Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts by Seuwen Klaus, Baumgarten Birgit, Brüngger Adrian, Ribrioux Sebastien, John Markus R

“…Select findings of our analysis revealed that the G-protein coupled receptor GPR27 is entirely contained within a frame -1 matreshka, thrombopoietin contains a matreshka which spans ~70% of its length, platelet glycoprotein IIIa (ITGB3) contains a matreshka with the predicted characteristics of a secreted peptide hormone, while the potassium channel KCNK12 contains a matreshka spanning >400 amino acids.…”
Get full text

Hepcidin is potential regulator for renin activity. by Jaakko Piesanen, Jarkko Valjakka, Sanna Niemelä, Marjut Borgenström, Seppo Nikkari, Vesa Hytönen, Juha Määttä, Tarja Kunnas

“…Proteins encoded by these genes participate in the signalling routes leading eventually to the production of the peptide hormone hepcidin. Mutations in these genes have been associated with the abnormal production of hepcidin in the body. …”
Get full text

Sandwich ELISA-Based Electrochemical Biosensor for Leptin in Control and Diet-Induced Obesity Mouse Model by Ryong Sung, Yun Seok Heo

“…Leptin is a peptide hormone produced primarily in adipose tissues. …”
Get full text

Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains by Sasano Yuko, Yoshimura Asami, Fukamachi Shoji

“…<p>Abstract</p> <p>Background</p> <p>Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. …”
Get full text

Iron supplementation in suckling piglets: how to correct iron deficiency anemia without affecting plasma hepcidin levels. by Rafał R Starzyński, Coby M M Laarakkers, Harold Tjalsma, Dorine W Swinkels, Marek Pieszka, Agnieszka Styś, Michał Mickiewicz, Paweł Lipiński

“…To better assess the iron status we developed a novel mass spectrometry assay to quantify pig plasma levels of the iron-regulatory peptide hormone hepcidin-25. This hormone is predominantly secreted by the liver and acts as a negative regulator of iron absorption and reutilization. …”
Get full text

Hepcidin is potential regulator for renin activity by Jaakko Piesanen, Jarkko Valjakka, Sanna Niemelä, Marjut Borgenström, Seppo Nikkari, Vesa Hytönen, Juha Määttä, Tarja Kunnas

“…Proteins encoded by these genes participate in the signalling routes leading eventually to the production of the peptide hormone hepcidin. Mutations in these genes have been associated with the abnormal production of hepcidin in the body. …”
Get full text

Characterization of seed nuclei in glucagon aggregation using light scattering methods and field-flow fractionation by Kirsch Lee E, Nguyen Lida T, Hoppe Cindy C, Wiencek John M

“…<p>Abstract</p> <p>Background</p> <p>Glucagon is a peptide hormone with many uses as a therapeutic agent, including the emergency treatment of hypoglycemia. …”
Get full text

Trends in insulin resistance: insights into mechanisms and therapeutic strategy by Mengwei Li, Xiaowei Chi, Ying Wang, Sarra Setrerrahmane, Wenwei Xie, Hanmei Xu

“…Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues. …”
Get full text

Daily Treatment of Mice with Type 2 Diabetes with Adropin for Four Weeks Improves Glucolipid Profile, Reduces Hepatic Lipid Content and Restores Elevated Hepatic Enzymes in Serum by Marek Skrzypski, Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Tatiana Wojciechowicz, Paulina Janicka, Małgorzata Krążek, Emilian Małek, Mathias Z. Strowski, Krzysztof W. Nowak

“…Adropin is a peptide hormone encoded by Energy Homeostasis Associated gene. …”
Get full text

MOTS-c Functionally Prevents Metabolic Disorders by Yue Gao, Xinran Wei, Pingying Wei, Huijie Lu, Luying Zhong, Jie Tan, Hongbo Liu, Zheng Liu

“…As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, enhance immune regulation, and postpone aging. …”
Get full text

Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle by Alberto Ferlin, Luca De Toni, Alexander I. Agoulnik, Giorgia Lunardon, Andrea Armani, Sergia Bortolanza, Bert Blaauw, Marco Sandri, Marco Sandri, Carlo Foresta

“…The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3). INSL3 displays anabolic activity on bone, a target tissue of androgens, and its plasma concentrations are diminished in male hypogonadism. …”
Get full text

The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study by Leila Mahmoodnia, Sara Beigrezaei, Mohammad Reza Tamadon, Tina Jafari, Marzieh Kafeshani, Fatemeh Mahmoodi, Ali Hasanpour Dehkordi, Masoud Amiri

“…Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversible destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger sensation, may increase body fat percentage and might adjust the long-term body weight and is mostly secreted in the stomach. …”
Get full text

Structures of ferroportin in complex with its specific inhibitor vamifeport by Elena Farah Lehmann, Márton Liziczai, Katarzyna Drożdżyk, Patrick Altermatt, Cassiano Langini, Vania Manolova, Hanna Sundstrom, Franz Dürrenberger, Raimund Dutzler, Cristina Manatschal

“…A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe2+ transport and induces internalization and degradation of FPN. …”
Get full text

Not Only Systemin: Prosystemin Harbors Other Active Regions Able to Protect Tomato Plants by Donata Molisso, Mariangela Coppola, Martina Buonanno, Ilaria Di Lelio, Anna Maria Aprile, Emma Langella, Maria Manuela Rigano, Silvana Francesca, Pasquale Chiaiese, Gianna Palmieri, Rosarita Tatè, Martina Sinno, Eleonora Barra, Andrea Becchimanzi, Simona Maria Monti, Francesco Pennacchio, Francesco Pennacchio, Rosa Rao, Rosa Rao

“…Prosystemin is a 200-amino acid precursor expressed in Solanaceae plants which releases at the C-terminal part a peptidic hormone called Systemin in response to wounding and herbivore attack. …”
Get full text

Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues by Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E. Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka, Paolo Rovero, Christian W. Gruber, Michael Chorev, Anna Maria Papini

“…AbstractOxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. …”
Get full text

Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives by Rafał Sibiak, Maurycy Jankowski, Paweł Gutaj, Paul Mozdziak, Bartosz Kempisty, Ewa Wender-Ożegowska

“…Placental lactogen (PL) is a peptide hormone secreted throughout pregnancy by both animal and human specialized endocrine cells. …”
Get full text

Nanoscale Surface Topography Modulates hIAPP Aggregation Pathways at Solid–Liquid Interfaces by Marcel Hanke, Yu Yang, Yuxin Ji, Guido Grundmeier, Adrian Keller

“…In this work, therefore, we investigate the aggregation of the type 2 diabetes-associated peptide hormone hIAPP in contact with flat and nanopatterned silicon oxide surfaces. …”
Get full text

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2 by Thomas N. G. Handley, Praveen Praveen, Julien Tailhades, Hongkang Wu, Ross A. D. Bathgate, Mohammed Akhter Hossain

“…Human relaxin-2 (H2 relaxin) is a peptide hormone with potent vasodilatory and anti-fibrotic effects, which is of interest for the treatment of heart failure and fibrosis. …”
Get full text

Leptin as an important link between obesity and cardiovascular risk factors in men with acute myocardial infarction by Nergis Ekmen, Aysen Helvaci, Meral Gunaldi, Hadi Sasani, Sembol Turkmen Yildirmak

“…Leptin is produced by adipose tissue and is a peptide hormone, which has strong association with obesity, elevated cardiovascular risk, and morbidity. …”
Get full text

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. by Guillem Casanovas, Anashua Banerji, Flavia d'Alessio, Martina U Muckenthaler, Stefan Legewie

“…Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. …”
Get full text