Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report by Georgia Koukou, Sandra Niendorf, Britt Hornei, Jan-U Schlump, Andreas C. Jenke, Sonja Jacobsen

“…However, her mental status remained altered, and after seizure recurrence, she was transferred to our pediatric intensive care unit. Seizure control was achieved by a combination of high-dose levetiracetam and phenobarbital, but she remained unconscious. …”
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Impact of a multifaceted early mobility intervention for critically ill children — the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled... by Razvan Azamfirei, Colleen Mennie, Victor D. Dinglas, Arooj Fatima, Elizabeth Colantuoni, Ayse P. Gurses, Michele C. Balas, Dale M. Needham, Sapna R. Kudchadkar, on behalf of the PICU Up! Investigators

“…However, the clinical effectiveness of early and progressive mobility in the pediatric intensive care unit has never been rigorously studied. …”
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Diagnostic and Therapeutic Approach to Children and Adolescents with Obstructive Sleep Apnea Syndrome (OSA): Recommendations in Emilia-Romagna Region, Italy by Susanna Esposito, Giampiero Ricci, Riccardo Gobbi, Claudio Vicini, Fabio Caramelli, Silvia Pizzi, Agatina Fadda, Salvatore Ferro, Giuseppe Plazzi

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Extracorporeal Carbon Dioxide Removal: From Pathophysiology to Clinical Applications; Focus on Combined Continuous Renal Replacement Therapy by Francesca Cappadona, Elisa Costa, Laura Mallia, Filippo Sangregorio, Lorenzo Nescis, Valentina Zanetti, Elisa Russo, Stefania Bianzina, Francesca Viazzi, Pasquale Esposito

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A validity study of the rapid emergency Triage and treatment system for children by Siv Steinsmo Ødegård, Thuy Tran, Lars E. Næss-Pleym, Kari Risnes, Henrik Døllner

“…In the entire population and the sub-disciplines, a high priority rate was significantly associated with hospitalization to wards, a longer hospital stay and referral to the pediatric intensive care unit compared to patients with low priority. …”
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Long-term outcome in survivors of neonatal tetanus following specialist intensive care in Vietnam by Huynh T. Trieu, Nguyen Thi Kim Anh, Huynh Ngoc Thien Vuong, T. T. M. Dao, Nguyen Thi Xuan Hoa, Vo Ngoc Cat Tuong, Pham Tam Dinh, Bridget Wills, Phan Tu Qui, Le Van Tan, Lam Minh Yen, Saraswathy Sabanathan, Catherine Louise Thwaites

“…Methods We assessed long-term outcome following neonatal tetanus in infants treated in a pediatric intensive care unit in southern Vietnam. Neurological and neurodevelopmental testing was performed in 17 survivors of neonatal tetanus and 18 control children from the same communities using tools previously validated in Vietnamese children. …”
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Role of Montelukast in modulation of response to sepsis in preterm infants: a randomized-controlled trial by Nouran El-Shehaby, Heba Abdelhameed El-Shahawy, Nehad Nasef, Shadia El-Sallab, Hanan EL-Halaby

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Evolution of the nutritional support pattern in Pediatric Intensive Care by Heitor Pons Leite, Simone Brasil de Oliveira Iglesias, Cacilda Maria de Santana Faria, Angela Maria Ikeda, Maria Paula de Albuquerque, Werther Brunow de Carvalho

“…In a second phase of the study, the same parameters were reevaluated in children who received nutritional support throughout the year 1995. SETTING: Pediatric Intensive Care Unit of Department of Pediatrics, Escola Paulista de Medicina. …”
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Lactate clearance and mortality in pediatric sepsis by Dedi K. Saputra, Ari L. Runtunuwu, Suryadi N. N. Tatura, Jeanette I. Ch. Manoppo, Julius H. Lolombulan

“…Background Sepsis is a life-threatening condition often encountered in the pediatric intensive care unit. In the last five decades, despite the use of aggressive antibiotics and advances in intensive care medicine, the mortality rate of sepsis remains high. …”
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MyD 88 Polymorphisms in Children Diagnosed with Sepsis by Sinem Sarı Gökay, Rıza Dinçer Yıldızdaş, Mustafa Yılmaz, Kıymet Aksoy, Ali Erdinç Yalın, Yaşar Sertdemir, Gülsüm Uçar, Özden Özgür Horoz, Fatma Derya Özduran, Hayri Levent Yılmaz

“…Methods: Sixty-five patients diagnosed with sepsis in the Pediatric Intensive Care Unit during the period from April 2010 to January 2012 were included as the study group. …”
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Caregiver dissatisfaction with their child’s participation in home activities after pediatric critical illness by Jessica M. Jarvis, Nora Fayed, Ericka L. Fink, Karen Choong, Mary A. Khetani

“…Preliminary evidence suggests children’s participation in home activities has a slow trajectory post-pediatric intensive care unit (PICU) discharge, however, additional and more granular knowledge on specific problematic activities is needed to inform patient-centric rehabilitative care. …”
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Born into an isolating world: family-centred care for babies born to mothers with COVID-19Research in context by G. Dowse, E.J. Perkins, H.M. Stein, G. Chidini, O. Danhaive, Y.N. Elsayed, W.B. Carvalho, N. AlNaqeeb, S. Rooze, M. Cetinkaya, S. Vetter-Laracy, F.J. Pilar-Orive, P. Torpiano, W.A. Gonçalves Ferri, D. Buonsenso, B. Rogdo, A. Medina, A. Polito, C.N.M. Brouwer, M.C.J. Kneyber, D. De Luca, D.G. Tingay, G. Dowse, E.J. Perkins, D.G. Tingay, D. De Luca, H.M. Stein, W.B. Carvalho, O. Danhaive, Y. Elsayed, G. Chidini, M.C.J. Kneyber, A. MedinaVillanueva, A. Polito, J. Shoemaker, O. Danhaive, B. Piersigilli, O. Bekkouch, S. Rooze, W.A. Gonçalves Ferri, A.A. Oliveira, R. Morello, V. Krebs, D. Buonsenso, R. Morello, P. Valentini, N. Al-Naqeeb, S.M.H. Sabbour, A.E.A. Hegazi, P. Torpiano, P. Sammut, D. Pace, S. Vetter-Laracy, M. Roldán, F.J. Pilar-Orive, B. Rogdo, M. Cetinkaya, B. Yasa, E. Letamendia-Richard, G. Regiroli, A. Vivanti, R. Centorrino, N.F. Oliveira, M.H.M. Dittrich, R. Felgueira, C. Neves, P. Tissieres, A. Amigoni, M. Daverio, A. Tosoni, M.C. Andre, B. Wagner, T. Riedel, P. Rimensberger, A.-S. Ramelet, M.-H. Perez, M. Marston, V. Chanez, D. Longchamp, J. Natterer, T. Ferry, B. Brotschi

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Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit by Rama Shankar, Mara L. Leimanis, Patrick A. Newbury, Ke Liu, Jing Xing, Derek Nedveck, Eric J. Kort, Jeremy W Prokop, Guoli Zhou, André S Bachmann, Bin Chen, Surender Rajasekaran

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Association between fluid overload and mortality in children with sepsis: a systematic review and meta-analysis by Jaime Fernández-Sarmiento, Marco Fidel Sierra-Zuñiga, María Paula Salazar González, Natalia Lucena, Vanessa Soares Lanziotti, Sergio Agudelo

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Major pneumothorax during pediatric cardiac MRI procedure under general anesthesia: step-by-step analysis and importance of a well-known environment and material by Quentin Delhez, Laurent Bairy, John Mitchell, Adrien Maseri

“…A chest drain was placed, and the child was extubated and transferred to the pediatric intensive care unit (PICU). Despite the anesthesiologist’s belief that PEEP was minimal, critical analysis revealed that PEEP was maintained at a high level throughout anesthesia. …”
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Neonatal Hemodynamic Characteristics of the Recipient Twin of Twin-To-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery by Edouard Chambon, Taymme Hachem, Elodie Salvador, Virginie Rigourd, Claire Bellanger, Julien Stirnemann, Elsa Kermorvant-Duchemin, Pierre Tissieres, Yves Ville, Alexandre Lapillonne

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Direct vs. redirected admission of critically ill children to PICU after interfacility transfer: a retrospective cohort study by C. Halgren, C. Halgren, C. Halgren, G. M. Annich, G. M. Annich, G. M. Annich, C. Maratta, C. Maratta, C. Maratta, C. Maratta

“…This study aims to describe and compare characteristics and outcomes in patients presenting in the community and requiring inter-facility transport and admission to a Pediatric Intensive Care Unit (PICU).MethodsThis is a retrospective cohort study of children admitted to the ICU at the Hospital for Sick Children from 2016 to 2019 after inter-facility transport. …”
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Postnatal Right Ventricular Developmental Track Changed by Volume Overload by Sijuan Sun, Yuqing Hu, Yingying Xiao, Shoubao Wang, Chuan Jiang, Jinfen Liu, Hao Zhang, Haifa Hong, Fen Li, Lincai Ye

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Comparison of clinical characteristics and healthcare resource use of pediatric chronic and non-chronic critically ill patients in intensive care units: a retrospective national re... by Chantal Grandjean, Chantal Grandjean, Marie-Hélène Perez, Marie-Hélène Perez, Anne-Sylvie Ramelet, Anne-Sylvie Ramelet, The OCToPuS Consortium, Anne-Laure Lauria, Angelo Polito, Nathalie Bochaton, Daniel Trachsel, Mark Marston, Silvia Schnidrig, Tilman Humpl, Bjarte Rogdo, Ellen Wild, Thomas Neuhaus, Sandra Stalder, Barbara Brotschi, Franziska von Arx, Anna-Barbara Schlüer, Thomas Riedel, Pascale Van Kleef

“…IntroductionChronic critically ill patients (CCI) in pediatric intensive care unit (PICU) are at risk of negative health outcomes, and account for a considerable amount of ICU resources. …”
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Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support by Yixue Wang, Weiming Chen, Yidie Huang, Guangfei Wang, Zhiping Li, Gangfeng Yan, Chao Chen, Guoping Lu

“…Objectives: To develop a population pharmacokinetic model of meropenem in children with sepsis receiving extracorporeal life support (ECLS) and optimize the dosage regimen based on investigating the probability of target attainment (PTA).Methods: The children with sepsis were prospectively enrolled in a pediatric intensive care unit from January 2018 to December 2019. …”
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