Plant growth and phytoactive alkaloid synthesis in kratom [Mitragyna speciosa (Korth.)] in response to varying radiance. by Mengzi Zhang, Abhisheak Sharma, Francisco León, Bonnie Avery, Roger Kjelgren, Christopher R McCurdy, Brian J Pearson

“…In recent years, increased interest in the application and use of kratom has emerged globally, including North America, for its potential application as an alternative source of medicine for pain management and opioid withdrawal syndrome mitigation. …”
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Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport by Tim Quach, Luojuan Hu, Sifei Han, Shea F. Lim, Danielle Senyschyn, Preeti Yadav, Natalie L. Trevaskis, Jamie S. Simpson, Christopher J. H. Porter

“…Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism. …”
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Pain Informed Movement for people with knee osteoarthritis: Protocol for a pilot randomized controlled trial by Shirin Modarresi, Neil Pearson, Kim Madden, Kim L. Bennell, Margaret Fahnestock, Tuhina Neogi, Lisa C. Carlesso

“…Objective: Conservative pain management strategies for knee osteoarthritis (KOA) have limited effectiveness and do not employ a pain-mechanism informed approach. …”
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Effects of two different topographic approaches for combined sciatic and femoral nerve block in calves, guided by ultrasound and neurostimulation by Marcos Paulo Antunes de Lima, Renata Andrade Silva, Patrícia de Castro Duarte, Sérgio da Silva Rocha Júnior, Stephanie Elise Muniz Tavares Branco, Cahuê Francisco Rosa Paz, Pablo Ezequiel Otero, Rafael Resende Faleiros, Suzane Lilian Beier

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Challenges, Concerns, and Experiences of Community-Dwelling Older Women with Chronic Low Back Pain—A Qualitative Study in Hong Kong, China by Tiffany H. T. Wong, Kaden S. K. Lee, Sharon M. C. Lo, Mandy M. P. Kan, Crystal Kwan, Emmanuelle Opsommer, Shahnawaz Anwer, Heng Li, Arnold Y. L. Wong, Veronika Schoeb

“…Discussion and implications: Negative physical and psychosocial impacts of CLBP were common among older women, and they adopted diverse pain management strategies, although some of their treatment options were influenced by the Chinese culture. …”
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Circadian Rhythm Sleep Disorders in the Young Population and Their Relationship with Psychological Distress and Disability by Habibolah Khazaie, Farid Najafi, Azita Chehri, Afarin Rahimi-Movaghar, Masoumeh Amin-Esmaeili, Mehdi Moradi-Nazar, Ali Zakiei, Yahya Pasdar, Alireza Ahmadi, Reza Mohammadi

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Effective prevention of post-dural puncture headache with insertion of an intrathecal catheter in parturients: a retrospective study and meta-analysis by F. Creazzola, M. Aversano, F. Prencipe, R. Barelli, P. Pasqualetti, I. Simonelli, M. G. Frigo

“…Conclusions Intrathecal catheter placement is a promising measure to prevent post-dural puncture headache, especially if followed by a pain management protocol and a continuous saline infusion.…”
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Impact of Canine Amniotic Mesenchymal Stem Cell Conditioned Media on the Wound Healing Process: In Vitro and In Vivo Study by Filip Humenik, Marcela Maloveská, Nikola Hudáková, Patrícia Petroušková, Zuzana Šufliarska, Ľubica Horňáková, Alexandra Valenčáková, Martin Kožár, Barbora Šišková, Dagmar Mudroňová, Martin Bartkovský, Daša Čížková

“…After 15 days of therapy, we observed a 98.47% reduction in the wound surface area as opposed to 57.135% in the control group treated by conventional therapy based on debridement of necrotic tissue, antibiotic therapy, pain management, and change of wound dressing.…”
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Effects of single-injection intercostal nerve block as a component of multimodal analgesia for pediatrics undergoing autologous auricular reconstruction: A double-blinded, prospect... by Kang Zheng, Bin Li, Jie Sun

“…Background: ː Pain management is essential in postoperative settings, especially with pediatric patients. …”
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An online acceptance, commitment, and self-compassion based treatment to decrease psychological distress in people with type 2 diabetes: A feasibility randomised-controlled trial by Ayşenur Kılıç, Joanna Hudson, Whitney Scott, Lance M. McCracken, Ruth A. Hackett, Lyndsay D. Hughes

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Utility of Goal Attainment Scaling (GAS) in evaluating a multicomponent exercise programme for community-dwelling pre-frail older adults by Jinjing Wang, Lin Xie, Jianping Ren, Juan Fang, Xiantao Qiu, Shiyan Zhang, Shuang Yuan, Liangfeng Wu, Le Yu

“…The top three individualised goals for all participants were vestibular functions (53.5%), pain management (43.1%) and lifting and carrying objects (31.9%). …”
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Distinct host-response signatures in circulatory shock: a narrative review by Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine Pöss, Hannah Schaubroeck, Filio Billia, John C. Marshall, Patrick R. Lawler

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Pressure Algometry Validation and Determination of Efficacy of Articaine Hydrochloride Ring Block in Antler Removal in Red Deer (<i>Cervus elaphus</i>) by Farzin Sahebjam, Kavitha Kongara, John Paul Chambers, Ruth Ellen Walker, Rafea Naffa, Nicolas Lopez-Villalobos, Preet Mohinder Singh

“…These findings lay a foundation for future studies in the topics of peri-operative and postoperative pain management in deer antler removal, and a possible alternative use for articaine.…”
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Subcutaneous ICD implantation under ultrasound-guided serratus anterior plane block: Single-center experience in the Netherlands by Jan Elders, Hisham AlHashimi, Marc Gomes, Ivo Panhuizen, Sander van Kuijk, Kevin Vernooy

“…Introduction: To avoid general anesthesia (GA) and improve postoperative pain management for subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation there is a growing interest for alternative methods. …”
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An expert panel Delphi consensus statement on the use of palliative care in the management of patients with pulmonary arterial hypertension by Melisa Wilson, Rebekah H. Anguiano, Rana L. A. Awdish, James C. Coons, Amy Kimber, Melissa Morrison, Sara Paulus, Ann Schmit, Frank Spexarth, Keith M. Swetz, Nathan J. Verlinden, Mary E. Whittenhall, Margaret R. Sketch, Meredith Broderick, Jacqueline Brewer

“…Services that achieved consensus were pain management techniques, end‐of‐life care, and psychosocial recommendations. …”
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Is there any Synergistic Effect of Perioperative Use of Pregabalin in Addition to Naproxen in Ankle Fractures? A Prospective, Randomized, Multicenter Study by Dong Woo Shim MD, PhD, Yeokwon Yoon MD, Seung Hwan Han MD, PhD, Jin Woo Lee MD, PhD, Kwang Hwan Park MD, PhD, Gi-Won Choi MD

“…Category: Ankle; Trauma Introduction/Purpose: Opioid-centric pain management strategies have created an epidemic of prescription opioid abuse in the United States. …”
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The Influence of PRO-SELF Cancer Pain Control Programme on Patients’ Self-Management Ability by Xin Yin, Zi-Jing Chu, Yuan-Yuan Ni, Hong-Wei Li, Hong-Yan Li

“…Conclusion: The PRO-SELF pain symptoms in patients with a cancer pain management programme improved degree of social support, life quality, self-efficacy, anxiety, depression which is worthy of clinical application.…”
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Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Cav3.2 channels by Deyuan Su, Deyuan Su, Deyuan Su, Ye Gong, Songyu Li, Songyu Li, Jian Yang, Yin Nian

“…Our work reveals that a currently in-use cardiovascular drug has strong analgesic effects mainly via blockade of Cav3.2 and provides a compelling rationale and foundation for conducting clinical studies to repurpose cyclovirobuxine D in pain management.…”
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Immediate postoperative topical lidocaine gel for the treatment of eye pain following corneal abrasion in descemet membrane endothelial keratoplasty (DMEK) under general anaesthesi... by Nicolas Leister, Björn Bachmann, Mario Matthaei, Uwe Trieschmann, Christine Schumacher, Vanessa Löw, Bernd W. Böttiger, Silvia Schrittenlocher, Ludwig M. Heindl, Claus Cursiefen

“…This study aims to evaluate postoperative pain management using topical lidocaine gel after DMEK with iatrogenic corneal abrasion. …”
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Emergency Department Visits Within 90 Days of Total Ankle Replacement by Philip P. Ratnasamy BS, Alexander J. Kammien BS, Michael J. Gouzoulis BS, Irvin Oh MD, Jonathan N. Grauer MD

“…The highest incidence of ED visits was in the first 2 postoperative weeks, and surgical site pain was the most common reason. Pain management pathways following TAR should be able to be adjusted to minimize the occurrence of postoperative ED visits, thereby improving patient experiences and decreasing health care utilization/costs. …”
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