Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies by David Standing, Prasad Dandawate, Shrikant Anant

“…Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. …”
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Leptin and its receptor gene polymorphism as a target for pharmacotherapy in T2DM and COPD by Yu. A. Sorokina, O. V. Zanozina, E. V. Makarova, S. G. Salcev, G. N. Varvarina, L. V. Lovtsova

“…One of the ways to individualize pharmacotherapy is to identify polymorphic genes that can account not only to the predisposition to the disease, but also to the formation of a pharmacological response, thus determining the effectiveness of drug therapy. A peptide hormone leptin along with its receptors in various tissues could be the milestone of unifying pathology that contributes both to the development of diseases - chronic obstructive pulmonary disease (COPD) and T2DM. …”
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High Affinity Binding of Indium and Ruthenium Ions by Gastrins. by Graham S Baldwin, Graham N George, M Jake Pushie

“…The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated forms of the hormone. …”
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Gastrin and Gastric CancerSummary by Jill P. Smith, Sandeep Nadella, Nick Osborne

“…Despite progress in understanding its development, challenges with treatment remain. Gastrin, a peptide hormone, is trophic for normal gastrointestinal epithelium. …”
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Insulin and glucagon regulate pancreatic α-cell proliferation. by Zhuo Liu, Wook Kim, Zhike Chen, Yu-Kyong Shin, Olga D Carlson, Jennifer L Fiori, Li Xin, Joshua K Napora, Ryan Short, Juliana O Odetunde, Qizong Lao, Josephine M Egan

“…Glucagon is a 29 amino acid peptide hormone, which is secreted from pancreatic α cells: excessively high circulating levels of glucagon lead to excessive hepatic glucose output. …”
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Impact of hepcidin, interleukin 6, and other inflammatory markers with respect to erythropoietin on anemia in chronic hemodialysis patients by Ihab A. Ibrahim, Usama M. Mohamad, Hatem A. Darweesh, Amal M. Rashad

“…Background /objective Hepcidin is a peptide hormone produced by the liver and appears to be the master regulator of iron homeostasis. …”
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Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. by Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe

“…Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. …”
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A fit-for-purpose validation of a commercial radioimmunoassay for measurement of human peripheral oxytocin by Keenan Gerred, Amita Kapoor

“…Oxytocin (OT) is a peptide hormone synthesized in the hypothalamus and released into systemic circulation or other areas of the brain. …”
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Gene Expression Analysis Links Autocrine Vasoactive Intestinal Peptide and ZEB1 in Gastrointestinal Cancers by Ishani H. Rao, Edmund K. Waller, Rohan K. Dhamsania, Sanjay Chandrasekaran

“…VIP (vasoactive intestinal peptide) is a 28-amino acid peptide hormone expressed by cancer and the healthy nervous system, digestive tract, cardiovascular, and immune cell tissues. …”
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Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation. by Nadia A Rivero-Segura, Edgar Flores-Soto, Selene García de la Cadena, Isabel Coronado-Mares, Juan C Gomez-Verjan, Diana G Ferreira, Erika Alejandra Cabrera-Reyes, Luísa V Lopes, Lourdes Massieu, Marco Cerbón

“…Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions in the brain. …”
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Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling. by Stephanie Rock, Xian Li, Jun Song, Courtney M Townsend, Heidi L Weiss, Piotr Rychahou, Tianyan Gao, Jing Li, B Mark Evers

“…Neurotensin is a peptide hormone released from enteroendocrine cells in the small intestine in response to fat ingestion. …”
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Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and patho... by Chun Wu, Joan-Emma Shea

“…IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsically disordered protein that is coexpressed and cosecreted along with insulin by pancreatic islet β-cells in response to meals. …”
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In Situ Localization and Rhythmic Expression of Ghrelin and ghs-r1 Ghrelin Receptor in the Brain and Gastrointestinal Tract of Goldfish (Carassius auratus). by Aída Sánchez-Bretaño, Ayelén M Blanco, Suraj Unniappan, Olivier Kah, Marie-M Gueguen, Juan I Bertucci, Ángel L Alonso-Gómez, Ana I Valenciano, Esther Isorna, María J Delgado

“…Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) to regulate a wide variety of biological processes in fish. …”
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Quantification of rat kisspeptin using a novel radioimmunoassay. by James S Kinsey-Jones, Kylie E Beale, Joy Cuenco, Xiao Feng Li, Stephen R Bloom, Kevin T O'Byrne, Kevin G Murphy

“…Kisspeptin is a hypothalamic peptide hormone that plays a pivotal role in pubertal onset and reproductive function. …”
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The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study by Leonardo Tomiatti da Costa, Laura Gonzalez dos Anjos, Luciane Tsukamoto Kagohara, Giovana Tardin Torrezan, Claudia A. Andrade De Paula, Edmund Chada Baracat, Dirce Maria Carraro, Katia Candido Carvalho

“…In silico pathway analyses demonstrated that many genes mutated in ULMS and ESS have functions associated with the cellular response to hypoxia and cellular response to peptide hormone stimulus. In UCS and ADS, genes with most alterations have functions associated with phosphatidylinositol kinase activity and glycerophospholipid metabolic process. …”
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A role of TDIF peptide signaling in vascular cell differentiation is conserved among euphyllophytes by Yuki eHirakawa, Yuki eHirakawa, John L Bowman, John L Bowman

“…During Arabidopsis thaliana vascular development, a CLE (CLAVATA3/EMBRYO SURROUNDING REGION-related) family peptide hormone, TDIF (tracheary element differentiation inhibitory factor), regulates procambial cell fate by its inhibitory activity on xylem differentiation. …”
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Acute sleep fragmentation does not alter pro-inflammatory cytokine gene expression in brain or peripheral tissues of leptin-deficient mice by Jennifer E. Dumaine, Noah T. Ashley

“…Obesity and sleep fragmentation (SF) are often co-occurring pro-inflammatory conditions in patients with obstructive sleep apnea. Leptin is a peptide hormone produced by adipocytes that has anorexigenic effects upon appetite while regulating immunity. …”
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Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes by Marie-Claude Gaudreau, Radhika R. Gudi, Gongbo Li, Benjamin M. Johnson, Chenthamarakshan Vasu

“…Here, we report the use of mesenchymal stromal/stem cells (MSCs) for the production and delivery of Gastrin, a peptide hormone that is produced by intestinal cells and foetal islets and can increase β-Cell mass, to promote protection from T1D. …”
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Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. by Vittoria Massafra, Alexandra Milona, Harmjan R Vos, Boudewijn M T Burgering, Saskia W C van Mil

“…Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). …”
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Molecular evolution of the proopiomelanocortin system in Barn owl species. by Karin Löw, Anne-Lyse Ducrest, Luis M San-Jose, Céline Simon, Vera Uva, Nabil G Seidah, Antonella Pasquato, Stefan Kunz, Alexandre Roulin

“…Extension of the γ3-MSH poly-serine stretches ≥7 further markedly increases peptide hormone stability in plasma, which is conserved in humans, and is likely relevant to its endocrine function. …”
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