Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis by Amandine Jarysta, Abigail LD Tadenev, Matthew Day, Barry Krawchuk, Benjamin E Low, Michael V Wiles, Basile Tarchini

“…The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all GNAI proteins and included non-physiological approaches. Pertussis toxin can downregulate functionally redundant GNAI1, GNAI2, GNAI3, and GNAO proteins, but may also induce unrelated defects. …”
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Niacin induces PPARγ expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways by Knowles, H, Poole, R, Workman, P, Harris, A

“…This was sensitive to pertussis toxin and to inhibition of phoshopipase A₂ and cyclo-oxygenase activity. …”

Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice by Santosh Rijal, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M. Ábrahám, Seong Kyu Han

“…However, the response was completely abolished by pretreatment with pertussis toxin. These results suggest that melatonin can regulate GnRH neuronal activities in prepubertal mice by partially suppressing the excitatory signaling mediated by kainate receptors through pertussis toxin-sensitive G-protein-coupled receptors.…”
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Extra Virgin Olive Oil Phenols Vasodilate Rat Mesenteric Resistance Artery via Phospholipase C (PLC)-Calcium Microdomains-Potassium Channels (BK_Ca) Signals by Rossana D’Agostino, Laura Barberio, Mariacarmela Gatto, Teresa Tropea, Maria De Luca, Maurizio Mandalà

“…A pressure myograph was used to test the effect of EVOO phenols on isolated mesenteric arteries in the presence of specific inhibitors of: (1) BKca channels (Paxillin, 10⁻⁵ M); (2) L-type calcium channels (Verapamil, 10⁻⁵ M); (3) Ryanodine receptor, RyR (Ryanodine, 10⁻⁵ M); (4) inositol 1,4,5-triphosphate receptor, IP3R, (2-Aminoethyl diphenylborinate, 2-APB, 3 × 10⁻³ M); (5) phospholipase C, PLC, (U73122, 10⁻⁵ M), and (6) GPCR-G_αi signaling, (Pertussis Toxin, 10⁻⁵ M). EVOO phenols induced vasodilation of mesenteric arteries in a dose-dependent manner, and this effect was reduced by pre-incubation with Paxillin, Verapamil, Ryanodine, 2-APB, U73122, and Pertussis Toxin. …”
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Randomized clinical trial of the safety and immunogenicity of the Tdap vaccine in pregnant Mexican women by Jesús Zacarías Villarreal Pérez, José Manuel Ramírez Aranda, Manuel de la O Cavazos, Michelle de J. Zamudio Osuna, José Perales Dávila, María Romelia Ballesteros Elizondo, Marco Vinicio Gómez Meza, Francisco Javier García Elizondo, Azucena M. Rodríguez González

“…In the experimental group, antibodies against Bordetella pertussis pertactin (anti-PRN) (112 E/mL 95% CI 89.9–139.9) and antibodies against pertussis toxin (anti-PT) (24.0 E/mL, 95% CI 18.3–31.4) were elevated in the mother before vaccination. …”
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The Possible Mechanisms by which Borapetol B Stimulates Insulin Release from Rat Islets by Ezarul Faradianna, Lokman, Gu, Harvest F., Wan Nazaimoon, Wan Mohamud, M. M., Yusoff, Keh, Leong Chia, Östenson, Claes-Göran

“…At 16.7 mM glucose, pertussis toxin decreased the insulin response to C1 in the W (P<0.01) and GK rat islets (P<0.05). …”
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Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype by Siu-Kei Chow, Arturo Casadevall

“…This review summarizes the mAb studies for 6 toxins—Shiga toxin, pertussis toxin, anthrax toxin, ricin toxin, botulinum toxin, and Staphylococcal enterotoxin B (SEB)—and analyzes the prevalence of mAb functions and their isotypes. …”
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Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over th... by Raymond S.W. Tsang, Michelle Shuel, Frances B. Jamieson, Steven Drews, Linda Hoang, Greg Horsman, Brigitte Lefebvre, Shalini Desai, Monique St-Laurent

“…Pertactin-negative isolates were characterized by serotyping, pulsed-field gel electrophoresis (PFGE), and genotyping of their pertactin, fimbriae 3, pertussis toxin subunit 1, and pertussis toxin gene promoter region, as well as the complete sequence of the pertactin gene. …”
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AGS3 and Gα_i3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells by Jackson L. K. Yip, Maggie M. K. Lee, Crystal C. Y. Leung, Man K. Tse, Annie S. T. Cheung, Yung H. Wong

“…Moreover, the binding of Gα_i3 to AGS3 was suppressed by GTPγS and pertussis toxin. Disruption of AGS3/Gα_i3 interaction by pertussis toxin indicates that AGS3 may recognize the same site on the Gα subunit as G protein-coupled receptors. …”
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Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion. by Moonga, B, Pazianas, M, Alam, A, Shankar, V, Huang, C, Zaidi, M

“…Cholera toxin, a Gs stimulator and a selective Q effect agonist, similarly abolished bone resorption and enhanced TRAP secretion. In contrast, pertussis toxin, a Gi inhibitor and a selective R effect agonist, inhibited bone resorption significantly, but slightly reduced enzyme release. …”

Development and migration of plasma cells in the mouse lymph node. by Fooksman, DR, Schwickert, T, Victora, G, Dustin, M, Nussenzweig, M, Skokos, D

“…Although chemotaxis via Galphai coupled-receptors has been implicated in PC migration, treatment with Pertussis toxin (Ptx), which ablates these signals, did not prevent movement of pre-PCs while it arrested other lymphocytes. …”

Clinico-Epidemiological And Microbiological Evolution Of Pertussis by I. V. Babachenko

“…Strains of B. рertussis of serotypes 1.0.3., IVb EFPP-group (during electrophoresis in pulsating gel), pertussis toxin A, pertactin 2 are associated with less severe illness forms (by 2,5 times), as well as specific complications (breath-holding and pertussis encephalopathy).…”
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Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. by Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn

“…Both GI-20 and LL-37 increase neutrophil intracellular calcium levels and their ability to increase neutrophil activation responses was calcium dependent and partially inhibited by pertussis toxin. These studies show that the central helix of LL-37 retains the ability of LL-37 to modulate neutrophil responses through FPR-2. …”
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Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination by Aapo Knuutila, Carita Rautanen, Jussi Mertsola, Qiushui He

“…Most of the current serological diagnosis of pertussis is based on pertussis toxin (PT) IgG antibodies and does not differentiate between vaccination and infection-induced antibodies. …”
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Prevention of pertussis: An unresolved problem by Susanna Esposito, Nicola Principi

“…Of these others, five pertussis antigens were considered possible components of acellular vaccines (aPs): pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and fimbria proteins 2 and 3. …”
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Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. by Gromada, J, Høy, M, Olsen, H, Gotfredsen, C, Buschard, K, Rorsman, P, Bokvist, K

“…Channel activation was prevented by pre-treating the cells with pertussis toxin, indicating the involvement of G-proteins. …”

Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model by Kyu-Ri Kang, Ji-Ahn Kim, Gyu-Won Cho, Han-Ul Kang, Hyun-Mi Kang, Jin-Han Kang, Baik-Lin Seong, Soo-Young Lee

“…We evaluated and compared the immunogenicity and the protective efficacy of aP and raP vaccines in an experimental murine challenge model: humoral immunity in serum, IgA secretion in nasal lavage, bacterial clearance after challenge, PTx (pertussis toxin) CHO cell neutralization titer, cytokine secretion in spleen single cell, and tissue resident memory CD4+ T cell (CD4+ T_RM cell) in lung tissues. …”
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Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR autoantibodies by Noriko Makita, Junichiro Sato, Katsunori Manaka, Kimiko Akahane, Takahiro Ito, Hajime Yamazaki, Akira Mizoguchi, Yusuke Hikima, Hirofumi Horikoshi, Masaomi Nangaku, Taroh Iiri

“…This emphasizes the importance of the Gi/o (pertussis toxin–sensitive G proteins, whose βγ subunits activate multiple signals, including ERK1/2) in regulating parathyroid hormone secretion. …”
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FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA by V. A. Aleshkin, O. Yu. Borisova, N. T. Gadua, I. K. Mazurova

“…Dynamics of formation of population of strains of the causative agent of whooping cough is tracked and is established that population of strains of B.pertussis is formed by clonal expansion of strains with, new genetic structure of major factors of pathogenicity - pertussis toxin and. pertactin. The structure of population of strains of B.pertussis causing a disease by whooping cough, at the present stage of epidemic process of a pertussis infection - domination. of strains with new «non-vaccine» alleles genes - ptxA1 (97,7 %), ptxC2 (87,4 %), prn2 (89,5 %) and. ptxP3 (93,3 %), in 2,2 % cases with ptxB2 allele and. in 1,3 % cases with. prn9 allele circulate.…”
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Pertussis-induced cough. by Wang, K, Harnden, A

“…Single estimates of anti-pertussis toxin (PT) antibody titres in blood or oral fluid samples are highly specific. …”