Oxygenases for oxygen sensing by Loenarz, C, Chowdhury, R, Schofield, C, Flashman, E

“…All four identified human HIF hydroxylases are members of the Fe(II) and 2-oxoglutarate (20G)-dependent family of oxygenases. Inhibition of HIF hydroxylases mimics the hypoxic response resulting in the upregulation of erythropoietin (EPO), vascular endothelial growth factor (VEGF), and other proteins of biomedicinal importance. …”

Studies on ribosomal oxygenases by Sekirnik, R

“…It was recently proposed that 2OG oxygenases catalyse the hydroxylation of ribosomal proteins in prokaryotes (ycfD) and in humans (NO66 and MINA53), raising the possibility that 2OG oxygenases also control translation. …”

Palmitoylation of Metazoan Carotenoid Oxygenases by Sheetal Uppal, Igor B. Rogozin, T.Michael Redmond, Eugenia Poliakov

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2-oxoglutarate-dependent oxygenases by Islam, M, Leissing, T, Chowdhury, R, Hopkinson, R, Schofield, C

“…2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. …”

Custom tuning of Rieske oxygenase reactivity by Jiayi Tian, Jianxin Liu, Madison Knapp, Patrick H. Donnan, David G. Boggs, Jennifer Bridwell-Rabb

“…Abstract Rieske oxygenases use a Rieske-type [2Fe-2S] cluster and a mononuclear iron center to initiate a range of chemical transformations. …”
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Structural and functional studies on human oxygenases by Islam, S

“…<p>The work described in this thesis focused on 2-oxoacid-dependent oxygenase enzymes. Most of the work focused on iron- and 2-oxoglutarate (2OG)-dependent oxygenases including JMJD6 and JMJD5, which are human enzymes of unassigned or controversial functions. …”

Chemical and biological studies on human oxygenases by Thinnes, C, Dr Cyrille C. Thinnes

“…Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. …”

Oxygenase catalyzed 5-methylcytosine hydroxylation. by Loenarz, C, Schofield, C

“…Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). …”

Roles of oxygenases in the regulation of gene expression by Schofield, C

NMR studies on 2-oxoglutarate oxygenases by Leung, IKH

“…By replacing the active site metal of 2OG oxygenases by paramagnetic metal Mn(II), the relaxation rates of bulk water were increased. …”

Inhibition of 2-oxoglutarate dependent oxygenases. by Rose, N, McDonough, M, King, O, Kawamura, A, Schofield, C

“…2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. …”

Roles of oxygenases in nucleic acid modification by Bagg, E

“…<p>2-Oxoglutarate (2OG) and Fe(II) dependent oxygenases have a broad range of substrates, extending from histones to fatty acids. …”

Immune-Related Functions of Heme Oxygenase-1 by Elias A. Lianos, Maria G. Detsika

“…Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]…”
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Role of Heme Oxygenase in Gastrointestinal Epithelial Cells by Reiko Akagi

Subjects: “…heme oxygenase-1…”
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THE ROLE OF HEME OXYGENASE AND HSP70 IN TRAUMA by Paolo Murabito

“…In the present review we focus our attention on the possible role and different clinical significance of two important heat shock proteins (i.e. heme oxygenase-1 and Hsp70) in traumatic injury.…”

Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis by Yohei Sanada, Sho Joseph Ozaki Tan, Nobuo Adachi, Shigeru Miyaki

Subjects: “…heme oxygenase-1 (HO-1)…”
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Pharmacological and Clinical Significance of Heme Oxygenase-1 by David E. Stec, Nader G. Abraham

“…This Special Issue collates and updates the current knowledge of the pharmacology and clinical applications concerning the enzyme heme oxygenase (HO) [...]…”
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The roles of heme oxygenase-1 in renal disease by Hongfu Zhai, Lihua Ni, Xiaoyan Wu, Xiaoyan Wu

Subjects: “…heme oxygenase…”
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Crystallographic studies on 2-oxoglutarate dependent oxygenases by Aik, WS

“…<p>The Fe(II) and 2-oxoglutarate dependent oxygenases (2OG oxygenases) catalyse a broad range of oxidative reactions in various organisms. 2OG oxygenases use 2OG and molecular oxygen to catalyse the oxidation of a variety of substrates including small molecules, fatty acids, nucleic acids and proteins. …”

The roles of Jumonji-type oxygenases in human disease. by Johansson, C, Tumber, A, Che, K, Cain, P, Nowak, R, Gileadi, C, Oppermann, U

“…The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. …”