Comparison of pain with bupivacaine and bupivacaine-sufentanil combination in women undergoing cesarean section with spinal anesthesia: A double-blind randomized clinical trial by Hasan Zabetian, Mohammad Rahmanian, Nahid Tadayon, Navid Kalani

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Assessing Cannabidiol as a Therapeutic Agent for Preventing and Alleviating Alzheimer’s Disease Neurodegeneration by Long Chen, Yuan Sun, Jinran Li, Sai Liu, Hancheng Ding, Guangji Wang, Xinuo Li

“…Cannabidiol (CBD), derived from cannabis, is noted for its neuroprotective and anti-inflammatory properties, having shown efficacy in neuropathic pain management for epilepsy. To investigate the therapeutic efficacy of CBD in AD and to elucidate its underlying mechanisms, we aimed to contribute valuable insights for incorporating AD prevention recommendations into future CBD nutritional guidelines. …”
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Clinical relevance of deep learning models in predicting the onset timing of cancer pain exacerbation by Yeong Hak Bang, Yoon Ho Choi, Mincheol Park, Soo-Yong Shin, Seok Jin Kim

“…Our study demonstrated the possibility of predicting CPE using deep learning models, thereby suggesting that preemptive cancer pain management using deep learning could potentially improve patients’ daily life.…”
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The holistic effects of medical cannabis compared to opioids on pain experience in Finnish patients with chronic pain by Jussi Jylkkä, Aleksi Hupli, Aleksandra Nikolaeva, Sandra Alanen, Anna Erika Back, Sara Lindqvist, Andreas Krabbe, Maya Lavie-Ajayi, Oskari Kantonen

“…Abstract Background Medical cannabis (MC) is increasingly used for chronic pain, but it is unclear how it aids in pain management. Previous literature suggests that MC could holistically alter the pain experience instead of only targeting pain intensity. …”
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Postoperative Pain Is Driven by Preoperative Pain, Not by Endometriosis by Panagiotis Kanellos, Konstantinos Nirgianakis, Franziska Siegenthaler, Christian Vetter, Michael D. Mueller, Sara Imboden

“…These findings support the need for careful postsurgical pain management in patients with pain identified as an indication for hysterectomy, independent of the extent of the surgery or underlying diagnosis.…”
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Stability Testing of Compounding Capsule Combination between Paracetamol and Tramadol in a Private Hospital Semarang by Shirley Candra Kurniawan, Michael Raharja Gani, Sri Hartati Yuliani

“…A combination of Paracetamol and Tramadol is used in mild to severe pain management. In a private Hospital Semarang, this combination is included in fast-moving drugs that it is frequently compounded and prepared in advance. …”
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The Benefits and Barriers of Providing Non-Pharmacological Pain Relief to Women in Labour during COVID-19: A Qualitative Study of Midwives in South Africa by Limakatso Elizabeth Parkies, Daphne Murray, Uchenna Benedine Okafor

“…Prioritising midwife training in non-pharmacological labour pain management is crucial for delivering the best possible care during childbirth.…”
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Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations by Fangling Chen, Wenxin Huang, Tao Jiang, Rilei Yu

“…Voltage-gated sodium (NaV) channels generate and propagate action potentials in excitable cells, and several NaV subtypes have become important targets for pain management. The μ-conotoxins inhibit subtypes of the NaV with varied specificity but often lack of specificity to interested subtypes. …”
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Low-Carbohydrate High-Fat Diet: A SWOC Analysis by Dena Nuwaylati, Basmah Eldakhakhny, Abdulhadi Bima, Hussein Sakr, Ayman Elsamanoudy

“…Furthermore, the implementation of the KD as a potential adjuvant therapy for many diseases, including cancer, neurodegenerative disorders, polycystic ovary syndrome, and pain management was proven. On the other hand, the short and long-term possible undesirable KD-related effects, including nutritional deficiencies, growth retardation and nephrolithiasis, should be considered and strictly monitored. …”
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Restoring the neuroprotective capacity of glial cells under opioid addiction by Alexis C. Spencer, Bapurao Surnar, Nagesh Kolishetti, Michal Toborek, Shanta Dhar

“…Opioid addiction is a worldwide public health crisis stemming from the well-intentioned efforts of physicians to improve pain management in the 1990’s. The lack of knowledge behind the addictive tendencies of opioids, led to what is now known as the opioid epidemic causing significant social and economic burdens across the globe. …”
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FBG-Based Soft System for Assisted Epidural Anesthesia: Design Optimization and Clinical Assessment by Francesca De Tommasi, Chiara Romano, Daniela Lo Presti, Carlo Massaroni, Massimiliano Carassiti, Emiliano Schena

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Narrative review of current neuromodulation modalities for spinal cord injury by Roi Medina, Alison Ho, Rajiv Reddy, Jeffrey Chen, Joel Castellanos

“…Additional research is warranted to further support the clinical use of these emerging modalities to provide improved pain management, increased level of function, and ultimately an overall better quality of life in the SCI population.…”
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Managing the acute painful episode in sickle cell disease by B. Kaya

“…Addressing psycho-social aspects, defining and modifying precipitating factors, if any are identified, and having a holistic approach to pain management is helpful. Education and use of self-management techniques can also be productive. …”
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Risk Factors for Respiratory Depression Associated with Tramadol Based on the Global Pharmacovigilance Database (VigiBase) by Sunny Park, Geon-Ho Lee, Soyun Kim, Solee Kim, Yeju Kim, Soo-An Choi

“…Tramadol, a weak μ-opioid receptor agonist, has been used worldwide for pain management. It is considered to have a favorable safety profile without serious adverse events; however, safety issues of respiratory depression were proposed by regulatory governments. …”
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Hypertensive Hypoalgesia in a Complex Chronic Disease Population by Meaghan Ferguson, Maxwell Slepian, Christopher France, Anton Svendrovski, Joel Katz

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Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers by A. O. C. Costa, R. I. A. Rego, H. H. N. Andrade, T. K. V. L. Costa, M. G. S. S. Salvadori, R. N. Almeida, R. D. Castro

“…Abstract Due to the complex nature of pain and the participation of physical, cognitive, psychological and behavioral aspects, pain management has several approaches. The use of medicinal plants in developing countries is quite expressive. …”
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Nocebo effects in clinical studies: hints for pain therapy by Regine Klinger, Maxie Blasini, Julia Schmitz, Luana Colloca

“…These effects may be triggered through multiple channels and can lead to significant alterations in a patient's perception of pain, consequently producing a weakening of the specific positive effects of pharmacological, psychological, or physical pain-management interventions. Conclusion:. To minimize nocebo effects in clinical settings, we identified and discussed five contextual aspects relevant to the treatment of patients with chronic pain: (1) negative patient–clinician communication and interaction during treatment; (2) emotional burden of patients during treatment with analgesic medication; (3) negative information provided via informational leaflets; (4) cued and contextual conditioning nocebo effects; and (5) patient's lack of positive information. …”
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Combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma patients: a comparison with a historical control grou... by Reza Safaee, Ahmad Ahmadzadeh, Ramezanali Sharifian, Amirhossein Emami, Mir Saeed Yekaninejad, Mohammad Hossein Jalili, Armita Valizadeh

“…Another 15 patients with refractory multiple myelomas that had previously received only supportive therapy and pain management formed a historical control group. The follow-up period was 12 months for each study group. …”
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Mechanism of Glucose Water as a Neural Injection: A Perspective on Neuroinflammation by Yung-Tsan Wu, Yen-Po Chen, King Hei Stanley Lam, Kenneth Dean Reeves, Jui-An Lin, Cheng-Yi Kuo

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Massage-therapy and post cesarean pain control by Rozita Rezaei, Susan Saatsaz, Abbas Alipour, Zahra Beheshti

“…Introduction: Cesarean section is a common surgical surgery in women, and post-cesarean pain and stress are the problems which are faced by young women keen to care of their newborns. Post-operative pain management reduces patient's discomfort, enables quicker walking, reduces hospital stay, and increases patient's satisfaction. …”
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