Viral hepatitis B and C in HIV-infected patients in Saudi Arabia by Ahmad Alhuraiji, Ali Alaraj, Saad Alghamdi, Abdullah Alrbiaan, Abdulrahman A. Alrajhi

“…We excluded patients who were deceased prior to completing work-up, lost follow-up, or acquired HIV perinatally. RESULTS: Among 341 HIV-infected patients, hepatitis C infection was found in 41 (12%) patients. …”
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Mobile interventions targeting common mental disorders among pregnant and postpartum women: An equity-focused systematic review by Ammar Saad, Olivia Magwood, Tim Aubry, Qasem Alkhateeb, Syeda Shanza Hashmi, Julie Hakim, Leanne Ford, Azaad Kassam, Peter Tugwell, Kevin Pottie

“…Mobile interventions had a clinically important impact on reducing the occurrence of depression (OR = 0.51 [95% CI 0.41 to 0.64]; absolute risk reduction RD: 7.14% [95% CI 4.92 to 9.36]; p<0.001) and preventing its severity perinatally (MD = -3.07; 95% CI -4.68 to -1.46; p<0.001). …”
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Delayed cortical development in mice with a neural specific deletion of β1 integrin by Mamunur Rashid, Mamunur Rashid, Eric C. Olson

“…Similar to our prior findings with conditional paxillin deficiency, we found that both homozygous and heterozygous deletion of β1 integrin causes transient mispositioning of cortical neurons in the developing cortex when analyzed pre- and perinatally. Paxillin and β1 integrin colocalize in the migrating neurons and deletion of paxillin in the migrating neuron causes an overall reduction of the β1 integrin immunofluorescence signal and reduction in the number of activated β1 integrin puncta in the migrating neurons. …”
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Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014. by Patricia Rojas Sánchez, Luis Prieto, Santiago Jiménez De Ory, Elisa Fernández Cooke, Maria Luisa Navarro, José Tomas Ramos, África Holguín, Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Network (CoRISPe)

“…Patients were mainly Spaniards (81.9%), perinatally infected (96.5%) with subtype-B (65.3%) and HIV-diagnosed before year 2000 (67.8%). …”
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Developmental Pb2+-Exposure induces cardiovascular pathologies in adult male rats by Evelyn Okeke, Lorenz S Neuwirth, Abdeslem El Idrissi

“…Aims and Objectives: To generate a model system of Pb2+-induced cardiovascular pathology that would be consistent with past reports, the present study examined male Long–Evans Hooded rats that were perinatally Pb2+ exposed (i.e., via their food with 996 ppm lead acetate in the rat chow) up until weaning (i.e., postnatal day 22; blood lead levels [BLLs]: 10–15 μg/dL) and were then removed from Pb2+ exposure for nearly 1.5 months (i.e., BLLs >3.33 μg/dL). …”
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Is it safe? Talking to teens with HIV/AIDS about death and dying: a 3-month evaluation of Family Centered Advance Care (FACE) planning &amp;ndash; anxiety, depression, quality of l... by Maureen E Lyon, Patricia A Garvie, Linda Briggs, et al

“…Three-month post-intervention outcomes were: completion of advance directive (Five Wishes&amp;copy;); psychological adjustment (Beck Depression, Anxiety Inventories); quality of life (PedsQL&amp;trade;); and HIV symptoms (General Health Self-Assessment).Results: Adolescents had a mean age, 16 years; 40% male; 92% African-American; 68% with perinatally acquired HIV, 29% had AIDS diagnosis. FACE participants completed advance directives more than controls, using time matched comparison (P &amp;lt; 0.001). …”
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Psychiatric disorders in adolescents living with HIV in Botswana by Anthony A. Olashore, Saeeda Paruk, Oluyemi O. Akanni, Bonginkosi Chiliza

“…Abstract Background As children living with HIV transition from adolescence into adulthood, they face a considerable burden of psychiatric disorders (PDs) which may vary between the perinatally and behaviorally infected. The knowledge of the pattern of these PDs in relation to the varying needs of the adolescents living with HIV (ALWHIV) is unclear but necessary for maximizing their linkage to care and improving their quality of life in Botswana.  …”
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Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2 by Hannan, FM, Stevenson, M, Bayliss, AL, Stokes, VJ, Stewart, M, Kooblall, KG, Gorvin, CM, Codner, G, Teboul, L, Wells, S, Thakker, RV

“…Homozygous (Ap2s1L15/L15) mice invariably died perinatally. Co-immunoprecipitation studies showed that the AP2S1 p.Arg15Leu mutation impaired protein–protein interactions between AP2σ2 and the other AP2 subunits, and also with the CaSR. …”

Changes in resting-state functional brain activity are associated with waning cognitive functions in HIV-infected children by Santosh K. Yadav, Rakesh K. Gupta, Sheema Hashem, Ajaz A. Bhat, Ravindra K. Garg, Vimala Venkatesh, Pradeep K. Gupta, Alok K. Singh, Saurabh Chaturvedi, Sabha Nisar Ahmed, Muhammad W. Azeem, Mohammad Haris

“…Delayed brain development in perinatally HIV-infected children may affect the functional brain activity and subsequently cognitive function. …”
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Validación de un modelo de predicción de necesidad de cirugía cardiovascular o cateterismo terapéutico neonatal en fetos con cardiopatías congénitas by Sofía, Grinenco, María A, Segovia, Gabriela, Peña, Fernando, Olmedo, Pablo, Marantz, Gustavo, Izbizky

“…CONCLUSIONES: La aplicación del modelo estudiado en fetos con cardiopatías congénitas es factible, presenta una capacidad diagnóstica satisfactoria y constituye una herramienta útil para el manejo perinatal…”
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Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring by Lukas F. Reissig, Atieh Seyedian Moghaddam, Fabrice Prin, Robert Wilson, Antonella Galli, Catherine Tudor, Jaqueline K. White, Stefan H. Geyer, Timothy J. Mohun, Wolfgang J. Weninger

“…Indeed for null mutations, around one-third have proved to be pre- or perinatally lethal, their analysis resting entirely upon phenotyping of accessible embryonic stages.To simplify the identification of potentially useful mouse mutants, we have conducted three-dimensional phenotype analysis of approximately 500 homozygous null mutant embryos, produced from targeting a variety of mouse genes and harvested at embryonic day 14.5 as part of the “Deciphering the Mechanisms of Developmental Disorders” www.dmdd.org.uk program. …”
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Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice by Stefanie Bobe, Stefanie Bobe, Daniel Beckmann, Dorothee Maria Klump, Cathrin Dierkes, Nils Kirschnick, Esther Redder, Nadine Bauer, Michael Schäfers, Raghu Erapaneedi, Benjamin Risse, Serge A. van de Pavert, Friedemann Kiefer

“…After entry into the lymphatic initials, the lymph drained retrograde to the portal blood flow towards the exit at the liver hilum. Perinatally, the liver undergoes complex changes transforming from the main hematopoietic to the largest metabolic organ. …”
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Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice by Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner

“…Kctd1 I27N homozygous mutant mice die perinatally. Standardized, systemic phenotypic analysis of Kctd1 I27N heterozygous mutants was carried out in the German Mouse Clinic (GMC). …”
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HDAC6 regulates primordial follicle activation through mTOR signaling pathway by Tuo Zhang, Meina He, Lihua Zhao, Shaogang Qin, Zijian Zhu, Xinhua Du, Bo Zhou, Yi Yang, Xinfeng Liu, Guoliang Xia, Tengxiang Chen, Yuanxi Wang, Hua Zhang, Chao Wang

“…Abstract Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. …”
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Evaluation of submaximal endurance in young children living with HIV by Joanne Potterton, Renate Strehlau, Stephanie Shiau, Nicolette Comley-White, Louise Kuhn, Michael Yin, Stephen Arpadi

“…Background: There is growing concern about the long-term sequelae [a condition which is the consequence of a previous disease or injury] of perinatally acquired human immunodeficiency virus (HIV). …”
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Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay by Anke Vermehren-Schmaedick, Jeffrey Y. Huang, Madison Levinson, Matthew B. Pomaville, Sarah Reed, Gary A. Bellus, Fred Gilbert, Boris Keren, Delphine Heron, Damien Haye, Christine Janello, Christine Makowski, Katharina Danhauser, Lev M. Fedorov, Tobias B. Haack, Kevin M. Wright, Michael S. Cohen

“…Homozygous Parp6^TR do not exhibit obvious neuromorphological defects during development, but nevertheless die perinatally. This suggests that Parp6 catalytic activity is important for postnatal survival. …”
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Detailed characterizations of cranial nerve anatomy in E14.5 mouse embryos/fetuses and their use as reference for diagnosing subtle, but potentially lethal malformations in mutants by Lukas F. Reissig, Stefan H. Geyer, Viola Winkler, Ester Preineder, Fabrice Prin, Robert Wilson, Antonella Galli, Catherine Tudor, Jaqueline K. White, Timothy J. Mohun, Wolfgang J. Weninger

“…Careful phenotype analysis of genetically altered mouse embryos/fetuses is vital for deciphering the function of pre- and perinatally lethal genes. Usually this involves comparing the anatomy of mutants with that of wild types of identical developmental stages. …”
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B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with Antibody Responses to the Pentavalent Rotavirus Vaccine by Adriana Weinberg, Adriana Weinberg, Adriana Weinberg, Jane Lindsey, Ronald Bosch, Deborah Persaud, Paul Sato, Anthony Ogwu, Aida Asmelash, Mutsa Bwakura-Dangarambezi, Benjamin H. Chi, Jennifer Canniff, Shahin Lockman, Shahin Lockman, Simani Gaseitsiwe, Simani Gaseitsiwe, Sikhulile Moyo, Christiana Elizabeth Smith, Natasha O. Moraka, Myron J. Levin, Myron J. Levin, for the P1072 and Tshipidi Study Teams, Charles Fane, Dudu Kooreng, Tebogo J. Kakhu, Loeto Mazhani, Tumalano Sekoto, Lesedi Tirelo, Tshepo T. Frank, Mpho Raesi, Grace Kinabo, Boniface Njau, Anne Buchanan, Janeth Kimaro, Felistus Mbewe, Ellen Shingalili, Fyatilani Chirwa, Helen Bwalya Mulenga, Tapiwa Mbengeranwa, Taurai Beta, Ethel Dauya, Hilda Mujuru

“…We examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine (RV5) in perinatally HIV-infected (PHIV) infants on antiretroviral therapy and in HIV-exposed uninfected (PHEU) infants enrolled in International Maternal Pediatric Adolescent AIDS Clinical Trials P1072 study (NCT00880698). …”
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The influence of timing of Maternal administration of Antibiotics during cesarean section on the intestinal Microbial colonization in Infants (MAMI-trial): study protocol for a ran... by Thomas H. Dierikx, Daniel J. C. Berkhout, Laura Visser, Marc A. Benninga, Guus Roeselers, Nanne K. H. de Boer, Johanna I. P. de Vries, Tim G. J. de Meij

“…Recent revisions to international obstetric guidelines have resulted in the exposure of all infants born by caesarean section (CS) to broad-spectrum antibiotics perinatally. To date, the consequences of these new guidelines on neonatal gut colonisation and the associated short- and long-term health implications have not yet been addressed. …”
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Reducing mother-to-child transmission of HIV: findings from an early infant diagnosis program in south-south region of Nigeria by Anoje Chukwuemeka, Aiyenigba Bolatito, Suzuki Chiho, Badru Titilope, Akpoigbe Kesiena, Odo Michael, Odafe Solomon, Adedokun Oluwasanmi, Torpey Kwasi, Chabikuli Otto N

“…</p> <p>Methods</p> <p>This was a retrospective study. Records of 702 perinatally exposed babies aged six weeks to 18 months who had a DNA PCR test between November 2007 and July 2009 were reviewed. …”
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