Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens by Adiwidjaja, Jeffry, Gross, Annette S., Boddy, Alan V., McLachlan, Andrew J.

“…Aims: This study implements a physiologically-based pharmacokinetic (PBPK) modelling approach to investigate inter-ethnic differences in imatinib pharmacokinetics and dosing regimens. …”
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A Three-Pulse Release Tablet for Amoxicillin: Preparation, Pharmacokinetic Study and Physiologically Based Pharmacokinetic Modeling. by Jin Li, Hongyu Chai, Yang Li, Xuyu Chai, Yan Zhao, Yunfan Zhao, Tao Tao, Xiaoqiang Xiang

“…Box-Behnken design, Scanning Electron Microscope and in vitro drug release test were used to help the optimization of formulations. A crossover pharmacokinetic study was performed to compare the pharmacokinetic profile of our in-house pulsatile tablet with that of commercial immediate release tablet. …”
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Factors Influencing Pharmacokinetics of Tamoxifen in Breast Cancer Patients: A Systematic Review of Population Pharmacokinetic Models by Jaya Shree Dilli Batcha, Arun Prasath Raju, Saikumar Matcha, Elstin Anbu Raj S., Karthik S. Udupa, Vikram Gota, Surulivelrajan Mallayasamy

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Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study. by Muhammad Usman, Qurrat-Ul-Ain Shaukat, Muhammad Imran Khokhar, Rabiea Bilal, Rizwan Rasul Khan, Hafiz Asad Saeed, Mohsin Ali, Humaira Majeed Khan

“…This study is aimed to compare the pharmacokinetics of valproic acid in Pakistani and South Korean patients.…”
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Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma by Yumi Yamamoto, Patricia Sanwald Ducray, Marcus Björnsson, Kevin Smart, Paul Grimsey, Suresh Vatakuti, Agnes Portron, Benoit Massonnet, Daniel A. Norris, Hanna E. Silber Baumann

“…Nonlinear mixed‐effect population pharmacokinetic (PopPK) modeling was conducted to characterize the CSF and plasma pharmacokinetics (PK) of tominersen, and to identify and quantify the covariates that affect tominersen PKs. …”
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A population pharmacokinetic and pharmacokinetic‐pharmacodynamic analysis of vupanorsen from phase I and phase II studies by Jae Eun Ahn, Steven G. Terra, Jing Liu

“…Using pooled data from two phase I studies of participants with elevated triglycerides (Western: n = 48 and Japanese: n = 12), and two phase II studies of patients with hypertriglyceridemia, diabetes, and nonalcoholic fatty liver disease (n = 105), and statin‐treated patients with dyslipidemia (n = 286), we developed population pharmacokinetic (PK) and PK/pharmacodynamic (PK/PD) models. …”
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Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats by Dandan Liu, Yunjiao Liu, Xian Qian, Junwei Yang, Chengjian Li, Lingfeng Zhu, Jin Zhou

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Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases by Muhammad F. Rasool, Shazia Ali, Sundus Khalid, Ramsha Khalid, Abdul Majeed, Imran Imran, Hamid Saeed, Muhammad Usman, Mohsin Ali, Amer S. Alali, Abdullah F. AlAsmari, Nemat Ali, Ali Mohammed Asiri, Fawaz Alasmari, Faleh Alqahtani

“…Abstract The advancement in the processing speeds of computing machines has facilitated the development of complex physiologically based pharmacokinetic (PBPK) models. These PBPK models can incorporate disease-specific data and could be used to predict pharmacokinetics (PK) of administered drugs in different chronic conditions. …”
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Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug–drug interaction prediction by Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy

“…Abstract The gold‐standard approach for modeling pharmacokinetic mediated drug–drug interactions is the use of physiologically‐based pharmacokinetic modeling and population pharmacokinetics. …”
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A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations by Muhammad Talha Zahid, Ammara Zamir, Abdul Majeed, Imran Imran, Sary Alsanea, Tanveer Ahmad, Faleh Alqahtani, Muhammad Fawad Rasool

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Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes by Kate White, Mohammed Aldurdunji, John Harris, Catherine Ortori, Stuart Paine

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Bayesian estimation of pharmacokinetic parameters: an important component to include in the teaching of clinical pharmacokinetics and therapeutic drug monitoring by Dion R Brocks, Dalia A Hamdy

“…Bayesian estimation of pharmacokinetic parameters (PKP), as discussed in this review, provides a powerful approach towards the individualization of dosing regimens. …”
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Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice by Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock, Veena A. Thomas

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Pharmacokinetics and Disposition of Heparin-Binding Growth Factor Midkine Antisense Oligonucleotide Nanoliposomes in Experimental Animal Species and Prediction of Human Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model by Haihong Bai, Haihong Bai, Yuanguo Cheng, Jinjing Che, Jinjing Che

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Pharmacokinetic modelling using Stella on the Apple Macintosh / by 264867 Washington, Clive, Washington, Neena, Wilson, Clive

Subjects: “…Pharmacokinetics…”

Mass spectrometry in drug metabolism and pharmacokinetics / by Ramanathan, Ragu

Reference physiological parameters in pharmacokinetic modeling / by 268339 Arms, Angela D., Travis, Curtis C., United States. Environmental Protection Agency. Office of Health and Environmental Assessment, United States. Environmental Protection Agency. Office of Research and Development

Subjects: “…Pharmacokinetics…”

The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics by Jiagen Wen, Meizi Zeng, Zhaoqian Liu, Honghao Zhou, Heng Xu, Min Huang, Wei Zhang

“…Keywords: Telmisartan, Metformin, Pharmacokinetics, Pharmacodynamics, Drug–drug interaction…”
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Pharmacokinetic (Bioavailability) Studies of Magnesium Preparations by N. N. Eremenko, E. V. Shikh, N. E. Uvarova

“…The evaluation of endogenous magnesium levels as part of bioavailability studies is necessary to adjust pharmacokinetic parameters and to obtain valid study results. …”
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Population Pharmacokinetics of Primaquine in the Korean Population by Woo-Yul Lee, Dong-Woo Chae, Choon-Ok Kim, Sang-Eun Lee, Yee-Gyung Kwak, Joon-Sup Yeom, Kyung-Soo Park

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