COMPARATIVE PHARMACOEPIDEMIOLOGICAL ASSESSMENT OF ANTIHYPERTENSIVE DRUGS PRESCRIPTION IN OUTPATIENT PRACTICE IN KURSK AND CHISINAU by S. V. Povetkin, O. V. Levashova, V. I. Ghicavii, N. G. Batchinschi, L. A. Pjdgurschi, L. M. Turca

“…In Kursk, the ratio of these specified tactics of combined therapy was 53.5 and 34.1%, respectively. Among the pharmaceutical companies whose medicines were preferred by doctors in Kursk and in Chisinau, the leading positions were taken by KRKA (38.0 and 25.4%, respectively), Gideon Richter (13.5 and 28.7%, respectively) and Berlin-Chemie (26.7 and 15.6%, respectively).Conclusion. …”
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Optimization of the production process for the anticancer lead compound illudin M: downstream processing by Lillibeth Chaverra-Muñoz, Theresa Briem, Stephan Hüttel

“…However, limitations related to the discovery and supply of these molecules by biotechnological means led to the retraction of big pharmaceutical companies from this field. The reasons included problems associated with strain culturing, screening, re-discovery, purification and characterization of novel molecules from natural sources. …”
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Companies’ Health Technology Assessment Strategies and Practices in Australia, Canada, England, France, Germany, Italy and Spain: An Industry Metrics Study by Ting Wang, Ting Wang, Neil McAuslane, Lawrence Liberti, Helga Gardarsdottir, Wim Goettsch, Wim Goettsch, Hubert Leufkens

“…Background: Health technology assessment (HTA) has increased in importance in supporting payer decision making by assessing the relative effectiveness and cost effectiveness of new medicines. Thus, pharmaceutical companies need to address the HTA requirements early during development to improve reimbursement outcomes. …”
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Phenotypic variation in biomass and related traits among four generations advanced lines of Cleome (Gynandropsis gynandra L. (Briq.)). by Aristide Carlos Houdegbe, Enoch G Achigan-Dako, E O Dêêdi Sogbohossou, M Eric Schranz, Alfred O Odindo, Julia Sibiya

“…Gynandropsis gynandra (spider plant) is an African traditional leafy vegetable rich in minerals, vitamins and health-promoting compounds with potential for health promotion, micronutrients supplementation and income generation for stakeholders, including pharmaceutical companies. However, information on biomass productivity is limited and consequently constrains breeders' ability to select high-yielding genotypes and end-users to make decisions on suitable cultivation and production systems. …”
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Cemiplimab in locally advanced or metastatic cutaneous squamous cell carcinoma: prospective real-world data from the DRUG Access ProtocolResearch in context by Karlijn Verkerk, Birgit S. Geurts, Laurien J. Zeverijn, Vincent van der Noort, Henk M.W. Verheul, John B.A.G. Haanen, Astrid A.M. van der Veldt, Ferry A.L.M. Eskens, Maureen J.B. Aarts, Carla M.L. van Herpen, Mathilde Jalving, Jourik A. Gietema, Lot A. Devriese, Mariette Labots, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Egbert F. Smit, Haiko J. Bloemendal

“…Funding: The DRUG Access Protocol is supported by all participating pharmaceutical companies: Bayer, Janssen, Lilly, Merck, Novartis, Roche, and Sanofi.…”
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Does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis. by Cipriani, A, Furukawa, T, Geddes, J, Malvini, L, Signoretti, A, McGuire, H, Churchill, R, Nakagawa, A, Barbui, C

“…Reference lists of relevant papers and previous systematic reviews were hand-searched. Pharmaceutical companies and experts in this field were contacted for supplemental data. …”

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge by Beattie, K, Luscombe, C, Williams, G, Munoz-Muriedas, J, Gavaghan, D, Cui, Y, Mirams, G

“…Introduction: Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QT prolongation remains a major cause of attrition during compound development. …”

Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data by Shinohara, K, Tanaka, S, Imai, H, Noma, H, Maruo, K, Cipriani, A, Yamawaki, S, Furukawa, T

“…<br/><strong>Methods: </strong>We identified all placebo-controlled, double-blind randomised controlled trials (RCTs) of second generation antidepressants for major depressive disorder conducted in Japan and requested their individual patient data (IPD) to pharmaceutical companies. We obtained IPD (n=1493) from four phase II/III RCTs comparing mirtazapine, escitalopram, duloxetine, paroxetine and placebo. …”

Recommendations for the reporting of harms in manuscripts on clinical trials assessing osteoarthritis drugs: A consensus statement from the European Society for Clinical and Econom... by Honvo, G, Bannuru, RR, Bruyère, O, Rannou, F, Herrero-Beaumont, G, Uebelhart, D, Cooper, C, Arden, N, Conaghan, PG, Reginster, J-Y, Thomas, T, McAlindon, T

“…CONCLUSIONS:These recommendations may contribute to improve transparency in the field of safety of anti-OA medications. Pharmaceutical companies developing drugs for OA, and researchers conducting clinical trials, are encouraged to comply with them when reporting harms-related results in manuscripts on RCTs. …”

Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR) by Mojdeh Dinarvand, Malcolm Spain

“…This method is a novel strategy to overcome insufficient quantities of pure material (NPs) for drug discovery and development which is a big challenge for pharmaceutical companies. The antibacterial screening of the marine extracts has shown several of the compounds exhibited potent in-vitro antibacterial activity, especially against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) with minimum inhibitory concentration (MIC) values between 15.6 to 62.5 microg mL⁻¹. …”
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Attitudes towards the COVID-19 Vaccine and Willingness to Get Vaccinated among Healthcare Workers in French Guiana: The Influence of Geographical Origin by Nicolas Vignier, Kepha Brureau, Sybille Granier, Jacques Breton, Céline Michaud, Mélanie Gaillet, Camille Agostini, Mathilde Ballet, Mathieu Nacher, Audrey Valdes, Philippe Abboud, Antoine Adenis, Félix Djossou, Loïc Epelboin, Maylis Douine

“…Conversely, participants were less likely to have been vaccinated or willing to if they were nurses or of another non-medical profession, born in French Guiana, feared adverse effects, or if they did not trust pharmaceutical companies and management of the epidemic by authorities. …”
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Neglected Tropical Diseases and the Millennium Development Goals-why the "other diseases" matter: reality versus rhetoric by Molyneux David H, Malecela Mwele N

“…This has been made possible by donations from major pharmaceutical companies of quality and efficacious drugs which have a proven track record of safety. …”
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Quality assurance in non-interventional studies by Capan, Müge, Theobald, Karlheinz, Schinzel, Stefan, Herbold, Marlis, Hundt, Ferdinand

“…In addition in Germany the Federal Institute for Drugs and Medical Devices (BfArM) together with the Paul Ehrlich Institute (PEI) and the German Association of Research-Based Pharmaceutical Companies (VFA) have published respectively recommendations dealing with quality aspects of non-interventional observational studies. …”
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Hesitancy to COVID-19 Vaccines among University Students in Lebanon by M. Bou Hamdan, S. Singh, M. Polavarapu, T. Jordan, N. Melhem

“…Students reporting that pharmaceutical companies adequately tested the safety of the vaccine (OR=0.52; 95% CI=0.19-1.43; p value=0.21) and those who consider the vaccine in agreement with their personal views (OR= 0.11, 95% CI= 0.02-0.51, p value= 0.004) were less likely to be hesitant. …”
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Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization studyResearch in context by Ching-Lung Cheung, Kathryn C.B. Tan, Philip C.M. Au, Gloria H.Y. Li, Bernard M.Y. Cheung

“…Although many pharmaceutical companies are developing drugs targeting GFRAL, whether the findings from animal studies can be extrapolated to man is unknown. …”
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Global trends in the health economics field of PD-1/PD-L1 inhibitors: A bibliometric and visualized study by Sicen Lai, Sicen Lai, Sicen Lai, Sicen Lai, Licong Xu, Licong Xu, Licong Xu, Licong Xu, Liang Zhang, Lanyuan Peng, Lanyuan Peng, Lanyuan Peng, Lanyuan Peng, Yixin Li, Yixin Li, Yixin Li, Yixin Li, Yuancheng Liu, Yuancheng Liu, Yuancheng Liu, Yuancheng Liu, Nianzhou Yu, Nianzhou Yu, Nianzhou Yu, Nianzhou Yu, Wangqing Chen, Wangqing Chen, Wangqing Chen, Wangqing Chen, Kai Huang, Kai Huang, Kai Huang, Kai Huang

“…Findings from this study may provide governments and pharmaceutical companies with a strong reference for future research.…”
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Complementary and Alternative Medicines in Northern Cyprus: Public Awareness, Patterns of Use, and Attitudes by Doğa Ünlüyol, Hüseyin Gökçekuş, Youssef Kassem, Murat Tezer, Filiz Meriçli, Dudu Özkum Yavuz

“…Given our finding that dissatisfaction with modern medicine is the most important reason for the preferred use of herbal medicines, government agencies, physicians, and pharmaceutical companies should be aware of this issue and should aim to create some level of awareness among users.…”
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The Quality of Instructional YouTube Videos for the Administration of Intranasal Spray: Observational Study by Peters-Geven, Marije M, Rollema, Corine, Metting, Esther I, van Roon, Eric N, de Vries, Tjalling W

“…ResultsWe identified 33 YouTube videos made by different health care professionals and pharmaceutical companies around the world. None of the videos displayed all the steps correctly, while 5 of the 33 (15%) videos displayed over 75% of the steps correctly. …”
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Intranasal Corticosteroids for the Medical Management of Nasal Polyps in Adults: a Meta-Analysis by Natividad A. Almazan-Aguilar

“…Search Strategy: Comprehensive search of Cochrane's Controlled Trials Registry (CCTR) Issue 2, 2003, Medline 1966 to 2002, and Embase 1974 - 2002 bibliographic review, requests for information from authors and pharmaceutical companies.   Data collection and analysis:  Sixteen studies were evaluated for inclusion, and trial quality, validity assessment, and completion of data extraction were done. …”
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State capture through indemnification demands? Effects on equity in the global distribution of COVID-19 vaccines by Ariel Gorodensky, Jillian C. Kohler

“…Background State capture by the pharmaceutical industry is a form of corruption whereby pharmaceutical companies shift laws or policies about their products away from the best interest of the public and toward their private benefit. …”
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