New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates by Valérie Bouchez, Nicolas Hegerle, Francesco Strati, Elisabeth Njamkepo, Nicole Guiso

“…More sporadic filamentous hemagglutinin (FHA) or pertussis toxin (PT) deficient isolates were also collected. …”
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Acellular Pertussis Vaccine from Antigens of Freshly Isolated and Vaccine Strains of Bordetella pertussis with Different Genotypic Characteristics by E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina, N. U. Mertsalova, M. N. Ozeretskovskaya

“…Freshly isolated (No. 287, and No. 317) and vaccine (No. 305 and No. 475) B. pertussis strains with «non-vaccine» and «vaccine» allelic variants of the pertussis toxin (PT) subunit A gene, the PT promoter gene, the pertactin gene, the fimbria 2 gene, and the fimbria 3 gene strains were used for the production of AcPV.Results. …”
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High post-exposure prophylaxis (PEP) uptake among household contacts of pertussis patients enrolled in a PEP effectiveness evaluation - United States, 2015-2017. by Lucy A McNamara, Amy B Rubis, Lucia Pawloski, Elizabeth Briere, Lara Misegades, Aurora A Brusseau, Sandra Peña, Karen Edge, Rachel Wester, Kari Burzlaff, Victor Cruz, Lucia Tondella, Tami H Skoff, Pertussis Post-Exposure Prophylaxis Study Team

“…Of 156 contacts with serologic results, 14 (9%) had blood specimens that were positive for IgG anti-pertussis toxin (PT) antibodies; all had received PEP.…”
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In silico prediction of molecular mechanisms of toxicity mediated by the leptospiral PF07598 gene family-encoded virulence-modifying proteins by Reetika Chaurasia, Joseph M. Vinetz

“…VM proteins belongs to classical AB toxin paradigm though have a unique AB domain architecture, unlike other AB toxins such as diphtheria toxin, pertussis toxin, shiga toxin, or ricin toxin which are typically encoded by two or more genes and self-assembled into a multi-domain holotoxin. …”
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Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. by Pascale Labrecque, Sébastien J Roy, Louis Fréchette, Christian Iorio-Morin, Maxime A Gallant, Jean-Luc Parent

“…This reduction in cAMP levels was not altered by pertussis toxin treatment, indicating that MK-0524 did not induce coupling of DP1 to Gα(i/o) proteins and that this ligand is a DP1 inverse agonist. …”
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Oxytocin Downregulates the Ca_V1.2 L-Type Ca²⁺ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes by Masaki Morishima, Shintaro Tahara, Yan Wang, Katsushige Ono

“…OT downregulates the phosphorylated component of a transcription factor adenosine-3′,5′-cyclic monophosphate (cAMP) response element binding protein (CREB), whose action is blocked by OTR antagonist and pertussis toxin, a specific inhibitor of the inhibitory GTP-binding regulators of adenylate cyclase, Gi. …”
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Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte... by Mohammad Mehdi Ghorbani, Touraj Farazmandfar, Mehrab Nasirikenari, Saeid Abediankenari, Ali Meamarian, Majid Shahbazi

“…Mice were immunized subcutaneously with 50 μg, 100 μg, 150 μg and 200 μg myelin oligodendrocyte glycoprotein in complete Freund’s adjuvant containing 4 mg/Ml Mycobacterium tuberculosis and two injections of 800 ng of pertussis toxin intraperitoneally, on day 0 and 2 post immunization. …”
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The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis by Fatemeh Kamankesh, Ali Ganji, Ali Ghazavi, Ghasem Mosayebi

“…Background: Experimental autoimmune encephalomyelitis (EAE), as an autoimmune disease in the central nervous system (CNS), is an animal model for multiple sclerosis (MS) mediated by T lymphocytes.Objective: To investigate ginger extract’s effect on reducing inflammation and improving the symptoms in the EAE model.Methods: The EAE was induced by injecting MOG35-55 and pertussis toxin into eight-week-old female C57BL6 mice. …”
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Anti-IL-6 Receptor Antibody Inhibits Spontaneous Pain at the Pre-onset of Experimental Autoimmune Encephalomyelitis in Mice by Kenichi Serizawa, Haruna Tomizawa-Shinohara, Hideyuki Yasuno, Kenji Yogo, Yoshihiro Matsumoto

“…EAE was induced in female C57BL/6J mice by subcutaneous immunization with myelin oligodendrocyte glycoprotein 35–55 emulsified in adjuvant and administration of pertussis toxin. Mice were placed individually in cubicles and filmed for about 10 min. …”
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Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties by Giulia Puja, Gabriele Losi, Lucio Rovati, Marco Lanza, Gianfranco Caselli, Rita Bardoni

“…CR4056 antagonism is reversible, not competitive and voltage-independent and it is not blocked by pertussis toxin. CR4056 interacts with the co-agonist glycine site in a competitive way, indeed high glycine concentrations diminish its effect. …”
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Comprehensive Grading System for Experimental Autoimmune Uveitis in Mice by Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal

“…EAU was induced following immunisation with interphotoreceptor retinoid-binding protein (IRBP) and pertussis toxin. Weekly fundus and optical coherence tomography (OCT) images were acquired over 12 weeks using a Micron IV imaging system. …”
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Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration by Chulo Park, Jin-Woo Lee, Kiheon Kim, Dong-Seung Seen, Jae-Yeon Jeong, Won-Ki Huh

“…Synergistic effects on calcium flux and cell migration are inhibited by the Gαi inhibitor pertussis toxin and the Gαq inhibitor YM254890, suggesting that the Gαi and Gαq pathways are involved in the synergy. …”
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Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2 by Rubio Ignacio, Böhmer Frank D, Grün Michael, Löffler Ivonne

“…Consistent with a major role for cAMP, cAMP raising agents and pertussis toxin revert the mitogenic response to PGE2. …”
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Seroprevalence Study of Pertussis in Adults at Childbearing Age and Young Infants Reveals the Necessity of Booster Immunizations in Adults in China by Zhiyun Chen, Jie Pang, Nan Zhang, Ning Chen, Yiwei Ding, Qiushui He

“…This study evaluates the prevalence of serum anti-pertussis toxin (PT) IgG antibodies in adults at childbearing age and infants before the age of primary immunization in Beijing, China. …”
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Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E₂from human articular chondrocytes by Nishioka Kusuki, Yudoh Kazuo, Nakamura Hiroshi, Murata Minako, Masuko Kayo, Kato Tomohiro

“…S1P stimulated extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in HAC, and the PGE₂induction was abrogated by PD98059 and SB203580. <it>Pertussis toxin </it>inhibited the PGE₂induction from HAC by S1P, suggesting an essential role for Gi protein. …”
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Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in rat. by Nolwenn Merlet, Nicolas Piriou, Bertrand Rozec, Amandine Grabherr, Benjamin Lauzier, Jean-Noël Trochu, Chantal Gauthier

“…Inhibition of Gi protein with pertussis toxin did not affect β2-AR response in Dox-CM hearts, suggesting a decoupling of β2-AR to Gi protein. …”
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Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site mediating intracellular Ca2+ mobilization and cell retra... by Alam, A, Bax, C, Shankar, V, Bax, B, Bevis, P, Huang, C, Moonga, B, Pazianas, M, Zaidi, M

“…A novel R effect site, possibly coupled via a pertussis toxin-sensitive G protein to a [Ca2+]i elevating mechanism is predicted from this study.…”

Development and characterisation of a novel vaccine for Bordetella pertussis (whooping cough) by Kristof, M

“…</p> <p>In this thesis, I explored the use of replication-deficient adenovirus (Ad) and modified vaccinia virus Ankara (MVA) vectors as platforms for development of novel pertussis vaccines. Pertussis toxin (PT), fimbriae adhesins (Fim2, Fim3 and FimD), iron-binding proteins (IRP1-3 and AfuA) and adenylate cyclase toxin (ACT) were selected as vaccine candidate antigens. …”

The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a rand... by Nash, S, Mentzer, AJ, Lule, SA, Kizito, D, Smits, G, van der Klis, FRM, Elliott, AM

“…Strongyloidiasis was associated with enhanced responses to pertussis toxin, HiB and Hep B vaccine antigens. Conclusions/Significance Our results do not support the hypothesis that routine anthelminthic treatment during pregnancy has a benefit for the infant’s vaccine response, or that maternal helminth infection has a net suppressive effect on the offspring’s response to vaccines..…”

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. by Digby, J, McNeill, E, Dyar, O, Lam, V, Greaves, D, Choudhury, R

“…The effect on gene expression was neutralised by pre-treatment with pertussis toxin. NA attenuated macrophage chemotaxis (by 27+/-3.5%, P&lt;0.001) towards adipocyte conditioned media. …”