New nanoprobe for breast cancer cell imaging based on low-density lipoprotein by Mehdi Mirzaei, Mojdeh Mohseni, Neda Iranpour Anaraki, Elham Mohammadi, Sepideh Safari, Bita Mehravi, Alireza Ghasempour, Omid Pourdakan

“…This study lays the basis for exploring a personalised medicine strategy by directing a patient’s own LDL to cancer cell imaging in the early stages.…”
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Virtual reality for the observation of oncology models (VROOM): immersive analytics for oncology patient cohorts by Chng Wei Lau, Zhonglin Qu, Daniel Draper, Rosa Quan, Ali Braytee, Andrew Bluff, Dongmo Zhang, Andrew Johnston, Paul J. Kennedy, Simeon Simoff, Quang Vinh Nguyen, Daniel Catchpoole

“…Our approach allows the clinician to interrogate the information that is familiar and meaningful to them while providing them immersive analytics capabilities to make new discoveries toward personalised medicine.…”
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The Role of Genetic Polymorphism and Other Factors on Clopidogrel Resistance (CR) in an Asian Population with Coronary Heart Disease (CHD) by Mohammed Ahmed Akkaif, Nur Aizati Athirah Daud, Abubakar Sha’aban, Mei Li Ng, Muhamad Ali Sk Abdul Kader, Dzul Azri Mohamed Noor, Baharudin Ibrahim

“…In conclusion, understanding the prevalence of drug metabolism-related genetic polymorphism, especially <i>CYP2C19</i> alleles, will enhance clinical understanding of racial differences in drug reactions, contributing to the development of personalised medicine in Asia.…”
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To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes by Jan Domaradzki, Justyna Czekajewska, Dariusz Walkowiak

“…Abstract Background Over the last few decades biobanks have been recognised as institutions that may revolutionise biomedical research and the development of personalised medicine. Poland, however, still lacks clear regulations regarding the running of biobanks and the conducting of biomedical research. …”
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Case Report: The effect of intravenous and oral antibiotics on the gut microbiome and breath volatile organic compounds over one year [version 3; peer review: 2 approved] by Farah Shahi, James P.J. Chong, Kelly Redeker, Gavin Barlow, Sarah Forrester

“…Background: Antimicrobial resistance (AMR) is a global concern and better understanding of the gut microbiome, a known ‘amplifier’ of AMR, may allow future clinicians to tailor therapy to minimise this risk and offer a personalised medicine approach. To examine the gut microbiome, patients are required to provide faecal samples; more convenient and cheaper solutions need to be found. …”
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Assumption-based argumentation with preferences and goals for patient-centric reasoning with interacting clinical guidelines by Kristijonas Čyras, Tiago Oliveira, Amin Karamlou, Francesca Toni

“… A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines in multimorbidity settings. …”
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Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data. by Taosheng Xu, Thuc Duy Le, Lin Liu, Rujing Wang, Bingyu Sun, Jiuyong Li

“…BACKGROUND:Identifying cancer subtypes is an important component of the personalised medicine framework. An increasing number of computational methods have been developed to identify cancer subtypes. …”
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Author Correction: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis by Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh, Sheren Al-Obaidi, Ian Luk, Mercedes Dávalos-Salas, Fiona Chionh, Carmel Murone, Daniel D. Buchanan, Zac Chatterton, Oliver M. Sieber, Diego Arango, Niall C. Tebbutt, David Williams, Amardeep S. Dhillon, John M. Mariadason

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NetControl4BioMed: a pipeline for biomedical data acquisition and analysis of network controllability by Krishna Kanhaiya, Vladimir Rogojin, Keivan Kazemi, Eugen Czeizler, Ion Petre

“…Conclusion The pipeline can be used by researchers for controlling and better understanding of molecular interaction networks through combinatorial multi-drug therapies, for more efficient therapeutic approaches and personalised medicine.…”
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Genetic Biomarkers as Predictors of Response to Tocilizumab in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis by Sivakami Janahiraman, Chun Lai Too, Kai Wei Lee, Nor Shuhaila Shahril, Chee Onn Leong

“…Inconsistent finding remains as a great challenge to forge ahead towards personalised medicine for RA management.…”
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The Role of Metabolism in Migraine Pathophysiology and Susceptibility by Olivia Grech, Susan P. Mollan, Benjamin R. Wakerley, Daniel Fulton, Gareth G. Lavery, Alexandra J. Sinclair

“…Energetic imbalance in migraine may be relevant in driving the tissue towards maximum metabolic capacity, leaving the brain lacking in free energy. Personalised medicine considering an individual’s deficiencies may provide an approach to ameliorate migraine.…”
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Targeted Therapies for Perihilar Cholangiocarcinoma by Simon Gray, Angela Lamarca, Julien Edeline, Heinz-Josef Klümpen, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle

“…This review aims to provide a focus on the current molecular characterisation of pCCA, targeted therapies applicable to pCCA, and future directions in applying personalised medicine to this difficult-to-treat malignancy.…”
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Predictive and Diagnostic Biomarkers of Anastomotic Leakage: A Precision Medicine Approach for Colorectal Cancer Patients by Mark Gray, Jamie R. K. Marland, Alan F. Murray, David J. Argyle, Mark A. Potter

“…Although no AL biomarker has yet been validated in large-scale clinical trials, there is confidence that personalised medicine, through biomarker analysis, could be realised for colorectal cancer intestinal resection and anastomosis patients in the years to come.…”
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Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight against Cancer by Ahmad K. Al-Khazaleh, Kayla Jaye, Dennis Chang, Gerald W. Münch, Deep Jyoti Bhuyan

“…The diversity in gut microbiota may lead to variations in cannabinoid metabolism and treatment responses, emphasising the need for personalised medicine approaches. The growing interest in understanding how the gut microbiome and cannabis may impact cancer has created a demand for up-to-date, comprehensive reviews to inform researchers and healthcare practitioners. …”
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A Focused Clinical Review of Lynch Syndrome by Georgiou D, Monje-Garcia L, Miles T, Monahan K, Ryan NAJ

“…Demetra Georgiou,1 Laura Monje-Garcia,2,3 Tracie Miles,4 Kevin Monahan,2,5 Neil AJ Ryan6,7 1Genomics and Personalised Medicine Service, Charing Cross Hospital, London, UK; 2The St Mark’s Centre for Familial Intestinal Cancer Polyposis, St Mark’s Hospital, London, UK; 3School of Public Health, Imperial College, London, UK; 4South West Genomics Medicine Service Alliance, Bristol, UK; 5Department of Gastroenterology, Imperial College, London, UK; 6Department of Gynaecological Oncology, Royal Infirmary of Edinburgh, Edinburgh, UK; 7The College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UKCorrespondence: Neil AJ Ryan, Department of Gynaecology Oncology, Royal Infirmary of Edinburgh, Edinburgh, UK, Email neilryan@nhs.netAbstract: Lynch syndrome (LS) is an autosomal dominant condition that increases an individual’s risk of a constellation of cancers. …”
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Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects by Karl Payne, Jill Brooks, Rachel Spruce, Nikolaos Batis, Graham Taylor, Paul Nankivell, Hisham Mehanna

“…HNC single-CTC characterisation, including single-cell sequencing, to identify actionable mutations and gene-expression signatures has the potential to both guide the understanding of patient tumour heterogeneity and support the adoption of personalised medicine strategies. Microfluidic approaches for isolating CTCs and cell clusters are emerging as novel technologies which can be incorporated with computational platforms to complement current diagnostic and prognostic strategies. …”
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ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon by Sylvia Hartmann, Summaira Yasmeen, Benjamin M. Jacobs, Spiros Denaxas, Munir Pirmohamed, Eric R. Gamazon, Mark J. Caulfield, Genes & Health Research Team, Harry Hemingway, Maik Pietzner, Claudia Langenberg

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SARS-CoV-2 variants of concern surveillance including Omicron using RT-PCR–based genotyping offers comparable performance to whole genome sequencing by Simone Vanoni, Arnoldas Matulevicius, Besard Avdiu, Giada Scantamburlo, Camilla Ulekleiv, Pius M. Brzoska, Manohar R. Furtado, Jelena D. M. Feenstra, Alain Rico, Manoj Gandhi, Elisabetta Giacobazzi, Elisa Masi, Markus Paulmichl, Charity Nofziger

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The Use of Medicinal Plant-Derived Metallic Nanoparticles in Theranostics by Jabulile Happiness Xulu, Tanaka Ndongwe, Kenneth M. Ezealisiji, Vuyelwa J. Tembu, Nontobeko P. Mncwangi, Bwalya A. Witika, Xavier Siwe-Noundou

“…The application of theranostics is rising exponentially due to the urgent need for treatments that can be utilized for diagnostic imaging as an aid in precision and personalised medicine. Subsequently, the emergence of nanobiotechnology and the green synthesis of metallic nanoparticles (MNPs) has provided one such avenue for nanoscale development and research. …”
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PathExNET: A tool for extracting pathway expression networks from gene expression statistics by George Minadakis, Alfonso Muñoz-Pomer Fuentes, George Tsouloupas, Irene Papatheodorou, George M. Spyrou

“…The unique numeric characterization of pathway expression status related to a specific biological experiment (or disease), as well as the creation of diverse combination of pathway networks generated by PathExNET, is expected to provide a concrete contribution towards the individualization of disease, and further lead to a more precise personalised medicine and management of treatment.PathExNET is available at: https://bioinformatics.cing.ac.cy/PathExNET and at https://pathexnet.cing-big.hpcf.cyi.ac.cy/…”
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