Towards deep cellular phenotyping in placental histology by Ferlaino, M, Glastonbury, C, Motta-Mejia, C, Vatish, M, Granne, I, Kennedy, S, Lindgren, C, Nellaker, C

“…Furthermore, we learn deep embeddings encoding phenotypic knowledge that is capable of both stratifying five distinct cell populations and learn intraclass phenotypic variance. …”

The role of CT scanning in multidimensional phenotyping of COPD. by Bafadhel, M, Umar, I, Gupta, S, Raj, J, Vara, D, Entwisle, J, Pavord, I, Brightling, C, Siddiqui, S

“…CT imaging is emerging as an important, noninvasive tool in phenotyping COPD. However, the use of CT imaging in defining the disease heterogeneity above lung function is not fully known. …”

Reproducibility and replicability of rodent phenotyping in preclinical studies by Kafkafi, N, Agassi, J, Chesler, E, Crabbe, J, Crusio, W, Eilam, D, Gerlai, R, Golani, I, Gomez-Marin, A, Heller, R, Iraqi, F, Jaljuli, I, Karp, N, Morgan, H, Nicholson, G, Pfaff, D, Richter, S, Stark, P, Stiedl, O, Stodden, V, Tarantino, L, Tucci, V, Valdar, W, Williams, R, Würbel, H, Benjamini, Y

“…The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. …”

Vision tests in the mouse: Functional phenotyping with electroretinography. by Tanimoto, N, Muehlfriedel, R, Fischer, M, Fahl, E, Humphries, P, Biel, M, Seeliger, M

Phenotyping airways disease: an A to E approach. by Gonem, S, Raj, V, Wardlaw, A, Pavord, I, Green, R, Siddiqui, S

Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: report of two siblings by Truck, J, Kelly, D, Taylor, J, Kienzler, A, Lester, T, Seller, A, Pollard, A, Patel, S

“…We describe the phenotype of 2 siblings with combined immunodeficiency due to CTPS1 deficiency and demonstrate the value of WES for rapid diagnosis of primary immunodeficiency even for conditions whose phenotype is not well recognized.…”

Multiscale 3D phenotyping of human cerebral organoids by Albanese, Alexandre, Swaney, Justin M, Yun, Dae Hee, Evans, Nicholas B, Antonucci, Jenna M, Velasco, Silvia, Sohn, Chang Ho, Arlotta, Paola, Gehrke, Lee, Chung, Kwanghun

“…Comprehensive analysis of 46 intact organoids and ~ 100 million cells reveals quantitative multiscale “phenotypes" for organoid development, culture protocols and Zika virus infection. …”
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Registration of spatio-temporal point clouds of plants for phenotyping by Chebrolu, N, Magistri, F, Läbe, T, Stachniss, C

“…Plant phenotyping is a central task in crop science and plant breeding. …”

The UK Biobank resource with deep phenotyping and genomic data by Bycroft, C, Freeman, C, Petkova, D, Band, G, Elliott, L, Sharp, K, Motyer, A, Vukcevic, D, Delaneau, O, O'Connell, J, Cortes, A, Welsh, S, Young, A, Effingham, M, McVean, G, Leslie, S, Allen, N, Donnelly, P, Marchini, J

“…The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. …”

Editorial: Physiological phenotyping in respiratory diseases: new approaches by King, GG, Formenti, F, Petousi, N

Mouse embryonic phenotyping by morphometric analysis of MR images. by Zamyadi, M, Baghdadi, L, Lerch, J, Bhattacharya, S, Schneider, J, Henkelman, R, Sled, J

“…Together these findings suggest the power of this technique for detecting subtle phenotypic differences arising from mutated genes.…”

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping by Tir, S, Foster, RG, Peirson, SN

“…Here we assess a novel method, the Digital Ventilated Cage (DVC®, Tecniplast SpA, Italy), for circadian phenotyping. Based upon capacitive sensors mounted under black individually ventilated cages with inbuilt LED lighting, each cage becomes an independent light-controlled chamber. …”

Circulating tumor cell phenotyping via high‐throughput acoustic separation by Wu, Mengxi, Huang, Po-Hsun, Zhang, Rui, Mao, Zhangming, Chen, Chuyi, Kemeny, Gabor, Li, Peng, Lee, Adrian V., Gyanchandani, Rekha, Armstrong, Andrew J., Dao, Ming, Suresh, Subra, Huang, Tony Jun

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Development of compartment phenotypes in the mammalian striatum by Fusco, Eleonora

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Phenotype of ribonuclease 1 deficiency in mice by Garnett, Emily Rose, Lomax, Jo E., Mohammed, Bassem M., Gailani, David, Sheehan, John P., Raines, Ronald T

“…Moreover, the plasma of Rnase1–/– mice clots more rapidly than does wild-type plasma. This phenotype appeared to be due to increased levels of the active form of FXII (FXIIa) in the plasma of Rnase1–/– mice compared to Rnase1+/+ mice, and is consistent with the known effects of eRNA on FXII activation. …”
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Exploring the role of aneuploidy in phenotypic variability by Moomau, Christine Anne

“…Phenotypic variability is a noted feature of human trisomies. …”
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Proxy genotypes and phenotypes for human genetics by Yelensky, Roman

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Prions, protein homeostasis, and phenotypic diversity by Lindquist, Susan, Halfmann, Randal Arthur, Alberti, Simon

“…In fungi, prions alter the relationship between genotype and phenotype in a heritable way that diversifies clonal populations. …”
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Strategically developed phenotypes and the evolution of signals by Siller, S, Siller, Steven

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Olmsted syndrome: exploration of the immunological phenotype. by Danso-Abeam, D, Zhang, J, Dooley, J, Staats, K, Van Eyck, L, Van Brussel, T, Zaman, S, Hauben, E, Van de Velde, M, Morren, M, Renard, M, Van Geet, C, Schaballie, H, Lambrechts, D, Tao, J, Franckaert, D, Humblet-Baron, S, Meyts, I, Liston, A

“…CONCLUSIONS: These results provide the first comprehensive assessment of the immunological features of Olmsted syndrome. The systemic phenotype of hyper IgE and persistent eosinophilia suggest a primary or secondary role of immunological processes in the pathogenesis of Olmsted syndrome, and have important clinical consequences with regard to the treatment of Olmsted syndrome patients.…”