Psychotherapies and digital interventions for OCD in adults: What do we know, what do we need still to explore? by David Castle, Jamie Feusner, Judith M. Laposa, Peggy M.A. Richter, Rahat Hossain, Ana Lusicic, Lynne M. Drummond

“…Biomarkers, including genetic and neuroimaging, are starting to point to a future with more ‘personalised medicine informed’ treatment strategizing for OCD. …”
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Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care by Malvika Gulati, Malvika Gulati, Gretchen Brewer, Andrew Judge, Andrew Judge, Andrew Judge, Donna Kennedy, Tonia L. Vincent, Tonia L. Vincent, Fiona E. Watt, Fiona E. Watt, Fiona E. Watt

“…Further investigation is indicated of sex-specific subtypes and potential for personalised medicine for post-menopausal women with hand osteoarthritis, as a clearly definable high-risk subgroup.…”
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A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity by Barbara Oliveira‐Mendes, Sylvain Feliciangeli, Mélissa Ménard, Frank Chatelain, Malak Alameh, Jérôme Montnach, Sébastien Nicolas, Béatrice Ollivier, Julien Barc, Isabelle Baró, Jean‐Jacques Schott, Vincent Probst, Florence Kyndt, Isabelle Denjoy, Florian Lesage, Gildas Loussouarn, Michel De Waard

“…This information is meant to fill a patient database, as a basis for personalised medicine. The next steps will be to further accelerate the process using an automated patch‐clamp system.…”
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Patient preferences in genetic newborn screening for rare diseases: study protocol by Antonio Novelli, Alessandra Ferlini, Ferdinand Knieling, Brett Hauber, Jorien Veldwijk, Mats Hansson, Janbernd Kirschner, Åsa Grauman, Sylvia MARTIN, Emanuele Angolini, Jennifer Audi, Dr. Enrico Bertini, Lucia Pia Bruno, Joshua Coulter, Fernanda Fortunato, Vera Frankova, Nicolas Garnier, Edith Gross, Gergana Kyosovksa, Silvia Ottombrino, Roman Raming, Stefaan Sansen, Christina Saier

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Clinical Translation of Three-Dimensional Scar, Diffusion Tensor Imaging, Four-Dimensional Flow, and Quantitative Perfusion in Cardiac MRI: A Comprehensive Review by Sophie Paddock, Sophie Paddock, Vasiliki Tsampasian, Hosamadin Assadi, Bruno Calife Mota, Andrew J. Swift, Amrit Chowdhary, Peter Swoboda, Eylem Levelt, Eva Sammut, Amardeep Dastidar, Jordi Broncano Cabrero, Javier Royuela Del Val, Paul Malcolm, Julia Sun, Alisdair Ryding, Chris Sawh, Richard Greenwood, David Hewson, Vassilios Vassiliou, Pankaj Garg, Pankaj Garg

“…Several emerging CMR methods have the potential to offer a personalised medicine approach to treatment. CMR tissue characterisation is used to assess myocardial oedema, inflammation or thrombus in various disease conditions. …”
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Primary Head and Neck Tumour-Derived Fibroblasts Promote Lymphangiogenesis in a Lymphatic Organotypic Co-culture Model by Karina M. Lugo-Cintrón, José M. Ayuso, Mouhita Humayun, Max M. Gong, Sheena C. Kerr, Suzanne M. Ponik, Paul M. Harari, María Virumbrales-Muñoz, David J. Beebe

“…IGF-1, upregulated among patients, was targeted to validate our personalised medicine approach. Interestingly, IGF-1 blockade was not effective across different patients. …”
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Prediction of Successful Pharmacological Cardioversion in Acute Symptomatic Atrial Fibrillation: The Successful Intravenous Cardioversion for Atrial Fibrillation (SIC-AF) Score by Jan Daniel Niederdöckl, Alexander Simon, Nina Buchtele, Nikola Schütz, Filippo Cacioppo, Julia Oppenauer, Sophie Gupta, Martin Lutnik, Sebastian Schnaubelt, Alexander Spiel, Dominik Roth, Fritz Wimbauer, Isabel Fegers-Wustrow, Katrin Esefeld, Martin Halle, Jürgen Scharhag, Thomas Laschitz, Harald Herkner, Hans Domanovits, Michael Schwameis

“…Background: Modern personalised medicine requires patient-tailored decisions. …”
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Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics? by Andrew F. Cumpstey, Magdalena Minnion, Bernadette O. Fernandez, Monika Mikus-Lelinska, Kay Mitchell, Daniel S. Martin, Michael P.W. Grocott, Martin Feelisch

“…This novel redox metabolomic approach of obtaining quantifiable ‘metabolic signatures’ to a defined physiological challenge could potentially offer new avenues for personalised medicine. Keywords: Thiols, Altitude, Hypoxia, Oxygen, Oxidative stress, Hydrogen sulfide…”
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Novel MYO1D Missense Variant Identified Through Whole Exome Sequencing and Computational Biology Analysis Expands the Spectrum of Causal Genes of Laterality Defects by Rabab Said Alsafwani, Khalidah K. Nasser, Khalidah K. Nasser, Thoraia Shinawi, Babajan Banaganapalli, Babajan Banaganapalli, Hanan Abdelhalim ElSokary, Zhaher F. Zaher, Zhaher F. Zaher, Noor Ahmad Shaik, Noor Ahmad Shaik, Noor Ahmad Shaik, Gaser Abdelmohsen, Gaser Abdelmohsen, Jumana Yousuf Al-Aama, Jumana Yousuf Al-Aama, Adam J. Shapiro, Osman O. Al-Radi, Ramu Elango, Ramu Elango, Turki Alahmadi, Turki Alahmadi

“…In conclusion, our findings show the expanded genetic spectrum of LD, which could potentially pave way for the novel drug target identification and development of personalised medicine for high-risk families.…”
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Quality Outcomes in Appendicitis Care: Identifying Opportunities to Improve Care by Syed Mohammad Umar Kabir, Magda Bucholc, Carol-Ann Walker, Opeyemi O. Sogaolu, Saqib Zeeshan, Michael Sugrue

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Soluble Non-Starch Polysaccharides From Plantain (Musa x paradisiaca L.) Diminish Epithelial Impact of Clostridioides difficile by Hannah L. Simpson, Carol L. Roberts, Louise M. Thompson, Cameron R. Leiper, Nehana Gittens, Ellie Trotter, Carrie A. Duckworth, Stamatia Papoutsopoulou, Stamatia Papoutsopoulou, Fabio Miyajima, Fabio Miyajima, Paul Roberts, Paul Roberts, Niamh O’Kennedy, Jonathan M. Rhodes, Barry J. Campbell

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Climate Clever Clovers: New Paradigm to Reduce the Environmental Footprint of Ruminants by Breeding Low Methanogenic Forages Utilizing Haplotype Variation by Parwinder Kaur, Parwinder Kaur, Parwinder Kaur, Parwinder Kaur, Rudi Appels, Philipp E. Bayer, Gabriel Keeble-Gagnere, Jiankang Wang, Hideki Hirakawa, Kenta Shirasawa, Philip Vercoe, Philip Vercoe, Katia Stefanova, Katia Stefanova, Zoey Durmic, Zoey Durmic, Phillip Nichols, Phillip Nichols, Clinton Revell, Clinton Revell, Sachiko N. Isobe, David Edwards, David Edwards, William Erskine, William Erskine, William Erskine

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RESEARCH IN BASIC MEDICAL SCIENCES: CHALLENGES AND OPPORTUNITIES by Zilli Huma, Jawad Ahmad

“…The 21st Century has seen the continuing development of sciences amalgamated and rearranged according to the techniques used from in-vitro cell cultures, to in-vivo animal studies and even virtual modeling of proteins and enzymes.2 Research over the past 50 years with the discovery of the Double helix of the DNA and the human genome project has led to the newer and emerging fields like molecular biology and genetics leading to a better understanding of causative mechanisms of illnesses.3 This breakthrough research at the cellular, sub-cellular and molecular levels has expanded the frontiers of research further than the mere scope of human senses with the advent of more powerful hyper-resolution microscopes and precision techniques.4 How else would there be the fields of personalised medicine or theranostics working through cancer genomics, pharmacogenomics or systems biology; tailored to the individual, based on their predicted response or risk of disease.5 Scientists have defined basic science research as aimed towards pursuing fundamental questions of natural systems and organisms. …”
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Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression by Ana Teresa Pinto, Ana Beatriz Machado, Hugo Osório, Marta Laranjeiro Pinto, Rui Vitorino, Gonçalo Justino, Cátia Santa, Flávia Castro, Tânia Cruz, Carla Rodrigues, Jorge Lima, José Luís R. Sousa, Ana Patrícia Cardoso, Rita Figueira, Armanda Monteiro, Margarida Marques, Bruno Manadas, Jarne Pauwels, Kris Gevaert, Marc Mareel, Sónia Rocha, Tiago Duarte, Maria José Oliveira

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The possible role of machine learning in detection of increased cardiovascular risk patients – KSC MR Study (design) by Daniel Pella, Stefan Toth, Jan Paralic, Jozef Gonsorcik, Jan Fedacko, Peter Jarcuska, Dominik Pella, Zuzana Pella, Frantisek Sabol, Monika Jankajova, Gabriel Valocik, Alina Putrya, Andrea Kirschová, Lukas Plachy, Miroslava Rabajdova, Mikulas Hunavy, Bibiana Kafkova, Ivan Doci, Silvia Timkova, Mariana Dvorožňáková, Frantisek Babic, Peter Butka, Lucia Dimunova, Maria Marekova, Zuzana Paralicova, Jaroslav Majernik, Jan Luczy, Jakub Janosik, Martin Kmec

“…Conclusions The KSC MR study results, if positive, could establisha base for development of proper software for revealing high-risk patients, as well as patients with suggested positive coronary angiography findings, based on the principles of personalised medicine.…”
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Outcome of Second Primary Malignancies Developing in Multiple Myeloma Patients by Irit Avivi, David H. Vesole, Julio Davila-Valls, Lidia Usnarska-Zubkiewicz, Magdalena Olszewska-Szopa, Vibor Milunovic, Bartłomiej Baumert, Bogumiła Osękowska, Anna Kopińska, Massimo Gentile, Borja Puertas-Martinez, Paweł Robak, Edvan Crusoe, Luis Gerardo Rodriguez-Lobato, Małgorzata Gajewska, Gergely Varga, Michel Delforge, Yael Cohen, Alessandro Gozzetti, Camila Pena, Chaim Shustik, Gabor Mikala, Klara Zalac, H. Denis Alexander, Peter Barth, Katja Weisel, Joaquín Martínez-López, Anna Waszczuk-Gajda, Mateusz Krzystański, Artur Jurczyszyn

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Monitoring multidimensional aspects of quality of life after cancer immunotherapy: protocol for the international multicentre, observational QUALITOP cohort study by Geertruida H De Bock, Delphine Maucort-Boulch, Clémence Leyrat, Amélie Anota, Stephane Dalle, Susana Puig, Marie Préau, Mohammad S Jalali, Marie-Jose Kersten, Martijn GH van Oijen, Mathieu Fauvernier, Petra C. Vinke, Marc Combalia, Anne Mea Spanjaart, Maria Gomes da Silva, Aurore Fouda Essongue, Aurélie Rabier, Myriam Pannard, Amal Elgammal, Mike Papazoglou, Mohand-Said Hacid, Catherine Rioufol, Erick Suazo-Zepeda, Ananya Malhotra, Emmanuel Coquery, Elsa Coz

“…These will (1) help increase knowledge about the impact of immunotherapy, (2) facilitate improved interactions between patients, clinicians and the general population and (3) contribute to personalised medicine.Trial registration number NCT05626764.…”
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The Singapore national precision medicine strategy by Wong, Eleanor, Bertin, Nicolas, Hebrard, Maxime, Tirado-Magallanes, Roberto, Bellis, Claire, Lim, Weng Khong, Chua, Chee Yong, Tong, Philomena Mei Lin, Chua, Raymond, Mak, Kenneth, Lim, Tit Meng, Cheong, Wei Yang, Thien, Kwee Eng, Goh, Khean Teik, Chai, Jin-Fang, Lee, Jimmy, Sung, Joseph Jao Yiu, Wong, Tien Yin, Chin, Calvin Woon Loong, Gluckman, Peter D., Goh, Liuh Ling, Ban, Kenneth Hon Kim, Tan, Tin Wee, Sim, Xueling, Cheng, Ching-Yu, Davila, Sonia, Karnani, Neerja, Leong, Khai Pang, Liu, Jianjun, Prabhakar, Shyam, Maurer-Stroh, Sebastian, Verma, Chandra Shekhar, Krishnaswamy, Pavitra, Goh, Rick Siow Mong, Chia, Irenaeus, Ho, Clarissa, Low, Doreen, Virabhak, Suchin, Yong, Jacklyn, Zheng, Weiling, Seow, Shih Wee, Seck, Yee Kwang, Koh, Mingshi, Chambers, John Campbell, Tai, E Shyong, Tan, Patrick

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Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe by Giulia Veronesi, David R. Baldwin, Claudia I. Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J. De Koning, Joseph Shemesh, John K. Field, Javier J. Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio Valentino Infante, Pierluigi Novellis, Rachael L. Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Witold Rzyman, Giorgio Vittorio Scagliotti, Martin C. Tammemagi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P. Van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, Giuseppe Pelosi

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A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip by Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam, Norzahirah Binti Ahmad, Daisuke Ino, Haruma Nashimoto, Yoshifumi Matsumoto, Masato Moriyama, Arata Horii, Chie Kondo, Ryosuke Ochiai, Hiroyuki Kusuhara, Yasuo Saijo, Yasuaki Einaga, Hiroshi Hibino

“…This approach with the ‘reusable’ sensor may improve point-of-monitoring systems and personalised medicine while reducing medical costs.…”
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