p53’s Extended Reach: The Mutant p53 Secretome by Evangelos Pavlakis, Thorsten Stiewe

Subjects: “…p53…”
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Interaction of p53 with the Δ133p53α and Δ160p53α isoforms regulates p53 conformation and transcriptional activity by Fanny Tomas, Pierre Roux, Véronique Gire

“…Abstract The TP53 gene encodes p53, a transcription factor involved in tumor suppression. …”
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Analyze p53 degradation by 35S p53 Pulse Chase Analysis by Megan Astle, Richard Pearson, Katherine Hannan

“…p53, is known as the guardian of the genome and as such requires exquisite regulation not only of its abundance but also its activity. …”
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Role of p53 serine 46 in p53 target gene regulation. by Leonie Smeenk, Simon J van Heeringen, Max Koeppel, Bianca Gilbert, Eva Janssen-Megens, Hendrik G Stunnenberg, Marion Lohrum

“…The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. …”
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Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis by Hiraki, Masatsugu, Hwang, So-Young, Cao, Shugeng, Ramadhar, Timothy R., Byun, Sanguine, Yoon, Kyoung Wan, Lee, Jung Hyun, Chu, Kiki, Gurkar, Aditi U., Kolev, Vihren, Zhang, Jianming, Namba, Takushi, Murphy, Maureen E., Newman, David J., Clardy, Jon, Lee, Samuel W., Mandinova, Anna

“…A cell-based, high-throughput small-molecule screen identified chetomin (CTM) as a mutant p53 R175H reactivator. CTM enabled p53 to transactivate target genes, restored MDM2 negative regulation, and selectively inhibited the growth of cancer cells harboring mutant p53 R175H in vitro and in vivo. …”
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MDMX in Cancer: A Partner of p53 and a p53-Independent Effector by Lin W, Yan Y, Huang Q, Zheng D

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Recent Advances in p53 by Gabriella D’Orazi

“…Tumor suppressor protein p53 (TP53) is a key transcription factor that, in response to various stress signals, regulates numerous genes involved in a broad range of cellular functions including DNA repair, apoptosis, cell cycle arrest, senescence, metabolism, etc [...]…”
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Mechanism of Action p53 by Ghorbat Saleh Ali

Subjects: “…p53, cell arrest, apoptosis, senescence and cancer…”
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p53: Guardian of ploidy by Yael Aylon, Moshe Oren

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Tanning, p53 and PCMR. by Goding, C

Constant rate of p53 tetramerization in response to DNA damage controls the p53 response by Giorgio Gaglia, Galit Lahav

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Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide by Benjamin L. Allen, Kim Quach, Taylor Jones, Cecilia B. Levandowski, Christopher C. Ebmeier, Jonathan D. Rubin, Timothy Read, Robin D. Dowell, Alanna Schepartz, Dylan J. Taatjes

“…Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to block p53 function by disrupting the p53-Mediator interaction. …”
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Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest. by Julie Lafontaine, Francis Rodier, Véronique Ouellet, Anne-Marie Mes-Masson

“…While Necdin is induced following p53 activation with different genotoxic stresses, Necdin induction by PyLT did not involve p53 activation or the Rb-binding site of PyLT. …”
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Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins. by Ronen Gabizon, Tobias Brandt, Shahar Sukenik, Noa Lahav, Mario Lebendiker, Deborah E Shalev, Dmitry Veprintsev, Assaf Friedler

“…Those can either depend on or regulate p53 oligomerization. Here we screened an array of peptides derived from proteins known to bind the tetrameric p53 C-terminal domain (p53CTD) and identified ten binding peptides. …”
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Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome. by Pellagatti, A, Marafioti, T, Paterson, J, Barlow, J, Drynan, L, Giagounidis, A, Pileri, SA, Cazzola, M, McKenzie, A, Wainscoat, J, Boultwood, J

Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation by Teng, Ma, Yamada, Shumpei, Ichwan, Solachuddin J. A., Ohtani, Kiyoshi, Otsu, Megumi, Ikeda, Masa-Aki

“…Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53- mediated apoptosis. …”
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Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53 by Phong Lu, Erica R. Vander Mause, Katherine E. Redd Bowman, Sarah M. Brown, Lisa Ahne, Carol S. Lim

Subjects: “…p53…”
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p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts by Boyd, Scott D. (Scott Dexter), 1970-

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Molecular regulation of p53-dependent tumour suppressor responses by the p53 binding protein 1 by Cuella-Martin, R

“…<p>The tumour suppressor p53 binding protein 1 (53BP1), a fundamental node in DNA double strand break (DSB) repair, was identified as a p53-interacting protein over two decades ago. …”

Functional characterization of the p53 “mutome” by Eran Kotler, Eran Segal, Moshe Oren

Subjects: “…mutant p53…”
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