CD4+/CD8+ T lymphocytes imbalance in children with severe 2009 pandemic influenza A (H1N1) pneumonia by Ji Eun Kim, Siegfried Bauer, Kyong Suk La, Kee Hyoung Lee, Ji Tae Choung, Kyoung Ho Roh, Chang Kyu Lee, Young Yoo

“…The clinical profiles, humoral and cell-mediated immune responses of the 16 H1N1 pneumonia patients who were admitted to the pediatric intensive care unit (severe pneumonia group), 16 H1N1 pneumonia patients admitted to the pediatric general ward (moderate pneumonia group) and 13 control subjects (control group) were measured.ResultsTotal lymphocyte counts were significantly lower in patients with H1N1 pneumonia than in the control group (P=0.02). …”
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Two Novel AGXT Mutations Cause the Infantile Form of Primary Hyperoxaluria Type I in a Chinese Family: Research on Missed Mutation by Xiulan Lu, Xiulan Lu, Weijian Chen, Weijian Chen, Liping Li, Xinyuan Zhu, Caizhi Huang, Saijun Liu, Yongjia Yang, Yaowang Zhao, Yaowang Zhao

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Occurrence of marked sepsis-induced immunosuppression in pediatric septic shock: a pilot study by Solenn Remy, Karine Kolev-Descamps, Morgane Gossez, Fabienne Venet, Julie Demaret, Etienne Javouhey, Guillaume Monneret

“…Methods Single-center prospective observational study, including children aged between 1 month and 18 years admitted to pediatric intensive care unit (PICU) for septic shock. Age-matched controls were children hospitalized for elective surgery without any infectious criteria. …”
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Epidemiological Analysis of the Emergency Vascular Access in Pediatric Trauma Patients: Single-Center Experience of Intravenous, Intraosseous, Central Venous, and Arterial Line Pla... by Manuel Florian Struck, Franziska Rost, Thomas Schwarz, Peter Zimmermann, Manuela Siekmeyer, Daniel Gräfe, Sebastian Ebel, Holger Kirsten, Christian Kleber, Martin Lacher, Bernd Donaubauer

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Dose recommendations for intravenous colistin in pediatric patients from a prospective, multicenter, population pharmacokinetic study by Noppadol Wacharachaisurapol, Warumphon Sukkummee, Orawan Anunsittichai, Panida Srisan, Siriporn Sangkhamal, Prawat Chantharit, Warunee Punpanich Vandepitte, Thitima Wattanavijitkul, Thanyawee Puthanakit

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The Temporal Relationship Between Local School Closure and Increased Incidence of Pediatric Diabetic Ketoacidosis by Casey K. McCluskey, Janine E. Zee-Cheng, Margaret J. Klein, Matthew C. Scanlon, Alexandre T. Rotta, Kenneth E. Remy, Christopher L. Carroll, Steven L. Shein

“…ImportanceThe incidence of pediatric diabetic ketoacidosis (DKA) increased early in the COVID-19 pandemic, but the relative contribution of behavioral changes and viral-related pathophysiology are unknown.ObjectiveTo evaluate the relationship between school closure date and onset of increased DKA to help clarify the etiology of the increased incidence.DesignA multi-center, quality-controlled Pediatric Intensive Care Unit (PICU) database was used to identify the number of admissions to a participating PICU with DKA on each calendar day from 60 days before local school closure to 90 days after, and compared to baseline data from the same periods in 2018–2019. …”
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Continuous EEG Monitoring in Critically Ill Children and Prognostic Factors for Short-term Outcome: An Observational Study by Özlem Özdemir Balcı, Erdem Şimşek, Pınar Yazıcı Özkaya, Seda Kanmaz, İpek Dokurel, Hepsen Mine Serin, Sanem Yılmaz, Gül Aktan, Hasan Tekgül, Bülent Karapınar, Sarenur Gökben

“…Aim:To evaluate the association of etiology, continuous electroencephalography (cEEG) findings and neuroimaging findings with short-term outcomes for patients admitted to a pediatric intensive care unit (PICU) for acute encephalopathy.Materials and Methods:A total of 24 children admitted to a PICU for acute encephalopathy were enrolled into this study. …”
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Multicenter validation of a deep-learning-based pediatric early-warning system for prediction of deterioration events by Yunseob Shin, Kyung-Jae Cho, Yeha Lee, Yu Hyeon Choi, Jae Hwa Jung, Soo Yeon Kim, Yeo Hyang Kim, Young A Kim, Joongbum Cho, Seong Jong Park, Won Kyoung Jhang

“…Using patient electronic medical records, we evaluated the clinical performance of the pDEWS for identifying deterioration events defined as in-hospital cardiac arrest (IHCA) and unexpected general ward-to-pediatric intensive care unit transfer (UIT) within 24 hours before event occurrence. …”
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Medium-term outcomes after laparoscopic revision of laparoscopic Kasai portoenterostomy in patients with biliary atresia by Yi Ji, Xuepeng Zhang, Siyuan Chen, Yanan Li, Kaiying Yang, Jiangyuan Zhou, Zhicheng Xu

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Faktor yang Berhubungan dengan Hiperglikemia dan Luarannya pada Anak Sakit Kritis by Rosary Rosary, Imral Chair, Pustika Amalia, Agus Firmansyah, Irawan Mangunatmadja, Mulyadi M. Djer

“…Studi analitik potong lintang dilakukan pada anak sakit kritis di Pediatric Intensive Care Unit (PICU) Rumah Sakit Cipto Mangunkusumo (RSCM) usia 1 bulan-18 tahun, dilakukan antara Maret-Juni 2011. …”
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Phylogenetic characterization of rhinovirus and adenovirus in hospitalized children aged ≤ 18 years with severe acute respiratory infection in Iran by Simin Abbasi, Nazanin Zahra Shafiei-Jandaghi, Azadeh Shadab, Seyed Abbas Hassani, Abbas Rahimi Foroushani, Nazanin Hosseinkhan, Fahimeh Aghamir, Talat Mokhtari-Azad, Jila Yavarian

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Prevalence and risk factors of nocturnal enuresis among children ages 5–12 years in Xi’an, China: a cross-sectional study by Hui-Mei Huang, Jing Wei, Shristi Sharma, Ying Bao, Fei Li, Jian-Wen Song, Hai-Bin Wu, Hong-Li Sun, Zhi-Juan Li, Huan-Nan Liu, Qian Wu, Hong-Li Jiang

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Ruptura traumática de via aérea em criança: um desafio diagnóstico Traumatic airway disruption in a child: a diagnostic challenge by Andréa Maria Cordeiro Ventura, Patrícia Freitas Góes, José Pinhata Otoch, José Carlos Fernandes

“…A 34-month old boy victim of thoracic trauma was seen at the pediatric intensive care unit of a university hospital. Plain chest radiograph, thoracic computed tomography, bronchoscopy, thoracotomy, antibiotics, hemodynamic and respiratory support were performed. …”
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The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population by Jinqing Li, Huazhong Zhou, Bing Wei, Di Che, Yufen Xu, Lei Pi, Lanyan Fu, Jie Hong, Xiaoqiong Gu

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Socioeconomic factors, perceived stress, and social support effect on neonatal nurse burnout in China: a cross-sectional study by Zhen-peng Huang, Fang Huang, Qun Liang, Feng-zhen Liao, Chuan-zhuang Tang, Min-lan Luo, Si-lan Lu, Jing-jing Lian, Shan-e Li, Su-qiao Wei, Bin Wu

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Vasoactive-ventilation-renal score and outcomes in infants and children after cardiac surgery by Pota Abhay, Rajesh Sharma, Anil Bhan, Manan Raina, Ananya Vadhera, Romel Akole, Firdoos Ahmad Mir, Pankaj Bajpai, Amit Misri, Swarnika Srivastava, Ved Prakash, Tanmoy Mondal, Anvitha Soundararajan, Abhishek Tibrewal, Shyam Bihari Bansal, Sidharth Kumar Sethi

“…Similarly, at the 48th h, AUC (95% CI) values were higher for the VVR score than those for the other clinical scores measured for the length of stay and mechanical ventilation.DiscussionThe VVR score at 48 h postoperation was found to best correlate with prolonged pediatric intensive care unit (PICU) stay, length of hospitalization, and ventilation duration, with the greatest AUC-receiver operating characteristic (0.715, 0.723, and 0.843, respectively). …”
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Understanding Suicide in Our Community through the Lens of the Pediatric ICU: An Epidemiological Review (2011–2017) of One Midwestern City in the US by Andrew Kampfschulte, Matthew Oram, Alejandra M. Escobar Vasco, Brittany Essenmacher, Amy Herbig, Aniruddh Behere, Mara L. Leimanis-Laurens, Surender Rajasekaran

“…Suicide frequency has tripled for some pediatric age groups over the last decade, of which, serious attempts result in pediatric intensive care unit (PICU) admissions. We paired clinical, aggregate geospatial, and temporal demographics to understand local community variables to determine if epidemiological patterns emerge that associate with risk for PICU admission. …”
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Comparative Analysis of Intensive Care Prognosis Scoring Systems and Acute Kidney Injury Scores (AKIN and pRIFLE) in Critically Ill Children by Ayben Leblebici, Gurkan Bozan, Asli Kavaz Tufan, Eylem Kiral, Ebru Kacmaz, Ener Cagri Dinleyici

“…The development of AKI (acute kidney injury) in critically ill patients in pediatric intensive care units (PICUs) is one of the most important factors affecting mortality. …”
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Why do infants need out-of-hospital emergency medical services? A retrospective, population-based study by Jelena Oulasvirta, Heini Harve-Rytsälä, Mitja Lääperi, Markku Kuisma, Heli Salmi

“…Methods In a population-based 5-year retrospective cohort of all 1712 EMS responses for infants (age < 1 year) in Helsinki, Finland (population 643,000, < 1-year old population 6548), we studied 1) the characteristics of EMS missions with infants; 2) mortality within 12 months; 3) pediatric intensive care unit (PICU) admissions; 4) medical state of the infant upon presentation to the emergency department (ED); 5) any medication or respiratory support given at the ED; 6) hospitalization; and 7) surgical procedures during the same hospital visit. …”
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Identification of key genes and pathways using bioinformatics analysis in septic shock children by Yang J, Zhang S, Zhang J, Dong J, Wu J, Zhang L, Guo P, Tang S, Zhao Z, Wang H, Zhao Y, Zhang W, Wu F

“…Junting Yang,1,* Shunwen Zhang,1,2,* Jie Zhang,3 Jiangtao Dong,3 Jiangdong Wu,1 Le Zhang,1 Peng Guo,3 Suyu Tang,3 Zhengyong Zhao,1 Hongzhou Wang,1 Yanheng Zhao,3 Wanjiang Zhang,1 Fang Wu1 1Department of Pathophysiology, Shihezi University School of Medicine Shihezi, Xinjiang, China; 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; 3The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang, China *These authors contributed equally to this work Background and hypothesis: Sepsis is still one of the reasons for serious infectious diseases in pediatric intensive care unit patients despite the use of anti-infective therapy and organ support therapy. …”
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