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The Two Faces of Pharmacokinetics
Published 2010-02-01“…There are two main branches of Mathematics: Calculus and Geometry; in Physics there are Constructive Theories and Principle Theories. Similarly in Pharmacokinetics we can build models with two opposite approaches, the bottom-up and the top-down point of view. …”
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Pharmacokinetic Studies of Radiopharmaceuticals
Published 2022-12-01Subjects: Get full text
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Pharmacokinetics and Pharmacogenetics of Dabigatran
Published 2021-03-01Subjects: Get full text
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Pharmacokinetics of intravenous amodiaquine.
Published 1987“…The plasma concentration-time profiles were biphasic with the following estimated pharmacokinetic parameters (geometric mean; range) alpha = 1.87 (0.60-8.52) h-1, beta = 0.069 (0.021-0.265) h-1, V1: 4.6 (0.5-29.3) 1 kg-1, Vss: 38.3 (3.7-127.9) 1 kg-1 and systemic clearance CL (1.6-17.3) 1 kg-1 h-1. …”
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Clinical pharmacokinetics of mefloquine.
Published 1990“…Several assay methodologies have been developed, but high performance liquid chromatography has been the most used in recent pharmacokinetic studies. These have shown in healthy volunteers that mefloquine is absorbed with a half-life of 1 to 4 hours and a time to peak concentration of 7 to 24 hours (median 16.7 hours). …”
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Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
Published 2022-12-01Subjects: “…physiologically based pharmacokinetic modeling…”
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Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design.
Published 2015-01-01“…The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insufficient information on oseltamivir PK. …”
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Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice
Published 2021-01-01Subjects: Get full text
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Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE)
Published 2021-03-01Subjects: Get full text
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Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions
Published 2021-10-01“…Physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) modeling were used throughout the pediatric development of rivaroxaban according to the learn‐and‐confirm paradigm. …”
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Application of Physiologically Based Pharmacokinetic Modeling to Predict Maternal Pharmacokinetics and Fetal Exposure to Oxcarbazepine
Published 2022-11-01Subjects: Get full text
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Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application
Published 2022-02-01“…We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD) relationship was present. …”
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Pharmacokinetic-pharmacodynamic modeling and simulation /
Published 2005Subjects: “…Pharmacokinetics…”
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