Effects of pharmacogenetic profiles on pediatric pain relief and adverse events with ibuprofen and oxycodone by Samina Ali, Aran Yukseloglu, Colin J. Ross, Rhonda J. Rosychuk, Amy L. Drendel, Robin Manaloor, David W. Johnson, Sylvie Le May, Bruce Carleton

“…This pragmatic prospective, observational cohort included children aged 4 to 16 years who were seen in a pediatric emergency department with an acute fracture and prescribed ibuprofen or oxycodone for at-home pain management. Saliva samples were obtained for genotyping of allelic variants, and daily telephone follow-up was conducted for 3 days. …”
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Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studies by Arnav Agarwal, Jason W Busse, Rachel Couban, Patrick Hong, Dena Zeraatkar, Thomas Agoritsas, Robin W M Vernooij, Brian Y Hong, Muhammad Muneeb Ahmed, Jared E Dookie, Matthew Adam Cooper, Gareth Leung, Kevin Loniewski, Chris Hong

“…We found insufficient evidence addressing the harms of medical cannabis compared with other pain management options, such as opioids.Conclusions There is very low certainty evidence that adverse events are common among people living with chronic pain who use medical cannabis or cannabinoids, but that few patients experience serious adverse events.…”
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Five healthcare trajectories in the year before suicide and what they tell us about opportunities for prevention: a population-level case series studyResearch in context by Kate M. Chitty, Sandro Sperandei, Gregory L. Carter, Zein Ali, Jacques E. Raubenheimer, Andrea L. Schaffer, Andrew Page, Nicholas A. Buckley

“…Trajectories B and D might benefit from opioid dispensing limits and access to psychological pain management. Trajectory C had high mental health medicine use, indicating that the time that medicines are prescribed or dispensed are important touchpoints. …”
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Efficacy and Safety of Naloxegol in Patients with Chronic Non-Cancer Pain Who Experience Opioid-Induced Constipation: A Pooled Analysis of Two Global, Randomized Controlled Studies by Chey WD, Brenner DM, Cash BD, Hale M, Adler J, Jamindar MS, Rockett CB, Almenoff JS, Bortey E, Gudin J

“…William D Chey,1 Darren M Brenner,2 Brooks D Cash,3 Martin Hale,4 Jeremy Adler,5 Mansi S Jamindar,6 Carol B Rockett,6 June S Almenoff,6 Enoch Bortey,7 Jeffrey Gudin8 1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, MI, USA; 2Departments of Medicine and Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 3Division of Gastroenterology, Hepatology, and Nutrition at the University of Texas Health Science Center at Houston, Houston, TX, USA; 4Gold Coast Research, L.L.C, Miami, FL, USA; 5Pacific Pain Medicine Consultants, Encinitas, CA, USA; 6Medical Affairs, RedHill Biopharma, Inc, Raleigh, NC, USA; 7Pharmaceutical Development Strategies, L.L.C, Chapel Hill, NC, USA; 8Department of Anesthesiology and Pain Management, University of Miami, Miami, FL, USACorrespondence: June S Almenoff, Email jalmenoff@redhillus.comObjective: This study evaluates the onset, magnitude, and consistency of improvement of opioid-induced constipation (OIC) symptoms with naloxegol treatment.Methods: This was a pooled analysis of two Phase 3, double-blind, randomized, placebo-controlled studies (KODIAC-04/05, NCT01309841/NCT01323790) in patients with chronic non-cancer pain and OIC treated with naloxegol 25mg or 12.5mg daily. …”
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Applying a knowledge translation framework for triaging low back pain and radicular pain at an emergency department: an iterative process within an uncontrolled before-and-after de... by Sanne Peters, Bart Depreitere, Karel Jacobs, Peter Van Wambeke, Sofie Rummens, Sebastiaan Schelfaut, Lieven Moke, Joost Dejaegher, Ann Spriet, Anne-lies Van den Broeck, Johan Vliers

“…Although evidence-based guidelines for LBP and radicular pain management exist, a protocol for use at the ED in the Belgian University Hospitals Leuven was not available, resulting in high practice variation. …”
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Proteomics-Based Serum Alterations of the Human Protein Expression after Out-of-Hospital Cardiac Arrest: Pilot Study for Prognostication of Survivors vs. Non-Survivors at Day 1 aft... by Jochen Hinkelbein, Lydia Kolaparambil Varghese Johnson, Nikolai Kiselev, Jan Schmitz, Martin Hellmich, Hendrik Drinhaus, Theresa Lichtenstein, Christian Storm, Christoph Adler

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Protocol for double-blind RCT of acupuncture for vulvodynia by Judith M. Schlaeger, Marie L. Suarez, Jennifer E. Glayzer, William H. Kobak, Monya Meinel, Alana D. Steffen, Larisa A. Burke, Heather A. Pauls, Yingwei Yao, Miho Takayama, Hiroyoshi Yajima, Ted J. Kaptchuk, Nobuari Takakura, David Foster, Diana J. Wilkie

“…Conclusion: This study is responsive to the need for efficacious pain management for women with vulvodynia.ClinicalTrials.gov Identifier: NCT03364127.…”
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The Effectiveness of Intravenous lidocaine in Burn Pain Relief: A Randomized Double-Blind Controlled Trial by Mohammad Haghighi, Bahram Naderi Nabi, Hossein Khoshrang, Siamak Rimaz, Soudabeh Haddadi, Arman Parvizi, Mohammadreza Mobayen, Gelareh Biazar, Tayebeh Zarei

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Tafalgin is a Russian innovative tetrapeptide pharmaceutical for subcutaneous injection: review of the results of phase I and II clinical trials by V. S. Kosorukov, G. R. Abuzarova, E. R. Zakharochkina, O. Yu. Gamzeleva, K. A. Yatsenko

“…Tafalgin is characterized by fast absorption after subcutaneous administration (less than 30 minutes) which allows for fast clinical effect and absence of accumulation in the body. use of this pharmaceutical in patients with cancer allowed to maintain appropriate pain management achieved earlier through intramuscular morphine administration in 100 % of cases. …”
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Lung Thermal Ablation: Comparison between an Augmented Reality Computed Tomography (CT) 3D Navigation System (SIRIO) and Standard CT-Guided Technique by Rosario Francesco Grasso, Flavio Andresciani, Carlo Altomare, Giuseppina Pacella, Gennaro Castiello, Massimiliano Carassiti, Carlo Cosimo Quattrocchi, Eliodoro Faiella, Bruno Beomonte Zobel

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A remote group-mediated daylong physical activity intervention for older adults with chronic pain: Results of the MORPH-II randomized pilot trial by Jason Fanning, Amber K. Brooks, Sherri Ford, Justin T. Robison, Megan B. Irby, W. Jack Rejeski

“…Chronic pain is a debilitating condition that affects many older adults who often have limited access to non-pharmacological pain management strategies. One potentially effective and novel lifestyle medicine for chronic pain involves increasing physical activity through frequent movement across the day, thereby also decreasing the presence of extended sedentary bouts. …”
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Efficacy and safety of tranexamic acid in geriatric hip fracture with hemiarthroplasty: a retrospective cohort study by Jinwei Xie, Qinsheng Hu, Qiang Huang, Guo Chen, Zongke Zhou, Fuxing Pei

“…All patients underwent a fast-track program including nutrition, blood, and pain management; VTE prophylaxis; early mobilization; and early intake. …”
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Botulinum Toxin-A Injection in Chronic Pelvic Pain Syndrome Treatment: A Systematic Review and Pooled Meta-Analysis by Andrea Panunzio, Alessandro Tafuri, Giovanni Mazzucato, Clara Cerrato, Rossella Orlando, Vincenzo Pagliarulo, Alessandro Antonelli, Maria Angela Cerruto

“…Introduction: Pain management of patients with chronic pelvic pain syndrome (CPPS) is challenging, because pain is often refractory to conventional treatments. …”
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Analgesic Effect of Intraoperative Intravenous S(+)-Ketamine During Total Knee Arthroplasty Surgery: Study Protocol for a Randomized Controlled Clinical Trial by Shiyuan Deng, Lina Chen, Xiao Song, Liang Guo, Fei Zhao, Jing Liu, Ling Dong

“…ObjectiveEffective multimodal pain management in the early postoperative period is essential for anesthesiologists. …”
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Acupuncture versus massage for pain in patients living with advanced cancer: a protocol for the IMPACT randomised clinical trial by Han Xiao, Katherine Panageas, Jun J Mao, Kevin Liou, Sally A D Romero, Nicholas Emard, Raymond E Baser, Jodi MacLeod, Desiree Walker, Margaret Barton-Burke, Gary Deng, John Farrar, Andrew Epstein

“…Clinical guidelines recommend non-pharmacological interventions, including acupuncture and massage, for pain management in adult patients with cancer in adjunct to conventional care. …”
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Definition and Differences of Determination Criteria of the Rate of Chronic Low Back Pain Response to Integrated Traditional Chinese and Western Medicine Treatment in Clinical Stud... by Xia LI, Duoduo LI, Luyao CHENG, Ying WAN, Changhe YU

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Continuous wound infusion catheter as part of a multimodal analgesia regimen for post-Caesarean delivery pain: a quality improvement impact study by Cedar Fowler, Emily Stockert, Dan Hoang, Nan Guo, Edward Riley, Pervez Sultan, Brendan Carvalho

“…Conclusions: The addition of continuous wound infusion catheters to a multimodal analgesia regimen for post-Caesarean delivery pain management demonstrated minimal clinically significant analgesic benefits. …”
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A rare case of successful pain control in a prostate cancer patient with bone metastasis undergoing hemodialysis by measuring the serum oxycodone level and using an activity tracke... by Yoshihisa Mimura, Yosuke Sugiyama, Taku Naiki, Tomoya Kataoka, Yoshihiko Tasaki, Toshiki Etani, Nami Tomiyama, Nayuka Matsuyama, Kunihiro Odagiri, Kazunori Kimura, Takahiro Yasui

“…Case Presentation: A 72-year-old male, with a history of hemodialysis induced by diabetic nephropathy for 16 years and prostate cancer for three years, was diagnosed with metastasis in his 12th thoracic and 2nd lumbar vertebrae, and treated with analgesic pain management (oxycodone, acetaminophen, and pregabalin) and radiotherapy. …”
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Epidemiological Factors Associated with Prescription of Opioids for Chronic Non-Cancer Pain in Adults: A Country-Wide, Registry-Based Study in Denmark Spans 2004–2018 by Hansen CA, Ernst MT, Smith CD, Abrahamsen B

“…Carrinna Aviaja Hansen,1– 4 Martin Thomsen Ernst,4,5 Christopher Dyer Smith,4 Bo Abrahamsen4,6 1Department of Orthopedic Surgery, Zealand University Hospital, University of Copenhagen, Koege, Denmark; 2Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; 3Department of Anesthesia, Respiratory Support and Pain Management, the Neuroscience Centre, Rigshospitalet, Glostrup, University of Copenhagen, Copenhagen, Denmark; 4Odense Patient Data Explorative Network, University of Southern Denmark, Odense, Denmark; 5Department of Public Health, University of Southern Denmark, Odense, Denmark; 6Department of Medicine, Holbaek Hospital, Holbaek, DenmarkCorrespondence: Carrinna Aviaja Hansen, Zealand University Hospital, University of Copenhagen, Department of Orthopedic Surgery, Lykkebaekvej 1, Koege, 4600, Denmark, Tel +45 9357 6524, Email carrh@regionsjaelland.dkPurpose: Denmark has a high consumption of prescribed opioids, and many citizens with chronic non-cancer pain (CNCP). …”
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TEleRehabilitation Nepal (TERN) for People With Spinal Cord Injury and Acquired Brain Injury: A Feasibility Study by Raju Dhakal, Mandira Baniya, Rosie M Solomon, Chanda Rana, Prajwal Ghimire, Ram Hariharan, Sophie G Makower, Wei Meng, Stephen Halpin, Sheng Quan Xie, Rory J O’Connor, Matthew J Allsop, Manoj Sivan

“…The telerehabilitation programme facilitated the delivery of support around multiple aspects of rehabilitation care, such as spasticity treatments and pain management. Outcome measures indicated a significant improvement in functional independence ( P  < .001), depression, anxiety and stress ( P  < .001) and quality of life ( P  < .001). …”
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