Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)... by Thomas Lehnert, Christian Röver, Sascha Köpke, Jordi Rio, Declan Chard, Andrea V. Fittipaldo, Tim Friede, Christoph Heesen, Anne C. Rahn

“…Based on the heterogeneity of the disease and the partial effectiveness of therapies, a personalised medicine approach would be valuable taking individual prognosis and suitability of a chosen therapy into account to gain the best possible treatment effect. …”
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Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury by Farah Tasnim, Farah Tasnim, Xiaozhong Huang, Xiaozhong Huang, Xiaozhong Huang, Christopher Zhe Wei Lee, Christopher Zhe Wei Lee, Christopher Zhe Wei Lee, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu, Hanry Yu

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Mapping the use of computational modelling and simulation in clinics: A survey by Raphaëlle Lesage, Michiel Van Oudheusden, Silvia Schievano, Silvia Schievano, Ine Van Hoyweghen, Liesbet Geris, Liesbet Geris, Liesbet Geris, Liesbet Geris, Claudio Capelli, Claudio Capelli

“…The CM&S terms “Personalised medicine” and “Patient-specific modelling” were the most well-known within the respondents. …”
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CD169+ Monocyte and Regulatory T Cell Subsets Are Associated with Disease Activity in Rheumatoid Arthritis by Amanda J. Eakin, Tahanver Ahmed, Cathy M. McGeough, Stephen Drain, H. Denis Alexander, Gary D. Wright, Philip V. Gardiner, Dawn Small, Anthony J. Bjourson, David S. Gibson

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PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories by Kenneth D. Doig, Andrew Fellowes, Anthony H. Bell, Andrei Seleznev, David Ma, Jason Ellul, Jason Li, Maria A. Doyle, Ella R. Thompson, Amit Kumar, Luis Lara, Ravikiran Vedururu, Gareth Reid, Thomas Conway, Anthony T. Papenfuss, Stephen B. Fox

“…PathOS is focused on providing clinical variant curators and pathology laboratories with a decision support system needed for personalised medicine. While the genesis of PathOS has been within cancer molecular diagnostics, the system is applicable to NGS clinical reporting generally. …”
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Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study by Fei Yee Lee, Farida Islahudin, Aina Yazrin Ali Nasiruddin, Abdul Halim Abdul Gafor, Hin-Seng Wong, Sunita Bavanandan, Shamin Mohd Saffian, Adyani Md Redzuan, Nurul Ain Mohd Tahir, Mohd Makmor-Bakry

“…Personalised medicine is potentially useful to delay the progression of chronic kidney disease (CKD). …”
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SERIES: eHealth in primary care. Part 2: Exploring the ethical implications of its application in primary care practice by Sarah N. Boers, Karin R. Jongsma, Federica Lucivero, Jiska Aardoom, Frederike L. Büchner, Martine de Vries, Persijn Honkoop, Elisa J. F. Houwink, Marise J. Kasteleyn, Eline Meijer, Hilary Pinnock, Martina Teichert, Paul van der Boog, Sanne van Luenen, Rianne M. J. J. van der Kleij, Niels H. Chavannes

“…Background eHealth promises to increase self-management and personalised medicine and improve cost-effectiveness in primary care. …”
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Combination of Chemotherapy and Mild Hyperthermia Using Targeted Nanoparticles: A Potential Treatment Modality for Breast Cancer by Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker

“…The results not only demonstrate targeted pSiNPs as a successful nanocarrier for combination therapy but also confirm it as a versatile platform with the potential to be used for personalised medicine.…”
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“A very big challenge”: a qualitative study to explore the early barriers and enablers to implementing a national genomic medicine service in England by Bettina Friedrich, Cecilia Vindrola-Padros, Anneke M. Lucassen, Anneke M. Lucassen, Chris Patch, Angus Clarke, Monica Lakhanpaul, Celine Lewis, Celine Lewis

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The RNA editing patterns are different in blood of euthymic and depressed bipolar patients by M. Hayashi, N. Salvetat, C. Cayzac, F. J. Checa-Robles, C. Lozano, J.-D. Abraham, B. Dubuc, S. Mereuze, J. V. Nani, F. Molina, E. Brietske, D. Weissmann

“…Conclusions In conclusion of this study, we confirm that RNA editing is a key mechanism in the physiopathology of mental disorders in general, and in BD in particular, and that measuring changes in this mechanism at the peripheral level allowed us to stratify BD patients not only with respect to their symptomatology, but also with respect to the pathophysiology, thus paving the way for personalised medicine in psychiatry. Disclosure of Interest None Declared…”
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Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition by Holly R. Keir, Christopher J. Fong, Megan L. Crichton, Philip Barth, Eric Chevalier, Gill Brady, Gwen Kennedy, Johann Zimmermann, Piet L.B. Bruijnzeel, Alison J. Dicker, James D. Chalmers

“…Methods We tested whether a single baseline sputum NE measurement or a combination of clinical parameters could enrich patient populations with elevated NE activity for “personalised medicine”. Intra- and interindividual variations of total and active NE levels in induced sputum from patients with CF or bronchiectasis were monitored over 14 days. …”
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Integrated Analysis of Key Differentially Expressed Genes Identifies DBN1 as a Predictive Marker of Response to Endocrine Therapy in Luminal Breast Cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Brendah K. Masisi, Ruth Parks, Omar J Mohammed, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…Therefore, as part of the growing concept of personalised medicine, the need for identification of predictive markers of endocrine therapy response at an early stage, is recognised. …”
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Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal cord progenitor cells by Nguyen, Tan Dai, Chooi, Wai Hon, Jeon, Hyungkook, Chen, Jiahui, Tan, Jerome, Roxby, Daniel N., Lee, Cheryl Yi-Pin, Ng, Shi-Yan, Chew, Sing Yian, Han, Jongyoon

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Endocrine effects of adipose tissue on cardiovascular redox state: the antioxidant benefits from targeting insulin signalling by Polkinghorne, M

“…Rather than simply seeking to add “years to life” by treating conditions in isolation, medical science is moving towards a paradigm of adding “life to years” by taking a systems-wide approach to human health that will soon allow for truly preventative, and personalised, medicine. In the context of cardiometabolic disease, disruption of the homeostatic mechanisms governing the cardiovascular redox state is seen as an initiating element in the development of atherosclerosis and heart failure. …”

Technical considerations on the use of Granger causality in neuromonitoring by Michał M. Placek, Erta Beqiri, Marek Czosnyka, Peter Smielewski

“…Neuromonitoring-derived indices play an important role in implementing personalised medicine for traumatic brain injury patients. …”
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Ionizing Radiation Protein Biomarkers in Normal Tissue and Their Correlation to Radiosensitivity: A Systematic Review by Prabal Subedi, Maria Gomolka, Simone Moertl, Anne Dietz

“…Although predicting radiosensitivity is the way forward in the field of personalised medicine, there is limited information on the potential biomarkers. …”
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Metabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects by Marek Samec, Alena Liskova, Lenka Koklesova, Kevin Zhai, Elizabeth Varghese, Samson Mathews Samuel, Miroslava Šudomová, Vincent Lucansky, Monika Kassayova, Martin Pec, Kamil Biringer, Aranka Brockmueller, Karol Kajo, Sherif T. S. Hassan, Mehdi Shakibaei, Olga Golubnitschaja, Dietrich Büsselberg, Peter Kubatka

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The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review by Ian A. Cree, Lesley Uttley, Helen Buckley Woods, Hugh Kikuchi, Anne Reiman, Susan Harnan, Becky L. Whiteman, Sian Taylor Philips, Michael Messenger, Angela Cox, Dawn Teare, Orla Sheils, Jacqui Shaw, For the UK Early Cancer Detection Consortium

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A web-based clinical decision tool to support treatment decision-making in psychiatry: a pilot focus group study with clinicians, patients and carers by Catherine Henshall, Lisa Marzano, Katharine Smith, Mary-Jane Attenburrow, Stephen Puntis, Jakov Zlodre, Kathleen Kelly, Matthew R Broome, Susan Shaw, Alvaro Barrera, Andrew Molodynski, Alastair Reid, John R Geddes, Andrea Cipriani

“…CDST was considered a useful clinical decision support, with recognised value in promoting clinician-patient collaboration and contributing to the development of personalised medicine. One major benefit of the CDST was perceived to be the open discussion about the possible side-effects of medications. …”
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Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis by May Soe Thu, May Soe Thu, May Soe Thu, Korn Chotirosniramit, Tanawin Nopsopon, Tanawin Nopsopon, Tanawin Nopsopon, Nattiya Hirankarn, Krit Pongpirul, Krit Pongpirul, Krit Pongpirul, Krit Pongpirul, Krit Pongpirul

“…The microbiota abundance pattern was identified in different sample types, detection methods, menopausal status, nationality, obesity, sleep quality, and several interventions using qualitative analysis.ConclusionsThis systematic review elucidates the complex network of the microbiome, breast cancer, and therapeutic options, with the objective of providing a link for stronger research studies and towards personalised medicine to improve their quality of life.…”
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