On the Rational Drug Design for Hypertension through NMR Spectroscopy by Eleni Chontzopoulou, Andreas G. Tzakos, Thomas Mavromoustakos

“…Antagonists of the AT1receptor (AT1R) are beneficial molecules that can prevent the peptide hormone angiotensin II from binding and activating the specific receptor causing hypertension in pathological states. …”
Get full text

Cholecystokinin elevates mouse plasma lipids. by Lichun Zhou, Hong Yang, Xinghua Lin, Emmanuel U Okoro, Zhongmao Guo

“…Cholecystokinin (CCK) is a peptide hormone that induces bile release into the intestinal lumen which in turn aids in fat digestion and absorption in the intestine. …”
Get full text

The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice. by Xiaofan Zhang, Qi Li, Min Zhang, Sylvia Lam, Pak Chung Sham, Bitao Bu, Siew Eng Chua, Wei Wang, Grainne Mary McAlonan

“…Our results here encourage further research into the clinical application of this peptide hormone, which may potentially extend treatment options across a spectrum of neurodevelopmental conditions.…”
Get full text

The Effect of Intrahippocampal Injection of Ghrelin on Morphine-Induced Amnesia by Passive Avoidance Task in Male Laboratory Rats by Niloufar Darbandi, Farzaneh Nazari serenjeh, Parham Moradi

“…Background and Objectives: Ghrelin is a peptide hormone, which is secreted by stomach cells and has an important role in the metabolism and energy homeostasis. …”
Get full text

Development of identification test methods for triptorelin acetate and goserelin acetate substances using NMR spectroscopy by S. V Moiseev, N. E. Kuz’mina, A. I. Luttseva

“…The work is a continuation of the research on the use of NMR spectroscopy in the quality control of natural peptide hormone-based active substances and their synthetic analogues. …”
Get full text

Theory of Liquids for Studying the Conformational Flexibility of Biomolecules with Reference Interaction Site Model Approximation by Alexey Danilkovich, Dmitry Tikhonov

“…The free energy of oxytocin, which is a peptide hormone, as well as self-assembled ionic peptide complexes calculated using both the traditional RISM and the new RISM with average matrix (RISM-AM) approach are estimated. …”
Get full text

Inherited Disorders of Iron Overload by Kostas Pantopoulos, Kostas Pantopoulos

“…Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal enterocytes and tissue macrophages. …”
Get full text

Prosystemin overexpression induces transcriptional modifications of defense-related and receptor-like kinase genes and reduces the susceptibility to Cucumber mosaic virus and its s... by Giovanni Bubici, Anna Vittoria Carluccio, Livia Stavolone, Fabrizio Cillo

“…Systemin is a plant signal peptide hormone involved in the responses to wounding and insect damage in the Solanaceae family. …”
Get full text

Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study by Sood Manu R, Rudolph Colin D, Venkatasubramani Narayanan

“…<p>Abstract</p> <p>Background</p> <p>Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. …”
Get full text

Lack of association between genetic polymorphisms in IGF1 and IGFBP3 with twin births in a Brazilian population (Cândido Godói, Rio Grande do Sul) by Mariana de Oliveira-Klein, Augusto César Cardoso-dos-Santos, Alice Tagliani-Ribeiro, Nelson Rosa Fagundes, Ursula Matte, Lavinia Schuler-Faccini

“…Abstract Insulin-like growth factor (IGF-1) is an important peptide hormone involved in the reproduction and fetal development of mammals, and it is suggested that it may influence the human twinning rate. …”
Get full text

Insulin Preferentially Regulates the Activity of Parasympathetic Preganglionic Neurons over Sympathetic Preganglionic Neurons by Uisu Hyun, Yoon Young Kweon, Jong-Woo Sohn

“…Background Insulin is a peptide hormone that regulates post-prandial physiology, and it is well known that insulin controls homeostasis at least in part via the central nervous system. …”
Get full text

Molecular simulations of SSTR2 dynamics and interaction with ligands by Silvia Gervasoni, Camilla Guccione, Viviana Fanti, Andrea Bosin, Giancarlo Cappellini, Bruno Golosio, Paolo Ruggerone, Giuliano Malloci

“…Abstract The cyclic peptide hormone somatostatin regulates physiological processes involved in growth and metabolism, through its binding to G-protein coupled somatostatin receptors. …”
Get full text

Application of Growth Hormone in in vitro Fertilization by Yue-Ming Xu, Gui-Min Hao, Bu-Lang Gao

“…Growth hormone (GH) is a peptide hormone secreted mainly by the anterior part of the pituitary gland and plays a critical role in cell growth, development, and metabolism throughout the body. …”
Get full text

Somatostatin inhibits cell migration and reduces cell counts of human keratinocytes and delays epidermal wound healing in an ex vivo wound model. by Matthias Vockel, Simone Pollok, Ute Breitenbach, Ina Ridderbusch, Hans-Jürgen Kreienkamp, Johanna M Brandner

“…The peptide hormone somatostatin (SST) and its five G protein-coupled receptors (SSTR1-5) were described to be present in the skin, but their cutaneous function(s) and skin-specific signalling mechanisms are widely unknown. …”
Get full text

Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway. by Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Yu-Jen Cheng, Jhi-Jhu Hwang, Inn-Wen Chong

“…Adiponectin, a 244-amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. …”
Get full text

Oral Semaglutide, the First Ingestible Glucagon-Like Peptide-1 Receptor Agonist: Could It Be a Magic Bullet for Type 2 Diabetes? by Hwi Seung Kim, Chang Hee Jung

“…Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone released from the lower digestive tract that stimulates insulin secretion, suppresses glucagon secretion, and decreases hunger. …”
Get full text

Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance. by Jeannette A E Söderberg, Ryan T Birse, Dick R Nässel

“…Our findings are the first to demonstrate DILP signaling originating in the renal tubules and that this signaling is under control of stress-induced release of peptide hormone.…”
Get full text

A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. by Brian H Lee, Kaveh Ashrafi

“…We found that OCR-2, a transient receptor potential vanilloid (TRPV) channel that localizes to the cilia of this subset of neurons, regulates peptide-hormone secretion and L1 starvation survival. …”
Get full text

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis by Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate

“…Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. …”
Get full text

Role of Adropin in Cardiometabolic Disorders: From Pathophysiological Mechanisms to Therapeutic Target by Josko Bozic, Marko Kumric, Tina Ticinovic Kurir, Ivan Males, Josip A. Borovac, Dinko Martinovic, Marino Vilovic

“…Adropin, a highly conserved peptide hormone secreted primarily by the liver, recently emerged as an important regulatory component of the vascular endothelium. …”
Get full text