Dynamic nanoassemblies derived from small-molecule homodimeric prodrugs for in situ drug activation and safe osteosarcoma treatment by Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li

“…In a preclinical orthotopic model of human osteosarcomas, nanoparticle administration exhibited durable antitumor efficacy. …”
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Pyroptosis-Related Gene Signature Predicts Prognosis and Response to Immunotherapy and Medication in Pediatric and Young Adult Osteosarcoma Patients by Guo C, Yang X, Li L

“…A nomogram model for predicting OS of osteosarcoma patients was constructed. Single-cell RNA-sequencing data display the expression patterns of the hub PRGs. …”
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A deep learning algorithm with good prediction efficacy for cancer-specific survival in osteosarcoma: A retrospective study. by Yang Liu, Lang Xie, Dingxue Wang, Kaide Xia

“…<h4>Objective</h4>Successful prognosis is crucial for the management and treatment of osteosarcoma (OSC). This study aimed to predict the cancer-specific survival rate in patients with OSC using deep learning algorithms and classical Cox proportional hazard models to provide data to support individualized treatment of patients with OSC.…”
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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy by Yani Xu, Lan Yang, Min Li, Haozhou Shu, Na Jia, Yunzhen Gao, Rongying Shi, Xiaojia Yang, Zhirong Zhang, Ling Zhang

Subjects: “…Osteosarcoma…”
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Effect of co‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma by Sheng‐Fan Wang, Kuan‐Wei Huang, Yueh‐Ching Chou, Hsin‐Chen Lee, Po‐Kuei Wu, Wei‐Ming Chen, Giun‐Yi Hung, Yuh‐Lih Chang

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Corrigendum: Sestrin2-mediated autophagy contributes to drug resistance via endoplasmic reticulum stress in human osteosarcoma by Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao

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MAT2A inhibits the ferroptosis in osteosarcoma progression regulated by miR-26b-5p by Shuchi Xia, Yun Liang, Yuqing Shen, Wuxue Zhong, Yiqun Ma

Subjects: “…Osteosarcoma…”
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TRIM26 inhibited osteosarcoma progression through destabilizing RACK1 and thus inactivation of MEK/ERK signaling by Kezhou Xia, Di Zheng, Zhun Wei, Wenda Liu, Weichun Guo

“…Abstract Osteosarcoma is a highly aggressive malignant tumor that is common in the pediatric population and has a high rate of disability and mortality. …”
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[Translated article] Skin Lesions Associated With a New Mutation in the RECQL4 Gene in a Patient With Osteosarcoma by F. Tous-Romero, C. Palma-Milla, J. Ortiz-de Frutos

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Highly active selenium nanotherapeutics combined with metformin to achieve synergistic sensitizing effect on NK cells for osteosarcoma therapy by Du Yanxin, Zhang Zehang, Yang Yu, Liu Ting, Chen Tianfeng, Li Xiaoling

“…Moreover, it provides a multidrug strategy to improve immune cell function in practical applications, especially for synergistic immunotherapy of osteosarcoma.…”
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Development of the Osteosarcoma Lung Nodules Detection Model Based on SSD-VGG16 and Competency Comparing With Traditional Method by Chanunya Loraksa, Sirima Mongkolsomlit, Nitikarn Nimsuk, Meenut Uscharapong, Piya Kiatisevi

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CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation by Shiqi Lu, Tong Lu, Jiayu Zhang, Lunbiao Gan, Xinjie Wu, Donghui Han, Keying Zhang, Chao Xu, Shaojie Liu, Weijun Qin, Fa Yang, Weihong Wen

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Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma by Weidong Chen, Yan Liao, Pengxiao Sun, Jian Tu, Yutong Zou, Ji Fang, Ziyun Chen, Hongbo Li, Junkai Chen, Yuzhong Peng, Lili Wen, Xianbiao Xie

Subjects: “…Osteosarcoma…”
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Chemical bonding of Epigallocatechin-3-gallate to the surface of nano-hydroxyapatite to enhance its biological activity for anti-osteosarcoma by Jian Ren, Lingli Sun, Cairong Xiao, Shuoshuo Zhou, Qingyou Liang, Shili Sun, Chunlin Deng

Subjects: “…Osteosarcoma…”
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma by Lander, Eric Steven

“…Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. …”
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Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells by Bronkhorst, A, Wentzel, J, Ungerer, V, Peters, D, Aucamp, J, De Villiers, E, Holdenrieder, S, Pretorius, P

Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. by Locklin, R, Federici, E, Espina, B, Hulley, P, Russell, R, Edwards, C

“…However, unlike most cancers, many osteosarcomas are resistant to TRAIL. To investigate this resistance, we characterized the response of MG-63 osteosarcoma cells and hPOB-tert osteoblast-like cells to TRAIL and agonist antibodies to death receptor 4 (DR4) and death receptor 5 (DR5). …”

Utility of VS38c in the diagnostic and prognostic assessment of osteosarcoma and other bone tumours/tumour-like lesions by Hookway, E, Orosz, Z, Uchihara, Y, Grigoriadis, A, Hassan, A, Oppermann, U, Athanasou, N

“… <p><b>Background:</b></p> <p>VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons. …”

Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. by Yamazaki, H, Handa, A, Nishi, M, Tokunaga, T, Tomisawa, M, Hatanaka, H, Abe, Y, Kijima, H, Ueyama, Y, Nakamura, M

“…The growth of the osteosarcoma cell line HOS may be regulated by autocrine or paracrine loop TSP1 and CD36.…”

Differential sensitivity of normal osteoblast-like cells and osteosarcoma cells to TRAIL and an agonist antibody to TRAIL receptor-2 by Locklin, R, Federici, E, Croucher, P, Russell, R, Shipman, C