Morphine promotes migration and lung metastasis of mouse melanoma cells by Golnaz Vaseghi, Nasim Dana, Ahmad Ghasemi, Reza Abediny, Ismail Laher, Shaghayegh Haghjooy Javanmard

“…Background: Morphine is an analgesic agent used for cancer pain management. There have been recent concerns that the immunosuppressant properties of morphine can also promote cancer metastasis. …”
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Physical activity advice given by French general practitioners for low back pain and the role of digital e-health applications: a qualitative study by Marion Dehainault, Olivia Gaillard, Bintou Ouattara, Matthieu Peurois, Cyril Begue

“…Further research is needed into the implementation of e-health apps for low back pain management. Trial registration Not applicable.…”
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Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial by Li X, Wu J, Lan H, Shan W, Xu Q, Dong X, Duan G

“…The secondary outcomes included the severity of delirium, onset and duration of delirium, emergence agitation, adverse events, total propofol dose, intraoperative opioid dosage, length of post-anesthesia care unit stay, extubation time, and patient satisfaction with postoperative pain management.Results: All 100 patients completed the study. …”
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Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis by Ian A. Jones, MD, Arad Talehakimi, MS, Linda S. Murphy, MS, Jennifer C. Wang, BS, Amit S. Piple, MD, Alexander B. Christ, MD, Nathanael D. Heckmann, MD

“…Methods: A literature search was performed, identifying randomized controlled trials investigating duloxetine for pain management after total hip and total knee arthroplasty. …”
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Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesi... by Vera B. Plakhova, Dmitriy M. Samosvat, Georgy G. Zegrya, Valentina A. Penniyaynen, Arina D. Kalinina, Ma Ke, Svetlana A. Podzorova, Boris V. Krylov, Ilya V. Rogachevskii

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Analgesic Strategies for Urologic Videolaparoscopic or Robotic Surgery in the Context of an Enhanced Recovery after Surgery Protocol: A Prospective Study Comparing Erector Spinae P... by Marco Micali, Giada Cucciolini, Giulia Bertoni, Michela Gandini, Marco Lattuada, Gregorio Santori, Carlo Introini, Francesco Corradi, Claudia Brusasco

“…Regional anesthesia in postoperative pain management has developed in recent years, especially with the advent of fascial plane blocks. …”
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Effect of acupressure on pain intensity and physiological indices in patients undergoing extracorporeal shock wave lithotripsy: a randomized double-blind sham-controlled clinical t... by Ali Safdari, Salman Khazaei, Mahdi Biglarkhani, Seyed Habibollah Mousavibahar, Seyed Reza Borzou

“…Thus, acupressure can be considered a simple, easy, and effective option for pain management in patients during this procedure. Trial registration [ https://en.irct.ir/trial/69117 ], identifier [IRCT20190524043687N4].…”
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The potentiating effect of intravenous dexamethasone upon preemptive pudendal block analgesia for hypospadias surgery in children managed with Snodgrass technique: a randomized con... by Sonia Ben Khalifa, Ahmed Ben Slimene, Hajer Blaiti, Refka Kaddour, Amjed Fekih Hassen, Pierre Pardessus, Christopher Brasher, Souhayl Dahmani

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Posterior minimally invasive scoliosis surgery versus the standard posterior approach for the management of adolescent idiopathic scoliosis: an updated meta-analysis by Honghao Yang, Xiangyuan Jia, Yong Hai

“…MISS was associated with adequate deformity correction, better restoration of sagittal alignment, less EBL, fewer transfusions, shorter LOS, and better pain management compared to PSF. Further research is required to determine the detailed indications for the MISS procedure.…”
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Measuring deliberate reflection in residents: validation and psychometric properties of a measurement tool by Richard H. Blum, Christine L. Mai, John D. Mitchell, Daniel Saddawi-Konefka, Jeffrey B. Cooper, George Shorten, Audrey DunnGalvin

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Efficacy of Adding Acetaminophen to Preemptive Multimodal Analgesia in Total Knee Arthroplasty: A Double‐blinded Randomized Study by Qiuru Wang, Ting Ma, Liying Wang, Chengcheng Zhao, Pengde Kang

“…The current work aimed to assess the efficacy of adding acetaminophen to preemptive multimodal analgesia for clinical pain management after TKA. Methods This was a double‐blinded randomized study including 80 cases randomized to the acetaminophen and control groups, respectively. …”
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Preference of musculoskeletal pain treatment in middle-aged and elderly chinese people: a machine learning analysis of the China health and retirement longitudinal study by Fengyao Mei, Shengjie Dong, Jiaojiao Li, Dan Xing, Jianhao Lin

“…To help improve clinical decision making, it’s important to estimate the current state of musculoskeletal pain management and analyze the contribution of patient treatment preference. …”
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Anatomical Safety Area for Periarticular Analgesic Infiltration through the Posterior Capsule in Total Knee Arthroplasty: Radiological Study in Magnetic Resonance by Marta Mifsut-Aleixandre, Damián Mifsut, Eva María González-Soler, Arantxa Blasco-Serra, Alfonso Amador Valverde

“…<b>Background</b>: One of the main challenges of orthopedic surgery is adequate pain management after total knee arthroplasty. This work aimed to determine the anatomical safety area for infiltration through the posterior capsule of the knee in prosthetic surgery using Magnetic Resonance Imaging (MRI). …”
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Implementation of an online pain science education for chronic musculoskeletal pain in Brazilian public health system: protocol for a hybrid type III randomised controlled trial wi... by Marina P. Baroni, Luiz Hespanhol, Gisela C. Miyamoto, Christiane R. Daniel, Lívia G. Fernandes, Felipe J. J. dos Reis, Joshua W. Pate, Bruno T. Saragiotto

“…In addition to promoting better pain management, this study will also contribute to the field of implementation science in public health by generating important insights and recommendations for future interventions. …”
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Chitosan-Based Nanogels: Synthesis and Toxicity Profile for Drug Delivery to Articular Joints by Seng Manivong, Araceli Garcia Ac, Shunmoogum A. Patten, Julio C. Fernandes, Mohamed Benderdour, Xavier Banquy, Florina Moldovan, Valérie Gaëlle Roullin

“…One important challenge in treating avascular-degraded cartilage is the development of new drugs for both pain management and joint preservation. Considerable efforts have been invested in developing nanosystems using biomaterials, such as chitosan, a widely used natural polymer exhibiting numerous advantages, i.e., non-toxic, biocompatible and biodegradable. …”
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Thoracic spinal anesthesia with intrathecal sedation for lower back surgery: a retrospective cohort study by Nikolay Boykov, Dilyan Ferdinandov, Dilyan Ferdinandov, Petra Vasileva, Petra Vasileva, Dimo Yankov, Dimo Yankov, Stefan Burev, Rositsa Tanova, Rositsa Tanova

“…No significant complications were detected.ConclusionThoracic spinal anesthesia incorporating adjuvants such as midazolam, clonidine or dexmedetomidine, and dexamethasone demonstrates not only efficient conditions for spine surgery, a favorable safety profile, high patient satisfaction, and intrathecal sedation but also effective opioid-free pain management.…”
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Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain by Qing Ye, Jie Li, Wen-Jing Ren, Ying Zhang, Tao Wang, Patrizia Rubini, Hai-Yan Yin, Peter Illes, Peter Illes, Yong Tang, Yong Tang

“…BackgroundSeveral studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management approach, the mechanism of electroacupuncture (EA) treatment of acidification-induced pain is not fully understood. …”
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Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics by Ma H, Pan Z, Lai B, Zan C, Liu H

“…Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. …”
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Effective Local Anesthetic Use in Nasal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Studies by Leonardo Alaniz, BBA, Cindy Vu, BS, Jagmeet Arora, BS, Avril Stulginski, BS, Xiao Zhu, MD, Justin Cordero, BS, Raj M. Vyas, MD, Miles J. Pfaff, MD, MHS

“…These findings support the efficacy of nerve blocks in providing postoperative pain relief and enhancing patient satisfaction with pain management. Perioperative nerve blocks, in combination with general anesthesia, should be considered for postoperative pain control.…”
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Dopamine D₄ Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum by Alicia Rivera, Diana Suárez-Boomgaard, Cristina Miguelez, Alejandra Valderrama-Carvajal, Jérôme Baufreton, Kirill Shumilov, Anne Taupignon, Belén Gago, M. Ángeles Real

“…Thus, D₄R could represent a valuable pharmacological target for the safety use of morphine in pain management.…”
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