“…Among the benign tumors vertebral hemangiomas were most commonly found 5 (10.0%) followed by osteochondroma which was 4 (8.0%), while among malignant tumors metastatic deposits/secondaries were most commonly found 11 (22.0%), followed by multiple myeloma 6 (12.0%) then Ewing Sarcoma and Osteosarcomas. Study showed sensitivity, specificity and accuracy in differentiating benign from malignant of 94.12%, 90% and 92.59%. …”
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What is the patient acceptance when only scapulectomy is possible in case of malignant tumor? A case series by Hugo Barret, MD, Olivier Bozon, MD, Guillaume Fassot, MD, Michel Chammas, MD, PhD, Bertrand Coulet, MD, PhD, Cyril Lazerges, MD

“…There were 6 chondrosarcomas, 2 high-grade osteosarcomas, 1 malignant peripheral nerve sheath tumor, and 1 low-grade atypical epithelioid sarcoma. …”
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Clinicopathological and prognostic value of hypoxia-inducible factor-1α in patients with bone tumor: a systematic review and meta-analysis by Deqing Luo, Hongyue Ren, Wenjiao Zhang, Hang Xian, Kejian Lian, Hui Liu

“…Results A total of 28 studies including 1443 patients were included in this meta-analysis, which were involved in three different types of bone tumor including 3 chondrosarcomas, 2 giant cell tumors of bone, and 23 osteosarcomas. Our results showed that high expression levels of HIF-1α were associated with poorer OS (overall survival) (HR = 2.61, 95% CI 2.11–3.23, P <  0.001) and shorter DFS (disease-free survival) (HR = 2.02, 95% CI 1.41–2.89, P <  0.001) in bone tumor. …”
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A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas by Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang, Xiaoshuang Li, Qingcheng Yang, Haiyan Hu, Yang Yao

“…For the 13 patients with soft-tissue sarcomas, the ORR was 30.8%, DCR was 76.9%, and median PFS was 12.9 months; for the 6 patients with osteosarcomas, the ORR was 33.3%, the DCR was 50.0%, and median PFS was 5.7 months. …”
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Adrenocortical carcinoma in a pediatric patient with li-fraumeni-like Syndrome: an endemic condition in southern Brazil by Mariana Mendes Knabben, Renan Reis Caldas, Jéssica Onofre de Brito Lima, Aline Spader Casagrande, Caroline Lorenzoni Almeida Ghezzi

“…The incidence of this mutation in southern Brazil is 1:300 individuals in the general population, while in Europe and North America it is 1:2000 - 1:5000 people. (2)  The LFS and similar phenotypes are characterized by an autosomal dominant inheritance pattern linked to a mutation in the TP53 tumor suppressor gene, associated with the diagnosis of various tumor types at a young age, such as ACC, breast cancer, central nervous system tumors, osteosarcomas and soft-tissue sarcomas. (3)  The diagnosis of cancer has a bimodal age distribution, with the highest peak before the age of 10 and a second peak between 30-50 years old.  …”
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