Utility of Physiologically Based Pharmacokinetic Modeling to Investigate the Impact of Physiological Changes of Pregnancy and Cancer on Oncology Drug Pharmacokinetics by Xinxin Yang, Manuela Grimstein, Michelle Pressly, Elimika Pfuma Fletcher, Stacy Shord, Ruby Leong

Subjects: “…physiologically based pharmacokinetic (PBPK)…”
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Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers by Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh, Yaichiro Kotake

“…However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of such compounds. Although in vitro–in vivo extrapolation is widely used to predict human CL, its application has been limited for low‐CLint compounds because of the low turnover of parent compounds in metabolic stability assays. …”
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Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach by Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee

“…This study aims to evaluate and mechanistically characterize the effect of genetic polymorphism of SLC22A1, which encodes OCT1, on the pharmacokinetics (PKs) of proguanil and cycloguanil in Korean. …”
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Identification of pharmacokinetic markers for safflower injection using a combination of system pharmacology, multicomponent pharmacokinetics, and quantitative proteomics study by Peiying Shi, Peiying Shi, Yijun Ruan, Chenhui Zhong, Linglin Teng, Liyuan Ke, Hong Yao, Hong Yao

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Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects by Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu

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Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans by Min-Soo Kim, Yoo-Kyung Song, Ji-Soo Choi, Hye Young Ji, Eunsuk Yang, Joon Seok Park, Hyung Sik Kim, Min-Joo Kim, In-Kyung Cho, Suk-Jae Chung, Yoon-Jee Chae, Kyeong-Ryoon Lee

Subjects: “…physiologically based pharmacokinetic modelling…”
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Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling by Bu F, Cho YS, He Q, Wang X, Howlader S, Kim DH, Zhu M, Shin JG, Xiang X

“…In conclusion, our study enhances understanding of anlotinib’s interaction with medications, aiding scientists, prescribers, and drug labels in gauging the expected impact of CYP3A/1A2 modulators on anlotinib’s pharmacokinetics. Keywords: anlotinib, DDIs, CYP3A, CYP1A2, PBPK…”
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Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic Parameters to the Control State by Insulin Treatment by Myung G. Lee, Young H Choi, Inchul Lee

“…To test the effect of insulin treatment on the pharmacokinetics of metformin in rats with diabetes mellitus induced by alloxan (DMIA rats). …”
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Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model by Yawen Yuan, Zhihong Li, Ke Wang, Shunguo Zhang, Qingfeng He, Lucy Liu, Zhijia Tang, Xiao Zhu, Ying Chen, Weimin Cai, Chao Peng, Xiaoqiang Xiang

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Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations by Feray Altan, Orhan Corum, Duygu Durna Corum, Kamil Uney, Ertugrul Terzi, Soner Bilen, Adem Yavuz Sonmez, Muammer Elmas

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Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia by Xingchen Bian, Xingchen Bian, Xingchen Bian, Nanyang Li, Nanyang Li, Nanyang Li, Yi Li, Yi Li, Yi Li, Xu Zhu, Xu Zhu, Xu Zhu, Jicheng Yu, Jicheng Yu, Jicheng Yu, Yingying Hu, Yingying Hu, Yingying Hu, Haijing Yang, Haijing Yang, Haijing Yang, Qiong Wei, Qiong Wei, Qiong Wei, Xiaojie Wu, Xiaojie Wu, Xiaojie Wu, Jingjing Wang, Jingjing Wang, Jingjing Wang, Guoying Cao, Guoying Cao, Guoying Cao, Jufang Wu, Jufang Wu, Jufang Wu, Yang Wang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang

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Pharmacokinetic Characterization to Enable Medicine Use in Pregnancy, the Potential Role of Physiologically‐Based Pharmacokinetic Modeling: A Regulatory Perspective by Susan Cole, Paola Coppola, Essam Kerwash, Janet Nooney, Siu Ping Lam

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Quantitative pulmonary pharmacokinetics of tetrandrine for SARS-CoV-2 repurposing: a physiologically based pharmacokinetic modeling approach by Furun Wang, Furun Wang, Liuhan Dong, Juanwen Hu, Shijie Yang, Lingchao Wang, Zhiwei Zhang, Wenpeng Zhang, Xiaomei Zhuang

Subjects: “…physiologically based pharmacokinetic (PBPK)…”
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The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling by Karel Allegaert, Mohammad Yaseen Abbasi, Robin Michelet, Olusola Olafuyi

Subjects: “…physiologically based pharmacokinetic modelling…”
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Physiologically based pharmacokinetic modeling : science and applications / by Reddy, Micaela B.

Subjects: “…Pharmacokinetics…”

Drug discovery and evaluation : safety and pharmacokinetic assays / by Vogel, H. Gerhard, 1927-

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Assessment of Pharmacokinetic Effects of Herbal Medicines on Escitalopram by Jung YS, Jin BH, Choi JE, Park MS, Kim YW, Kang HW, Cho S, Kim CO

“…In this study, we investigated the pharmacokinetic (PK) effects of four herbal medicines (Gami-soyosan, Banhasasim-tang, Ojeok-san, and Bojungikgi-tang) on escitalopram, a commonly used antidepressant.Patients and Methods: In this open-label, fixed-sequence, three-period, crossover study, 18 participants were enrolled and divided into two groups. …”
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Population Pharmacokinetics in Oncology and Its Clinical Applications by Nicolas Widmer, Monia Guidi, Thierry Buclin

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Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions by Subrata Deb, Anthony Allen Reeves

“…Physiologically based pharmacokinetic (PBPK) modeling of GastroPlus was used to simulate different patient populations based on age, weight, liver function, and renal function status. …”
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Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin by Yu Yuan, Guangpeng Meng, Yuanbo Li, Chunjie Wu

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