Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia Type 4 by Christoph Kessler, Christoph Ruschil, Ahmed Abdelhak, Carlo Wilke, Aleksandra Maleska, Jens Kuhle, Markus Krumbholz, Markus C. Kowarik, Rebecca Schüle

“…In patients with slowly progressive spastic paraparesis, the differential diagnosis of primary progressive multiple sclerosis (PPMS) and hereditary spastic paraplegia (HSP) can be challenging. Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising fluid biomarkers to support the diagnostic workup. …”
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Application of a Clinical Workflow May Lead to Increased Diagnostic Precision in Hereditary Spastic Paraplegias and Cerebellar Ataxias: A Single Center Experience by Vittorio Riso, Salvatore Rossi, Tommaso F. Nicoletti, Alessandra Tessa, Lorena Travaglini, Ginevra Zanni, Chiara Aiello, Alessia Perna, Melissa Barghigiani, Maria Grazia Pomponi, Filippo M. Santorelli, Gabriella Silvestri

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Feasibility, Usability, and Safety of ParaGym, an Intelligent Mobile Exercise App for Individuals With Paraplegia: Protocol for a Pilot Block-Randomized Controlled Trial by Janika Bolz, Adrian Löscher, Rainer Muhl, Andreas Badke, Hans-Georg Predel, Claudio Perret

“… BackgroundExercise is crucial for individuals with paraplegia to reduce the risk of secondary diseases and improve independence and quality of life. …”
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Case report: Novel compound heterozygous missense mutations in the DDHD2 gene in a Chinese patient associated with spastic paraplegia type 54 by Xin Xu, Fen Lu, Senjie Du, Xiaoke Zhao, Hongying Li, Li Zhang, Jian Tang

Subjects: “…spastic paraplegia…”
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EMPIEMA EPIDURAL RESULTANDO EM PARAPLEGIA - RELATO DE CASO EM HOSPITAL DE INFECTOLOGIA E DOENÇAS TROPICAIS DA AMAZÔNIA OCIDENTAL by Brenda K.S. Silva, Renata Gonçalves Santos, Juliana A.S. Barros, Fellipe R. Pereira, Maiara C.F. Soares, Marcelo S.S. Carvalho, Elza G.B. Pereira, Angela G.C.S. Melo, Angelo F. Almeida, Erica M.G. Pinheiro

“…Paciente procurou pronto socorro do Centro de Medicina Tropical do estado de Rondônia com quadro de dorsalgia e febre há 8 dias evoluindo agudamente com paraplegia e disfunção esfincteriana 1 dia antes da admissão. …”
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The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias by Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao

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Case report: Novel mutations in the SPG11 gene in a case of autosomal recessive hereditary spastic paraplegia with a thin corpus callosum by Ji-Qing Duan, Hui Liu, Jia-Qiao Wu

Subjects: “…hereditary spastic paraplegia…”
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Correction: Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model

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Acute Paraplegia Result from Spinal Ischemia Nine Years After Hybrid Total Arch Repair with Frozen Elephant Trunk: A Case Report by Zeqin Xu, Zhu Tong, Jianming Guo, Yixia Qi, Liqiang Li, Lianrui Guo

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Rehabilitación de pacientes con paraplejía por mielitis transversa atribuible a dengue Rehabilitation of patients with paraplegia due to transverse myelitis attributable to dengue by Marcia Sandra Hernández Zayas, Isabel Adela Vigil Zulueta, Bertha Rubio Hernández, Manuel Esteban Uriarte Gómez, Liudmila Risset Castro Andión

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Generation of an iPSC line from a patient with spastic paraplegia type 10 carrying a novel mutation in KIF5A gene by Serena Santangelo, Patrizia Bossolasco, Stefania Magri, Claudia Colombrita, Sabrina Invernizzi, Cinzia Gellera, Lorenzo Nanetti, Daniela Di Bella, Vincenzo Silani, Franco Taroni, Antonia Ratti

“…We generated an iPSC line from a patient with spastic paraplegia type 10 (SPG10) carrying the novel missense variant c.50G > A (p.R17Q) in the N-terminal motor domain of the kinesin family member 5A (KIF5A) gene.This patient-derived in vitro cell model will help to investigate the role of different KIF5A mutations in inducing neurodegeneration in spastic paraplegia and in other KIF5A-related disorders, including Charcot-Marie-Tooth type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).…”
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Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients by Yongchao Mou, Ghata Nandi, Sukhada Mukte, Eric Chai, Zhenyu Chen, Jorgen E. Nielsen, Troels T. Nielsen, Chiara Criscuolo, Craig Blackstone, Matthew J. Fraidakis, Xue-Jun Li

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The risk of malnutrition in patients with spinal cord injury during inpatient rehabilitation–A longitudinal cohort study by Irene Flury, Gabi Mueller, Claudio Perret

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Mal de Pott: Uma Doença Milenar em um Novo Século by Frederico Soares Falcetta, Angélica Dal Pizzol, Juliana Bohn Assmann, Andreia Della Giustina, Mateus Franzoi, Alvaro Ernani Georg, Alan Christmann Fröhlich, Apio Claúdio Martins Antunes, Leonardo Vedolin, Marino Muxfeldt Bianchin

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How Elite Athletes with a Spinal Cord Injury Sweat during Exercise—An Exploratory Study by Anneke Hertig-Godeschalk, Claudio Perret

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Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders by Saadia Maryam Saadi, Elisa Cali, Lubaba Bintee Khalid, Hammad Yousaf, Ghazala Zafar, Haq Nawaz Khan, Muhammad Sher, Barbara Vona, Uzma Abdullah, Naveed Altaf Malik, Joakim Klar, Stephanie Efthymiou, Niklas Dahl, Henry Houlden, Mathias Toft, Shahid Mahmood Baig, Ambrin Fatima, Zafar Iqbal

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Labiaplasty of bilateral labia minora hypertrophy with recurrent abscesses by Yan-Shijing Zhou, Dan Wu, Han-Dan Xiong, Yong-Le Ruan, Bo Duan

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Hydatid Cyst of the Spine: A Rare Case Report by Sevil Alkan Çeviker, Cihan Yüksel, Alper Şener, Taylan Önder, Mehmet Hüseyin Metineren, Çisil Özel, Ömer Serdar Akgül

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Favorable evolution on functional key components but with multiple remaining phatological elements in a patient diagnosed with toraco-lombar SCI - Case report by PETCU Irina Raluca, SERBAN Daniel, DELCEA Florin, BADIU Dumitru Cristinel, OPREA (MANDU) Mihaela, POPESCU Cristina, ONOSE Gelu

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Spinal Intradural Schwannoma with Acute Intratumoural Haemorrhage: Case Report and Review by G. Lakshmi Prasad, Lakshman I. Kongwad, Manna G. Valiathan

Subjects: “…acute paraplegia…”
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