Effects of sodium octanoate, acylated ghrelin, and desacylated ghrelin on the growth of genetically engineered escherichia coli by Aydin Suleyman, Erenler Sebnem, Kendir Yalcin

“…Acylated ghrelin is a 28-amino acid peptide hormone bearing a fatty acid group based on octanoic acid (caprylic acid) at the serine which is located at position 3 and at the N-terminus. …”
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Protective Effects of Relaxin 2 (RLXH2) against Hypoxia-Induced Oxidative Damage and Cell Death via Activation of The Nrf2/HO-1 Signalling Pathway in Gastric Cancer Cells by Liguo Wang, Yi Zhou, Hui Lin, Kezhu Hou

“…Objective: This study aims to investigate the potential role of relaxin, a peptide hormone, in preventing cellulardeterioration and death in gastric carcinoma cells under hypoxic conditions. …”
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The ghrelin-GHSR-1a pathway inhibits high glucose-induced retinal angiogenesis in vitro by alleviating endoplasmic reticulum stress by Rong Li, Guomin Yao, Lingxiao Zhou, Min Zhang, Jin Yan

“…Abstract Background To investigate the effect of ghrelin, a brain-gut peptide hormone, on high glucose-induced retinal angiogenesis in vitro and explore its association with endoplasmic reticulum (ER) stress. …”
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Association of lower circulating Spexin levels with higher body mass indices and glucose metabolic profiles in adult subjects in Egypt by Eman Salah Albeltagy, Nashwa Mohamed Abd Elbaky

“…Objectives: Spexin (SPX) is a novel peptide hormone that lowers blood glucose levels and is protective against hepatic steatosis in diet induced obese mouse models. …”
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Association Analysis of the Leptin and Ghrelin Receptor Gene Polymorphism in the Human with BMI by Zuzana Lieskovská, Anna Trakovická, Anton Kováčik, Tomáš Minarovič, Alica Rafayová

“…The restriction site is located at the position 2549 bp (C→A). Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the endogenous ligand for the growth hormone secretagogue receptor. …”
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Pulsed Third-Spin-Assisted Recoupling NMR for Obtaining Long-Range 13 C– 13 C and 15 N– 13 C Distance Restraints by Gelenter, Martin D, Dregni, Aurelio J, Hong, Mei

“…We then apply these methods to the amyloid fibrils formed by the peptide hormone glucagon and show that long-range correlation peaks are readily observed to constrain intermolecular packing in this cross-β fibril. …”
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Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. by Aleksandrova, K, Boeing, H, Jenab, M, Bueno-de-Mesquita, H, Jansen, E, van Duijnhoven, F, Rinaldi, S, Fedirko, V, Romieu, I, Riboli, E, Gunter, M, Westphal, S, Overvad, K, Tjønneland, A, Halkjær, J, Racine, A, Boutron-Ruault, M, Clavel-Chapelon, F, Kaaks, R, Lukanova, A, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Mattiello, A, Pala, V

“…Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). …”

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patellar Tendon and Lateral Collateral Ligament of Female WKY Rats by Dehghan, F., Muniandy, S., Yusof, A.

“…This raised the possibility that female sex-steroids are involved in the mechanism underlying this injury via affecting the expression of the receptors for relaxin, a peptide hormone known to modulate ligament laxity. Therefore, this study aims to investigate the effect of sex-steroids on relaxin receptor isoforms (RXFP1 & RXFP2) expression in the ligaments and tendons of the knee. …”

Hepcidin Upregulation in Colorectal Cancer Associates with Accumulation of Regulatory Macrophages and Epithelial–Mesenchymal Transition and Correlates with Progression of the Disea... by Antonio Di Grazia, Davide Di Fusco, Eleonora Franzè, Marco Colella, Georgios Strimpakos, Silvia Salvatori, Vincenzo Formica, Federica Laudisi, Claudia Maresca, Alfredo Colantoni, Angela Ortenzi, Carmine Stolfi, Ivan Monteleone, Giovanni Monteleone

“…Recent studies have shown that hepcidin, a peptide hormone produced mainly by hepatocytes, is expressed by and enhances the growth of tumor cells. …”
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Phytosulfokine contributes to suspension culture of Cunninghamia lanceolata through its impact on redox homeostasis by Zhaodong Hao, Jinyu Shi, Hua Wu, Yiqing Yan, Kaifei Xing, Renhua Zheng, Jisen Shi, Jinhui Chen

“…Previously, we reported that the plant peptide hormone phytosulfokine (PSK) can tremendously decrease the hydrogen peroxide (H2O2) level and help to initiate somatic embryogenesis (SE) in recalcitrant C. lanceolata genotypes. …”
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Characterization of a novel spexin gene (spx2) in the half-smooth tongue sole and regulation of its expression by nutritional status by Bin Wang, Aijun Cui, Jing Tian, Yaxing Zhang, Yan Jiang, Yongjiang Xu, Xuezhou Liu

“…Spexin (SPX) is a newly identified peptide hormone of 14 amino acids (aa) with pleiotropic functions in vertebrates, and recently a second paralog of SPX (named SPX2) has been only found in some non-mammalian species (the previous form of SPX is now designated as SPX1). …”
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Islet amyloid polypeptide does not suppress pancreatic cancer by Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere

“…Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression. …”
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Ghrelin enhances cisplatin sensitivity in HO-8910 PM human ovarian cancer cells by Yun Leng, Can Zhao, Guoliang Yan, Shuangyue Xu, Yinggui Yang, Ting Gong, Xin Li, Chenglin Li

“…Ghrelin, a widely distributed peptide hormone, participates in a series of cancer progression. …”
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The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer by Yuxin Cui, Zhilei Li, Junxia Cao, Jane Lane, Emily Birkin, Xuefei Dong, Lijian Zhang, Wen G. Jiang

“…High throughput proteomic array indicates that DHX36 functions in lung cancer cells through regulating multiple signalling pathways including activation of protein activity, protein autophosphorylation, Fc-receptor signalling pathway, response to peptide hormone and stress-activated protein kinase signalling cascade. …”
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Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction by Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J. Wilson, Juan J. Marugan, Alexander I. Agoulnik

“…Diseases, such as diabetes and hypertension, often lead to chronic kidney failure. The peptide hormone relaxin has been shown to have therapeutic effects in various organs. …”
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Custodiol^® Supplemented with Synthetic Human Relaxin Decreases Ischemia-Reperfusion Injury after Porcine Kidney Transplantation by Augustinas Bausys, Juste Maneikyte, Bettina Leber, Jennifer Weber, Nicole Feldbacher, Kestutis Strupas, Thomas Bernd Dschietzig, Peter Schemmer, Philipp Stiegler

“…Relaxin-2 (RLX) is a promising insulin-related peptide hormone that protects against renal IRI in rodents, although large animal models are needed before RLX can be tested in a human setting. …”
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Correlation Networks Provide New Insights into the Architecture of Testicular Steroid Pathways in Pigs by Annie Robic, Thomas Faraut, Katia Feve, Sarah Djebali, Armelle Prunier, Catherine Larzul, Laurence Liaubet

“…This CYP11A1-group contained also <i>INSL3</i> and <i>AGT</i> genes encoding a peptide hormone and an angiotensin peptide precursor, respectively.…”
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Andrographolide, A Novel Repressor of Hepcidin Gene Expression by Vadoud Malekzadeh, Farideh Manafi, Reza Alipanah-Moghadam, Ali Nemati, Arash Mehri, Firouz Norouzi, Mohammad Mohammadzadeh-Vardin, Firouz Amani

“…Introduction: Hepcidin is the most important factor in iron metabolism and plays a potential role in erythropoiesis. It is a small peptide hormone which is cysteine-rich and is mostly secreted by hepatic cells. …”
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Study Protocol of the PreFiPS Study: Prevention of Postoperative Pancreatic Fistula by Somatostatin Compared With Octreotide, a Prospective Randomized Controlled Trial by Elisabeth Hain, Alexandre Challine, Stylianos Tzedakis, Alexandru Mare, Alessandro Martinino, David Fuks, Mustapha Adham, Guillaume Piessen, Jean-Marc Regimbeau, Emmanuel Buc, Louise Barbier, Jean-Christophe Vaillant, Florence Jeune, Laurent Sulpice, Fabrice Muscari, Lilian Schwarz, Sophie Deguelte, Antonio Sa Cunha, Stephanie Truant, Bertrand Dousset, Alain Sauvanet, Sébastien Gaujoux

“…We can hypothesize that continuous intravenous infusion of somatostatin-14, the natural peptide hormone, associated with 10–50 times stronger affinity with all somatostatin receptor compared with somatostatin analogs, will be associated with an improved PF prevention.Methods: A French comparative randomized open multicentric study comparing somatostatin vs. octreotide in adult patients undergoing pancreaticoduodenectomy (PD) or distal pancreatectomy with or without splenectomy. …”
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Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells by Ramona Clemen, Eduardo Fuentes-Lemus, Sander Bekeschus, Michael J. Davies

“…Chronic inflammation is characterized by increased oxidant formation, with this inducing protein modification, altered function and immunogenicity. Amylin, a peptide hormone co-secreted with insulin by β-cells, has attracted considerable interest for its amyloidogenic properties, however, the effects that oxidants have on amylin aggregation and function are poorly understood. …”
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