Clinical Spectrum of Hereditary Spastic Paraplegia in Children : A study of 74 cases by Roshan Koul, Fathiya M. Al-Murshedi, Faisal M. Al-Azri, Ranjit Mani, Rana A. Abdelrahim, Vivek Koul, Amna M. Alfutaisi

Subjects: “…spastic paraplegia, hereditary…”
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Primary plasma cell leukemia presented as progressive paraplegia: a case report by Hasmoni, Mohamed Hadzri, Abdul Wahid, Fadilah, Cheong, Soon Keng

“…To our knowledge, primary PCL presenting with progressive paraplegia has not been reported in the literature. …”
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Kualiti hidup penjaga keluarga yang menjaga pesakit Paraplegia di rumah by Nawawi, Nor Anida

“…Isu penjagaan pesakit Paraplegia adalah komplek dan memberi kesan kepada kualiti hidup penjaga keluarga yang terlibat.Objektif kajian ini adalah untuk mengkaji tahap kualiti hidup penjaga keluarga yang menjaga pesakit Paraplegia di rumah serta mengkaji faktor beban jagaan dan tahap penerimaan sokongan sosial dalam kalangan penjaga keluarga tersebut.Kajian ini menggunakan kaedah gabungan iaitu menggabungkan data kuantitatif dan kualitatif.Data telah dikumpulkan dengan menggunakan borang soal selidik kepada 81 orang penjaga keluarga dan temubual secara mendalam turut dijalankan kepada 8 orang penjaga keluarga pesakit Paraplegia yang menjalankan rawatan di PPUM.Kajian ini menggunakan instrumen World Health Organization Quality Of Life (WHOQOL)-Brief, Zarit Burden Interview (ZBI) dan Modified Social Support Scale (MSSS).Hasil kajian mendapati terdapat hubungan yang signifikan di antara kualiti hidup penjaga dengan beban jagaan dan tahap penerimaan sokongan sosial.Secara keseluruhan hasil kajian, WHOQOL-Brief mendapati penjaga pesakit Paraplegia mempunyai tahap kualiti hidup dari aspek hubungan sosial yang baik berbanding dengan kualiti hidup kesihatan fizikal, kesihatan psikologi dan persekitaran.Ianya selari dengan hasil kajian kualitatif yang melaporkan penjaga lebih terjejas dari segi emosi dan fizikal berbanding dengan hubungan sosial.Kajian ini mendapati beban jagaan, sokongan emosi dan tempoh penjagaan pesakit menjadi faktor peramal utama kepada perubahan kualiti hidup penjaga pesakit Paraplegia yang menjalankan penjagaan di rumah.Kesimpulannya, kualiti hidup penjaga yang baik turut menjamin kualiti hidup pesakit Paraplegia, oleh yang demikian intervensi dan keperihatinan daripada semua pihak dapat membantu mengurangkan beban jagaan serta bertindak sebagai sumber sokongan sosial, ini akan membantu kualiti hidup penjaga pesakit Paraplegia akan lebih terjamin.…”
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Motor and functional evaluation of patients with spastic paraplegia, optic atrophy, and neuropathy (SPOAN) Avaliação motora e funcional de pacientes com paraplegia espástica, atrofia óptica e neuropatia (SPOAN) by Zodja Graciani, Silvana Santos, Lucia Inês Macedo-Souza, Carlos Bandeira de Mello Monteiro, Maria Isabel Veras, Simone Amorim, Mayana Zatz, Fernando Kok

Subjects: “…paraplegia espástica hereditária…”
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Outcome Measures and Biomarkers for Clinical Trials in Hereditary Spastic Paraplegia: A Scoping Review by Sue-Faye Siow, Dennis Yeow, Laura I. Rudaks, Fangzhi Jia, Gautam Wali, Carolyn M. Sue, Kishore R. Kumar

Subjects: “…hereditary spastic paraplegia…”
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Spinal Subdural Hematoma With Paraplegia Mimicking Dorsolumbar Prolapsed Disc: A Case Report by Vishal Singh, Sajad Hussain Arif

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Hereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery by Alan Mackay-Sim

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From Backpain to Paraplegia: A Rare Primary Presentation of Metastatic Ovarian Cancer in Pregnancy by Filiz Çayan, Arzu Doruk, Aslı Köseoğlu, Mutlu Alımlı, Leyla Cinel, Saffet Dilek

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The therapeutic effects of physical treatment for patients with hereditary spastic paraplegia: a narrative review by Armando Di Ludovico, Francesca Ciarelli, Saverio La Bella, Giovanna Scorrano, Francesco Chiarelli, Giovanni Farello

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User-centered design and spatially-distributed sequential electrical stimulation in cycling for individuals with paraplegia by Roberto S. Baptista, Marina C. C. Moreira, Lucas D. M. Pinheiro, Tiago R. Pereira, Gabriel G. Carmona, Joao P. D. Freire, Julia A. I. Bastos, Antonio Padilha Lanari Bo

“…FES Cycling performance in SDSS trials was superior when compared to SES trials, indicating that this technique may enable faster and possibly longer FES cycling sessions for individuals with paraplegia. More extensive studies are required to assess these aspects.…”
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Case report: Hereditary spastic paraplegia with a novel homozygous mutation in ZFYVE26 by Ze-hua Lai, Ze-hua Lai, Xiao-ying Liu, Yuan-yue Song, Hai-yan Zhou, Li-li Zeng

Subjects: “…hereditary spastic paraplegia…”
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Increased baroreceptor sensitivity in a patient with hereditary spastic paraplegia – type SPG11 by Fischer Gerald, Baumgartner Sigl Sara, Baumgarten Daniel, Fortin Jürgen

Subjects: “…hereditary spastic paraplegia…”
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mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5 by Stefan Hauser, Marion Poenisch, Yvonne Schelling, Philip Höflinger, Stefanie Schuster, Axel Teegler, Rabea Betten, Jan-Åke Gustafsson, Jeannette Hübener-Schmid, Thomas Schlake, Frédéric Chevessier-Tünnesen, Nigel Horscroft, Ingemar Björkhem, Ludger Schöls

“…Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol 7-α-hydroxylase involved in bile acid synthesis in the liver. …”
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Delayed paraplegia after endovascular repair of an abdominal aortic aneurysm after lumboperitoneal shunting by Shuhei Nishijima, MD, Yoshitsugu Nakamura, PhD, Daiki Yoshiyama, MD, Yuto Yasumoto, MD, Yujiro Ito, MD

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Biallelic DDHD2 mutations in patients with adult‐onset complex hereditary spastic paraplegia by Ying‐Tsen Chou, Shao‐Lun Hsu, Yu‐Shuen Tsai, Yi‐Jiun Lu, Kai‐Wei Yu, Hsiu‐Mei Wu, Yi‐Chu Liao, Yi‐Chung Lee

“…Abstract Objective Hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative disorders characterized by slowly progressive lower limb spasticity and weakness. …”
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Pluripotent Stem Cells as a Preclinical Cellular Model for Studying Hereditary Spastic Paraplegias by Devid Damiani, Matteo Baggiani, Stefania Della Vecchia, Valentina Naef, Filippo Maria Santorelli

Subjects: “…hereditary spastic paraplegia…”
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Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias by Diana Maria Cubillos Arcila, Diana Maria Cubillos Arcila, Gustavo Dariva Machado, Valéria Feijó Martins, Vanessa Bielefeldt Leotti, Vanessa Bielefeldt Leotti, Rebecca Schüle, Leonardo Alexandre Peyré-Tartaruga, Leonardo Alexandre Peyré-Tartaruga, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute

Subjects: “…hereditary spastic paraplegias…”
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PLP1 gene mutations cause spastic paraplegia type 2 in three families by Li Yao, Zeyu Zhu, Chao Zhang, Wotu Tian, Li Cao

“…Abstract Objective Spastic paraplegia type 2 (SPG2) is an X‐linked recessive (XLR) form of hereditary spastic paraplegia (HSP) caused by mutations in proteolipid protein 1 (PLP1) gene. …”
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Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia by Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Schöls, Martin Giese, Daniel F. B. Haeufle

“…Abstract Background In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. …”
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FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia by Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim

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