A boarding school outbreak of pertussis in adolescents: value of laboratory diagnostic methods. by Horby, P, Macintyre, C, McIntyre, P, Gilbert, G, Staff, M, Hanlon, M, Heron, L, Cagney, M, Bennett, C

“…B. pertussis PCR was performed on throat swabs, and sera were tested for IgA antibodies against whole-cell (WC) B. pertussis antigen and IgG antibodies to pertussis toxin (PT). The Centers for Disease Control and Prevention definition for pertussis was used to define clinical cases. …”

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin by Digby, J, McNeill, E, Dyar, O, Lam, V, Greaves, DR, Choudhury, R

“…The effect on gene expression was neutralised by pre-treatment with pertussis toxin. NA attenuated macrophage chemotaxis (by 27 ± 3.5%, P < 0.001) towards adipocyte conditioned media. …”

Evaluation of the effective time for GSK-3 inhibition in experimental autoimmune encephalomyelitis mouse model by tideglusib (NP-12) in preventing neuroinflammation by Al-Zaidi, Ahmed Salam

“…Female C57BL/6 mice were induced with myelin oligodendrocyte glycoprotein (MOG35-55) in conjunction with complete freund's adjuvant (CFA) and pertussis toxin. Inhibition of GSK-3 is performed by the administration of NP-12, a small heterocyclic Thiadiazolidinones (TDZD), intraperitoneally during pre-EAE induction, on the same day, and post-EAE. …”
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Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals by María Esther Castillo, Carlos Bada, Olguita del Aguila, Verónica Petrozzi-Helasvuo, Verónica Casabona-Ore, Isabel Reyes, Juana del Valle-Mendoza

“…A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. Results: The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. …”
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Antibody Response to Pertussis Vaccination in Pregnant and Non-Pregnant Women—The Role of Sex Hormones by Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S Green

“…In a cross-sectional study, blood samples were drawn from 174 pregnant and 74 non-pregnant women 45–60 days following immunization. Anti-pertussis toxin (Anti-PT) IgG antibody levels, estrogen, and progestogen concentrations were compared between the two groups. …”
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Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine by Rodríguez-Muñoz María, de la Torre-Madrid Elena, Garzón Javier, Vicente-Sánchez Ana, Sánchez-Blázquez Pilar

“…We found that both neural mu-opioid receptors (MORs) and CB1Rs interact with the HINT1-RGSZ module, thereby regulating pertussis toxin-insensitive Gz proteins. In mice with reduced levels of these Gz proteins, the CB1R agonists produced no such desensitization or morphine cross-tolerance. …”
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Seroepidemiology of pertussis and diphtheria among healthy adults in Shaanxi Province, northwest China: A large - scale cross-sectional study by Chao Zhang, Weijun Hu, Ruize Wang, Yinan Wang, Yajun Li, Yake Lv, Weixuan Li, Yuan Si, Shaobai Zhang

“…Serum immunoglobulin G (IgG) antibodies against pertussis toxin (PT) and diphtheria toxin (DT) were determined using enzyme-linked immunosorbent assay. …”
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Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells by Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Tomohiro Sugihara, Takashi Shimizu, Mitsumasa Koyanagi, Akihisa Terakita, Masahiko Hibi

“…Light stimulation of cardiomyocytes expressing the Gi/o-coupled mosquito Opn3, pufferfish TMT opsin, or lamprey parapinopsin induced cardiac arrest, and the effect was suppressed by treatment with pertussis toxin or barium, suggesting that Gi/o-dependent regulation of inward-rectifier K+ channels controls cardiac function. …”
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Multiple rib and vertebral fractures associated with Bordetella pertussis infection: a case report by Jingqiao Wang, Junxiang Gao, Hongwei Fan, Haonan Guo, Zundong Yin, Mei Dong, Xiaoming Huang

“…Her blood sample was sent to the CDC, revealing Bordetella pertussis toxin (PT) IgG titer of 110.68 IU/mL. The patient was diagnosed with pertussis and multiple stress fractures from violent coughing. …”
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Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. by Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali

“…Treatment of cells with pertussis toxin almost completely blocked both early and delayed C3a-induced ERK1/2 phosphorylation in β-arrestin1/2 knockdown cells.This study demonstrates distinct roles for β-arrestins-1 and β-arrestins-2 on C3aR desensitization, internalization, degranulation, NF-κB activation and chemokine generation in human mast cells. …”
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Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP by Melih Özgür Celik, Viola Seitz, Fatih Yergöz, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein

“…The inhibitory role of the G-protein subunits Gi/o and Gβγ on VDCCs was investigated using the blockers pertussis toxin and gallein, respectively. GTPγS binding, calcium signals and MOR phosphorylation were also investigated. …”
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Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting by Leah E. Cole, Jinrong Zhang, Kristl M. Pacheco, Philippe Lhéritier, Natalie G. Anosova, Julie Piolat, Lingyi Zheng, Nathalie Reveneau

“…While aP and wP vaccine priming initially elicited similar levels of anti-pertussis toxin antibody, titers declined more rapidly in aP vaccine primed animals leading to a 4-fold difference. …”
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Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China by Zhiyun Chen, Jie Pang, Yuxiao Zhang, Yiwei Ding, Ning Chen, Nan Zhang, Qiushui He

“…This study evaluated the prevalence of serum anti-pertussis toxin (anti-PT) IgG antibodies in adults at childbearing age pre- and post- COVID-19 in Beijing, China. …”
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Heterodimerization of Chemoreceptors TAS1R3 and mGlu₂ in Human Blood Leukocytes by Lena Ball, Julia Bauer, Dietmar Krautwurst

“…We demonstrate MSG-induced, mGlu₂/TAS1R3 heteromer-dependent gain-of-function and pertussis toxin-sensitive signaling in luminescence assays. …”
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Optimising DTwP-containing vaccine infant immunisation schedules (OptImms) — a protocol for two parallel, open-label, randomised controlled trials by Kelly, S, Liu, X, Theiss-Nyland, K, Voysey, M, Murphy, S, Li, G, Nyantaro, M, Gurung, M, Basnet, S, Pokhrel, B, Bijukchhe, SM, Eordogh, A, Gombe, B, Kakande, A, Kerridge, S, Kimbugwe, G, Kusemererwa, S, Lubyayi, L, Luzze, H, Mazur, O, Mujadidi, YF, Nabukenya, S, Nagumo, W-R, Nareeba, T, Noristani, R, O'Reilly, P, Roberts, A, Shah, G, Shrestha, S, Shrestha, LP, Thapa, SB, Kibengo, FM, Sharma, AK, Elliott, A, Shrestha, S, Pollard, AJ

“…The primary outcome is anti-pertussis toxin IgG antibodies measured at the time of the booster dose. …”

Understanding immunity differences induced by whole cell and acellular pertussis vaccines in a paediatric population by Martins Valente Pinto, AM

“…To further understand differences between wP and aP, this thesis aims: to characterise the immune response to an aP-booster in a UK cohort by age and priming backgrounds (wP/aP) using a broad variety of assays of humoral immunity; to investigate effect of HLA-DRB1-233Thr previously associated with pertussis toxin (PT) IgG antibody levels in wP-primed infants and protection from disease; to evaluate the use of continuous temperature monitoring as an objective method of evaluating reactogenicity.…”

Identification and characterisation of the genetic determinants of variable response to antigens from infectious agents by Mentzer, A

“…I identified strong genetic associations between variants in the class II major histocompatibility complex (MHC) locus and responses against five antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin; diphtheria toxin (DT); and hepatitis B surface antigen.…”

Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort stud... by Wang, K, Fry, N, Campbell, H, Amirthalingam, G, Harrison, T, Mant, D, Harnden, A

“…MAIN OUTCOME MEASURES: Evidence of recent pertussis infection based on an oral fluid anti-pertussis toxin IgG titre of at least 70 arbitrary units. …”

G-protein modulation of ionic currents in cardiac myocytes by Goodstadt, L, Leo Goodstadt

“…</p> <p>Pipette dialysis with GTPγS had a three-fold effect: pertussis toxin-sensitive inhibition of the ICa responses to isoprenaline, forskolin and photoreleased GTP; competitive inhibition of the enhancement of ICa by further photoreleased GTPγS; and modulation of the kinetics of cAMP-dependent activation of ICl,cAMP and ICa without any significant changes in their magnitudes.…”

Signalling pathways activated by 5-HT(1B)/5-HT(1D) receptors in native smooth muscle and primary cultures of rabbit renal artery smooth muscle cells. by Hinton, J, Hill, P, Jeremy, J, Garland, C

“…Application of 5-HT evoked a concentration-dependent, pertussis toxin (PTx)-sensitive reduction in cyclic AMP in both cultured cells and intact artery (cyclic AMP concentration reduced by 65.53 +/- 3.33 and 52.65 +/- 5.34% from basal with 10 microM 5-HT, respectively). …”