Familial Dysautonomia, Report of 3 Cases from Iran and a Discussion about Their General and Anaesthesia Care by Badiozaman Radpay, Mahtab Poor Zamany Nejat Kermany, Ali Asghar Halimi-Asl

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Relationship between breakthrough cancer pain, background cancer pain and analgesic treatment – case series and review of the literature by Chrysanthi Batistaki, Michal Graczyk, Marcin Janecki, Agata Anna Lewandowska, Rita Moutinho, Kiriaki Vagdatli

“…The aim of this paper is to provide healthcare professionals involved in cancer pain management with a review of the relevant literature on the relationship between background cancer pain and BTcP which, by definition, occurs despite adequately controlled background cancer pain. …”
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A Comprehensive Review on the Regulatory Action of TRP Channels: A Potential Therapeutic Target for Nociceptive Pain by Santosh Anand, Senthilkumar Rajagopal

“…The present review encompasses the current understanding of TRP channels and TRP modulators in pain and pain management.…”
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CURRENT PROSPECTS FOR THE TREATMENT OF DIABETES COMPLICATIONS by M. Y. OGARKOV, Y. V. KOVALEVA

“…In the treatment of DPN, activation of neural regeneration (reinnervation) and pain management are crucial. Neurotropic B vitamins with multimodal effect play a key role in this.…”
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Ultrasound-guided erector spinae plane block for postoperative analgesia in patients undergoing various types of surgery by Ahmet Selim Ozkan, Mukadder Sanli, Sedat Akbas, Erol Karaaslan

“…In all three patients, ESP block provided effective analgesia and increased patient satisfaction according to their pain management scores (numerical rating scale [NRS]). …”
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Managing acute phantom limb pain with transcutaneous electrical nerve stimulation: a case report by Katleho Limakatso

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Research progress on P2X7 receptor in cancer pain by ZHANG Zhongwen, ZHAO Rui, ZHANG Haolong, YANG Yuting, BAI Jinxia, ZHANG Haoling WANG Wei

“…In preclinical cancer pain models, it has the potential to serve as a new therapeutic target for cancer pain management.…”
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Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors? by Gertsch Jürg, Anavi-Goffer Sharon

“…<p>Abstract</p> <p>The cannabinoid type-2 G protein-coupled (CB₂) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer’s disease (AD) the orally administered natural product 4′-O-methylhonokiol (MH) has been shown to prevent amyloidogenesis and progression of AD by inhibiting neuroinflammation. …”
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I Feel! Therefore, I Am from Pain to Consciousness in DOC Patients by Francesco Riganello, Paolo Tonin, Andrea Soddu

“…Moreover, we highlight recent evidence suggesting that an accurate pain assessment may predict changes in the level of consciousness in unresponsive wakefulness syndrome/vegetative state patients, underscoring the importance of ongoing pain management in these patients.…”
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The Compound Effect of Cupping Therapy: Searching Beyond the Meridians by Mohamed K.M. Khalil, Saud AlSanad

“…There is growing evidence of CT’s effectiveness, specifically in chronic pain management when compared to an inactive control, but not against sham treatment. …”
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Introducing Australia’s clinical care standard for low back pain1 by Christopher G Maher, Aline Archambeau, Rachelle Buchbinder, Simon D French, Julia Morphet, Michael K Nicholas, Peter O’Sullivan, Marie Pirotta, Michael J Yelland, Leo Zeller, Elizabeth Marles, Alice L Bhasale, Christina Lane

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Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs by Samo Lešnik, Éva Bertalan, Urban Bren, Ana-Nicoleta Bondar

“…The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding to the opioid receptor, because opioid drugs typically have a protonated amino group that contributes to receptor binding, and the functioning of GPCRs may involve protonation change. …”
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The Use of Low-Dose Methadone as Add-On to Ongoing Opioid Treatment in Palliative Cancer Care—An Underrated Treatment? by Per Fürst

“…Negative attitudes towards methadone do not seem to prevent it from being used for pain management, and by starting with low doses and then increasing slowly and gradually, methadone can apparently be introduced safely. …”
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EFEKTIVITAS TERAPI �TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION� DALAM MENINGKATKAN KUALITAS TIDUR PADA PENDERITA OSTEOARTHRITIS by , WIDYA DWI ASTUTI, , Heru Subekti, S.Kep., Ns., MPH

“…Several studies have shown that there is a relationship between musculoskeletal pain and sleep quality in elderly, in which people with mild pain had better sleep quality than people with severe pain. Therefore pain management with TENS therapy in patients with osteoarthritis is necessary to reduce pain and this is expected to have an impact on improving sleep quality. …”

Talk of frustration in the narratives of people with chronic pain. by Dow, C, Roche, P, Ziebland, S

“…Sources of frustration include interference with everyday activities, the interruption of life goals and roles and the unpredictability of pain; here we focus on the frustrations associated with the invisibility of chronic pain and the perceived limitations of diagnosis and pain management (both related to the perceived legitimacy of the condition). …”

Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity by Baxter, L, Moultrie, F, Fitzgibbon, S, Aspbury, M, Mansfield, R, Bastiani, M, Rogers, R, Jbabdi, S, Duff, E, Slater, R

“…Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-individual variability in noxiousstimulus evoked brain activity. …”

Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice by Dilpreet Kour, Dilpreet Kour, Mehboob Ali, Mehboob Ali, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Palash Ghosh, Sukhleen Kaur, Sukhleen Kaur, Surbhi Mahajan, P. Ramajayan, P. Ramajayan, Sonali S. Bharate, Subhash Bhardwaj, Sanghapal D. Sawant, Sanghapal D. Sawant, D. Srinivasa Reddy, D. Srinivasa Reddy, Ajay Kumar, Ajay Kumar

“…The current sickle cell disease pain management regime relies mainly on opiate drugs, which is accompanied by several side effects without modifying the sickle cell disease-related pathology. …”
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The Role of Ketamine as a Component of Multimodal Analgesia in Burns: A Retrospective Observational Study by Marina Stojanović, Milana Marinković, Biljana Miličić, Milan Stojičić, Marko Jović, Milan Jovanović, Jelena Isaković Subotić, Milana Jurišić, Miodrag Karamarković, Aleksandra Đekić, Kristina Radenović, Jovan Mihaljević, Ivan Radosavljević, Branko Suđecki, Milan Savić, Marko Kostić, Željko Garabinović, Jelena Jeremić

“…Better post-procedural pain management, less opioid use, and consequently fewer side effects, which could prolong recovery and increase morbidity, are all benefits of this type of analgesia. …”
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A patient activation intervention in primary care for patients with chronic pain on long term opioid therapy: results from a randomized control trial by Monique B. Does, Sara R. Adams, Andrea H. Kline-Simon, Catherine Marino, Nancy Charvat-Aguilar, Constance M. Weisner, Andrea L. Rubinstein, Murtuza Ghadiali, Penney Cowan, Kelly C. Young-Wolff, Cynthia I. Campbell

“…Secondary outcomes included mood, function, overall health, non-pharmacologic pain management strategies, and patient portal use. We conducted a repeated measure analysis and reported between-group differences at 12 months. …”
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Development and validation of machine learning based prediction model for postoperative pain risk after extraction of impacted mandibular third molars by Dongsheng Yu, Zifeng Liu, Weijie Zhuang, Kechen Li, Yaxin Lu

“…Background: Predicting postoperative pain risk in patients with impacted mandibular third molar extractions is helpful in guiding clinical decision-making, enhancing perioperative pain management, and improving the patients’ medical experience. …”
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