Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials by Danielle Johnson, Dyfrig Hughes, Munir Pirmohamed, Andrea Jorgensen

Get full text

Endometrial SUSD2⁺ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse by David M. Z. B. Hennes, Anna Rosamilia, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee

“…Cellular therapy is an emerging field in clinical and personalised medicine. Many adult mesenchymal stem/progenitor cells (MSC) or pluripotent derivatives are being assessed simultaneously in preclinical trials for their potential treatment applications in chronic and degenerative human diseases. …”
Get full text

Understanding glioblastoma invasion using physically-guided neural networks with internal variables. by Jacobo Ayensa-Jiménez, Mohamed H Doweidar, Jose A Sanz-Herrera, Manuel Doblare

“…Besides, the possibility of working, for a particular tumor, with different boundary and initial conditions, permits the use of PGNNIV for defining virtual therapies and for drug design, thus making the first steps towards in silico personalised medicine.…”
Get full text

Correction: Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility by Ning Yuan Lee, Melissa Hum, Aseervatham Anusha Amali, Wei Kiat Lim, Matthew Wong, Matthew Khine Myint, Ru Jin Tay, Pei-Yi Ong, Jens Samol, Chia Wei Lim, Peter Ang, Min-Han Tan, Soo-Chin Lee, Ann S. G. Lee

Get full text

A systematic review and meta-analysis of the SIRT1 response to exercise by Ciara Gallardo Juan, Kyle B. Matchett, Gareth W. Davison

Get full text

Is air pollution affecting the disease activity in patients with systemic lupus erythematosus? State of the art and a systematic literature review by Gregory Winston Gilcrease, Dario Padovan, Enrico Heffler, Cristiana Peano, Stefano Massaglia, Dario Roccatello, Massimo Radin, Maria Josè Cuadrado, Savino Sciascia

Get full text

Unravelling the genetics of inherited retinal dystrophies: Past, present and future. by Broadgate, S, Yu, J, Downes, S, Halford, S

“…The continued development of sequencing technologies also holds great promise for the advent of truly personalised medicine.…”

Ethical issues in consent for the re-use of data in health data platforms by McKeown, AJ, Mourby, M, Harrison, P, Walker, S, Sheehan, M, Singh, I

“…In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised medicine approaches can be derived from their integration. …”

Sample selection bias in machine learning for healthcare by Chauhan, VK, Clifton, L, Salaün, A, Lu, HY, Branson, K, Schwab, P, Nigam, G, Clifton, DA

“…While machine learning algorithms hold promise for personalised medicine, their clinical adoption remains limited. …”

Three-dimensional, in-vitro approaches for modelling soft-tissue joint diseases by Johnson, PA, Ackerman, JE, Kurowska-Stolarska, M, Coles, M, Buckley, CD, Dakin, S

“…Use of these models could inform precision therapeutic targeting and advance the field towards personalised medicine for patients with common musculoskeletal diseases.…”

CM-Path Molecular Diagnostics Forum-consensus statement on the development and implementation of molecular diagnostic tests in the United Kingdom by Macklin, PS, Pillay, N, Lee, JL, Pitman, H, Scott, S, Wang, J, Craig, C, Jones, JL, Oien, KA, Colling, R, Coupland, SE, Verrill, C, CM-Path Molecular Diagnostics Working Group

“…By utilising these techniques and others, 'molecular diagnostics' acts as the cornerstone of precision/personalised medicine by attempting to match the underlying disease mechanisms to the most appropriate targeted therapy.…”

Oligogenic inheritance in severe adult obesity by Almansoori, S, Alsters, AI, Yiorkas, AM, Hashim, NAN, Walters, R, Chahal, HS, Purkayastha, S, Lessan, N, Blakemore, AIF

“…We also undertook re-analysis of WES data from 91 unrelated adults with severe obesity (86% white European ancestry) from the Personalised Medicine for Morbid Obesity (PMMO) cohort, recruited from the UK National Health Service. …”

Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios by Maria Luisa Matey-Hernandez, Danish Pan Genome Consortium, Søren Brunak, Jose M. G. Izarzugaza

“…Conclusions Although current computational methods for HLA typing generally provide satisfactory results, our benchmark – using data with ultra-high sequencing depth – demonstrates the incompleteness of current reference databases, and highlights the importance of providing genomic databases addressing current sequencing standards, a problem yet to be resolved before benefiting fully from personalised medicine approaches HLA phenotyping is essential.…”
Get full text

Automatic Detection of Colorectal Polyps Using Transfer Learning by Eva-H. Dulf, Marius Bledea, Teodora Mocan, Lucian Mocan

“…The results could have a direct impact on personalised medicine combining clinical knowledge with the computing power of intelligent algorithms.…”
Get full text

The effect of preprocessing filters on predictive performance in radiomics by Aydin Demircioğlu

“…Abstract Background Radiomics is a noninvasive method using machine learning to support personalised medicine. Preprocessing filters such as wavelet and Laplacian-of-Gaussian filters are commonly used being thought to increase predictive performance. …”
Get full text

Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded Affinisol^TM Filaments for 3D Printing by Gloria Mora-Castaño, Mónica Millán-Jiménez, Vicente Linares, Isidoro Caraballo

“…Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most frequently employed techniques for 3D printing. …”
Get full text

The effect of protein mutations on drug binding suggests ensuing personalised drug selection by Shunzhou Wan, Deepak Kumar, Valentin Ilyin, Ussama Al Homsi, Gulab Sher, Alexander Knuth, Peter V. Coveney

“…Abstract The advent of personalised medicine promises a deeper understanding of mechanisms and therefore therapies. …”
Get full text

Patient and Clinician Preferences for Genetic and Genomic Testing in Non-Small Cell Lung Cancer: A Discrete Choice Experiment by Simon Fifer, Robyn Ordman, Lisa Briggs, Andrea Cowley

“…Precision (personalised) medicine for non-small cell lung cancer (NSCLC) adopts a molecularly guided approach. …”
Get full text

Endometrial gland-specific progestagenassociated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss by Jennifer E Pearson-Farr, Gabrielle Wheway, Maaike S A Jongen, Patricia Goggin, Rohan M Lewis, Ying Cheong, Jane K Cleal

“…The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.…”
Get full text

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy by Lewis M. Dowling, Paul Roach, Eirik A. Magnussen, Achim Kohler, Srinivas Pillai, Daniel G. van Pittius, Ibraheem Yousef, Josep Sulé-Suso

“…The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. …”
Get full text