Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of <i>ob/ob</i> Mice by Barbara Leibiger, Tilo Moede, Ismael Valladolid-Acebes, Meike Paschen, Montse Visa, Ingo B. Leibiger, Per-Olof Berggren

“…The pancreatic islets of Langerhans consist of endocrine cells that secrete peptide hormones into the blood circulation in response to metabolic stimuli. …”
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Effects of 8 Weeks Aerobic Training on Plasma Ghrelin Level and Ghrelin Lymphocyte Gene Expression in Elderly Men by Seyyed Mahdi Ahmadi, Mehrdad Fathi, Amir RashidLamir, Farnaz Aminian

“…Objectives Ghrelin is a peptide hormone secreted from the endocrine cells of stomach, affecting feeding behavior, appetite, energy consumption, and body weight. …”
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Application of Piracetam Electrophoresis in Complex Sanatorium-Resort Treatment of Girls with Amenorrhea by Olga I. Garmash, Olga F. Gavrilova, Natalya V. Kosolapova

“…After the treatment, a significant positive dynamics of steroid and peptide hormones was revealed in girlswith primary and secondary amenorrhea. …”
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Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis by Valery Fuh-Ngwa, Yuan Zhou, Phillip E. Melton, Ingrid van der Mei, Jac C. Charlesworth, Xin Lin, Amin Zarghami, Simon A. Broadley, Anne-Louise Ponsonby, Steve Simpson-Yap, Jeannette Lechner-Scott, Bruce V. Taylor

“…We found 7 genetic loci (rs7731626: HR 0.92, P = 2.4 × 10–5; rs12211604: HR 1.16, P = 3.2 × 10–7; rs55858457: HR 0.93, P = 3.7 × 10–7; rs10271373: HR 0.90, P = 1.1 × 10–7; rs11256593: HR 1.13, P = 5.1 × 10–57; rs12588969: HR = 1.10, P = 2.1 × 10–10; rs1465697: HR 1.09, P = 1.7 × 10–128) associated with risk worsening of disability; most of which were located near or tagged to 13 genomic regions enriched in peptide hormones and steroids biosynthesis pathways by positional and eQTL mapping. …”
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脑啡肽酶和脑啡肽酶抑制剂对葡萄糖稳态的影响:一个有争议的观点和有前景的领域 by Faisal Holil AlAnazi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Yousef Abud Alanazi, Hebatallah M. Saad, Gaber El‐Saber Batiha

“…Abstract Neprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates various peptide hormones including glucagon‐like peptide 1 (GLP‐1). …”
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Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation by Rachele Garella, Caterina Bernacchioni, Flaminia Chellini, Alessia Tani, Francesco Palmieri, Martina Parigi, Daniele Guasti, Emanuele Cassioli, Giovanni Castellini, Valdo Ricca, Daniele Bani, Chiara Sassoli, Chiara Donati, Roberta Squecco

“…Adipokines are peptide hormones produced by the adipose tissue involved in several biological functions. …”
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Plants’ Physio-Biochemical and Phyto-Hormonal Responses to Alleviate the Adverse Effects of Drought Stress: A Comprehensive Review by Abdul Wahab, Gholamreza Abdi, Muhammad Hamzah Saleem, Baber Ali, Saqib Ullah, Wadood Shah, Sahar Mumtaz, Ghulam Yasin, Crina Carmen Muresan, Romina Alina Marc

“…Other plant hormones, such as abscisic acid, auxin, gibberellic acid, brassinosteroids, and peptide hormones, have been linked to plant defense signaling pathways in various ways.…”
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Differential H3K9me2 heterochromatin levels and concordant mRNA expression in postmortem brain tissue of individuals with schizophrenia, bipolar, and controls by Hooriyah S. Rizavi, Hooriyah S. Rizavi, Kayla A. Chase, Chunyu Liu, Chunyu Liu, Hannah Gavin, Cherise Rosen, Cuihua Xia, Alessandro Guidotti, Rajiv P. Sharma, Rajiv P. Sharma

“…Potentially dysregulated gene categories include postsynaptic proteins, processing enzymes (for proproteins, lipids, and oxidative stress), cadherin family genes, the complement system, and peptide hormones. Ten genes with significantly increased or decreased H3K9me2 promoter occupation were selected through statistical analysis, function, or previous GWAS association, and Quantitative RT-PCR (qRT-PCR) was performed on an extended sample of postmortem brain tissue, adding an additional 17 controls, 7 individuals with schizophrenia, and 19 individuals with bipolar samples (n = 32 control, 22 schizophrenia, 19 bipolar). …”
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Physiology, pharmacology and prospects for dipeptidilpeptidase-4 inhibitors use by D. V. Kurkin, D. A. Bakulin, E. I. Morkovin, A. V. Strygin, Yu. V. Gorbunova, E. V. Volotova, I. E. Makarenko, V. B. Saparova, R. V. Drai, V. I. Petrov

“…DPP-4 belongs to the serine proteases family and is involved in the degradation of various chemokines and peptide hormones, including incretins secreted by intestinal L- and K-cells – GLP-1 and GIP. …”
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The physiological and pathological aggregation of transforming growth factor-β-induced and amyloid precursor protein in drosophila secondary cells by Singh, PJ

“…Thus in humans, amyloid or pre-amyloid proteins function normally as peptide hormones, are required for nervous system development, are part of the coagulation cascade, provide a scaffolding for melanin in melanocytes, and are essential for the transparency of the cornea, to name but a few of their known roles.…”

Emerging Roles of Dipeptidyl Peptidase-4 Inhibitors in Delaying the Progression of Type 1 Diabetes Mellitus by Gurgel Penaforte-Saboia J, Couri CEB, Vasconcelos Albuquerque N, Silva VLL, Bitar da Cunha Olegario N, Oliveira Fernandes V, Montenegro RM Junior

“…DPP-4 degrades the peptide hormones GLP-1 and GIP. In addition to regulating glucose metabolism, DPP-4 exerts anti-apoptotic, regenerative, and proliferative effects to promote &beta;-cell mass expansion. …”
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Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice by Hira Sajjad Talpur, Zia ur Rehman, Mostafa Gouda, Aixing Liang, Iqra Bano, Mir Sajjad Hussain, FarmanUllah FarmanUllah, Liguo Yang

“…Inhibin is a molecule that belongs to peptide hormones and is excreted through pituitary gonadotropins stimulation action on the granulosa cells of the ovaries. …”
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Diagnostic value of exosomal miR-1246 for Parkinson’s disease by WANG Xiaobei, YANG Shan, LI Yatan, YANG Xinling

“…GO enrichment analysis indicated that the mechanism of action of target genes was involved with cellular junction assembly， cellular response to peptide hormones， GABA synapses， post-synaptic membranes， and transcriptional coactivator protein binding. …”
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PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis by Xiangpei Kong, Huiyu Tian, Qianqian Yu, Feng Zhang, Rong Wang, Shan Gao, Wenhong Xu, Jiajia Liu, Eilon Shani, Chunxiang Fu, Gongke Zhou, Liangran Zhang, Xiansheng Zhang, Zhaojun Ding

“…ERF115, ERF114, and ERF109 mediate ROS signaling, in a PLT-independent manner, to control root stem cell niche maintenance and root growth through phytosulfokine (PSK) peptide hormones in Arabidopsis. : Prohibitins (PHBs) have been identified as negative regulators of the cell cycle. …”
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Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression by Ariel Ernesto Cariaga-Martinez, María Angelica Lorenzati, Mario Alejandro Riera, Marisa Angelica Cubilla, Andrés De La Rossa, Ernesto Martín Giorgio, María Mercedes Tiscornia, Esteban Mariano Gimenez, María Eugenia Rojas, Bárbara Julieta Chaneton, Dora Isabel Rodríguez, Pedro Darío Zapata

“…Prostate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin. …”
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The effect of Tinospora crispa crude methanolic extract on hepatoma G2 cell line and wistar rats insulin resistance model / Mohd Nazri Abu by Abu, Mohd Nazri

“…The hyperinsulinemia condition and C-peptide hormones restored to the normal stage. The histological examination of the liver treated with T. crispa crude extract did not show evidence of cells toxicity. …”
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Mecanismos de acción de las hormonas Tiroideas by Alfredo Jácome Roca

“…SUMMARY MECHANISMS OF ACTION OF THYROID HORMONE The better known mechanisms of hormonal action are those of the large molecule, hydrosoluble peptide hormones that act through a membrane receptor that activates adenyl-cyclase to produce cyclis AMP, and those of the small molecule, hydrophobic steroid hormones that easily enter the cell and go to act at the nuclear level primarily. …”
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Normalization of puberty and adult height in girls with Turner syndrome: results of the Swedish Growth Hormone trials initiating transition into adulthood by Berit Kriström, Carina Ankarberg-Lindgren, Marie-Louise Barrenäs, Karl Olof Nilsson, Kerstin Albertsson-Wikland

“…Treatment given were recombinant human (rh)GH (Genotropin® Kabi Peptide Hormones, Sweden) 33 or 67 µg/kg/day, oral ethinyl-estradiol (2/3) or transdermal 17β-estradiol (1/3), and, after age 11 years, mostly oxandrolone. …”
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Leptin, but not ghrelin, is associated with food addiction scores in a population-based subject sample by Dirk Alexander Wittekind, Jürgen Kratzsch, Roland Mergl, Ronny Baber, Ronny Baber, Kerstin Wirkner, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Michael Kluge, Michael Kluge

“…BackgroundGhrelin and leptin are both peptide hormones and act as opposing players in the regulation of hunger, satiety and energy expenditure. …”
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Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis by Bhavani S. Sahu, Maria Razzoli, Seth McGonigle, Jean Pierre Pallais, Megin E. Nguyen, Masato Sadahiro, Cheng Jiang, Wei-Jye Lin, Kevin A. Kelley, Pedro Rodriguez, Rachel Mansk, Cheryl Cero, Giada Caviola, Paola Palanza, Loredana Rao, Megan Beetch, Emilyn Alejandro, Yuk Y. Sham, Andrea Frontini, Stephen R. Salton, Alessandro Bartolomucci

“…Objective: Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease. …”
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