How to Balance Prognostic Factors in Controlled Phase II Trials: Stratified Permuted Block Randomization or Minimization? An Analysis of Clinical Trials in Digestive Oncology by Elodie Martin, Karine Le Malicot, Catherine Guérin-Charbonnel, François Bocquet, Olivier Bouché, Anthony Turpin, Thomas Aparicio, Jean-Louis Legoux, Laetitia Dahan, Julien Taieb, Côme Lepage, Louis-Marie Dourthe, Caroline Pétorin, Vincent Bourgeois, Jean-Luc Raoul, Valérie Seegers

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Interpreting a Bayesian phase II futility clinical trial by Jonathan Beall, Christy Cassarly, Renee Martin

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Exploratory Efficacy Evaluation of Apremilast for the Treatment of Japanese Patients with Palmoplantar Pustulosis: 32-Week Results from a Phase 2, Randomized, Placebo-Controlled St... by Yukari Okubo, Tadashi Terui, Satomi Kobayashi, Shigetoshi Sano, Akimichi Morita, Shinichi Imafuku, Yayoi Tada, Masatoshi Abe, Masafumi Yaguchi, Takeshi Kimura, Junichiro Shimauchi, Wendy Zhang, Hamid Amouzadeh, Masamoto Murakami

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Anthocyanins and Their C₆-C₃-C₆ Metabolites in Humans and Animals by Wilhelmina Kalt

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Sample size determination and evaluation for two-stage adaptive designs of single arm clinical trials based on median event time test by Yeonhee Park, Yi Chen

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Bayesian sequential monitoring strategies for trials of digestive cancer therapeutics by Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

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L1 Triggering on High-Granularity Information at the HL-LHC by Louis Portalès

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Editorial - Variation in Phase II Metabolism of Sex Steroids- Causes and Consequences by Jenny Jakobsson Schulze, Lena eEkström

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ELEVATE – evaluating Temozolomide and Nivolumab in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma with MGMT methylation: study protocol for... by Elizabeth Smyth, Kelly Cozens, Daniel Griffiths, Kathryn L. Clark, Sean Ewings, Russell Petty, Tim Underwood, Rebecca C. Fitzgerald, James Tanner, Olivier Giger, Shubha Anand, Gareth Griffiths

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A multicenter, phase II trial of triplet antiemetic therapy with palonosetron, aprepitant, and olanzapine for highly emetogenic chemotherapy in breast cancer (PATROL-II) by Kenichi Suzuki, Takashi Yokokawa, Takashi Kawaguchi, Shinya Takada, Shinya Tamaki, Yohei Kawasaki, Takumi Yamaguchi, Kei Koizumi, Takuma Matsumoto, Yukio Sakata, Yuichiro Arakawa, Hideaki Ayuhara, Mari Hosonaga, Masakazu Yamaguchi, Daiki Tsuji

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Stress and strain analysis in the rock massif during coal exploitation with large diameter boreholes in east field pit RMU Bogovina by Ivaz Jelena, Ignjatović Dragan, Ljubojev Milenko, Softić Sead

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Racial and Ethnic Demographic Reporting in Phase 2 Proton Therapy Clinical Trials: A Review by Jonathan S. Fakhry, M. Juliana Pena, Ariel Pomputius, Fantine Giap, MD, Raymond B. Mailhot Vega, MD

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Final Overall Survival, Safety, and Quality of Life Results From a Phase 2 Study of Crizotinib in East Asian Patients With ROS1-Positive Advanced NSCLC by Yi-Long Wu, MD, Shun Lu, MD, PhD, James Chih-Hsin Yang, MD, PhD, Jianying Zhou, MD, Takashi Seto, MD, Myung-Ju Ahn, MD, PhD, Wu-Chou Su, MD, Noboru Yamamoto, MD, PhD, Dong-Wan Kim, MD, PhD, Jolanda Paolini, MSc, Tiziana Usari, BSc, Laura Iadeluca, PhD, Keith D. Wilner, PhD, Koichi Goto, MD, PhD

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Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1 by Yanan Sun, David Machalz, Gerhard Wolber, Maria Kristina Parr, Matthias Bureik

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A phase II trial of S-1 and oxaliplatin in patients with advanced hepatocellular carcinoma by Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Tae-You Kim

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Multicentre, phase II study of eribulin in combination with S-1 in patients with advanced breast cancer by Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike, Kazuhiko Nakagawa

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A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases by Rodrigues George, Yartsev Slav, Tay Keng, Pond Gregory R, Lagerwaard Frank, Bauman Glenn

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A phase II, multicenter, open-label, randomized trial of pegfilgrastim for patients with alcohol-associated hepatitis by John A. Tayek, Andrew A. Stolz, Danh V. Nguyen, M. Wayne Fleischman, John A. Donovan, Joseph M. Alcorn, Daniel C-K. Chao, Aliya Asghar, Timothy R. Morgan, Divya Birudaraju, Greg Botwin, Hema Buddha, Lavanya Cherukuri, Sheena Cruz, Monique French, Rachel Gonzalez, Jessica Gozum, Rebecca Gutierrez, Sajad Hamal, Preston Head, Carol Jones, Neil Kaplowitz, Robert Lee, Lauren MacHarg, Susan Milstein, Yuxin Ouyang, Christy Rico, Cory Zarick

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Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma by Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Elena Pistocchini, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta

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A Retrospective Analysis of the Effects of Cardiac Rehabilitation on Health Markers and Performance Outcomes among Diabetic and Non-Diabetic Patients with Coronary Artery Bypass Gr... by Amy N. McKeever, Phillip C. Drouet, Jesus A. Vera, William E. Thomas, Jared W. Coburn, Pablo B. Costa

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