Stratified primary care versus non-stratified care for musculoskeletal pain : qualitative findings from the STarT MSK feasibility and pilot cluster randomized controlled trial by Saunders, Benjamin, Hill, Jonathan C., Foster, Nadine E., Cooper, Vince, Protheroe, Joanne, Chudyk, Adrian, Chew-Graham, Carolyn, Bartlam, Bernadette

“…Most GPs reported that the matched treatment options aided their clinical decision-making (Motivation), but identified some options that were not available to them (e.g. pain management clinics), and other options that were not included in the matched treatments but which were felt appropriate for some patients (e.g. consider imaging). …”
Get full text

Computer-based stratified primary care for musculoskeletal consultations compared with usual care : study protocol for the STarT MSK cluster randomized controlled trial by Hill, Jonathan, Garvin, Stefannie, Chen, Ying, Cooper, Vincent, Wathall, Simon, Bartlam, Bernadette, Saunders, Benjamin, Lewis, Martyn, Protheroe, Joanne, Chudyk, Adrian, Birkinshaw, Hollie, Dunn, Kate M., Jowett, Sue, Oppong, Raymond, Hay, Elaine, van der Windt, Danielle, Mallen, Christian, Foster, Nadine E.

“…We previously developed a prognostic tool (Start Back Tool) with demonstrated effectiveness in guiding primary care low back pain management by supporting decision making using matched treatments. …”
Get full text

The influence of multimorbidity on the management of patients with hip osteoarthritis by Ferguson, R

“…There is no successful disease modifying therapy, and treatment primarily consists of pain management with total hip replacement for advanced symptomatic disease. …”

Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK by Hauck, AGV, van der Vaart, M, Adams, E, Baxter, L, Bhatt, A, Crankshaw, D, Dhami, A, Evans Fry, R, Freire, MBO, Hartley, C, Mansfield, RC, Marchant, S, Monk, V, Moultrie, F, Peck, M, Robinson, S, Yong, J, Poorun, R, Cobo, MM, Slater, R

“…The trial highlighted the challenge of translating an experimental researcher-led tactile intervention into a parent-led approach, and the value of involving parents in their baby's pain management.</p> <p><strong>Funding</strong> Wellcome Trust and Bliss.…”

Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease by Yiping Cheng, Yiping Cheng, Qiang Zhang, Haizhen Li, Guangshuai Zhou, Ping Shi, Ping Shi, Xu Zhang, Xu Zhang, Liying Guan, Fang Yan, Chao Xu, Chao Xu

Get full text

El bloqueo de nervios pericapsulares (PENG) es una alternativa efectiva y segura para el manejo del dolor postoperatorio después de una artroplastia total de cadera primaria: ensay... by S.L. Iglesias, I. Nieto, P. López, A. Almada, I. Pioli, F. Astore, C. Rodríguez Urmenyi, B.L. Allende

“…The objective of this study is to compare pericapsular nerves group (PENG) block with pericapsular infiltration (PAI) and plexus nerve block (PNB) for postoperative pain management, response to physical therapy, opioid consumption, and length of hospital stay after a primary total hip arthroplasty. …”
Get full text

Perbandingan Efek Analgesi Infiltrasi Morfin 10 Mg dan Bupivakain 0,5% 2 Mg/KgBB pada Seksio Sesarea dengan Teknik Anestesi Spinal by Wulan Fadinie, Dadik Wahyu Wijaya, Hasanul Arifin

“…It is known that morphine has peripheral receptors, so subcutaneous administration can be a very effective method of postoperative pain management. Objective: To compare analgetic effect from local infiltration of 10 mg morphine with 2mg/BW bupivacaine 0.5% in post cesarean section with spinal anesthesia Subject and Methods: This study was done by double blinded randomized clinical trial with 100 samples of pregnant women, age 20-40 years, PS-ASA I-II that will undergo elective and emergency cesarean section with spinal anesthesia. …”
Get full text

The effect of thoracic paravertebral block on seroma reduction in breast surgery – a randomized controlled trial by Alparslan Kuş, Ufuk H. Yörükoğlu, Can Aksu, Saffet Çınar, Nuh Zafer Cantürk, Yavuz Gürkan

“…For postoperative pain management, Thoracic Paravertebral Block (TPVB) has long been considered the gold standard technique. …”
Get full text

Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents by Young-Seo Yoon, Han-Jun Hwang, Jae-Min Kim, Kyung-Sook Chung, Seo-Yun Jang, So-Won Heo, Su-Yeon Lee, Soo-Yeon Kim, Hyeon-A. Song, Seung-Jae Hong, Hyo-Jin An, Sang-Wook Park, Jhong-Jae Im, Dong-Ho Oh, Ah-Ram Lee, Kyung-Tae Lee

“…Although drugs such as acetaminophen, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly used for pain management, the side effects of these drugs such as hepatotoxicity, nephrotoxicity, nausea, and vomiting, can not be neglected. …”
Get full text

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study by Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N. Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

Get full text

Cohort Description: Preventing an Opioid Epidemic in Norway &ndash; Focusing on Treatment of Chronic Pain (POINT) &ndash; A National Registry-Based Study by Hamina A, Odsbu I, Borchgrevink PC, Chen LC, Clausen T, Espnes KA, Gjesdal K, Handal M, Hartikainen S, Hjellvik V, Holter MTS, Høibø T, Kurita GP, Langaas HC, Lid TG, Nøst TH, Sjøgren P, Skurtveit S

“…Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 8Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; 9Center for Alcohol and Drug Research (KORFOR), Stavanger University Hospital, Stavanger, Norway; 10Department of Chronic Diseases, Division of Mental and Physical Health, the Norwegian Institute of Public Health, Oslo, Norway; 11School of Pharmacy, University of Eastern Finland, Kuopio, Finland; 12Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway; 13Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway; 14Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 15Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; 16Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; 17Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway&ast;These authors contributed equally to this workCorrespondence: Ingvild Odsbu, Department of Mental Disorders, Division of Mental and Physical Health, Norwegian Institute of Public Health, PO Box 222 Skøyen, Oslo, 0213, Norway, Tel +47 41454379, Email ingvild.odsbu@fhi.noAim: The POINT project aims to provide evidence to optimise chronic pain management, prevent adverse consequences of opioids, and improve chronic pain patients’ pain relief, functional capacity, and quality of life. …”
Get full text

TECHNOLOGY AND ITS IMPACT ON PHYSICAL THERAPY by Abdul Haseeb Sahibzada, Mohammad Bin Afsar Jan

“…Virtual Reality is used in the rehabilitation for different purposes such as pain management, neurological rehabilitation, motor control and to improve functional ability.5 There is an increasing amount of evidence which suggests enhanced neuroplasticity after training of virtual reality in stroke patients. …”
Get full text

UK Medical Cannabis Registry palliative care patients cohort: initial experience and outcomes by Devaki Nimalan, Michal Kawka, Simon Erridge, Mehmet Ergisi, Michael Harris, Oliver Salazar, Rayyan Ali, Katerina Loupasaki, Carl Holvey, Ross Coomber, Michael Platt, James J. Rucker, Shaheen Khan, Mikael H. Sodergren

“…Abstract Introduction Palliative care aims to improve quality of life through optimal symptom control and pain management. Cannabis-based medicinal products (CBMPs) have a proven role in the treatment of chemotherapy-induced nausea and vomiting. …”
Get full text

Impact of CYP2D6 and CYP2B6 phenotypes on the response to tramadol in patients with acute post‐surgical pain by Ana Casajús, Pablo Zubiaur, Enrique Alday, Paula Soria‐Chacartegui, Miriam Saiz‐Rodríguez, Lara Gutierrez, Catalina Aragonés, Diana Campodónico, Antía Gómez‐Fernández, Marcos Navares‐Gómez, Gonzalo Villapalos‐García, Gina Mejía‐Abril, Dolores Ochoa, Francisco Abad‐Santos

“…Abstract Tramadol is an important minor opioid prescribed for pain management. In this study, we analyzed the well‐known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5, and CYP3A4) on tramadol efficacy and safety. …”
Get full text

A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma by Toshio Fujisawa, Takeshi Shimamura, Kaku Goto, Ryo Nakagawa, Ryosuke Muroyama, Yoshinori Ino, Hajime Horiuchi, Itaru Endo, Shin Maeda, Yasushi Harihara, Atsushi Nakajima, Nobuyuki Matsuhashi, Naoya Kato, Hiroyuki Isayama, Ankit Puri, Akiko Suzuki, Ian Bellayr, Pamela Leland, Bharat H. Joshi, Raj K. Puri

“…Our study uncovers a novel role of IL-13Rα2 in PNI as a key factor of the disease severity, thus revealing a therapeutically targetable option for PDAC and to facilitate PNI-associated pain management.…”
Get full text

Effects of caudal block in pediatric surgical patients: a randomized clinical trial by Anna Uram Benka, Marina Pandurov, Izabella Fabri Galambos, Goran Rakić, Vladimir Vrsajkov, Biljana Drašković

“…Objectives: The aim of this research was to determine the effectiveness of caudal blocks in intra- and postoperative pain management and in reducing the stress response in children during the same periods. …”
Get full text

Trajectories of interleukin 10 and heart fatty acid-binding protein levels in traumatic brain injury patients with or without extracranial injuries by Toni J. U. Niiranen, Anne-Cécile Chiollaz, Riikka S. K. Takala, Riikka S. K. Takala, Miko Voutilainen, Olli Tenovuo, Olli Tenovuo, Virginia F. J. Newcombe, Henna-Riikka Maanpää, Jussi Tallus, Jussi Tallus, Mehrbod Mohammadian, Iftakher Hossain, Iftakher Hossain, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Jean-Charles Sanchez, Jussi P. Posti, Jussi P. Posti, Jussi P. Posti

Get full text

Acupuncture for menstruation-related migraine prophylaxis: A multicenter randomized controlled trial by Lu Liu, Claire-Shuiqing Zhang, Hui-Lin Liu, Fan He, Tian-Li Lyu, Lin Zeng, Luo-Peng Zhao, Luo-Peng Zhao, Mi-Na Wang, Zheng-Yang Qu, Li-Min Nie, Jia Guo, Xiao-Zhe Zhang, Yong-Hui Lu, Ke-Lun Wang, Bin Li, Xiang-Hong Jing, Lin-Peng Wang

Get full text

Indicadores de qualidade sensíveis aos cuidados de enfermagem em lares de idosos Indicadores de calidad sensibles a los cuidados de enfermería en asilos de ancianos Quality indicat... by Telmo Aleixo, Ana Escoval, Rui Fontes, César Fonseca

“…The results show that the continuing introduction of these professionals has a direct impact on reducing the use of health services (emergency and hospital days), reducing the number of falls, on the prevalence of the number of pressure ulcers and on increasing functioning and pain management.…”
Get full text

Perioperative Factors Impact on Mortality and Survival Rate of Geriatric Patients Undergoing Surgery in the COVID-19 Pandemic: A Prospective Cohort Study in Indonesia by Nancy Margarita Rehatta, Susilo Chandra, Djayanti Sari, Mayang Indah Lestari, Tjokorda Gde Agung Senapathi, Haizah Nurdin, Belindo Wirabuana, Bintang Pramodana, Adinda Putra Pradhana, Isngadi Isngadi, Novita Anggraeni, Kenanga Marwan Sikumbang, Radian Ahmad Halimi, Zafrullah Khany Jasa, Akhyar Hamonangan Nasution, Mochamat Mochamat, Purwoko Purwoko

Get full text