RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy by Virginie Mariot, Romain Joubert, Laura Le Gall, Eva Sidlauskaite, Christophe Hourde, William Duddy, Thomas Voit, Maximilien Bencze, Julie Dumonceaux

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Precision Medicine on the Effects of Microbiota on Head–Neck Diseases and Biomarkers Diagnosis by Angelo Michele Inchingolo, Giuseppina Malcangi, Fabio Piras, Giulia Palmieri, Vito Settanni, Lilla Riccaldo, Roberta Morolla, Silvio Buongiorno, Elisabetta de Ruvo, Alessio Danilo Inchingolo, Antonio Mancini, Francesco Inchingolo, Gianna Dipalma, Stefania Benagiano, Gianluca Martino Tartaglia, Assunta Patano

“…Precision medicine using highly precise technologies and big data has produced personalised medicine with rapid and reliable diagnoses and targeted therapies. …”
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Intra-operative gallbladder scoring predicts conversion of laparoscopic to open cholecystectomy: a WSES prospective collaborative study by Michael Sugrue, Federico Coccolini, Magda Bucholc, Alison Johnston, Contributors from WSES

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Adjuvant Trastuzumab in HER2-Positive Early Breast Cancer by Age and Hormone Receptor Status: A Cost-Utility Analysis. by William Leung, Giorgi Kvizhinadze, Nisha Nair, Tony Blakely

“…Resource allocation and licensing of subsidised therapies such as trastuzumab should consider demographic and clinical heterogeneity; there is currently a profound disconnect between how funding decisions are made (largely agnostic to heterogeneity) and the principles of personalised medicine.…”
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Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology by Joaquim Aguirre-Plans, Janet Piñero, Jörg Menche, Ferran Sanz, Laura I. Furlong, Harald H. H. W. Schmidt, Baldo Oliva, Emre Guney

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Healthy bi-regional connection: The EU-LAC Health initiative has promoted equitable and collaborative health research and innovation by Teresa Corral, Mónica de Román, Antonio J. Gómez-Núñez, Bruno Mourenza, Cristiane Quental, Stephanie Splett-Rudolf, Rafael de Andrés

“…The project has also paved the way for more specific bi-regional initiatives such as a new initiative for bi-regional collaboration in personalised medicine that is being arranged by the partnership. …”
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Reading, Conducting, and Developing Systematic Review and Individual Patient Data Meta-Analyses in Psychiatry for Treatment Issues by Nadia Younes, Nadia Younes, Nadia Younes, Laurie-Anne Claude, Laurie-Anne Claude, Xavier Paoletti, Xavier Paoletti, Xavier Paoletti

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Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention by Lenka Koklesova, Alena Liskova, Marek Samec, Kevin Zhai, Raghad Khalid AL-Ishaq, Ondrej Bugos, Miroslava Šudomová, Kamil Biringer, Martin Pec, Marian Adamkov, Sherif T. S. Hassan, Luciano Saso, Frank A. Giordano, Dietrich Büsselberg, Peter Kubatka, Olga Golubnitschaja

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Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer by Sweta Sharma Saha, Lucy Gentles, Alice Bradbury, Dominik Brecht, Rebecca Robinson, Rachel O’Donnell, Nicola J. Curtin, Yvette Drew

“…In this era of personalised medicine, molecular/functional characterisation of DDR pathways could guide chemotherapy choices in the clinic allowing specific targeting of ovarian cancers.…”
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Personalised therapeutic approaches to glioblastoma: A systematic review by Oliver D. Mowforth, Oliver D. Mowforth, Jamie Brannigan, Marc El Khoury, Celine Iswarya Partha Sarathi, Harry Bestwick, Faheem Bhatti, Richard Mair, Richard Mair

“…IntroductionGlioblastoma is the most common and malignant primary brain tumour with median survival of 14.6 months. Personalised medicine aims to improve survival by targeting individualised patient characteristics. …”
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Treatment optimisation for hepatitis C in the era of combination direct-acting antiviral therapy: a systematic review and meta-analysis [version 1; peer review: 2 approved] by Christopher R. Jones, Barnaby F. Flower, Ella Barber, Bryony Simmons, Graham S. Cooke

“…Background: Prior to direct-acting antiviral (DAA) therapy, personalised medicine played an important role in the treatment of hepatitis C virus (HCV). …”
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The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS) by Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott

“…Conclusion Profiling of the gut microbiome has the potential to add an environmental component to rapidly advancing studies of ALS genetics and move research a step further towards personalised medicine for this disease. Moreover, should compelling evidence of upstream neurotoxicity or neuroprotection initiated by gut microbiota emerge, modification of the microbiome will represent a potential new avenue for disease modifying therapies. …”
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The importance of polymorphisms of regulatory and catalytic antioxidant proteins in chronic kidney disease by Jerotić Đurđa, Matić Marija, McClements Lana

“…New developments in the field of antioxidant polymorphisms in CKD patients could lead to better stratification of CKD patients, based on a prognostic antioxidant gene panel, and provide a more personalised medicine approach for the need of antioxidant therapy in these patients.…”
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Comparing image normalization techniques in an end-to-end model for automated modic changes classification from MRI images by Andrea Cina, Daniel Haschtmann, Dimitrios Damopoulos, Nicolas Gerber, Markus Loibl, Tamas Fekete, Frank Kleinstück, Fabio Galbusera

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“Girls Aren’t Meant to Exercise”: Perceived Influences on Physical Activity among Adolescent Girls—The HERizon Project by Emma S. Cowley, Paula M. Watson, Lawrence Foweather, Sarahjane Belton, Andrew Thompson, Dick Thijssen, Anton J. M. Wagenmakers

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The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury by Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick

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Plasma Galectin-3 and urine proteomics predict FEV1 improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study by Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Marta Bartezaghi, Fabiana Saccheri, Giorgio Walter Canonica

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Novel Ex Vivo Models of Epithelial Ovarian Cancer: The Future of Biomarker and Therapeutic Research by James Clark, Christina Fotopoulou, Christina Fotopoulou, Paula Cunnea, Jonathan Krell

“…The advent of next generation sequencing has led to notable advances in the field of personalised medicine for many cancer types. Success in achieving cure in advanced EOC has however been limited, although significant prolongation of survival has been demonstrated. …”
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Genetic polymorphism of organic cation transporter 2 (OCT2) and its effects on the pharmacokinetics and pharmacodynamics of Metformin: a narrative review by Swathi Swaroopa Borra, Niva Rose Jane, Dhivyaprasath Palaniappan, Rupakrishnan Subramanian, Mithila Amar Patankar, Sadagoban Gopal Krishnamoorthy, Arun Kanniyappan Parthasarathy

“…Patient-centered treatment would improve the Metformin efficacy leading to new research in personalised medicine.…”
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Improvement of patient-reported outcomes in severe allergic asthma by omalizumab treatment: the real life observational PROXIMA study by Giorgio Walter Canonica, Paola Rottoli, Caterina Bucca, Maria Cristina Zappa, Giovanni Michetti, Bruno Macciocchi, Cristiano Caruso, Pierachille Santus, Marta Bartezaghi, Laura Rigoni, on behalf of PROXIMA study centers

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