Showing 21 - 40 results of 20,688 for search '"pharmacokinetics"', query time: 0.17s Refine Results
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    The Two Faces of Pharmacokinetics by Aldo Rescigno

    Published 2010-02-01
    “…There are two main branches of Mathematics: Calculus and Geometry; in Physics there are Constructive Theories and Principle Theories. Similarly in Pharmacokinetics we can build models with two opposite approaches, the bottom-up and the top-down point of view. …”
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    Article
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    Pharmacokinetics of intravenous amodiaquine. by White, N, Looareesuwan, S, Edwards, G, Phillips, R, Karbwang, J, Nicholl, D, Bunch, C, Warrell, D

    Published 1987
    “…The plasma concentration-time profiles were biphasic with the following estimated pharmacokinetic parameters (geometric mean; range) alpha = 1.87 (0.60-8.52) h-1, beta = 0.069 (0.021-0.265) h-1, V1: 4.6 (0.5-29.3) 1 kg-1, Vss: 38.3 (3.7-127.9) 1 kg-1 and systemic clearance CL (1.6-17.3) 1 kg-1 h-1. …”
    Journal article
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    Clinical pharmacokinetics of mefloquine. by Karbwang, J, White, N

    Published 1990
    “…Several assay methodologies have been developed, but high performance liquid chromatography has been the most used in recent pharmacokinetic studies. These have shown in healthy volunteers that mefloquine is absorbed with a half-life of 1 to 4 hours and a time to peak concentration of 7 to 24 hours (median 16.7 hours). …”
    Journal article
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    Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design. by Micaela B Reddy, Kuo-Hsiung Yang, Gauri Rao, Craig R Rayner, Jing Nie, Chandrasena Pamulapati, Bindumadhav M Marathe, Alan Forrest, Elena A Govorkova

    Published 2015-01-01
    “…The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insufficient information on oseltamivir PK. …”
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    Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions by Stefan Willmann, Katrin Coboeken, Yang Zhang, Hannah Mayer, Ibrahim Ince, Emir Mesic, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Haitao Yang, Peijuan Zhu, Wolfgang Mück, Henk‐Jan Drenth, Jörg Lippert

    Published 2021-10-01
    “…Physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) modeling were used throughout the pediatric development of rivaroxaban according to the learn‐and‐confirm paradigm. …”
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    Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application by Jean Claude Alvarez, Benjamin Davido, Pierre Moine, Isabelle Etting, Djillali Annane, Islam Amine Larabi, Nicolas Simon

    Published 2022-02-01
    “…We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD) relationship was present. …”
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    Pharmacokinetic-pharmacodynamic modeling and simulation / by 192959 Bonate, Peter L.

    Published 2005
    Subjects: “…Pharmacokinetics…”
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    Basic pharmacokinetics [compact disc] / by 317664 Hedaya, Mohsen A.

    Published 2007
    Subjects: “…Pharmacokinetics…”