Clinical and Molecular Characteristics and Antibacterial Strategies of Klebsiella pneumoniae in Pyogenic Infection by Zhiyu Yang, Runmei Zhou, Yusheng Chen, Xiaotuan Zhang, Luogen Liu, Min Luo, Jinlin Chen, Kuilin Chen, Tong Zeng, Bin Liu, Yuan Wu, Jielite Huang, Zhuoran Liu, Jinglin Ouyang

“…ST11 strains carrying multiple drug resistance genes have a multidrug resistance phenotype, while non-ST11 strains carrying only intrinsic resistance genes are generally susceptible to antibiotics. …”
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A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway by Bo Huang, Junwu Ren, Qiang Ma, Feifei Yang, Xiaojuan Pan, Yuying Zhang, Yuying Liu, Cong Wang, Dawei Zhang, Ling Wei, Lingyu Ran, Hongwen Zhao, Ce Liang, Xiaolin Wang, Shiming Wang, Haiping Li, Hao Ning, Ai Ran, Wei Li, Yongquan Wang, Bin Xiao

“…Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal mediators in cancers. …”
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Transcriptome Analysis Revealed the Potential Molecular Mechanism of Anthocyanidins’ Improved Salt Tolerance in Maize Seedlings by Jie Wang, Zhipeng Yuan, Delin Li, Minghao Cai, Zhi Liang, Quanquan Chen, Xuemei Du, Jianhua Wang, Riliang Gu, Li Li

“…Notably, the anthocyanin synthesis related genes in RIL^pur–W22 were strongly induced under salt treatment conditions, which was consistented with the salt tolerance phenotype of its seedlings. In summary, the results of the transcriptome analysis not only expanded our understanding of the complex molecular mechanism of anthocyanin in improving the salt tolerance of maize seedlings, but also, the DEGs specifically expressed in the salt–tolerant line (RIL^pur–W22) provided candidate genes for further genetic analysis.…”
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Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) by Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang, Honghua Zheng

“…Conclusions Our study shows that CSF1R deficiency results in aberrant microglial activation, characterized by a pro-inflammatory phenotype and enhanced phagocytosis of myelin. Our results also indicate that microglial inhibition by minocycline can ameliorate behavioral impairment and ALSP pathogenesis in CSF1R-deficient male mice, suggesting a potential therapeutic target for CSF1R-related leukoencephalopathy. …”
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Maize ZmBES1/BZR1-3 and -9 Transcription Factors Negatively Regulate Drought Tolerance in Transgenic <i>Arabidopsis</i> by Wenqi Feng, Yuan Liu, Yang Cao, Yiran Zhao, Hongwanjun Zhang, Fuai Sun, Qingqing Yang, Wanchen Li, Yanli Lu, Xuecai Zhang, Fengling Fu, Haoqiang Yu

“…The transgenic lines showed a more serious wilting phenotype, shorter root length, lower fresh weight, and higher relative electrolyte leakage (REL) and malondialdehyde (MDA) content compared to the control under drought stress. …”
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Resilience: reference measures based on longer-term consequences are needed to unlock the potential of precision livestock farming technologies for quantifying this trait by Friggens, N.C., Adriaens, I., Boré, R., Cozzi, G., Jurquet, J., Kamphuis, C., Leiber, F., Lora, I., Sakowski, T., Statham, J., De Haas, Y.

“…Such measures are needed to provide more precise phenotypes of resilience for use in farm management, but also for use in animal breeding. …”
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Genetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies by Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Ślęczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam Ferdousi, Rayaz A. Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman Dib-Hajj, Stephen G. Waxman, Hubert J. M. Smeets, Monique M. Gerrits, Catharina G. Faber, Giuseppe Lauria, on behalf of the PROPANE Study Group

“…Patients were grouped based on phenotype and the presence of SCG variants. Screening of <i>SCN3A, SCN7A-SCN11A,</i> and <i>SCN1B-SCN4B</i> revealed 125 different (potential) pathogenic variants in 194 patients (17.2%, <i>n</i> = 194/1125). …”
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Effectiveness and usability of the system for assessment and intervention of frailty for community-dwelling pre-frail older adults: A pilot study by Ren Siang Tan, Eileen Fabia Goh, Di Wang, Robin Chung Leung Chan, Zhiwei Zeng, Audrey Yeo, Kalene Pek, Joanne Kua, Joanne Kua, Wei Chin Wong, Wei Chin Wong, Wei Chin Wong, Zhiqi Shen, Zhiqi Shen, Wee Shiong Lim, Wee Shiong Lim, Wee Shiong Lim

“…For outcomes, we assessed frailty status using the modified Fried Frailty Phenotype (FFP) and CFS; physical performance using Short Physical Performance Battery (SPPB); and Hand Grip Strength (HGS) at baseline and 8-week. …”
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MDR1-expressing CD4+ T cells with Th1.17 features resist to neoadjuvant chemotherapy and are associated with breast cancer clinical response by Christophe Caux, Olivier Tredan, Thomas Duhen, Christine Ménétrier-Caux, Raphael Schneider, Laurie Besson, Isabelle Treilleux, Yenkel Grinberg-Bleyer, Anthony Di Roio, Margaux Hubert, Marion Bossennec, Céline Rodriguez, Guilhem Lalle, Lyvia Moudombi, Cyril Degletagne, Daniel J Campbell, Séverine Metzger

“…Here we explored the expression, function and regulation of MDR1 on CD4+ T cells and investigated the role of this population in response to neoadjuvant chemotherapy (NAC) in BC.Methods Phenotypic and functional characteristics of MDR1+ CD4 Th cells were assessed on blood from healthy donors and patients with BC by flow cytometry. …”
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Genetic dissection of protein and starch during wheat grain development using QTL mapping and GWAS by Yingxin Guo, Yingxin Guo, Guanying Wang, Xin Guo, Xin Guo, Songqi Chi, Hui Yu, Kaituo Jin, Heting Huang, Dehua Wang, Chongning Wu, Jichun Tian, Jiansheng Chen, Yinguang Bao, Weidong Zhang, Zhiying Deng

“…A total of 29 unconditional QTLs, 13 conditional QTLs, 99 unconditional marker−trait associations (MTAs), and 14 conditional MTAs significantly associated (p &lt; 10−4) with four quality traits were found to be distributed on 15 chromosomes, with the phenotypic variation explained (PVE) ranging from 5.35% to 39.86%. …”
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Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells by Y. Sbirkov, Y. Sbirkov, Y. Sbirkov, T. Schenk, T. Schenk, T. Schenk, C. Kwok, S. Stengel, S. Stengel, R. Brown, G. Brown, L. Chesler, A. Zelent, A. Zelent, M. J. Fuchter, K. Petrie, K. Petrie

“…Furthermore, transcriptomic analysis revealed that in contrast to treatment with GSK-343, HKMTI-1-005 upregulated the expression of differentiation pathway genes with and without ATRA, while downregulating genes associated with a hematopoietic stem cell phenotype. These results pointed to a non-canonical role for EZH2, which was supported by the finding that EZH2 associates with the master regulator of myeloid differentiation, RARα, in an ATRA-dependent manner that was enhanced by HKMTI-1-005, possibly playing a role in co-regulator complex exchange during transcriptional activation. …”
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Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS) by Ruhee Patel, Stephanie Cosentino, Esther Zhiwei Zheng, Nicole Schupf, Sandra Barral, Mary Feitosa, Stacy L. Andersen, Paola Sebastiani, Svetlana Ukraintseva, Kaare Christensen, Joseph Zmuda, Bharat Thyagarajan, Yian Gu

“…Background and objectives: We previously found a substantial familial aggregation of healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. …”
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Peritumoral tertiary lymphoid structure and tumor stroma percentage predict the prognosis of patients with non-metastatic colorectal cancer by Qianyu Wang, Xiaofei Shen, Ran An, Junchao Bai, Junhua Dong, Huiyun Cai, Hongyan Zhu, Wentao Zhong, Wentao Zhong, Wenliang Chen, Wenliang Chen, Aijun Liu, Junfeng Du, Junfeng Du, Junfeng Du

“…The tumor stroma has a powerful immunosuppressive function that could exclude tumor-infiltrating lymphocytes from the tumor beds and lead to a “cold” phenotype. TLSs and tumor stroma percentage (TSP) are significantly associated with the prognosis of patients with certain cancers. …”
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Identification, Association of Natural Variation and Expression Analysis of <i>ZmNAC9</i> Gene Response to Low Phosphorus in Maize Seedling Stage by Javed Hussain Sahito, Xiao Zhang, Haixu Zhong, Xuan He, Chen Zhen, Peng Ma, Bowen Luo, Dan Liu, Ling Wu, Muhammad Hayder Bin Khalid, Hakim Ali Sahito, Zeeshan Ghulam Nabi Gishkori, Asif Ali, Shibin Gao

“…Haplotypes carrying more favorable alleles exhibited superior effects on phenotypic variation and could be helpful in developing molecular markers in maize molecular breeding programs. …”
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IL6/adiponectin/HMGB1 feedback loop mediates adipocyte and macrophage crosstalk and M2 polarization after myocardial infarction by Yue Zheng, Yue Zheng, Yue Zheng, Yuchao Wang, Yuchao Wang, Yuchao Wang, Bingcai Qi, Bingcai Qi, Bingcai Qi, Yuheng Lang, Yuheng Lang, Yuheng Lang, Zhibin Zhang, Zhibin Zhang, Zhibin Zhang, Jie Ma, Minming Lou, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Yun Chang, Yun Chang, Yun Chang, Qiang Zhao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Tong Li, Tong Li, Tong Li, Tong Li, Tong Li

“…In vivo, ADPN promoted lymphangiogenesis and decreased myocardial injury after MI. These phenotypes were rescued by macrophage depletion or HMGB1 knockdown in macrophages. …”
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Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials by Beau J. Fenner, Beau J. Fenner, Beau J. Fenner, Beau J. Fenner, Beau J. Fenner, Jonathan F. Russell, Jonathan F. Russell, Arlene V. Drack, Arlene V. Drack, Alina V. Dumitrescu, Alina V. Dumitrescu, Elliott H. Sohn, Elliott H. Sohn, Stephen R. Russell, Stephen R. Russell, H. Culver Boldt, H. Culver Boldt, Louisa M. Affatigato, Jeremy M. Hoffmann, Jeaneen L. Andorf, Edwin M. Stone, Edwin M. Stone, Ian C. Han, Ian C. Han

“…RS1 null genotypes had greater odds of at least moderate visual impairment at final follow-up (OR 7.81; 95% CI 2.17, 28.10; p = 0.002) which was independent of age at onset, initial CST, initial ORA, or previous RD.DiscussionOverall, long-term follow-up of XLRS patients demonstrated relatively stable VA, with presenting CST, development of ORA, and null RS1 mutations associated with poorer long-term visual outcomes, indicating a clinically relevant genotype-phenotype correlation in XLRS.…”
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Screening of Candidate Genes Associated with Brown Stripe Resistance in Sugarcane via BSR-seq Analysis by Wei Cheng, Zhoutao Wang, Fu Xu, Guilong Lu, Yachun Su, Qibin Wu, Ting Wang, Youxiong Que, Liping Xu

“…However, its outbreaks and epidemics require suitable climatic conditions, resulting in the inefficient improvement of the SBS resistance by phenotype selection. The sugarcane F₁ population of SBS-resistant YT93-159 × SBS-susceptible ROC22 was used for constructing the bulks. …”
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Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analysesResearch in context by Nikos Papadimitriou, Conghui Qu, Tabitha A. Harrison, Alaina M. Bever, Richard M. Martin, Konstantinos K. Tsilidis, Polly A. Newcomb, Stephen N. Thibodeau, Christina C. Newton, Caroline Y. Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J. Pellatt, Robert E. Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D. Buchanan, Brigid M. Lynch, Stephen B. Gruber, Yin Cao, Li Hsu, Jeroen R. Huyghe, Yi Lin, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H. Zaidi, Amanda E. Toland, Sonja I. Berndt, Wen-Yi Huang, Elom K. Aglago, David A. Drew, Amy J. French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A. Nowak, Claire E. Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A. Jenkins, Marc J. Gunter, Peter T. Campbell, Ulrike Peters, Mingyang Song, Amanda I. Phipps, Neil Murphy

“…Methods: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations). …”
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Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers by Spencer R. Rosario, Bowen Dong, Yali Zhang, Hua-Hsin Hsiao, Emily Isenhart, Jianmin Wang, Erin M. Siegel, Arta M. Monjazeb, Dwight H. Owen, Prasenjit Dey, Fred K. Tabung, Daniel J. Spakowicz, William J. Murphy, Stephen Edge, Sai Yendamuri, Sami Ibrahimi, Jill M. Kolesar, Patsy H. McDonald, Deepak Vadehra, Michelle Churchman, Song Liu, Pawel Kalinski, Sarbajit Mukherjee

“…Further, these alterations, such as kynurenine and tryptophan metabolism, which impact both metabolism and immune phenotype, vary with sex and obesity together. This study warrants further in-depth investigation into obesity and sex-related alterations in cancers that may better define biomarkers of response to immunotherapy.…”
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Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients by Anna Grigorevna Sorokina, Yana Arturovna Orlova, Olga Aleksandrovna Grigorieva, Ekaterina Sergeevna Novoseletskaya, Nataliya Andreevna Basalova, Natalya Andreevna Alexandrushkina, Maksim Aleksandrovich Vigovskiy, Karina Igorevna Kirillova, Alexander Vladimirovich Balatsky, Larisa Mihailovna Samokhodskaya, Natalya Vladimirovna Danilova, Uliana Denisovna Dyachkova, Victor Victorovich Kakotkin, David Albertovich Asratyan, Zhanna Alekseevna Akopyan, Anastasia Yurievna Efimenko

“…Systemic senescent cell-associated factors (insulin-like growth factor 1 (IGF-1), fibroblast growth factor 21 (FGF-21), osteoprogerin, ferritin, soluble vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule 1 (ICAM-1)) in peripheral blood as well as senescence-associated secretory phenotype (SASP) components in MSC and FB secretome were evaluated by ELISA. …”
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