Terapia com hormônio de crescimento nos estados hipercatabólicos em pediatria: revisão sistemática e metanálise Growth hormone therapy in pediatric hypercatabolic state: a systemat... by Ronaldo Arkader, Orlei Araújo, Dafne Cardoso Bourguignon da Silva, Mario R. Hirschheimer, Werther B. de Carvalho

“…<br>BACKGROUND AND OBJECTIVES: To assess the use of recombinant human growth hormone (rhGH) in pediatric patients with hypercatabolic state in the pediatric intensive care unit. METHODS: We searched the databases of MedLine (1990 to 2005), LILACS (1990 to 2005), OVID (1990 to 2006) and EMBASE (1990 to 2005). …”
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Plasma biomarker analysis in pediatric ARDS: generating future framework from a pilot randomized control trial of methylprednisoloneA framework for identifying plasma biomarkers re... by Dai eKimura, Dai eKimura, Jordy eSaravia, Jordy eSaravia, Cynthia R Rovnaghi, Gianfranco Umberto Meduri, Gianfranco Umberto Meduri, Andreas eSchwingshackl, Stephania eCormier, Stephania eCormier, Kanwaljeet J. S. Anand

“…Design: Double-blind, placebo-controlled randomized trialSetting: Tertiary-care Pediatric Intensive Care Unit Patients: Mechanically ventilated children (0-18 years) with early ARDS.Interventions: Blood samples were collected on Days 0 (before MPT), 7, and 14 during low-dose MPT (n=17) vs. placebo (n=18) therapy. …”
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Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway by Yingyi Xu, Na Zhang, Cheng Chen, Xinke Xu, Ailing Luo, Yaping Yan, Yanhua Lu, Jianhua Liu, Xinxu Ou, Yonghong Tan, Yufeng Liang, Yufeng Liang, Lihe Chen, Xingrong Song, Xiaoping Liu

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EPIDEMIOLOGICAL, CLINICAL AND PROGRESSIVE SPECTRUM OF MEASLES CASES ADMITTED TO „DR. VICTOR BABES“ CLINICAL HOSPITAL FOR INFECTIOUS AND TROPICAL DISEASES, BUCHAREST DURING THE ACTU... by Geta Vancea, Andreea Stoenescu, Irina Ianache, Cristina Iordache, Eugenia Ungureanu, Carmen Apostol, Gh. Enache, Dana Ispas, Nicoleta Voicu-Parvu, D. Serban, Roxana Cebuc, Alexandra Malciolu-Nica, Ana-Maria Dascalu, Emanoil Ceausu, Petre Calistru

“…Six patients required transfer to the pediatric intensive care unit for respiratory support and 2 died. …”
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Evaluation of the influenza-like illness surveillance system in Tunisia, 2012–2015 by Rihab Yazidi, Wafa Aissi, Hind Bouguerra, Mariem Nouira, Ghassen Kharroubi, Latifa Maazaoui, Mokhtar Zorraga, Naima Abdeddaiem, Sadok Chlif, Awatef El Moussi, Mohamed Ali Ben Hadj Kacem, Mohamed Ali Snoussi, Wissem Ghawar, Makram Koubaa, Lauren Polansky, Margaret McCarron, Mohamed Boussarsar, Khaled Menif, Slim Amine, Jalila Ben Khelil, Mounir Ben Jemaa, Jihene Bettaieb, Nissaf Bouafif Ben Alaya, Afif Ben Salah

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Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study by Huijie Miao, Yun Cui, Ye Lu, Ting Sun, Jiaying Dou, Yuqian Ren, Chunxia Wang, Yucai Zhang

“…Methods: We conducted a prospective study of PSS cases who were admitted to the pediatric intensive care unit (PICU) from January 2018 to December 2020. …”
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Bench surgery with autotransplantation for bilateral Wilms tumor—A feasible technique for renal sinus invasion by Pengfei Gao, Pengfei Gao, Jun Li, Huadong Chen, Wenrui Wu, Longshan Liu, Hong Jiang, Lingling Xu, Chenglin Wu, Qian Fu, Juncheng Liu, Changxi Wang, Changxi Wang, Changxi Wang

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Supervised Machine Learning Applied to Automate Flash and Prolonged Capillary Refill Detection by Pulse Oximetry by Ryan Brandon Hunter, Shen Jiang, Akira Nishisaki, Amanda J. Nickel, Natalie Napolitano, Koichiro Shinozaki, Timmy Li, Kota Saeki, Lance B. Becker, Vinay M. Nadkarni, Aaron J. Masino

“…ObjectiveDevelop an automated approach to detect flash (&lt;1.0 s) or prolonged (&gt;2.0 s) capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques to pulse oximeter plethysmography data.Materials and MethodsData was collected in the Pediatric Intensive Care Unit (ICU), Cardiac ICU, Progressive Care Unit, and Operating Suites in a large academic children’s hospital. …”
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Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic by Juan P. Torres, Giannina Izquierdo, Mirta Acuña, Daniela Pavez, Felipe Reyes, Ana Fritis, Ricardo González, Carolina Rivacoba, Verónica Contardo, Lorena I. Tapia

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Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy by Mei-Hsin Hsu, Hsuan-Chang Kuo, Jainn-Jim Lin, Ming-Yi Chou, Ying-Jui Lin, Pi-Lien Hung

“…Methods: Two-medical referral centers, retrospective cohort study. Pediatric Intensive Care Unit (PICU) at Taoyuan Chang Gung Children's hospital and Kaohsiung Chang Gung Memorial Hospital. …”
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Clinical Utility of Rapid Exome Sequencing Combined With Mitochondrial DNA Sequencing in Critically Ill Pediatric Patients With Suspected Genetic Disorders by Xuejun Ouyang, Yu Zhang, Lijuan Zhang, Jixuan Luo, Ting Zhang, Hui Hu, Lin Liu, Lieqiang Zhong, Shaoying Zeng, Pingyi Xu, Zhenjiang Bai, Lee-Jun Wong, Jing Wang, Jing Wang, Chunli Wang, Bin Wang, Victor Wei Zhang, Victor Wei Zhang

“…Genetic disorders are a frequent cause of hospitalization, morbidity and mortality in pediatric patients, especially in the neonatal or pediatric intensive care unit (NICU/PICU). In recent years, rapid genome-wide sequencing (exome or whole genome sequencing) has been applied in the NICU/PICU. …”
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The influence of methotrexate-related transporter and metabolizing enzyme gene polymorphisms on peri-engraftment syndrome and graft-versus-host disease after haplo-hematopoietic st... by Qi Ji, Yongping Zhang, Yixin Hu, Lixia Liu, Shanbo Cao, Li Gao, Bohan Li, Yuanyuan Tian, Lingjun Kong, Shuiyan Wu, Jing Ling, Peifang Xiao, Jun Lu, Jie Li, Yanhua Yao, Jiayue Qin, Shaoyan Hu

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Clinical characteristics of children with MIS-C fulfilling classification criteria for macrophage activation syndrome by Piotr Buda, Ewa Strauss, Danuta Januszkiewicz-Lewandowska, Ewa Czerwinska, Kamila Ludwikowska, Leszek Szenborn, Ewelina Gowin, Magdalena Okarska-Napierała, Ernest Kuchar, Janusz Ksia̧zyk

“…Fifty-nine patients fulfilled MAS classification criteria, nine of which required admission to the pediatric intensive care unit (PICU). MIS-C patients with MAS were significantly older than patients without MAS (median 11.2 vs. 8.1 years). …”
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The Utility of Bedside Assessment Tools and Associated Factors to Avoid Antibiotic Overuse in an Urban PICU of a Diarrheal Disease Hospital in Bangladesh by Farzana Afroze, Md. Tanveer Faruk, Mehnaz Kamal, Farhad Kabir, Monira Sarmin, Sharifuzzaman, Mithun Chakraborty, Md. Rezaul Hossain, Shamima Sharmin Shikha, Visnu Pritom Chowdhury, Md. Zahidul Islam, Tahmeed Ahmed, Mohammod Jobayer Chisti

“…Background: Antibiotic exposure in the pediatric intensive care unit (PICU) is very high, although 50% of all antibiotics may be unnecessary. …”
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Esophageal Trachea, a Unique Foregut Malformation Requiring Multistage Surgical Reconstruction: Case Report by Roberto Tambucci, Océane Wautelet, Astrid Haenecour, Geneviève François, Christophe Goubau, Isabelle Scheers, Marin Halut, Renaud Menten, Sandra Schmitz, Caroline de Toeuf, Thierry Pirotte, Beelke D'hondt, Raymond Reding, Alain Poncelet

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Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4+ T Cells in Children With Acute Kawasaki Disease by Nana Wang, Zhongyue Chen, Fan Zhang, Qianwen Zhang, Ling Sun, Haitao Lv, Bo Wang, Jie Shen, Xufang Zhou, Feiyan Chen, Binwei Zhang, Lijun Meng, Huiting Zhou, ZhenJiang Bai, Jie Huang

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Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges by Guillaume Voiriot, Mehdi Oualha, Alexandre Pierre, Charlotte Salmon-Gandonnière, Alexandre Gaudet, Youenn Jouan, Hatem Kallel, Peter Radermacher, Dominique Vodovar, Benjamine Sarton, Laure Stiel, Nicolas Bréchot, Sébastien Préau, Jérémie Joffre, la CRT de la SRLF

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Ethnic differences in parental experiences during the first six months after PICU discharge in Singapore: a qualitative study by Pei-Fen Poh, Pei-Fen Poh, Matthew C. Carey, Joseph C. Manning, Joseph C. Manning, Jan Hau Lee, Jan Hau Lee, Jos M. Latour, Jos M. Latour, Jos M. Latour, Jos M. Latour

“…Parents from global ethnic majority groups have reported worst psychological outcomes and required more social support after childhood critical illness.AimTo explore the experiences of Chinese, Malay, and Indian parents in the first six months after Pediatric Intensive Care Unit (PICU) discharge of their child in Singapore.MethodsSequential semi-structured qualitative interviews were conducted to collect data from a convenience sample of 28 parents at one month (n = 28) and at six months (n = 22) after their child's discharge from a multidisciplinary PICU. …”
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Ketogenic diet for super-refractory status epilepticus (SRSE) with NORSE and FIRES: Single tertiary center experience and literature data by Rima Nabbout, Rima Nabbout, Sara Matricardi, Sara Matricardi, Paola De Liso, Olivier Dulac, Mehdi Oualha

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Disappearance of Seasonal Respiratory Viruses in Children Under Two Years Old During COVID-19 Pandemic: A Monocentric Retrospective Study in Milan, Italy by Giulio Ippolito, Adriano La Vecchia, Giulia Umbrello, Giada Di Pietro, Patrizia Bono, Stefano Scalia Catenacci, Raffaella Pinzani, Claudia Tagliabue, Samantha Bosis, Carlo Agostoni, Carlo Agostoni, Paola Giovanna Marchisio, Paola Giovanna Marchisio

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