Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report by Emanuela Oldoni, Gary Saunders, Florence Bietrix, Maria Laura Garcia Bermejo, Anna Niehues, Anna Niehues, Peter A. C. ’t Hoen, Jessica Nordlund, Marian Hajduch, Andreas Scherer, Katja Kivinen, Katja Kivinen, Katja Kivinen, Esa Pitkänen, Esa Pitkänen, Esa Pitkänen, Tomi Pekka Mäkela, Tomi Pekka Mäkela, Ivo Gut, Serena Scollen, Łukasz Kozera, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Leming Shi, Anton Ussi, Antonio L. Andreu, Alain J. van Gool

Subjects: “…personalised medicine…”
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Sex as a Biological Variable in Early-Phase Oncology Clinical Trials: Enhancing the Path to Personalised Medicine by Lydia Sutherland, Louise Carter

“…Despite this, early-phase cancer clinical trials frequently neglect to consider sex as a variable, creating a barrier to the development of personalised medicine. This article argues that failure to identify and infer sex differences in early-phase clinical trials may result in suboptimal dosing, underestimation of toxicity, and the failure to identify potential sex-specific responses to new systemic anticancer therapies. …”
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Novel genetic assessments for cancer patients: where does medical imaging stand in the future of personalised medicine? by Sally L. Ayesa

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Implementation of personalised medicine policies in mental healthcare: results from a stated preference study in the UK by Alan J. McMichael, Joseph P. M. Kane, Jonathan J. Rolison, Francis A. O'Neill, Marco Boeri, Frank Kee

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Integrating China in the International Consortium for Personalised Medicine: a position paper on innovation and digitalization in Personalized Medicine by Flavia Beccia, Marzia Di Marcantonio, Francesco Andrea Causio, Lena Schleicher, Lili Wang, Chiara Cadeddu, Walter Ricciardi, Stefania Boccia

“…Based on the results collected by the project, the objective of this study is to discern the key priorities for the implementation of Personalised Medicine concerning Information and Communication Technologies (ICT) and Big Data and digital solutions, with a particular emphasis on data management and protection. …”
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Financing and reimbursement models for personalised medicine: A systematic review to identify current models and future options by Koleva-Kolarova, R, Buchanan, J, Vellekoop, H, Huygens, S, Versteegh, M, Mölken, MR-V, Szilberhorn, L, Zelei, T, Nagy, B, Wordsworth, S, Tsiachristas, A, HEcoPerMed Consortium

“…Background The number of healthcare interventions described as ‘personalised medicine’ (PM) is increasing rapidly. As healthcare systems struggle to decide whether to fund PM innovations, it is unclear what models for financing and reimbursement are appropriate to apply in this context. …”

Editorial: The Treatment of Metastatic Non-Small Cell Lung Cancer (NSCLC) in a New Era of Personalised Medicine by Vera eHirsh

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Dysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicine by Laura Carrasco-Hernández, Esther Quintana-Gallego, Carmen Calero, Rocío Reinoso-Arija, Borja Ruiz-Duque, José Luis López-Campos

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Patient perspectives on the use of digital medical devices and health data for AI-driven personalised medicine in Parkinson’s Disease by Ivana Paccoud, Ivana Paccoud, Mayca Marín Valero, Laura Carrasco Marín, Noémi Bontridder, Alzhraa Ibrahim, Alzhraa Ibrahim, Jüergen Winkler, Jüergen Winkler, Messaline Fomo, Messaline Fomo, Stefano Sapienza, Stefano Sapienza, Fouad Khoury, Jean-Christophe Corvol, Holger Fröhlich, Holger Fröhlich, Jochen Klucken, Jochen Klucken, Jochen Klucken

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Editorial: Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by Barbara Melosky

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A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine by Anne T. Collins, Shona H. Lang

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Prospects of using C3435T polymorphism in the <i>ABCB1</i> gene encoding P-glycoprotein in personalised medicine by R. E. Kazakov, V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, E. Yu. Demchenkova, E. V. Shikh

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The current understanding of precision medicine and personalised medicine in selected research disciplines: study protocol of a systematic concept analysis by Emma Matthews, Adam Henschke, Christine Phillips, Matthew Cook, Anne Parkinson, Ellen Brown, Karen Brown, Christopher J Nolan, Christian Lueck, Hanna Suominen, Jane Desborough, Nicola Brew-Sam, Lachlan Pedley, Harry Ebbeck, Kristine Wright, Anne Bruestle, Katrina Chisholm, Simone Collins, Eleni Daskalaki, Janet Drew, Mark Elisha, Vanessa Fanning, Jessica Herron, Krishnan Murugappan, Dragomir Neshev, Antonio Tricoli

“…Introduction The terms ‘precision medicine’ and ‘personalised medicine’ have become key terms in health-related research and in science-related public communication. …”
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Human Microbiota and Breast Cancer—Is There Any Relevant Link?—A Literature Review and New Horizons Toward Personalised Medicine by Diogo Alpuim Costa, Diogo Alpuim Costa, José Guilherme Nobre, Marta Vaz Batista, Catarina Ribeiro, Catarina Calle, Catarina Calle, Alfonso Cortes, Maximilian Marhold, Ida Negreiros, Paula Borralho, Paula Borralho, Paula Borralho, Paula Borralho, Miguel Brito, Javier Cortes, Javier Cortes, Javier Cortes, Sofia Azambuja Braga, Sofia Azambuja Braga, Sofia Azambuja Braga, Luís Costa, Luís Costa, Luís Costa, Luís Costa

“…In this review, we discuss the origin, composition, and dynamic evolution of human microbiota, the links between gut/breast microbiota and BC, and explore the potential implications of metabolomics and pharmacomicrobiomics that might impact BC development and treatment choices toward a more personalised medicine. Finally, we put in perspective the potential limitations and biases regarding the current microbiota research and provide new horizons for stronger accurate translational and clinical studies that are needed to better elucidate the complex network of interactions between host, microorganisms, and drugs in the field of BC.…”
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Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets by Sergio A. Sánchez-Guirales, Noelia Jurado, Aytug Kara, Aikaterini Lalatsa, Dolores R. Serrano

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Integrating pharmacogenomics- metabolomics towards realising personalised medicine for colorectal cancer patients treated with 5-fluorouracil / Hazwanie Hashim by Hashim, Hazwanie

“…We explore the value of pharmacogenomics and metabolomics in personalising medicine in patients treated with 5-FU. We intended to profile both the genetics and metabolomics markers that could be useful in the clinical monitoring of patients’ responses towards 5-FU and its disease. …”
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Successful long‐term treatment of pyoderma gangrenosum with secukinumab by Fabienne Froehlich, Miriam Dreßler, Ramon Staeger, Lars E. French, Barbara Meier‐Schiesser

Subjects: “…personalised medicine…”
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Personalized medicine in biomarker identification at their optimal cut-off selection by Tadeusz Lewandowski

Subjects: “…personalised medicine…”
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Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study by Kamlesh Khunti, Samantha Wilkinson, Liam Smeeth, Laurie A Tomlinson, Amanda I Adler, Ian J Douglas, Andrew Briggs, Richard Grieve, Stephen O’neill, Richard J Silverwood, Paul Charlton, Patrick Bidulka, Anirban Basu

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Human mesothelioma cell lines developed from malignant pleural effusions as tools to develop novel therapies and guide personalised medicine by Kanellakis, N, Asciak, R, Yao, X, Peng, Y, Mercer, R, Sherrill, T, Maldonado, F, Ebner, D, Seymour, L, Rintoul, R, Blackwell, T, Stathopoulos, G, Dong, T, Rahman, N, Psallidas, I