Trends in Sustainable Energy Innovation: transition teams by Dirk Franco, Jean-Pierre Segers, René Herlaar, Anna Richt Hannema

“…It is indicated how the transition team worked and progressed towards “coalitions for change” and how “change processes” have started. These paradigm shifts to new “energy systems” in combination with new business models and societal transition are needed to achieve a post carbon society.…”
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A Novel Grid-Forming Strategy for Self-Synchronous PMSG under Nearly 100% Renewable Electricity by Pan Hu, Kezhen Jiang, Xiaotong Ji, Yuze Cai, Bo Wang, Dan Liu, Kan Cao, Wei Wang

“…The demand for decarbonization calls for building up a nearly 100% renewable electricity resulting in Grid-forming (GFM) capability requirements. The foregoing paradigm shifts from synchronous AC systems to converter-based systems that need to remain stable and self-synchronous while providing GFM services. …”
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Recent Developments in Rodent Models of High-Fructose Diet-Induced Metabolic Syndrome: A Systematic Review by Alvin Man Lung Chan, Angela Min Hwei Ng, Mohd Heikal Mohd Yunus, Ruszymah Bt Hj Idrus, Jia Xian Law, Muhammad Dain Yazid, Kok-Yong Chin, Sharen Aini Shamsuddin, Yogeswaran Lokanathan

“…MetS model establishment is evaluated based on the significance of selected test parameters, paradigm shifts from new discoveries, and the accessibility of the latest technology or advanced methodologies. …”
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PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization by Min Wei, Min Wei, Min Wei, Min Wei, Min Wei, Xiao Shen, Xiao Shen, Xiao Shen, Xiao Shen, Xiao Shen, Xueqi Fan, Xueqi Fan, Xueqi Fan, Xueqi Fan, Xueqi Fan, Jiwei Li, Jingwen Bai, Jingwen Bai, Jingwen Bai, Jingwen Bai, Jingwen Bai, Jingwen Bai

“…Immune checkpoint blockade is now recognized as a paradigm-shifting cancer therapeutic strategy, whereas there remains difficulty in accurately predicting immunotherapy efficacy by PD-L1 expression. …”
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SERVICE DESIGN IN ACTION: TRANSFORMATION, CONSIDERATION, AND SYSTEM THINKING by Lee, Sheng-Hung, Yang, Maria, de Weck, Olivier L, Lee, Chaiwoo, Coughlin, Joseph F, Klopfer, Eric, Ochsendorf, John

“…The study focuses on the paradigm shifts of service from its definitions to applications by interviewing nine design experts from academia and industry, and utilizing survey results to help us explore applying service design to solve complicated social-technological challenges. …”
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Delivery of therapeutic carbon monoxide by gas-entrapping materials by Byrne, James D., Gallo, David, Boyce, Hannah, Becker, Sarah L., Kezar, Kristi M., Cotoia, Alicia T., Feig, Vivian R., Lopes, Aaron, Csizmadia, Eva, Longhi, Maria Serena, Lee, Jung Seung, Kim, Hyunjoon, Wentworth, Adam J., Shankar, Sidharth, Lee, Ghee Rye, Bi, Jianling, Witt, Emily, Ishida, Keiko, Hayward, Alison, Kuosmanen, Johannes L. P., Jenkins, Josh, Wainer, Jacob, Aragon, Aya, Wong, Kaitlyn, Steiger, Christoph, Jeck, William R., Bosch, Dustin E., Coleman, Mitchell C., Spitz, Douglas R., Tift, Michael, Langer, Robert, Otterbein, Leo E., Traverso, Giovanni

“…Collectively, foam GEMs have potential paradigm-shifting implications for the safe therapeutic use of CO across a range of indications.…”
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Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases by Lo, Chih Hung, Zeng, Jialiu

“…Both timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.…”
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Quality early care and learning: Exploring child-centered pedagogy a qualitative multi-case study by June Cade, Francis Wardle, Jan Otter

“…Early childhood education (ECE) programs in the United States are experiencing paradigm shifts resulting from the standards-based movement. …”
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Green process innovation, green product innovation, leverage, and corporate financial performance; evidence from system GMM by Yan Zhao Wang, Shafiq Ahmad

“…Particularly useful for policymakers in developing countries, the study's findings can be used to introduce paradigm-shifting legislation and penalties that speed up business adoption of green process innovation.…”
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DC Microgrids: Benefits, Architectures, Perspectives and Challenges by Vitor Fernão Pires, Armando Pires, Armando Cordeiro

“…One of the major paradigm shifts that will be predictably observed in the energy mix is related to distribution networks. …”
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Animal models of dystonia: Lessons from a mutant rat by Mark S. LeDoux

“…In particular, work with the dystonic (dt) rat has engendered dramatic paradigm shifts in dystonia research. The dt rat manifests generalized dystonia caused by deficiency of the neuronally restricted protein caytaxin. …”
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R. PLEČKAIČIO FILOSOFIJOS ISTORIJOS TYRIMŲ METODOLOGIJA by Gintaras Kabelka

“…The picture of progress of philosophy presented in the works of Plečkaitis involves the elements of paradigm shifts. He presents the radical modification of the solution of problems as the formation of a new problematic situation, which is regarded as paradigmatic for the solution of other remaining problems. …”
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Differential cardiovascular profiles of sodium-glucose cotransporter 2 inhibitors: critical evaluation of empagliflozin by Sanon VP, Patel S, Sanon S, Rodriguez R, Pham SV, Chilton R

“…The EMPA-REG trial is paradigm shifting because it demonstrates a clear mortality benefit to cardiovascular outcomes with a low side-effect profile, in contrast to prior outcome studies of hypoglycemic agents. …”
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Developing and Reflecting on a Black Disability Studies Pedagogy: Work from the National Black Disability Coalition by Jane Dunhamn, Jerome Harris, Shancia Jarrett, Leroy Moore, Akemi Nishida, Margaret Price, Britney Robinson, Sami Schalk

“…Although we believe that BDS should be integrated into every Disability Studies course, we recognize that, like disability itself, it cannot simply be “added and stirred”; rather, the inclusion of BDS is a paradigm-shifting change. The pieces included in this collection are enactments of an ongoing conversation--a conversation that we hope the readers of Disability Studies Quarterly will join thoughtfully. …”
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Laparoscopic partial nephrectomy: state of the art review by Faiena I, Han CS, Olweny EO

“…Izak Faiena, Christopher Sejong Han, Ephrem O Olweny Division of Urology, Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA Introduction: The surgical management of small renal masses (<4 cm) has greatly evolved over the last few decades, with the paradigm shifting from radical to partial nephrectomy. …”
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Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action by Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips

“…In light of these potentially paradigm-shifting, but highly controversial, findings, this review will summarise and critically evaluate the evidence for and against the NMDA receptor hypothesis of ketamine action, with a particular focus on (2R,6R)-HNK and the implications of its discovery for understanding ketamine’s mechanism of action in depression. …”
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PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma by Joshua W. D. Tobin, Karolina Bednarska, Ashlea Campbell, Colm Keane

“…However, while PD-1 blockade has been paradigm-shifting in many malignancies, the majority of cancers show high rates of primary resistance to this approach. …”
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New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor [version 1; referees: 2 approved] by Terry J Smith

“…Should those results prove reproducible in an ongoing phase III trial, therapeutic inhibition of IGF-IR could become the basis for paradigm-shifting treatment of this vexing disease.…”
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Towards a Sustainable Energy Planning Strategy: The Utilisation of Floor Area Ratio for Residential Community Planning and Design in China by Ali Cheshmehzangi, Ali Cheshmehzangi, Ayotunde Dawodu

“…The results support policy development on FAR monitory, and paradigm shifts for future urban development models, particularly for the small to medium-scale residential compounds in cities.…”
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The Role of Alternative RNA Splicing in the Regulation of <i>hTERT</i>, Telomerase, and Telomeres: Implications for Cancer Therapeutics by Aaron L. Slusher, Jeongjin JJ Kim, Andrew T. Ludlow

“…Approximately 90% of human tumors use telomerase to synthesize <i>de novo</i> telomere repeats and obtain telomere-dependent cellular immortality. Paradigm shifting data indicates that <i>hTERT</i> alternative splicing, in addition to transcription, plays an important role in the regulation of active telomerase in cells. …”
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