Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional Study by Danilo Buonsenso, Francesco Mariani, Luca Pierri, Rosa Morello, Adriana Yock-Corrales, Olguita Del Aguila, Ilaria Lazzareschi, Giuseppe Zampino, Francesco Nunziata, Piero Valentini, Andrea Lo Vecchio

“…The univariate analysis showed that age, high D-dimer values, hyperfibrinogenemia, INR and aPTT elongation, and low platelet count were associated with an increased risk of pediatric intensive care unit (PICU) admission (<i>p</i> < 0.01). …”
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Research and Innovation in Organ Donation: Recommendations From an International Consensus Forum by Manuel Escoto, MPH, Fadi Issa, DPhil, Florence Cayouette, MDCM, FRCPC, Henrietta Consolo, MBChB, MA, Prosanto Chaudhury, MD, FRCSC, Sonny Dhanani, MD, FRCPC, Wenshi Jiang, Msc, PhD, Gabriel C. Oniscu, MD, FRCS, Nicholas Murphy, PhD, Karen Rockell, Matthew J. Weiss, MD, Mélanie Dieudé, PhD

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Respiratory presentation of patients infected with enterovirus D68 in Taiwan by Hui-Hsien Pan, Chi-Ren Tsai, Pei-Ju Ting, Fang-Liang Huang, Li-Chung Wang, Chin-Fu Lin, Jiunn-Liang Ko, Ko-Huang Lue, Po-Yen Chen

“…One child was admitted to the pediatric intensive care unit. All the patients were cured. Cough, rhinorrhea, tachypnea and fever were the most common clinical symptoms among inpatients, while influenza-like illness (ILI) was prevalent in outpatients. …”
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Proxy-Reported Quality of Life and Access to Nusinersen Among Patients with Spinal Muscular Atrophy in Saudi Arabia by AlRuthia Y, Almuaythir GS, H Alrasheed H, Alsharif WR, Temsah MH, Alsohime F, Sales I, Alwhaibi M, Bashiri FA

“…Yazed AlRuthia,1,2 Ghadah S Almuaythir,1 Hala H Alrasheed,1 Wejdan R Alsharif,1 Mohamad-Hani Temsah,3,4 Fahad Alsohime,3,4 Ibrahim Sales,1 Monira Alwhaibi,1 Fahad A Bashiri3,5 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Pharmacoeconomics Research Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3College of Medicine, King Saud University, Riyadh, Saudi Arabia; 4Pediatric Intensive Care Unit, Pediatric Department, King Saud University Medical City, Riyadh, Saudi Arabia; 5Division of Neurology, Department of Pediatrics, King Saud University Medical City, Riyadh, Saudi ArabiaCorrespondence: Yazed AlRuthiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaTel +996 114677483Fax +966 114677480Email yazeed@ksu.edu.saBackground: The recent approval of innovative therapies for spinal muscular atrophy (SMA), such as nusinersen, has brought hope to patients and their families.Objective: The aims of this study were to compare the characteristics and HRQoL of SMA patients treated with nusinersen and those treated with the standard of care.Methods: This was a cross-sectional, interviewer-administered telephone questionnaire, which used a purposive sampling of SMA patients through a social support network. …”
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Pediatric Early Warning Systems (PEWS) improve provider‐family communication from the provider perspective in pediatric cancer patients experiencing clinical deterioration by Srinithya R. Gillipelli, Erica C. Kaye, Marcela Garza, Gia Ferrara, Mario Rodriguez, Dora Judith Soberanis Vasquez, Alejandra Mendez Aceituno, Federico Antillón‐Klussmann, Jami S. Gattuso, Belinda N. Mandrell, Justin N. Baker, Carlos Rodriguez‐Galindo, Asya Agulnik, Dylan E. Graetz

“…Methods Semi‐structured interviews were conducted with 83 ward and Pediatric Intensive Care Unit (PICU) providers involved in the care of patients with deterioration at two pediatric oncology hospitals of different resource levels: St. …”
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NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood by Juliette Bardet, Noémie Laverdure, Mathieu Fusaro, Capucine Picard, Lorna Garnier, Sébastien Viel, Sophie Collardeau-Frachon, Jean-Marie De Guillebon, Isabelle Durieu, Clémence Casari-Thery, Guillaume Mortamet, Audrey Laurent, Alexandre Belot

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Thromboelastography Variables, Immune Markers, and Endothelial Factors Associated With Shock and NPMODS in Children With Severe Sepsis by Arun Saini, Philip C. Spinella, Steven P. Ignell, John C. Lin

“…We explored the relationship between TEG variables, selective cytokines, and endothelial factors.Design: Prospective observational.Setting: Single-center, quaternary care pediatric intensive care unit.Patients: Children aged 6- months to 14- years with severe sepsis with expected PICU stay for &gt;72 h.Interventions: None.Measurements and Main Results: Twenty-eight children were enrolled with median (IQR) age of 7.3 years (4.4–11.4), PELOD score (study day-1) of 11(1.25–13), and PICU length of stay of 10 days (5–28). …”
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Pediatric delirium is associated with increased brain injury marker levels in cardiac surgery patients by Yujiro Matsuishi, Haruhiko Hoshino, Yuki Enomoto, Nobutake Shimojo, Muneaki Matsubara, Hideyuki Kato, Bryan J. Mathis, Kojiro Morita, Yuji Hiramatsu, Yoshiaki Inoue

“…We observed pediatric cardiac surgery patients from neonatal age to 18 years, who were admitted to our pediatric intensive care unit after cardiovascular operations between October 2019 to June 2020, up to post-operative day 3 (4 days total). …”
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Very High Negative Concordance Rate of RT-PCR for SARS-CoV-2 in Nasopharyngeal Swab and Tracheo-Bronchial Aspirate in Children by Anna Camporesi, Annalisa De Silvestri, Veronica Diotto, Stefania Ferrario, Laura Eccher, Alessandra De Ferrari, Francesco Messina, Gloria Pelizzo, Gloria Pelizzo, Davide Mileto, Valeria Calcaterra, Danilo Buonsenso

“…The aim of the study (IRB approval: ST/2020/405) is to prospectively compare RT-PCR results on NP and tracheo-bronchial aspirate (TA) in children admitted to the hospital for surgery or admitted to the Pediatric Intensive Care Unit (PICU) of a tertiary children hospital in Milano, Italy, during a peak of COVID-19 infections in the city. …”
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Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease by Setareh Mamishi, Babak Pourakbari, Mehrzad Mehdizadeh, Amene Navaeian, Hamid Eshaghi, Bahareh Yaghmaei, Reihaneh Hosseinpour Sadeghi, Shiva Poormohammadi, Yasmine Mahmoudieh, Shima Mahmoudi

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The Impact of Estimated Energy and Protein Balances on Extrauterine Growth in Preterm Infants by Ioanna Lygerou, Stavroula Ilia, Panagiotis Briassoulis, Anna Manousaki, Marina Koropouli, Eleftheria Hatzidaki, George Briassoulis

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Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures by Justin A. Seltzer, Sarah Friedland, Nathan A. Friedman, Garret A. Winkler, Emily Foreman, Yousef Al Mubarak, Brent Buccine, Branden Engorn, Allyson Kreshak, Alicia Minns, Christian A. Tomaszewski, Daniel R. Lasoff, Richard F. Clark

“…On arrival to the pediatric intensive care unit (ICU), both patients received pralidoxime with subsequent plasma exchange and continuous venovenous hemodiafiltration (CVVHDF). …”
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Emergency room visits and admission rates of children with neuromuscular disorders: A 10-year experience in a medical center in Taiwan by Wei-Tsun Kao, Yung-Hao Tseng, Yuh-Jyh Jong, Tai-Heng Chen

“…The outcomes were death inside or outside the ER, admission to the ward or pediatric intensive care unit (PICU), uneventful discharge, and repeated ER visits. …”
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Predictors of Failed Extubation in Mechanically Ventilated Children: Single Center Experience by Sally Kamal Ishak, Asmaa Salah Mohamed, Seham Awad El-Sherbini, Basant Salah Saied, Elshimaa Salah Ahmed

“…Patients and Methods: This is an observational prospective study that included all admitted children in Pediatric Intensive Care Unit (PICU), Cairo University Children Hospital who underwent mechanical ventilation (MV) through ETT for more than 48 hours (145 child) with Glasgow coma scale above 8. …”
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COVID-19–associated multisystem inflammatory syndrome in children: case series at a pediatric hospital in Peru by Liz E. De Coll-Vela, Mariela K. Zamudio-Aquise, Héctor Nuñez-Paucar, Raúl R. Bernal-Mancilla, Sandra C. Schult-Montoya, Manuel Ccorahua-De La Paz, Cynthia L. Huby-Muñoz, Carlos F. Castillo-Torres, Jorge L. Candela-Herrera, Franklin Aranda-Paniora, Raúl A. Rojas-Galarza

“…Only one developed miocarditis, shock and was admitted to the Pediatric Intensive Care Unit. Most patients recovered successfully. …”
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Emergency room endotracheal intubation in children with bronchiolitis: A cohort study using a multicenter database by Marla R. Carter, Aamer H. Khan, Tarek Salman, Richard Speicher, Alexandre T. Rotta, Steven L. Shein

“…Abstract Background and Aims Bronchiolitis and asthma have a clinical overlap, and it has been shown that pediatric intensive care unit (PICU) patients with asthma undergoing endotracheal intubation in a community hospital emergency room (ER) have a shorter duration of mechanical ventilation (MV) and PICU length of stay (LOS) vs children undergoing intubation in a children's hospital. …”
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Implementing Rounding Checklists in a Pediatric Oncologic Intensive Care Unit by Mary Katherine Gardner, Patricia J. Amado, Muhummad Usman Baig, Sana Mohiuddin, Avis Harden, Linette J. Ewing, Shehla Razvi, Jose A. Cortes, Rodrigo Mejia, Demetrios Petropoulos, Priti Tewari, Ali H. Ahmad

“…Standardized rounding checklists during multidisciplinary rounds (MDR) can reduce medical errors and decrease length of pediatric intensive care unit (PICU) and hospital stay. We added a standardized process for MDR in our oncologic PICU. …”
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Critically ill infants with SARS-COV-2 delta variant infection by Aida Borgi, Assaad Louati, Amal Miraoui, Lilia Lahmar, Ahmed Ayari, Ahmed Hajji, Asma Bouziri, Khaled Menif, Hanen Smaoui, Nejla Ben Jaballah

“…Aim: To describe clinical characteristics and outcomes of infants admitted in the pediatric intensive care unit (PICU) during the period of Delta variant predominance. …”
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Short- and long-term outcome of allogeneic stem cell transplantation in infants: A single-center experience over 20 years by Justyna Miśkiewicz-Bujna, Izabella Miśkiewicz-Migoń, Zofia Szmit, Dawid Przystupski, Monika Rosa, Anna Król, Krzysztof Kałwak, Marek Ussowicz, Ewa Gorczyńska

“…Twenty-two children (32.8%) required hospitalization in the pediatric intensive care unit (PICU). The median length of PICU hospitalization was 6 days (range 1 to 12 days). …”
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Distinct neonatal hyperammonemia and liver synthesis dysfunction: case report of a severe MEGDHEL syndrome by Ina Kirchberg, Elke Lainka, Andrea Gangfuß, Alma Kuechler, Fabian Baertling, Lea D. Schlieben, Lea D. Schlieben, Dominic Lenz, Eva Tschiedel

“…Differentiation from other metabolic disorders is difficult and requires a multidisciplinary approach.Case presentationA two-day-old small for gestational age neonate was admitted to our pediatric intensive care unit (PICU) due to severe liver failure with distinct hyperammonemia and hypoglycemia without elevation of transaminases or cholestasis. …”
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