<i>Gurltia paralysans</i>: A Neglected Angio-Neurotropic Parasite of Domestic Cats (<i>Felis catus</i>) and Free-Ranging Wild Felids (<i>Leopardus</i> spp.) in South America by Lisbeth Rojas-Barón, Anja Taubert, Carlos Hermosilla, Marcelo Gómez, Manuel Moroni, Pamela Muñoz

“…Feline gurltiosis has been associated with progressive thrombophlebitis of the meningeal veins, resulting in ambulatory paraparesis, paraplegia, ataxia, hindlimb proprioceptive deficit, uni- or bilateral hyperactive patellar reflexes, faecal and urinary incontinence, and tail paralysis. …”
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Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features by Ouyang, Qing, Nakayama, Tojo, Baytas, Ozan, Yang, Chendong, Schmidt, Michael, Lizarraga, Sofia B., Mishra, Sasmita, EI-Quessny, Malak, Niaz, Saima, Gul Butt, Mirrat, Imran Murtaza, Syed, Javed, Afzal, Chaudhry, Haroon Rashid, Vaughan, Dylan J., Hill, R. Sean, Partlow, Jennifer N., Yoo, Seung-Yun, Lam, Anh-Thu N., Nasir, Ramzi, Al-Saffar, Muna, Barkovich, A. James, Schwede, Matthew, Nagpal, Shailender, Rajab, Anna, DeBerardinis, Ralph J., Mochida, Ganeshwaran H., Morrow, Eric M., Davidson, Shawn M, Housman, David E

“…In addition to IDD, all affected individuals show postnatal microcephaly and ∼80% of those followed over time show progressive motor symptoms, a spastic paraplegia. Homozygous nonsense p.Arg404* and missense p.Pro272Leu mutations are shown biochemically to be loss of function. …”
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Genome-wide analyses identify KIF5A as a novel ALS gene by Nicolas, A, Kenna, KP, Renton, AE, Ticozzi, N, Faghri, F, Chia, R, Dominov, JA, Kenna, BJ, Nalls, MA, Keagle, P, Rivera, AM, Van Rheenen, W, Murphy, NA, Van Vugt, JJFA, Geiger, JT, Van Der Spek, RA, Pliner, HA, Shankaracharya, Smith, BN, Marangi, G, Topp, SD, Abramzon, Y, Gkazi, AS, Eicher, JD, Kenna, A, Italsgen Consortium, Mora, G, Calvo, A, Mazzini, L, Riva, N, Mandrioli, J, Caponnetto, C, Battistini, S, Volanti, P, La Bella, V, Conforti, FL, Borghero, G, Messina, S, Simone, IL, Trojsi, F, Salvi, F, Logullo, FO, D'Alfonso, S, Corrado, L, Capasso, M, Ferrucci, L, Genomic Translation For ALS Care (GTAC) Consortium, Moreno, CDAM, Kamalakaran, S, Goldstein, DB, ALS Sequencing Consortium, Gitler, AD, Harris, T, Myers, RM, NYGC ALS Consortium, Phatnani, H, Musunuri, RL, Evani, US, Abhyankar, A, Zody, MC, Answer ALS Foundation, Kaye, J, Finkbeiner, S, Wyman, SK, Lenail, A, Lima, L, Fraenkel, E, Svendsen, CN, Thompson, LM, Van Eyk, JE, Berry, JD, Miller, TM, Kolb, SJ, Cudkowicz, M, Baxi, E, Clinical Research In ALS And Related Disorders For Therapeutic Development (CREATE) Consortium, Benatar, M, Taylor, JP, Rampersaud, E, Wu, G, Wuu, J, Slagen Consortium, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, GP, Sorarù, G, Cereda, C, French ALS Consortium, Corcia, P, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, RW, Sidle, KC, Malaspina, A, Hardy, J, Singleton, AB, Johnson, JO, Arepalli, S, Sapp, PC, McKenna-yasek, D, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, De Belleroche, J, Baas, F, Asbroek, ALMA, Muñoz-Blanco, JL, Hernandez, DG, Ding, J, Gibbs, JR, Scholz, SW, Floeter, MK, Campbell, RH, Landi, F, Bowser, R, Pulst, SM, Ravits, JM, Macgowan, DJL, Kirby, J, Pioro, EP, Pamphlett, R, Broach, J, Gerhard, G, Dunckley, TL, Brady, CB, Kowall, NW, Troncoso, JC, Le Ber, I, Mouzat, K, Lumbroso, S, Heiman-Patterson, TD, Kamel, F, Van Den Bosch, L, Baloh, RH, Strom, TM, Meitinger, T, Shatunov, A, Van Eijk, KR, De Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, McLaughlin, RL, Van Es, MA, Weber, M, Boylan, KB, Van Blitterswijk, M, Rademakers, R, Morrison, KE, Basak, AN, Mora, JS, Drory, VE, Shaw, PJ, Turner, MR, Talbot, K, Hardiman, O, Williams, KL, Fifita, JA, Nicholson, GA, Blair, IP, Rouleau, GA, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Project Mine ALS Sequencing Consortium, Rogaeva, E, Zinman, L, Ostrow, LW, Maragakis, NJ, Rothstein, JD, Simmons, Z, Cooper-Knock, J, Brice, A, Goutman, SA, Feldman, EL, Gibson, SB, Taroni, F, Ratti, A, Gellera, C, Van Damme, P, Robberecht, W, Fratta, P, Sabatelli, M, Lunetta, C, Ludolph, AC, Andersen, PM, Weishaupt, JH, Camu, W, Trojanowski, JQ, Van Deerlin, VM, Brown, RH, Van Den Berg, LH, Veldink, JH, Harms, MB, Glass, JD, Stone, DJ, Tienari, P, Silani, V, Chiò, A, Shaw, CE, Traynor, BJ, Landers, JE

“…Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). …”

Clinical characteristics and proposed mechanism of pediatric spinal cord injury resulting from backbend practice by Shuang Guo, Shuang Guo, Huiming Gong, Huiming Gong, Peipei Xu, Peipei Xu, Yang Xie, Yang Xie, Degang Yang, Degang Yang, Zitong Liu, Yuwei Yang, Liang Chen, Liang Chen, Yongqi Xie, Yongqi Xie, Mingliang Yang, Mingliang Yang, Mingliang Yang

“…Most patients had complete paraplegia (32, 76%), and neurological levels were distributed mainly in thoracic segments (38, 91%). …”
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Transtornos neurológicos mais frequentes: contribuição para a definição de temas do conteúdo programático do curso de neurologia, para a graduação médica The most frequent neurolog... by JOÃO ELIEZER FERRI-DE-BARROS, JOSÉ CARLOS ESTEVES VEIGA, ANTONIO VITOR MARTINS PRIANTE, CESAR AUGUSTO CARDOSO, FÁBIO LUIZ ALVES, MARINA FERRI-DE-BARROS, ROSALIA MATERA TURRINI, SÍLVIA DANIELA SCARPEL OLIVEIRA, SILVINO FONTANA JUNIOR

“…The most frequent diagnosis in institutions were listed: alcoholism, cerebrovascular disease, coma, cranial trauma, dementia, dizziness, epilepsy, facial paralysis, faint, headache, hemiplegia or paraplegia, meningitis, others paralysis, periferical neuropathy and psychiatric disordes. …”
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Atlanto-occipital dislocation in a patient presenting with out-of-hospital cardiac arrest: a case report and literature review by Martin Rief, Philipp Zoidl, Paul Zajic, Stefan Heschl, Simon Orlob, Günther Silbernagel, Philipp Metnitz, Paul Puchwein, Gerhard Prause

“…It remains unclear, whether cardiac arrest due to a cardiac cause resulted in complete atony of the paravertebral muscles and caused this extremely severe lesion (atlanto-occipital dislocation) or whether cardiac arrest was caused by apnea due the paraplegia following the spinal injury of the trauma. …”
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Identification of key microRNAs and the underlying molecular mechanism in spinal cord ischemia-reperfusion injury in rats by Fengshou Chen, Jie Han, Dan Wang

“…Spinal cord ischemia-reperfusion injury (SCII) is a pathological process with severe complications such as paraplegia and paralysis. Aberrant miRNA expression is involved in the development of SCII. …”
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Thoracolumbar spine injury in Cameroon: etiology, management, and outcome by Paul Chinonso Shu, Mathieu Motah, Daniel Gams Massi, Yannick Lechedem Ngunyi, Ngenge Michael Budzi, Alain Chichom Mefire

“…Half of our patients (n = 35) had an incomplete neurological deficit (Frankel B – D). Paraplegia was the most common motor deficit (42.9%). …”
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Risk Factors for Pulmonary Embolism in Patients with Paralysis and Deep Venous Thrombosis by Karsten Keller, Jens Wöllner, Volker H. Schmitt, Mir A. Ostad, Ingo Sagoschen, Thomas Münzel, Christine Espinola-Klein, Lukas Hobohm

“…Cancer, heart failure, COPD, obesity and acute paraplegia were risk factors of PE.…”
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The Safety and Outcome of Minimally Invasive Staged Segmental Artery Coil Embolization (MIS²ACE) Prior Thoracoabdominal Aortic Aneurysm Repair: A Single-Center Study, Sy... by Vaiva Dabravolskaite, Eleni Xourgia, Drosos Kotelis, Vladimir Makaloski

“…Background: Minimally Invasive Staged Segmental Artery Coil Embolization (MIS²ACE) is a novel technique of spinal cord preconditioning used to reduce the risk of paraplegia in thoracoabdominal aortic aneurysm (TAAA) repair. …”
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Clinical applications of neurofeedback based on sensorimotor rhythm: a systematic review and meta-analysis by Tatiana Ferri Ribeiro, Marcelo Alves Carriello, Eugenio Pereira de Paula, Amanda Carvalho Garcia, Guilherme Luiz da Rocha, Helio Afonso Ghizoni Teive, Helio Afonso Ghizoni Teive

“…Studies on multiple sclerosis, insomnia, quadriplegia, paraplegia, and mild cognitive impairment were excluded due to the absence of a control group or results based only on post-intervention scales. …”
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Propensity score analysis of red cell distribution width to serum calcium ratio in acute myocardial infarction as a predictor of in-hospital mortality by Sulan Huang, Sulan Huang, Huijia Zhang, Zhijie Zhuang, Ning Guo, Quan Zhou, Xiangjie Duan, Liangqing Ge, Liangqing Ge

“…Analysis was performed based on stratified variables and interactions among sex, age, ethnicity, anemia, renal disease, percutaneous transluminal coronary intervention (PCI), coronary artery bypass grafting (CABG), atrial fibrillation, congestive heart failure, dementia, diabetes, paraplegia, hypertension, cerebrovascular disease, and Sequential Organ Failure Assessment (SOFA) score.ResultsA total of 4,105 ICU-admitted AMI patients were analyzed. …”
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Clinical and magnetic resonance imaging features, and pathological findings of spinal lymphoma in 27 cats by Valentina Lorenzo, João Ribeiro, João Ribeiro, Marco Bernardini, Marco Bernardini, Juan J. Mínguez, Juan J. Mínguez, Meritxell Moral, Carlos Blanco, Tina Loncarica, Araceli Gamito, Martí Pumarola

“…The most frequent neurological signs were rapidly progressive paraparesis (62.9%) or paraplegia (22.2%). Bimodal age distribution was found with 40.7% of cats aged ≤2.5 years (63.6% of them FeLV positive), and 44.4% of cats aged ≥8 years (16.7% of them FeLV positive). …”
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The Impact of Sub-maximal Exercise on Neuropathic Pain, Inflammation, and Affect Among Adults With Spinal Cord Injury: A Pilot Study by Kendra R. Todd, Kendra R. Todd, Jan W. Van Der Scheer, Jeremy J. Walsh, Jeremy J. Walsh, Garett S. Jackson, Gabriel U. Dix, Gabriel U. Dix, Jonathan Peter Little, John L. K. Kramer, John L. K. Kramer, Kathleen A. Martin Ginis, Kathleen A. Martin Ginis, Kathleen A. Martin Ginis, Kathleen A. Martin Ginis

“…This study examined the impact of sub-maximal aerobic exercise on NP, inflammation and psychological affect among adults with SCI.Methods: Eight active adults with tetraplegia (n-4, AIS A-C) and paraplegia (n = 4, AIS A-C) performed 30-min of arm-crank aerobic exercise and reported their ratings of perceived exertion (RPE) each minute. …”
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The 15q11.2 BP1-BP2 Microdeletion (<i>Burnside–Butler</i>) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Disorders by Syed K. Rafi, Merlin G. Butler

“…The cardinal disease associations for each of the four contiguous 15q11.2 BP1-BP2 genes are <i>NIPA1</i>- Spastic Paraplegia 6; <i>NIPA2</i>—Angelman Syndrome and Prader–Willi Syndrome; <i>CYFIP1</i>—Fragile X Syndrome and Autism; <i>TUBGCP5</i>—Prader–Willi Syndrome. …”
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A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy by Vincenzo Antona, Federica Scalia, Elisa Giorgio, Francesca C. Radio, Alfredo Brusco, Massimiliano Oliveri, Giovanni Corsello, Fabrizio Lo Celso, Maria Vadalà, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello, Mario Giuffrè

“…Examples of the former are hypomyelinating leukodystrophy 4 (HLD4 or MitCHAP60) and hereditary spastic paraplegia (SPG13). A distal sensory mutilating neuropathy has been linked to a mutation [p.…”
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Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant by Kelly A. Rich, Megan G. Pino, Mehmet E. Yalvac, Ashley Fox, Hallie Harris, Maria H.H. Balch, W. David Arnold, Stephen J. Kolb

“…Loss of function variants in the N-terminal, microtubule-binding domain are associated with hereditary spastic paraplegia and hereditary motor neuropathy. These variants result in a loss of the ability of the mutant protein to process along microtubules. …”
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Diagnóstico por tomografia computadorizada da extrusão de disco intervertebral em paciente geriatra: Relato de Caso by Jessyka Andréa Nascimento de Carvalho Almeida, Tiago Tavares Brito de Medeiros, Artur da Nóbrega Carreiro, Edson Mauro da Cunha, Débora Vitória Fernandes de Araújo, Brunna Muniz Rodrigues Falcão, Ana Yasha Ferreira de La Salles, Danilo José Ayres de Menezes

“…A doença do disco intervertebral (DDIV) é a causa mais comum de compressão medular em cães, resultando em problemas neurológicos, podendo ser classificada em dois tipos, Hansen tipo I (extrusão de disco) e Hansen tipo II (protrusão de disco), que pressionam os nervos da medula ocasionando quadro de dor, ataxia, paralisia e paraplegia. O tratamento à se indicar deve ser baseado no grau da lesão, podendo ser o tratamento clínico associado à fisioterapia, para casos menos graves, visto que é relatado sucessos na recuperação do quadro, na literatura. …”
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Integrative genetic and single cell RNA sequencing analysis provides new clues to the amyotrophic lateral sclerosis neurodegeneration by Hankui Liu, Hankui Liu, Liping Guan, Liping Guan, Min Deng, Lars Bolund, Lars Bolund, Karsten Kristiansen, Jianguo Zhang, Jianguo Zhang, Yonglun Luo, Yonglun Luo, Yonglun Luo, Zhanchi Zhang, Zhanchi Zhang

“…Moreover, we showed several cell types linked to other neurological diseases [i.e., spinocerebellar ataxia (SA), hereditary motor neuropathies (HMN)] and neuromuscular diseases [i.e. hereditary spastic paraplegia (SPG), spinal muscular atrophy (SMA)], including an association between Purkinje cells in brain and SA, an association between α-MNs in spinal cord and SA, an association between smooth muscle cells and SA, an association between oligodendrocyte and HMN, a suggestive association between γ-MNs and HMN, a suggestive association between mature skeletal muscle and HMN, an association between oligodendrocyte in brain and SPG, and no statistical evidence for an association between cell type and SMA.DiscussionThese cellular similarities and differences deepened our understanding of the heterogeneous cellular basis of ALS, SA, HMN, SPG, and SMA.…”
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Research on stem cell therapy for spinal cord injury: a bibliometric and visual analysis from 2018–2023 by Ruxing Liu, Ruxing Liu, Bo Peng, Bo Peng, Jie Yuan, Jie Yuan, Jiahao Hu, Jiahao Hu, Jianxin Yang, Nan Shan, Qichao Li, Bin Zhao, Bin Zhao, Chaojian Xu, Chaojian Xu, Yongfeng Wang, Yongfeng Wang

“…The top three high-frequency keyword clusters were hereditary paraplegia, reactive astrocytes and tissue engineering.Conclusion: With the help of visual analysis, we identified general trends and research topics of interest in the field of spinal cord injury over the last 5 years. …”
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