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A Parallel Derivation Theory of Adjuncts
Published 2022-10-01“…Finally, I show that this approach to adjuncts naturally accounts for Adjunct Islands and Parasitic Gaps and is consistent with adjective ordering constraints.…”
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The Radical Unacceptability Hypothesis: Accounting for Unacceptability without Universal Constraints
Published 2022-04-01“…We explore the RUH with respect to classical islands, and extend it to a broader range of phenomena, including freezing, A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mo>′</mo></msup></semantics></math></inline-formula> chain interactions, zero-relative clauses, topic islands, weak crossover, extraction from subjects and parasitic gaps, and sensitivity to information structure. …”
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Chains and anaphoric dependence : on reconstruction and its implications
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An NP-movement Account of Tough Constructions
Published 1996-01-01“…It is shown that this analysis accounts for a wide range of data, including tough constructions exhibiting wh-island effects and tough constructions containing a parasitic gap. If the solution advocated here is correct, then it must be concluded that the reintroduction of generalized transformations is simply not motivated in the case of these constructions.…”
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Development of whole sporozoite malaria vaccines
Published 2017-01-01“…Alternative whole sporozoite vaccines include immunization with fully infectious sporozoites under chloroquine prophylaxis (CPS) or as genetically-attenuated parasites (GAP). By also manufacturing purified infectious sporozoites, it is now possible to combine these with CPS and GAP, as well as perform challenge studies using controlled doses of sporozoites.…”
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A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites
Published 2014-11-01“…Immunization with genetically attenuated parasites (GAP) would be an attractive alternative approach. …”
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OX40 stimulation enhances protective immune responses induced after vaccination with attenuated malaria parasites
Published 2018“…In this study, we have analyzed the effect of agonistic OX40 monoclonal antibody treatment on protective immunity induced in mice immunized with genetically attenuated parasites (GAPs). OX40 stimulation enhanced protective immunity after vaccination as shown by an increase in the number of protected mice and delay to blood-stage infection after challenge with wild-type sporozoites. …”
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Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
Published 2022-11-01“…A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely administered to humans and immunogenicity is comparable to radiation-attenuated PfSPZ Vaccine. …”
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A Triple-Band Reflective Polarization Conversion Metasurface with High Polarization Conversion Ratio for Ism and X-Band Applications
Published 2022-10-01“…The unit cell of the metasurface is composed of S- and G-shaped patches separated with a parasitic gap and the grounded via is connected to the full ground plane. …”
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A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial
Published 2018-08-01“…Methods Genetically-attenuated parasites (GAP) were produced by targeted deletion of the gene encoding the knob associated histidine rich protein (kahrp) from P. falciparum strain 3D7. …”
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