Comparing Long-Term Prognosis in Chronic Critically Ill Patients: A Case Series Study of Medical versus Surgical Sepsis by Benjamin Mancini, Jiabin Liu, Abigail Samuelsen, Judie A. Howrylak, Lisa Schultz, Anthony S. Bonavia

Get full text

Whole-Body Electrostatic Pain Treatment in Adults with Chronic Pain: A Prospective Multicentric Observational Clinical Trial by Stephan Steinhauser, Michael Thomas Ganter, Vincent Stadelmann, Christoph Karl Hofer, for the ELES Study Group

“…Treatment was added to an established conservative pain management. Pain scores (visual analog scale (VAS) 0–100, primary outcome) and sleep quality (seven-point Likert scale, secondary outcome) were assessed before, during, and at the end of the treatment period; quality of life (SF-12: Physical Component Summary = PCS, Mental Component Summary = MCS; secondary outcome) was assessed before and at the end of the treatment period. …”
Get full text

Evaluation of 8% Capsaicin Patches in Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Study in a Comprehensive Cancer Center by Florent Bienfait, Arthur Julienne, Sabrina Jubier-Hamon, Valerie Seegers, Thierry Delorme, Virginie Jaoul, Yves-Marie Pluchon, Nathalie Lebrec, Denis Dupoiron

Get full text

Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis by Souvik Maitra, Dalim K. Baidya, Sulagna Bhattacharjee, Anirban Som

“…Methods: Published prospective human randomized clinical trials, which compared preoperative and/or postoperative gabapentin/pregabalin with placebo or no treatment for postoperative pain management after cardiac surgery has been included in this review. …”
Get full text

ASPECTS OF THE DEVELOPMENT OF THE PROGRAM OF PALLIATIVE ASSISTANCE FOR CHILDREN OF THE KHARKIV REGION THROUTH THE CHALLENGES OF THE MILITARY CONFLICT by О. Ріга, Д. Марстон, М. Хаустов, В. Мясоєдов, А. Пеньков, Р. Марабян

“… In the context of armed confl ict, palliative care, pain management, and care for the dying and bereaved require increased and urgent attention. …”
Get full text

Effect of neuro-dynamic technique on repetitive inward ankle rolls among young Malaysian athletes - a randomized controlled trial by Vinodhkumar Ramalingam, Viswanath Sundar, Saju Joseph

“…In addition, the participants received standard physiotherapy (pain management and exercise) whereas the group B participants received only standard physiotherapy. …”
Get full text

Effect of biopsychosocial coaching on improving return to work duration after involvement in commuting road crash by Sahak, Nurrul Hafeezah

“…Intervention: Biopsychosocial coaching intervention with the aim to reduce biopsychosocial barriers for recovery in order to fasten return to work duration through work goal, healthy living, and stress and pain management. The biopsychosocial coaching intervention was delivered concurrent to usual care and the average coaching involved three one-hour long sessions. …”
Get full text

Airway management in the paediatric difficult intubation registry: a propensity score matched analysis of outcomes over timeResearch in context by Mary Lyn Stein, Lina Andrea Sarmiento Argüello, Steven J. Staffa, Julia Heunis, Chinyere Egbuta, Stephen G. Flynn, Sabina A. Khan, Stefano Sabato, Brad M. Taicher, Franklin Chiao, Adrian Bosenberg, Angela C. Lee, H. Daniel Adams, Britta S. von Ungern-Sternberg, Raymond S. Park, James M. Peyton, Patrick N. Olomu, Agnes I. Hunyady, Annery Garcia-Marcinkiewicz, John E. Fiadjoe, Pete G. Kovatsis, Benjamin Bruins, Paul Stricker, Elizabeth Laverriere, Justin L. Lockman, Brian Struyk, Christopher Ward, Akira Nishisaki, Ramesh Kodavatiganti, Rodrigo Daly Guris, Luis Sequera-Ramos, Mark Teen, Ayodele Oke, Grace Hsu, Arul Lingappan, Rhae Battles, Ashley Bocanegra, Tally Goldfarb, Edgar Kiss, Peter Szmuk, Sam Mireles, Andrea Murray, Simon Whyte, Ranu Jain, Maria Matuszczak, Christopher Holmes, Alexander McCann, Clyde Matava, Nicholas Dalesio, Robert Greenberg, Angela Lucero, Sapna Desai, Sondra Rosander, Sindhu Samba, Charles Schrock, Sydney Nykiel-Bailey, Jennifer Marsh, Melissa Brooks Peterson, Amy Lee, Somaletha Bhattacharya, Nicholas Burjek, Narasimhan Jagannathan, David Lardner, Christy Crockett, Sara Robetson, Jasmine Patel, Aarti Sharma, Thomas Templeton, Piedad Echeverry Marín, Carolina Pérez-Pradilla, Neeta Singh, David Sommerfield, Neil Hauser, Emily Hesselink, Hilana Lewkowitz-Shpuntoff, Pilar Castro, N. Ricardo Riveros Perez, Eduardo Vega, Alejandro González, Paola Ostermann, Kasia Rubin, Jonathan Meserve, Charles Lord, Angela Lee, Songyos Valairucha, Priti Dalal, Thanh Tran, Taylor Anspach, Lisa K. Lee, Ihab Ayad, Mohamed Rehman, Allison Fernandez, Lillian Zamora, Niroop Ravula, Sadiq Shaik, Judit Szolnoki, Preethy Mathew, Sandhya Yaddanapudi, Indu Sen, Aakriti Gupta, Kathryn Handlogten, J. Michael Sroka, Vinícius Caldeira Quintão, Ricardo Vieira Carlos, Fernanda Leite

Get full text

Pregnancy in Congenital Heart Disease, Complicated by Pulmonary Arterial Hypertension—A Challenging Issue for the Pregnant Woman, the Foetus, and Healthcare Professionals by Virginija Rudienė, Lina Kaplerienė, Dovilė Jančauskaitė, Emilija Meškėnė, Eglė Palevičiūtė, Monika Laukytė-Slėnienė, Diana Gasiūnaitė, Diana Ramašauskaitė, Elena Jurevičienė, Lina Gumbienė

Get full text

Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study by Jordi Barrachina, Cesar Margarit, Javier Muriel, Vicente López-Gil, Santiago López-Gil, Pura Ballester, Laura Mira-Lorente, Laura Agulló, Ana M. Peiró

“…Despite the large body of research on sex differences in pain, there is a lack of translation to real-world pain management. Our aim was to analyse the sex differences in the analgesic response to oxycodone/naloxone (OXN) and tapentadol (TAP), in comparison with other opioids (OPO) commonly prescribed for chronic non-cancer pain (CNCP). …”
Get full text

Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells by Zhi-Hong Wen, Hsiao-Mei Kuo, Po-Chang Shih, Ling-Chen Hsu, Jimmy Ming-Jung Chuang, Nan-Fu Chen, Hsi-Wen Sun, Hsin-Tzu Liu, Chun-Sung Sung, Wu-Fu Chen

Get full text

Anti-TNF (adalimumab) injection for the treatment of adults with frozen shoulder during the pain predominant stage protocol for a multi-centre, randomised, double blind, parallel g... by Jagdeep Nanchahal, Nicola Kenealy, Sally Hopewell, Amar Rangan, Ruth Knight, Cynthia Srikesavan, Susan Dutton, Sarah Lamb, Marc Feldmann

“…All participants will receive a physiotherapy advice leaflet providing education and advice about frozen shoulder and pain management. The primary feasibility objectives are: 1) the ability to screen and identify potential participants with pain predominant early stage frozen shoulder; 2) willingness of eligible participants to consent and be randomised to intervention; 3) practicalities of delivering the intervention, including time to first injection and number of participants receiving second injection; 4) standard deviation of the Shoulder Pain and Disability Index (SPADI) score and attrition rate at 3 months from baseline in order to estimate the sample size for a definitive trial. …”
Get full text

Real World Clinical Utility of Neurophysiological Measurement Utilizing Closed-Loop Spinal Cord Stimulation in a Chronic Pain Population: The ECAP Study Protocol by Leitner A, Hanson E, Soliday N, Staats P, Levy R, Pope J, Kallewaard JW, Doleys D, Li S, Weisbein J, Amirdelfan K, Poree L

“…Angela Leitner,1 Erin Hanson,1 Nicole Soliday,1 Peter Staats,2 Robert Levy,3 Jason Pope,4 Jan W Kallewaard,5,6 Daniel Doleys,7 Sean Li,2 Jacqueline Weisbein,8 Kasra Amirdelfan,9 Lawrence Poree10 1Saluda Medical Pty Ltd, Artarmon, New South Wales, Australia; 2National Spine and Pain Centers, Shrewsbury, NJ, USA; 3Departments of Neurosurgery and Clinical Research, Anesthesia Pain Care Consultants, Tamarac, FL, USA; 4Evolve Restorative Center, Santa Rosa, CA, USA; 5Department of Anaesthesiology and Pain Management, Rijnstate Hospital, Arnhem, the Netherlands; 6Department of Anesthesiology and Pain Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands; 7Pain and Rehabilitation Institute, Birmingham, AL, USA; 8Napa Valley Orthopaedic Medical Group, Napa, CA, USA; 9Boomerang Healthcare, Walnut Creek, CA, USA; 10Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA, USACorrespondence: Angela Leitner, Saluda Medical, Ground Floor, 407 Pacific Hwy, Artarmon, NSW, 2064, Australia, Email angela.leitner@saludamedical.comBackground: Spinal cord stimulation (SCS) is an established chronic pain treatment, but the effectiveness of traditional, open-loop paradigms has been plagued by variable sustainability in a real-world setting. …”
Get full text

Somatosensory Outcomes Following Re-Surgery in Persistent Severe Pain After Groin Hernia Repair: A Prospective Observational Study by Jensen EK, Ringsted TK, Bischoff JM, Petersen MA, Møller K, Kehlet H, Werner MU

“…Elisabeth Kjær Jensen,1,* Thomas K Ringsted,1,* Joakim M Bischoff,1 Morten A Petersen,2 Kirsten Møller,3,4 Henrik Kehlet,5 Mads U Werner1,6 1Department of Anaesthesia, Pain and Respiratory Support, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark; 2Statistical Research Unit, Department of Palliative Care, Bispebjerg Hospital, Copenhagen, Denmark; 3Department of Neuroanaesthesiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark; 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 5Section for Surgical Pathophysiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark; 6Department of Clinical Sciences, Lund University, Lund, Sweden*These authors contributed equally to this workCorrespondence: Elisabeth Kjær Jensen, Multidisciplinary Pain Center 7612, Department of Anesthesia, Pain and Respiratory Support, Neuroscience Center, Rigshospitalet, Ole Maaløes Vej 26, Copenhagen N, 2200, Denmark, Tel +45 3545 7612, Email elisabeth.kjaer@live.dkPurpose: After groin hernia repair (globally more than 20 million/year) 2– 4% will develop persistent severe pain (PSPG). Pain management is challenging and may require multimodal interventions, including re-surgery. …”
Get full text

The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects by Ayman Alzu'bi, Worood Bani Baker, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Manal Isam AbuAlArjah, Ejlal Abu-El-Rub, Lena Tahat, Ahmed MNZ Helaly, Doaa S. Ghorab, Waseem El-Huneidi, Raed M. Al-Zoubi

“…Purpose: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. …”
Get full text

Application of analgesics in emergency services in Germany: a survey of the medical directors by Signe Vilcane, Olga Scharonow, Christian Weilbach, Maximilian Scharonow

“…Objective The aim of this study is to assess the current situation in out of hospital pain management in Germany regarding the substances, indications, dosage and the delegation of the use of analgesics to emergency medical service (EMS) staff. …”
Get full text

Measuring enhanced recovery in obstetrics: a narrative review by Sarah Ciechanowicz, BMBCh, MRes, Janny Xue Chen Ke, MD, MSc, Nadir Sharawi, MBBS, MSc, Pervez Sultan, MBChB, MD (Res), FRCA

Get full text

Patient perceptions of virtual reality for pain relief in labor: A qualitative study by Melissa S. Wong, Melissa S. Wong, Kimberly D. Gregory, Kimberly D. Gregory, Kimberly D. Gregory, Brennan M. R. Spiegel, Brennan M. R. Spiegel, Brennan M. R. Spiegel, Brennan M. R. Spiegel, Carine Khalil, Carine Khalil

“…IntroductionLabor represents the most common reason for hospitalization, and most patients will use some form of pain management during their labor. While some studies have suggested that virtual reality (VR) may be an effective option for managing pain, more study is necessary to understand the patient experience of VR. …”
Get full text

Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation by Huina Wei, Boyu Liu, Chengyu Yin, Danyi Zeng, Huimin Nie, Yuanyuan Li, Yan Tai, Xiaofen He, Boyi Liu

“…Abstract Background Gout results from disturbed uric acid metabolism, which causes urate crystal deposition in joints and surrounding tissues. Gout pain management is largely limited to colchicine and nonsteroidal anti-inflammatory drugs. …”
Get full text

Implementation and Preliminary Effectiveness of a Multidisciplinary Telemedicine Pilot Initiative for Patients with Chronic Non-Cancer Pain in Rural and Underserved Areas at a Majo... by Hayes CJ, Gannon MA, Woodward EN, Long CR, George M, Ray-Griffith S, Tobey LR, Goree J

“…To improve access to high-quality treatment of chronic pain, we developed the Arkansas Improving Multidisciplinary Pain Care and Treatment (AR-IMPACT) Telemedicine Clinic, a multidisciplinary and interprofessional team of specialists who provide evidence-based pain management for patients with chronic pain.Methods: We conducted a single-arm pilot trial of the AR-IMPACT Telemedicine Clinic with rural, university-affiliated primary care clinics. …”
Get full text