Computational platform for doctor–artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study by Vitaly O. Kheyfets, Andrew J. Sweatt, Mardi Gomberg-Maitland, Dunbar D. Ivy, Robin Condliffe, David G. Kiely, Allan Lawrie, Bradley A. Maron, Roham T. Zamanian, Kurt R. Stenmark

“…The computational platform presented in this study offers a critical step towards personalised medicine in which a clinician can interpret an algorithm's assessment of an individual patient.…”
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Improving breast cancer screening in Australia: a public health perspective by Carolyn Nickson, Louiza S Velentzis, Patrick Brennan, G Bruce Mann, Nehmat Houssami

“…The proposed framework assesses screening effectiveness in the era of personalised medicine, allows review of multiple factors that may together warrant change, and gives full, evidence-based consideration of the benefits, harms and costs of various approaches to breast cancer screening. …”
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Profiling the vendors of COVID‐19 related product on the Darknet: An observational study by Valeria Catalani, Honor D. Townshend, Mariya Prilutskaya, Andres Roman-Urrestarazu, Robin van Kessel, Robert P. Chilcott, Hani Banayoti, Tim McSweeney, Ornella Corazza

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Design and Development of Neomycin Sulfate Gel Loaded with Solid Lipid Nanoparticles for Buccal Mucosal Wound Healing by Khaled M. Hosny, N. Raghavendra Naveen, Mallesh Kurakula, Amal M. Sindi, Fahad Y. Sabei, Adel Al Fatease, Abdulmajeed M. Jali, Waleed S. Alharbi, Rayan Y. Mushtaq, Majed Felemban, Hossam H. Tayeb, Eman Alfayez, Waleed Y. Rizg

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The pharmacogenomic landscape of an Indigenous Australian population by Sumudu Rangika Samarasinghe, Wendy Hoy, Sudhir Jadhao, Brendan J. McMorran, Henk-Jan Guchelaar, Shivashankar H. Nagaraj, Shivashankar H. Nagaraj

“…Background: Population genomic studies of individuals of Indigenous ancestry have been extremely limited comprising <0.5% of participants in international genetic databases and genome-wide association studies, contributing to a “genomic gap” that limits their access to personalised medicine. While Indigenous Australians face a high burden of chronic disease and associated medication exposure, corresponding genomic and drug safety datasets are sorely lacking.Methods: To address this, we conducted a pharmacogenomic study of almost 500 individuals from a founder Indigenous Tiwi population. …”
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Evaluating diagnostic strategies for early detection of cancer: the CanTest framework by Fiona M. Walter, Matthew J. Thompson, Ian Wellwood, Gary A. Abel, William Hamilton, Margaret Johnson, Georgios Lyratzopoulos, Michael P. Messenger, Richard D. Neal, Greg Rubin, Hardeep Singh, Anne Spencer, Stephen Sutton, Peter Vedsted, Jon D. Emery

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Comparison of two human organoid models of lung and intestinal inflammation reveals Toll‐like receptor signalling activation and monocyte recruitment by Shyam Sushama Jose, Marco De Zuani, Federico Tidu, Marcela Hortová Kohoutková, Lucia Pazzagli, Giancarlo Forte, Roberta Spaccapelo, Teresa Zelante, Jan Frič

“…However, translational research and personalised medicine struggle to advance because of the lack of suitable preclinical models that successfully mimic the complexity of human tissues without relying on in vivo mouse models. …”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis by Michael Papanicolaou, Amelia L. Parker, Michelle Yam, Elysse C. Filipe, Sunny Z. Wu, Jessica L. Chitty, Kaitlin Wyllie, Emmi Tran, Ellie Mok, Audrey Nadalini, Joanna N. Skhinas, Morghan C. Lucas, David Herrmann, Max Nobis, Brooke A. Pereira, Andrew M. K. Law, Lesley Castillo, Kendelle J. Murphy, Anaiis Zaratzian, Jordan F. Hastings, David R. Croucher, Elgene Lim, Brian G. Oliver, Fatima Valdes Mora, Benjamin L. Parker, David Gallego-Ortega, Alexander Swarbrick, Sandra O’Toole, Paul Timpson, Thomas R. Cox

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Gender differences in asthma perception and its impact on quality of life: a post hoc analysis of the PROXIMA (Patient Reported Outcomes and Xolair® In the Management of Asthma) st... by Delia Colombo, Emanuela Zagni, Fabio Ferri, Giorgio Walter Canonica, the PROXIMA study centers

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Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells in vitro by Lei Yu, Zhichao Li, Hongbin Mei, Wujiao Li, Dong Chen, Lisa Liu, Zhongfu Zhang, Yangyang Sun, Fei Song, Wei Chen, Weiren Huang

“…Abstract Objectives Recent advances in patient‐derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an in vitro technological platform to evaluate chimeric antigen receptor (CAR)‐T cell‐mediated cytotoxicity against bladder cancer. …”
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OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics by Priska Schoenborn, Richard Osborne, Nick Toms, Karen Johnstone, Chlöe Milsom, Reema Muneer, Michael A. Jarvis, Robert Belshaw

“…Abstract Background Personalised medicine is rapidly changing the clinical environment, especially in regard to the management of cancer. …”
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Cutting edge rare earth radiometals: prospects for cancer theranostics by Alexander W. E. Sadler, Leena Hogan, Benjamin Fraser, Louis M. Rendina

“…Abstract Background With recent advances in novel approaches to cancer therapy and imaging, the application of theranostic techniques in personalised medicine has emerged as a very promising avenue of research inquiry in recent years. …”
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A Detailed Flow Cytometric Analysis of Immune Activity Profiles in Molecular Subtypes of Colorectal Cancer by Xingru Li, Agnes Ling, Therese G. Kellgren, Marie Lundholm, Anna Löfgren-Burström, Carl Zingmark, Martin Rutegård, Ingrid Ljuslinder, Richard Palmqvist, Sofia Edin

“…In the era of immunotherapy, a better understanding of the immune response in molecular subgroups of CRC may lead to significant advances in personalised medicine. On this note, microsatellite instable (MSI) tumours have been characterised by increased immune infiltration, suggesting MSI as a marker for immune inhibitor checkpoint therapy. …”
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A Deoxyribonucleic Acid Decoy Trapping DUX4 for the Treatment of Facioscapulohumeral Muscular Dystrophy by Virginie Mariot, Romain Joubert, Anne-Charlotte Marsollier, Christophe Hourdé, Thomas Voit, Julie Dumonceaux

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Label-free quantitative lymphocyte activation profiling using microfluidic impedance cytometry by Petchakup, Chayakorn, Hutchinson, Paul Edward, Tay, Hui Min, Leong, Sheng Yuan, Li, Holden King Ho, Hou, Han Wei

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The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility by Huang, Jiayi, Cui, Liang, Natarajan, Meenubharathi, Barone, Paul W., Wolfrum, Jacqueline M., Lee, Yie Hou, Rice, Scott A., Springs, Stacy L.

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Three-dimensional recapitulation of neuroblastoma: from model to drug screening platform by Bovornchutichai, P

“…These can be applied towards personalised medicine, where a patient’s biopsy specimen can be tested in the system against a series of drugs to identify ones giving rise to optimal therapeutic outcomes.…”

The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes by Taylor, GS, Smith, K, Scragg, J, McDonald, TJ, Shaw, JA, West, DJ, Roberts, LD

“…Conclusions/interpretation: The serum metabolome distinguishes high and low maximal aerobic capacity and has diagnostic potential for facilitating personalised medicine approaches to manage aerobic exercise and fitness in type 1 diabetes. …”

Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent by Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting, Bart Cornelissen

“…A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selection in a move towards more personalised medicine. The aim of this study was to synthesise and investigate the first 18F-labelled ATM inhibitor [18F]1 for non-invasive imaging of ATM protein and ATMi pharmacokinetics. …”
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Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier by Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Sabela Fernández-Rodicio, Marcos Bazarra-Barreiros, Alberto Ouro, Tomás Sobrino, Francisco Campos, José Castillo, Pablo Hervella, Ramón Iglesias-Rey

“…This could have a direct impact on clinical translation and personalised medicine.…”
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