Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background by M. N. Savini, A. Mingarelli, A. Peron, F. La Briola, F. Cervi, R. M. Alfano, M. P. Canevini, A. Vignoli

“…Methods We report on six infants diagnosed with TSC pre- or perinatally, who underwent serial Video-EEG recordings during the first two years of life. …”
Get full text

Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV by Fabiana Bononi Carmo, Maria Teresa Terreri, Regina Célia de Menezes Succi, Suenia Vasconcelos Beltrão, Aida de Fátima Tomé Barbosa Gouvea, Erica Regina Cruz Paulino, Daisy Maria Machado

“…Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. …”
Get full text

Reduced white matter maturation in the central auditory system of children living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Andre J. W. van der Kouwe, Martha Holmes, Martha Holmes

“…Children living with perinatally acquired HIV (CPHIVs) demonstrate hearing and neurocognitive impairments when compared to their uninfected peers (CHUUs), but investigations into the central auditory system (CAS) WM integrity are lacking. …”
Get full text

The role of etravirine in the management of treatment-experienced pediatric patients with HIV by Osterholzer D

“…Keywords: salvage, resistance, children, adolescents, NNRTI, perinatal…”
Get full text

Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort by Alltalents T. Murahwa, Tinashe Mudzviti, Racheal S. Dube Mandishora, Takudzwa Chatindo, Peace Chanetsa, Margaret Pascoe, Tinei Shamu, Wisdom Basera, Ruedi Luethy, Anna-Lise Williamson

“…This study was conducted to evaluate the potential role of prophylactic HPV vaccines in preventing new HPV infections among participants with perinatally acquired HIV who received the quadrivalent HPV vaccine at least five years before this study. …”
Get full text

Bone mineral density among children living with HIV failing first-line anti-retroviral therapy in Uganda: A sub-study of the CHAPAS-4 trial. by Eva Natukunda, Alex Szubert, Caroline Otike, Imerida Namyalo, Esther Nambi, Alasdair Bamford, Katja Doerholt, Diana M Gibb, Victor Musiime, Phillipa Musoke

“…<h4>Background</h4>Children living with perinatally acquired HIV (CLWH) survive into adulthood on antiretroviral therapy (ART). …”
Get full text

Decline in CD4 T lymphocytes with monotherapy bridging strategy for non-adherent adolescents living with HIV infection: Results of the IMPAACT P1094 randomized trial. by Allison L Agwu, Meredith G Warshaw, Elizabeth J McFarland, George K Siberry, Ann J Melvin, Andrew A Wiznia, Lee Fairlie, Sandra Boyd, Paul Harding, Hans M L Spiegel, Elaine J Abrams, Vincent J Carey, P1094 Study Team

“…RESULTS:Thirty-three perinatally acquired YLHIV participants (16 continuing cART and 17 3TC/FTC) enrolled in the study. …”
Get full text

Exploring the relationship between HIV and executive function in adolescents, and testing the feasibility of a music intervention aiming to improve executive function in HIV-positi... by Rowe, K

“…</p> <p>Study 1 found evidence for EF deficits in perinatally acquired HIV; evidence was limited for behaviourally acquired HIV. …”

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix by Marta Empere, Marta Empere, Xujia Wang, Carina Prein, Carina Prein, Anders Aspberg, Markus Moser, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Attila Aszodi, Paolo Alberton, Paolo Alberton

“…Homozygous mutant mice are perinatally lethal and characterized by short snout, cleft palate and disproportionate dwarfism. …”
Get full text

Adolescent experiences, perceptions, and preferences for the process of HIV status disclosure in Kenya by Cyrus Mugo, Cyrus Mugo, Irene N. Njuguna, Irene N. Njuguna, Kristin Beima-Sofie, Caren W. Mburu, Alvin Onyango, Janet Itindi, Barbra A. Richardson, Barbra A. Richardson, Laura Oyiengo, Grace John-Stewart, Grace John-Stewart, Grace John-Stewart, Grace John-Stewart, Dalton C. Wamalwa

“…We described their experiences and preferences using counts and proportions and assessed factors associated with satisfaction with the disclosure process using linear regression, reporting age-adjusted mean differences (aMD), and 95% confidence intervals (95%CIs).ResultsOf the 375 enrolled AYLH, 265 (71%) had perinatally acquired HIV, of whom 162 (61%) were female. …”
Get full text

Safety of Hepatitis B Vaccines (Monovalent or as Part of Combination) in Preterm Infants: A Systematic Review by Qiao Wen Tee, Ramin Odisho, Elisha Purcell, Rachael Purcell, Jim Buttery, Claudia A. Nold-Petry, Marcel F. Nold, Atul Malhotra

“…Hepatitis B vaccination at birth is clearly justified, represents a crucial step in the global control of perinatally acquired hepatitis B and there are no safety concerns in infants born at term. …”
Get full text

Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected by Abdulmumin Ibrahim, Abdulmumin Ibrahim, Fleur L. Warton, Fleur L. Warton, Samantha Fry, Mark F. Cotton, Sandra W. Jacobson, Sandra W. Jacobson, Joseph L. Jacobson, Joseph L. Jacobson, Christopher D. Molteno, Francesca Little, Andre J. W. van der Kouwe, Andre J. W. van der Kouwe, Andre J. W. van der Kouwe, Barbara Laughton, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Martha J. Holmes, Martha J. Holmes

“…IntroductionSuccessful programmes for prevention of vertical HIV transmission have reduced the risk of infant HIV infection in South Africa from 8% in 2008 to below 1% in 2018/2019, resulting in an increasing population of children exposed to HIV perinatally but who are uninfected (HEU). However, the long-term effects of HIV and antiretroviral treatment (ART) exposure on the developing brain are not well understood. …”
Get full text

A Digital Platform to Support HIV Case Management for Youth and Young Adults: Mixed Methods Feasibility Study by Connie Fee, Julia Fuller, Carly E Guss, Elizabeth R Woods, Ellen R Cooper, Urmi Bhaumik, Dionne Graham, Sandra K Burchett, Olivia Dumont, Emily B Martey, Maria Narvaez, Jessica E Haberer, Dallas Swendeman, Shelagh A Mulvaney, Vikram S Kumar, Jonathan L Jackson, Y Xian Ho

“… BackgroundAdvances in medical treatments in recent years have contributed to an overall decline in HIV-related opportunistic infections and deaths in youth; however, mortality and morbidity rates in perinatally and nonperinatally infected adolescents and young adults (AYA) living with HIV remain relatively high today. …”
Get full text

Real-Life Feasibility of HIV Drug Resistance Testing Using Dried Filter Analytes in Kenyan Children and Adolescents Living with HIV by Akarsh Manne, Alexander DeLong, Winstone Nyandiko, Allison K. DeLong, Rachel Vreeman, Vladimir Novitsky, Anthony Ngeresa, Edwin Sang, Ashley Chory, Josephine Aluoch, Eslyne Jepkemboi, Millicent Orido, Celestine Ashimosi, Festus Sang, Joseph W. Hogan, Rami Kantor

“…Youth infected with HIV perinatally were enrolled in 2016–2018 at the Academic Model Providing Access to Healthcare in Eldoret, western Kenya. …”
Get full text

Distinct fecal microbial signatures are linked to sex and chronic immune activation in pediatric HIV infection by Cecilia Rosel-Pech, Cecilia Rosel-Pech, Sandra Pinto-Cardoso, Monserrat Chávez-Torres, Nadia Montufar, Iván Osuna-Padilla, Santiago Ávila-Ríos, Gustavo Reyes-Terán, Charmina Aguirre-Alvarado, Norma Angelica Matías Juan, Héctor Pérez-Lorenzana, José Guillermo Vázquez-Rosales, Vilma Carolina Bekker-Méndez

“…IntroductionOur understanding of HIV-associated gut microbial dysbiosis in children perinatally-infected with HIV (CLWH) lags behind that of adults living with HIV. …”
Get full text

Change in HIV‐related characteristics of children hospitalised with infectious diseases in Western Cape, South Africa, 2008–2021: a time trend analysis by Shani T. deBeer, Amy L. Slogrove, Brian Eley, Suzanne M. Ingle, Hayley E. Jones, Florence Phelanyane, Kim Anderson, Emma Kalk, Andrew Boulle, Mary‐Ann Davies

“…Conclusions In recent years, among children hospitalised with infectious diseases, there were fewer children with perinatally acquired HIV, while an increased proportion of those without HIV acquisition are exposed to maternal HIV and ART. …”
Get full text

Persistence of Unintegrated HIV DNA Associates With Ongoing NK Cell Activation and CD34+DNAM-1brightCXCR4+ Precursor Turnover in Vertically Infected Patients Despite Successful Ant... by Lucia Taramasso, Federica Bozzano, Anna Casabianca, Chiara Orlandi, Francesca Bovis, Sara Mora, Mauro Giacomini, Lorenzo Moretta, Mauro Magnani, Antonio Di Biagio, Antonio Di Biagio, Andrea De Maria, Andrea De Maria

“…To evaluate its actual relevance in a cohort of perinatally-infected adult HIV patients (PHIV), we studied how peripheral blood mononuclear cell uDNA levels correlated with total HIV DNA (tDNA) and with overall replication or innate immune control parameters including NK cell activation/exhaustion and lymphoid turnover. …”
Get full text

Effect of calcium and vitamin D supplementation on bone mineral accrual among HIV-infected Thai adolescents with low bone mineral density by Thanyawee Puthanakit, Orasri Wittawatmongkol, Voraporn Poomlek, Tavitiya Sudjaritruk, Chantaphat Brukesawan, Torsak Bunupuradah, Sirintip Sricharoenchai, Thongsuai Chuanjaroen, Wasana Prasitsuebsai, Kulkanya Chokephaibulkit

“…This study assessed the changes in bone mineral density (BMD) during periods without and with calcium and vitamin D supplementation among HIV-infected adolescents with low BMD.Method: Perinatally HIV-infected Thai adolescents aged 12–20 years were enrolled into Phase 1 (pre-supplementation) to evaluate longitudinal change of BMD. …”
Get full text

Attrition and treatment outcomes among adolescents and youths living with HIV in the Thai National AIDS Program by Sirinya Teeraananchai, Thanyawee Puthanakit, Stephen J. Kerr, Suchada Chaivooth, Sasisopin Kiertiburanakul, Kulkanya Chokephaibulkit, Sorakij Bhakeecheep, Achara Teeraratkul, Matthew Law, Kiat Ruxrungtham

“…We assessed attrition and treatment outcomes among youths with behaviourly acquired HIV (BIY) and adolescents with perinatally acquired HIV (PIY) who initiated antiretroviral treatment (ART) through the National AIDS Program (NAP) in Thailand. …”
Get full text

Children of a syndemic: co‐occurring and mutually reinforcing adverse child health exposures in a prospective cohort of HIV‐affected mother‐infant dyads in Cape Town, South Africa... by Stanzi M. leRoux, Elaine J. Abrams, Allison Zerbe, Tamsin K. Phillips, Landon Myer

“…We compared those who were perinatally HIV exposed (CHEU) to those who were not (CHU), under conditions of universal maternal antiretroviral therapy (ART) and breastfeeding. …”
Get full text