Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid by O. Petteri Hirvonen, Maarit Lehti, Heikki Kyröläinen, Heikki Kainulainen

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The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines by Keqiang Fan, Qian Zhang

“…Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways. Two families of oxygenases, the FAD-dependent oxygenases and the ring opening oxygenases, contribute to the formation of some unique skeletons of atypical angucyclines. …”
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Heme Oxygenase-1 Exerts Antiviral Activity against Hepatitis A Virus In Vitro by Dong-Hwi Kim, Hee-Seop Ahn, Hyeon-Jeong Go, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi

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Expression Dynamics of Heme Oxygenase-1 in Tumor Cells and the Host Contributes to the Progression of Tumors by Jun Fang, Rayhanul Islam, Shanghui Gao, Cheng Zhang, Ryotaro Kunisaki, Shogo Sakaguchi, Naoya Honda, Jian-Rong Zhou, Kazumi Yokomizo

Subjects: “…heme oxygenase-1…”
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Changes in heme oxygenase level during development affect the adult life of Drosophila melanogaster by Bernadetta Bilska, Milena Damulewicz, Terence Al L. Abaquita, Elzbieta Pyza

“…Heme oxygenase (HO) has been shown to control various cellular processes in both mammals and Drosophila melanogaster. …”
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Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase by Mohamed A. Sobhy, Lingyun Zhao, Dalaver Anjum, Ali Behzad, Masateru Takahashi, Muhammad Tehseen, Alfredo De Biasio, Rachid Sougrat, Samir Hamdan

“…First, we determined the structure of the Sulfur Oxygenase Reductase (SOR) enzyme that catalyzes both the oxygenation and disproportionation of elemental sulfur in Archea and is composed of 24 homomeric units each of MW ≃ 35 kDa arranged in octahedral symmetry. …”
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Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure by Valeria Sorrenti, Luca Vanella, Chiara Bianca Maria Platania, Khaled Greish, Claudio Bucolo, Valeria Pittalà, Loredana Salerno

Subjects: “…heme oxygenase (HO)…”
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Tobacco Plastid Transformation as Production Platform of Lytic Polysaccharide MonoOxygenase Auxiliary Enzymes by Rachele Tamburino, Daniela Castiglia, Loredana Marcolongo, Lorenza Sannino, Elena Ionata, Nunzia Scotti

“…Lytic Polysaccharide MonoOxygenases (LPMOs) are accessory enzymes able to break recalcitrant polysaccharides, boosting biomass conversion and subsequently reducing costs. …”
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Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction by Masakazu Sugishima, Junichi Taira, Tatsuya Sagara, Ryota Nakao, Hideaki Sato, Masato Noguchi, Keiichi Fukuyama, Ken Yamamoto, Takuo Yasunaga, Hiroshi Sakamoto

“…Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH–cytochrome P450 oxidoreductase (CPR). …”
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Progress of Heme Oxygenase-1 Mediated Ferroptosis in Non-alcoholic Fatty Liver Disease by CAO Jiacen, ZHANG Hongkun, ZHAO Wen, NAN Yuemin, LI Dongdong

Subjects: “…non-alcoholic fatty liver disease|heme oxygenase-1|ferroptosis|review…”
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An association study between Heme oxygenase-1 genetic variants and Parkinson´s disease by Pedro eAyuso, Pedro eAyuso, Carmen eMartinez, Carmen eMartinez, Pau ePastor, Pau ePastor, Pau ePastor, Oswaldo eLorenzo-Betancor, Oswaldo eLorenzo-Betancor, Antonio eLuengo, Félix Javier eJiménez-Jiménez, Hortensia eAlonso, José A G Agúndez, José A G Agúndez, Elena eGarcía-Martín, Elena eGarcía-Martín

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Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase. by Mohamed A Sobhy, Lingyun Zhao, Dalaver Anjum, Ali Behzad, Masateru Takahashi, Muhammad Tehseen, Alfredo De Biasio, Rachid Sougrat, Samir Hamdan

“…First, we determined the structure of the Sulfur Oxygenase Reductase (SOR) enzyme that catalyzes both the oxygenation and disproportionation of elemental sulfur in Archea and is composed of 24 homomeric units each of MW ≃ 35 kDa arranged in octahedral symmetry. …”
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Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD by Yi Li, Ying Yang, Tingting Guo, Chengxin Weng, Yongfeng Yang, Zhoufeng Wang, Li Zhang, Weimin Li

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Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice by Christiaan M. Suttorp, René E. M. van Rheden, Natasja W. M. van Dijk, Maria P. A. C. Helmich, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener

“…We postulated that exposure of pregnant mice to heme during palatogenesis would initiate oxidative and inflammatory stress, leading to pathological pregnancy, increasing the incidence of palatal clefting and abortion. Both heme oxygenase isoforms (HO-1 and HO-2) break down heme, thereby generating anti-oxidative and -inflammatory products. …”
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Reducing agent-mediated nonenzymatic conversion of 2‐oxoglutarate to succinate: implications for oxygenase assays by Khan, A, Schofield, C, Claridge, T

“…l‐Ascorbate (l‐Asc) is often added to assays with isolated FeII‐ and 2‐oxoglutarate (2OG)‐dependent oxygenases to enhance activity. l‐Asc is proposed to be important in catalysis by some 2OG oxygenases in vivo. …”

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase by Pfeffer, I

Focused screening identifies different sensitivities of human TET oxygenases to the oncometabolite 2-hydroxyglutarate by Belle, R, Saraç, H, Salah, E, Bhushan, B, Szykowska, A, Roper, G, Tumber, A, Kriaucionis, S, Burgess-Brown, N, Schofield, CJ, Brown, T, Kawamura, A

“…<p>Ten-eleven translocation enzymes (TETs) are Fe(II)/2-oxoglutarate (2OG) oxygenases that catalyze the sequential oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine in eukaryotic DNA. …”

Characterisation of 2-oxoglutarate- and fe(II)-dependent oxygenases targeting the protein synthesis apparatus by Feng, T

“…<p>Members of the 2-oxoglutarate (2OG)- and Fe(II)-dependent oxygenase (2OG oxygenase) superfamily catalyse a wide range of oxidative reactions in biology. 2OG oxygenases require Fe(II) and atmospheric oxygen for their activity, and couple substrate oxidation with the decarboxylation of 2OG into succinate and carbon dioxide. …”

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. by Islam, MS, McDonough, MA, Chowdhury, R, Gault, J, Khan, A, Pires, E, Schofield, CJ

“…JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. …”

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. by Tarhonskaya, H, Rydzik, A, Leung, I, Loik, N, Chan, M, Kawamura, A, McCullagh, J, Claridge, T, Flashman, E, Schofield, C

“…Here we investigate the mechanism of 2-hydroxyglutarate-enabled activation of 2-oxoglutarate oxygenases, including prolyl hydroxylase domain 2, the most important human prolyl hydroxylase isoform. …”