The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases by Markolovic, S, Zhuang, Q, Wilkins, SE, Eaton, CD, Abboud, MI, Katz, MJ, McNeil, HE, Leśniak, R, Hall, C, Struwe, WB, Konietzny, R, Davis, S, Yang, M, Ge, W, Benesch, JLP, Kessler, BM, Ratcliffe, PJ, Cockman, ME, Fischer, R, Wappner, P, Chowdhury, R, Coleman, M, Schofield, CJ

“…Biochemical, structural, and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) as a 2-oxoglutarate (2OG)-dependent oxygenase catalyzing a previously unreported type of post translational modification, (3S)-lysyl hydroxylation. …”

Inhibitors of both the N-methyl lysyl- and arginyl- demethylase activities of the JmjC oxygenases by Bonnici, J, Tumber, A, Kawamura, A, Schofield, C

“…The Jumonji C (JmjC) family of 2-oxoglutarate (2OG) dependent oxygenases have established roles in the regulation of transcription via the catalysis of demethylation of Nε-methylated lysine residues in histone tails, especially the N-terminal tail of histone H3. …”

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases by Horita, S, Scotti, J, Thinnes, C, Taromsari, Y, Thalhammer, A, Ge, W, Aik, W, Loenarz, C, Schofield, C, McDonough, M

“…Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases, and occurs in prokaryotes and eukaryotes. …”

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases by Tarhonskaya, H

“…<p>The Fe(II)/2-oxoglutarate (2OG) dependent oxygenases are a widespread enzyme family, which are characterised by structurally similar active sites and proposed to employ a common reaction mechanism. …”

Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock. by Reade, M, Millo, J, Young, J, Boyd, C

“…There are no conclusive studies of human disease, and the cellular source of nitric oxide in human sepsis is not known. Haem oxygenase is upregulated by oxidative stress, but little is known about haem oxygenase expression in human sepsis. …”

CYCLO-OXYGENASE 2 IS PRESENT IN THE MAJORITY OF LESIONAL SKIN FROM PATIENTS WITH AUTOINMUNE BLISTERING DISEASES by Ana Maria Abreu Velez, Juliana Calle Isaza, Michael S. Howard

Subjects: “…Cyclo-oxygenase 2…”
Get full text

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5 by Md. Saiful Islam, Marios Markoulides, Rasheduzzaman Chowdhury, Christopher J. Schofield

“…JMJD5 is a 2-oxoglutarate (2OG) and Fe(II) dependent oxygenase of the JmjC subfamily, which includes histone Nε-methyl lysine-demethylases (KDMs) and hydroxylases catalysing formation of stable alcohol products. …”
Get full text

Role of cysteine residues in the structure, stability, and alkane producing activity of cyanobacterial aldehyde deformylating oxygenase. by Yuuki Hayashi, Fumitaka Yasugi, Munehito Arai

“…Aldehyde deformylating oxygenase (AD) is a key enzyme for alkane biosynthesis in cyanobacteria, and it can be used as a catalyst for alkane production in vitro and in vivo. …”
Get full text

Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases by Hui Tao, Ikuro Abe

Subjects: “…Fe(II)/αKG-dependent oxygenases…”
Get full text

Exacerbation of Neonatal Hemolysis and Impaired Renal Iron Handling in Heme Oxygenase 1-Deficient Mice by Aleksandra Bednarz, Paweł Lipiński, Rafał R. Starzyński, Mateusz Tomczyk, Izabela Kraszewska, Sylwia Herman, Kacper Kowalski, Ewelina Gruca, Aneta Jończy, Rafał Mazgaj, Mateusz Szudzik, Zenon Rajfur, Zbigniew Baster, Alicja Józkowicz, Małgorzata Lenartowicz

Subjects: Get full text

Characterization and evaluation of catechol oxygenases by twelve bacteria, isolated from oil contaminated soils in Malaysia by Arezoo Tavakoli, Ainon Hamzah

Subjects: “…Catechol oxygenase…”
Get full text

Crosstalk between Heme Oxygenase-1 and Iron Metabolism in Macrophages: Implications for the Modulation of Inflammation and Immunity by Joseana de Oliveira, Marina B. Denadai, Diego L. Costa

Subjects: “…heme oxygenase-1…”
Get full text

Carbon Monoxide (CO) as a Retinal Regulator of Heme Oxygenases -1, and -2 (HO’s) Expression by Sławomir Nowak, Przemysław Gilun, Katarzyna Kozioł, Maria Romerowicz-Misielak, Magdalena Koziorowska-Gilun, Barbara Wąsowska

Subjects: “…heme oxygenase -1 and -2…”
Get full text

Heme Oxygenase-1 Overexpression Promotes Uveal Melanoma Progression and Is Associated with Poor Clinical Outcomes by Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittalà, Michele Reibaldi, Guido Nicola Zanghì, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolò Musso

Subjects: Get full text

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention by Stephen J. Peterson, Abu Choudhary, Amardeep K. Kalsi, Shuyang Zhao, Ragin Alex, Nader G. Abraham

Subjects: “…heme oxygenase…”
Get full text

Heme Oxygenase-1 Contributes to Both the Engulfment and the Anti-Inflammatory Program of Macrophages during Efferocytosis by Éva Fige, Judit Szendrei, László Sós, Izabela Kraszewska, László Potor, József Balla, Zsuzsa Szondy

Subjects: “…heme oxygenase-1…”
Get full text

Effect of Heme Oxygenase-1 on Melanoma Development in Mice—Role of Tumor-Infiltrating Immune Cells by Halina Was, Tomasz Cichon, Ryszard Smolarczyk, Bozena Lackowska, Agnieszka Mazur-Bialy, Magdalena Mazur, Agata Szade, Pawel Dominik, Milena Mazan, Jerzy Kotlinowski, Anna Zebzda, Anna Kusienicka, Claudine Kieda, Jozef Dulak, Alicja Jozkowicz

“…Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. …”
Get full text

Nuclear Localization of Heme Oxygenase-1 in Pathophysiological Conditions: Does It Explain the Dual Role in Cancer? by Marilina Mascaró, Eliana N. Alonso, Exequiel G. Alonso, Ezequiel Lacunza, Alejandro C. Curino, María Marta Facchinetti

Subjects: “…heme oxygenase-1…”
Get full text

Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis <i>In Vitro</i> by Marco Raffaele, Giuseppe Carota, Giuseppe Sferrazzo, Maria Licari, Ignazio Barbagallo, Valeria Sorrenti, Salvatore S. Signorelli, Luca Vanella

Subjects: “…heme oxygenase…”
Get full text

Heme oxygenase 2 genetic variants alter hormonal and metabolic traits in polycystic ovary syndrome by Xinyuan Zhang, Suiyan Li, Hongwei Liu, Huai Bai, Qingqing Liu, Chunyi Yang, Ping Fan

Subjects: Get full text